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tuberculosis vaccine

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SK Chemicals · 细胞治疗 · 细胞治疗

什么是 tuberculosis vaccine？

tuberculosis vaccine 是一种细胞治疗，由SK Chemicals研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intradermal Injection。

药物档案

公司SK Chemicals
药物类别细胞治疗, 疫苗
给药途径Injectable (Others), Intradermal Injection
状态Approved
来源： ClinicalTrials.gov, SK Chemicals

相关研究文献

PubMedFrontiers in immunology2026-09-10

A bivalent oral yeast vaccine displaying Nocardia seriolae FHA and LMBV MCP confers protection in largemouth bass (Micropterus salmoides).

Lu Jianfei J, Gu Boge B, Yu Pengzhen P, Chen Jiong J

Largemouth bass ranavirus (LMBV) and Nocardia seriolae are major pathogens affecting largemouth bass (Micropterus salmoides), causing significant economic losses. In this study, recombinant yeasts expressing the fibronectin-binding protein A (FHA) of N. seriolae or the major capsid protein (MCP) of LMBV were constructed using the yeast surface display (YSD) system. Based on these recombinant strains, a bivalent oral yeast-based vaccine was developed and its protective efficacy was systematically evaluated. Oral administration of the vaccine induced specific antibodies against FHA and MCP in serum, as well as increased the transcription levels of adaptive immune genes (IgM, IgT, MHC-II) and innate immune genes (IL-1β, TNF-α, IFN-1, Mx2) in the hindgut, liver, and spleen. Importantly, the bivalent oral vaccine provided significant protection against both pathogens in largemouth bass, with relative percent survival (RPS) values of 56.7% against N. seriolae and 63.3% against LMBV. Meanwhile, the oral vaccine reduced pathogen loads and alleviated histopathological lesions. In summary, these findings suggest that the bivalent oral vaccine developed in this study could serve as a promising strategy for controlling N. seriolae and LMBV infections in largemouth bass aquaculture.

PMID 42718698
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PubMedClinical case reports2026-09-10

Laparoscopy and Peritoneal Biopsy in the Diagnosis of Peritoneal Tuberculosis: A Case Report.

Gundapaneni Sri Ram Charan SRC, Divity Shravani S, Banka Amulya Varshini AV, Burri Rithwik Goud RG et al.

A 48-year-old male was initially diagnosed with pulmonary tuberculosis (TB) based on presenting symptoms, abdominal complications, and systemic symptoms, despite anti-TB treatment. Diagnostic laparoscopy and histopathological examination of biopsy samples confirmed peritoneal TB, leading to an adjusted anti-TB regimen and significant clinical improvement over six months.

PMID 42719061
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PubMedRSC medicinal chemistry2026-09-10

Development of macrocyclic peptide inhibitors of Mycobacterium tuberculosis MurF via mRNA display with genetic reprogramming.

Carlos Patrick W PW, Franck Charlotte C, Clarke-Shepperson Caitlin E CE, Strong Emily J EJ et al.

The development of new antibacterials for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains critical due to the continued global burden of disease and the emergence of multi-drug resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains. The MurF enzyme, which catalyses the ATP-dependent ligation of d-Ala-d-Ala to a UDP-MurNAc-tripeptide precursor in peptidoglycan biosynthesis, represents a promising therapeutic target. In this work, random non-standard peptide integrated discovery (RaPID) mRNA display with genetic reprogramming of a non-canonical uracil-derived amino acid was applied to Mtb MurF, leading to the identification of several high-affinity thioether-linked cyclic peptide ligands, several of which also inhibited the catalytic activity of the Mtb MurX enzyme.

PMID 42719787
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PubMedReumatismo2026-09-10

An overview of the relation between tuberculosis and autoantibodies: a systematic review.

Mohamadzadeh Dena D, Assar Shirin S, Farsad Faraneh F

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global health concern. While traditionally viewed as an infectious disease primarily affecting the lungs, accumulating evidence suggests a complex interplay between TB and the host's immune system, potentially leading to the production of autoantibodies. This systematic review aims to investigate the frequency of autoantibody positivity among active TB patients. A comprehensive search of major electronic databases such as PubMed, Scopus, Google Scholar, and Web of Science was performed. The search strategy employed keywords including "tuberculosis", "autoantibodies", and specific autoantibody names such as "ANA", "Anti-dsDNA", "Anti-phospholipid", "ANCA", "RF" and "ACPA" to study the link between TB and autoantibodies. How often autoantibodies are found in TB patients and what this means for diagnosis and treatment, was analyzed. The results indicate a diverse spectrum of autoantibodies among patients with TB. Some of the autoantibodies, such as rheumatoid factor and anti-phospholipid antibodies, are frequently detected. This can pose diagnostic challenges by mimicking autoimmune diseases and may have implications for monitoring treatment response. Furthermore, the bidirectional relationship between TB and autoimmune diseases, where one can increase the risk of the other, underscores the need for careful clinical consideration. Understanding this complex association is crucial for improving the management of TB, especially in individuals with or at risk of autoimmune conditions.

PMID 42719997
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PubMedRSC advances2026-09-10

Discovery of new diaminoquinazolines against Mycobacterium tuberculosis: chemical synthesis and in vitro evaluation.

Kore Mukul M, Sundaramoorthy Niranjana Sri NS, Kidwai Saqib S, Singh Ramandeep R et al.

Despite the availability of multiple treatment options, the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains presents a significant health concern worldwide. This necessitates the development of novel antitubercular agents with distinct mechanisms of action. Diaminoquinazolines (DAQs) have demonstrated antimicrobial and antiparasitic potential, yet their exploration against Mtb remains underexplored. To expand the DAQ SAR, we have synthesized diverse derivatives featuring novel C2/C4 amine combinations and core modifications and evaluated their activity against Mtb. SAR analysis identified 1-benzylpiperidin-4-amine at C4 paired with 4-phenoxyaniline at C2 as optimal, delivering analogues 14c and 14f-14k with potent activity against wild-type and MDR Mtb strains. The analogues were also active against M. bovis BCG harboring mutations in mmpL3, hadC and katG, indicating these targets are not involved in DAQs mechanism of action. Therefore, these DAQ analogues offer promising starting points for the design of molecules against drug-resistant tuberculosis.

PMID 42719720
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PubMedMicrobiology resource announcements2026-09-10

Genomic characterization of the attenuated human cytomegalovirus strain TR-VAC developed for subviral particle vaccine production.

Schmidt Hanno H, Hewel Charlotte C, Büscher Nicole N, Linke Matthias M et al.

We report the complete genome sequence of the attenuated human cytomegalovirus strain TR-VAC, developed for subviral particle vaccine production. Oxford Nanopore duplex sequencing confirmed all engineered modifications, including UL130 repair, UL25 stop codons, ddFKBP insertion, GFP deletion, and retention of the bacterial artificial chromosome backbone, without large-scale structural rearrangements.

PMID 42720293
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