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superoxide dismutase (bSOD, OXIS / Orgotase / Peroxinorm)

✓ Approved

GT Biopharma, Inc. · 治疗药物

什么是 superoxide dismutase？

superoxide dismutase 是一种治疗药物，由GT Biopharma, Inc.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名bSOD, OXIS, Orgotase, Peroxinorm
公司GT Biopharma, Inc.
状态Approved
来源： ClinicalTrials.gov, GT Biopharma, Inc.

治疗适应症

superoxide dismutase 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersAmyotrophic lateral sclerosis✓ Approved
Musculoskeletal and connective tissue disordersArthritis✓ Approved

相关研究文献

PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Involvement of SIX9 in Growth and Pathogenicity in Fusarium oxysporum f. sp. fragariae.

Li Long L, Yang Wenbo W, Mao Chengxing C, Liu Yahui Y et al.

Strawberries, as an important economic crop, are widely planted worldwide. Fusarium oxysporum, belonging to FOSC (Fusarium oxysporum species complex), is widely present in plants. Among them, Fusarium oxysporum f. sp. fragariae (Fof) is one of the most important pathogens on strawberry and has pathogenic specificity toward strawberry hosts. In recent years, diseases caused by Fof have seriously threatened the strawberry industry. Secreted in Xylem (SIX) genes play important and different roles in F. oxysporum. In this study, we knocked out SIX9 in Fof to analyze its functions. The mycelial growth rate of ΔFofSIX9 was significantly lower than that of the wild type, but the difference in spore production was not significant. The pathogenicity of ΔFofSIX9 toward four different representative strawberry varieties was significantly reduced, manifested by the decrease in the severity of plant wilt, root rot, and crown rot. In addition, compared to the wild type, the activities of superoxide dismutase (SOD) and catalase (CAT) in ΔFofSIX9-infected plants were significantly increased, while the content of malondialdehyde (MDA), hydrogen peroxide (H2O2), and superoxide anion (O2-) were significantly decreased. So ∆FofSIX9 could reduce the pathogenicity of the wild type by affecting the host plant's defense response against infection of Fof.

PMID 42506237
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PubMedJournal of biochemical and molecular toxicology2026-07-27

Protective Potential of Vinpocetine on Acrylamide Induced Liver Toxicity in Male Albino Rats.

Shaheen Eman M S EMS, El-Maksoud Marwa A E Abd MAEA

Acrylamide is a highly reactive carbonyl compound extensively utilized in industrial applications. It shows a significant association with oxidative stress, neurotoxic, and genotoxic effects. This study sought to assess the protective effects of vinpocetine, a synthetic analog of the natural alkaloid vincamine, which exhibits strong antioxidant and anti-inflammatory properties, against ACR-induced hepatic injury. Experimental animals were categorized into four groups and orally treated as follows: control group, Vinpo. group (5 mg/kg bw), Acrylamide group (38.27 mg/kg bw), and Vinpo. plus acrylamide group. Following the experimental period, biochemical analyses revealed that ACR administration significantly elevated hepatic marker enzymes and lipid profile as well as increased oxidative stress markers such as malondialdehyde (MDA) and tumor necrosis factor (TNF-α) immunoexpression levels, with concomitant reductions in antioxidant defenses (catalase "CAT" and superoxide dismutase "SOD"). Conversely, co-administration of vinpocetine mitigated the ACR-induced alterations and helped in the normalization of biochemical parameters, enhancing antioxidant capacity and attenuation of histopathological damage and apoptotic processes.

PMID 42504613
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PubMedJournal of studies on alcohol and drugs2026-07-27

High-Intensity Interval Training Ameliorates Oxidative Stress and Mitophagy in Heart Tissue of Healthy Rats Following the Combination Use of Methylphenidate and Ethanol.

Shirazpour Sara S, Sepehri Gholamreza G, Rostamzadeh Farzaneh F, Mansouri Sobhan S et al.

The concurrent consumption of methylphenidate (MPD) and ethanol are prevalent among young individuals and those diagnosed with attention deficit hyperactivity disorder (ADHD). This study investigated the effects of high-intensity interval training (HIIT) on probable cardiac complications caused by the combined use of MPD and ethanol (ET), with a particular focus on oxidative stress and mitochondrial fission, fusion and mitophagy. This study was carried on male Wistar rats that received saline (CTL), HIIT, MPD, ET, MPD+ET, or a combination of HIIT with MPD, ET, or MPD+ET. Cardiac tissue damage and fibrosis were assessed using hematoxylin and eosin and Masson's trichrome staining. The expression of mRNAs was quantified using Real-time PCR, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and malondialdehyde (MDA) levels were measured, calorimetrically. The combination of ET and MPD increased the levels of MDA, decreased the activity of SOD and GPX, and increased mRNA expression of DRP1, PINK, and Parkin compared to the CTL group. HIIT was associated with a significant reduction in oxidative stress and mitochondrial fission and mitophagy parameters in ethanol and MPD treated groups. HIIT reduced histopathological changes in MDA+ET group and fibrosis in groups receiving ET and combination of MDA and ET. The findings of this study showed that HIIT intervention could be associated with significant reduction in adverse effects of concurrent consumption of MPD and ethanol on oxidative stress, mitochondrial fission and mitophagy, and injury in heart of healthy male rats.

PMID 42504879
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PubMedToxins2026-07-27

Aflrpn4 Represents a Promising Target for Mitigating Aspergillus flavus Growth and Aflatoxin Contamination.

Liu Xingsai X, Xin Yanli Y, Sahibzada Kashif Iqbal KI, Zhang Xiujia X et al.

Aspergillus flavus and its primary secondary metabolite, aflatoxin B1, pose a persistent threat to global food security and public health, highlighting the need to identify novel molecular targets for the development of highly specific fungicides. In this study, the transcription factor Aflrpn4 was investigated by constructing gene deletion and complementation strains to elucidate its regulatory mechanisms in controlling the growth, development, and pathogenicity of A. flavus. Phenotypic analysis revealed that, compared with the wild-type and complemented strains, loss of Aflrpn4 severely restricted radial colony growth, reduced conidial yield, and caused structural defects in conidiophores. Furthermore, AFB1 content was reduced by 52% compared with the wild-type. In storage simulation assays using peanut and maize kernels, the ΔAflrpn4 strain exhibited significantly compromised colonization capacity, reduced biomass, and lower AFB1 accumulation. Under aflatoxin-inducing YES culture conditions, deletion of Aflrpn4 was associated with significant downregulation of key pathway-specific regulatory and structural genes, including aflR, aflS, and aflP. Furthermore, under osmotic stress induced by 1.2 M NaCl and KCl, the growth inhibition rates of the ΔAflrpn4 strain reached 70% and 59%, respectively, and cell membrane integrity was severely compromised. Loss of Aflrpn4 also disrupted intracellular redox homeostasis, characterized by a significant decrease in superoxide dismutase activity, compensatory increases in catalase and peroxidase activities, and substantial accumulation of reactive oxygen species. Collectively, these findings demonstrate that Aflrpn4 acts as a pivotal regulator coordinating vegetative growth, asexual development, stress adaptation, and aflatoxin biosynthesis in A. flavus. Consequently, Aflrpn4 represents a promising molecular target for developing targeted interventions to control A. flavus and aflatoxin contamination during grain storage.

PMID 42506704
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PubMedMetabolites2026-07-27

Impact of Ear Stage Drought Stress on Yield and Rhizosphere Metagenomic Profiles in Maize Cultivars with Contrasting Drought Tolerance.

Lu Qi Q, Zhao Hongqun H, RuKeye Kureshi K, Geng Yao Y et al.

Background/Objectives: Drought stress is a primary constraint on maize productivity, yet the role of rhizosphere microbial communities in modulating cultivar-specific drought resilience remains poorly understood. This study aimed to investigate the physiological and microbiome-mediated responses underlying differences in drought tolerance between contrasting cultivars to better understand drought tolerance mechanisms. Methods: Two maize cultivars with contrasting drought tolerance-NK718 (tolerant) and Zhongdan 808 (sensitive)-were subjected to drought stress at the V12 stage. We assessed yield components, oxidative stress indicators (Malondialdehyde (MDA)), and antioxidant enzyme activities (Superoxide Dismutase (SOD), Peroxidase (POD), Catalase (CAT)). Metagenomic sequencing was employed to analyze structural and functional shifts in the rhizosphere microbiota. Results: Drought significantly suppressed yield and physiological performance in both cultivars. However, the sensitive cultivar suffered more pronounced yield losses and severe oxidative stress, indicated by elevated Malondialdehyde (MDA) and decreased antioxidant enzyme activities. Conversely, the tolerant cultivar maintained superior physiological homeostasis. Metagenomic sequencing revealed drought-induced microbial shifts, including decreased Proteobacteria and Ascomycota, alongside increased Actinobacteriota and Mucoromycota. Notably, the drought-tolerant cultivar exhibited enhanced microbial community stability and more complex co-occurrence networks. Furthermore, it enriched specific functional pathways, such as phenylpropanoid biosynthesis, which positively correlated with yield stability and antioxidant capacity. Conclusions: Maize drought tolerance is underpinned by the coordinated regulation of plant physiological adaptation and the structural and functional stabilization of the rhizosphere microbiome. These findings offer a theoretical framework for developing breeding strategies that leverage root-microbe interactions to optimize maize yields under water-limited conditions.

PMID 42506444
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PubMedJournal of the science of food and agriculture2026-07-27

Effects of exogenous glycine betaine on isoflavone accumulation in germinated soybeans under UV-B irradiation.

Xue Dongyu D, Li Man M, Cheng Fansheng F, Zhu Dan D et al.

Isoflavones, the key phenolic compounds in soybeans, can help scavenge free radicals and reduce oxidative damage in humans. Germination can promote isoflavone accumulation in soybeans, and UV-B irradiation during germination further enhances this effect. However, UV-B also induces oxidative stress and inhibits the growth of germinated soybeans. Here we report the effects of glycine betaine (GB), a plant growth regulator on growth, isoflavone content, and antioxidant defense systems of germinated soybeans under UV-B irradiation. This study explored the effects of glycine betaine (GB) on the growth, isoflavone content and antioxidant system of germinated soybeans under UV-B irradiation. UV-B irradiation reduced the length, fresh weight and dry weight of germinated soybeans, at the same time as increasing the isoflavone content by 4.08 g kg-1. UV-B + GB reversed growth inhibition, further increased isoflavone content by 4.71 g kg-1, and enhanced isoflavone biosynthetic key enzyme activities (PAL, C4H and 4CL by 88.81%, 47.51% and 70.76%) and gene expression (PAL, C4H and 4CL by 56.22%, 110.43% and 75.23%). UV-B + GB also enhanced the activities of antioxidant enzymes (superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) and ascorbate peroxidase (APX) increased by 14.68%, 60.95%, 49.59% and 52.21%, respectively) and up-regulated the expression of their corresponding genes (SOD, POD, CAT and APX increased by 15.72%, 48.14%, 50.35% and 46.91%, respectively). Meanwhile, UV-B + GB significantly reduced the levels of oxidative stress. Hydrogen peroxide, malondialdehyde and electrolyte leakage decreased by 16.52%, 19.62% and 8.47%, respectively. These results demonstrate that GB enhances isoflavone accumulation and antioxidant defense, alleviates oxidative damage, and promotes the growth of germinated soybeans under UV-B stress. © 2026 Society of Chemical Industry.

PMID 42503736
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