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miriplatin hydrate (miriplatin hydrate / SMP 11355 / Miripla)

✓ Approved

Sumitomo Pharma Co., Ltd. · 小分子 · 小分子

什么是 miriplatin hydrate？

miriplatin hydrate 是一种小分子，由Sumitomo Pharma Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intraarterial Injection。

药物档案

商品名miriplatin hydrate, SMP 11355, Miripla
公司Sumitomo Pharma Co., Ltd.
药物类别小分子
给药途径Injectable (Others), Intraarterial Injection
状态Approved
来源： ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

治疗适应症

miriplatin hydrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hepatic cancer✓ Approved

相关研究文献

PubMedJournal of agricultural and food chemistry2026-07-27

Selective Fractionation of Larch into Oligosaccharides and Less-Condensed Lignin in a Novel Molten Salt/n-Butanol System.

Huang Yuetong Y, Zhang Xinyan X, Liu Qiyu Q, Ma Qiaozhi Q et al.

Efficient fractionation of lignocellulosic components is a prerequisite for full-component utilization. Conventional methods rely on harsh conditions, causing severe degradation of cellulose and hemicellulose and lignin condensation, while milder conditions compromise fractionation efficiency. To balance native structure preservation and fractionation efficiency, a biphasic system composed of lithium bromide molten salt hydrate (MSH) and n-butanol was developed. At 110 °C for 1 h, cellulose and hemicellulose were selectively hydrolyzed into oligosaccharides in the MSH phase with yields of 81.4% and 88.1%, respectively. The isolated lignin retained 96.1% of β-O-4 ether bonds (38.5/100 C9 units), and its catalytic hydrogenolysis delivered a monophenol yield of 82.1% to the theoretical value. The light-colored lignin (ΔE = 31.28) achieved SPF 28.2 as a sole sunscreen active ingredient, demonstrating commercial potential. This biphasic system enables highly selective fractionation of lignocellulosic components with limited condensation, yielding key feedstocks for bioenergy and biorefinery, including oligosaccharides and native structure-preserved lignin.

PMID 42504519
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PubMedEuropean journal of pediatrics2026-07-27

Febrile seizure during the acute phase of Kawasaki disease: a Korean nationwide cohort study.

Choi Hee Joung HJ, Gwon So Hyeon SH, Son Nak-Hoon NH, Byun Jun Chul JC

This study aimed to investigate the characteristics of febrile seizure (FS) associated with Kawasaki disease (KD) using nationwide population-based data. Children aged ≤ 5 years were analyzed using claims data from the Korean Health Insurance Review and Assessment Service between 2007 and 2022. FS and KD were identified using ICD-10 codes R56.0 and M30.3, respectively. Clinical characteristics were compared between FS associated with KD (KD-FS) and FS without KD (non-KD-FS). Of 1,230,434 children with FS, 1,683 (0.1%) had concomitant KD. Children with KD-FS were younger (1.66 vs. 1.81 years, p < 0.0001) and more likely to be male (58.8% vs. 55.9%, p = 0.0163) than those with non-KD-FS. During the coronavirus disease 2019 pandemic, the overall incidence of FS decreased markedly, whereas that of KD-FS increased. KD-FS occurred more frequently in winter and showed a distinct seasonal pattern, whereas the incidence of non-KD-FS peaked in summer. Children with KD-FS were more frequently treated in secondary or tertiary hospitals and had longer hospital stays. Chloral hydrate and acute/emergency anticonvulsants were more frequently administered in the KD-FS group; however, maintenance anticonvulsant use did not differ. Cerebrospinal fluid analysis and brain computed tomography were performed more frequently in the KD-FS group; brain magnetic resonance imaging and electroencephalography utilization and mortality rates were comparable. KD-FS is rare and does not appear to be associated with a more severe neurological course than non-KD-FS. • Kawasaki disease (KD) is a systemic vasculitis that can be accompanied by neurological manifestations, including febrile seizures (FS). • FS during acute KD is rare and remain insufficiently characterized in large population-based studies. • In this nationwide study, FS associated with KD are rare but show distinct demographic and seasonal features, including younger age and winter predominance. • However, FS associated with KD are not associated with worse neurological outcomes or mortality compared with non-KD febrile seizures.

PMID 42503538
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PubMedSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2026-07-25

Raman characterization for vibrations of aqueous methanediol and its oligomers.

Tsai Cheng-Te CT, Chiu Cheng-Chau CC, Qiu Liang-Yu LY, Wu Pei-Chen PC et al.

Methanediol (CH2(OH)2) and its oligomers, HO(CH2O)nH (with n≥2), in aqueous phase are regarded to play a role in the multiphase chemistry of the atmosphere. However, the unambiguous characterization of these species via spectroscopic analysis remains limited. In this work, a Raman spectroscopic analysis was conducted on aqueous solutions of formaldehyde where its hydrate, i.e., methanediol, and corresponding formation of its oligomers (n up to 3) were equilibrated. And then, a spectral decomposition of the Raman data was performed to extract the individual Raman spectra of the monomer, dimer and trimer. The retrieved Raman features of these species were further assigned via theoretical calculation on the basis of density functional theory calculations. The results reveal that only oligomer species, i.e., dimer and trimer, exhibit two characteristic COC stretching bands at 921cm-1 and 1121cm-1 and one characteristic CH2 rocking mode near 1319cm-1. Notably, the trimer is distinguished by an additional COC stretching band near 937cm-1. The characteristic OCO stretching band of the monomer near 1048cm-1 exhibits a moderate shift to 1063cm-1 upon oligomerization into the dimer and trimer.

PMID 42501436
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PubMedFrontiers in pharmacology2026-07-25

Fibroblast growth factor 2 (FGF2) modulates the excitability of brain noradrenergic and serotonergic neurons: possible involvement of FGFR1 and FGFR4 receptors.

Paliokha Ruslan R, Racicky Matej M, Grinchii Daniil D, Khoury Talah T et al.

Fibroblast growth factor 2 (FGF2), in addition to its primary function in the connective tissue, plays also a role in the central nervous system (CNS). Thus, anxiolytic, antidepressant, and pro-addictive properties of this molecule have been reported. Our previous study showed that pro-alcohol consumption effect of FGF2 is mediated, at least in part, via its interaction with the central dopaminergic system. The present study aimed to test the hypothesis that pro-addictive and/or antidepressant-like effects of FGF2 can also be linked with FGF2-noradrenaline and FGF2-serotonin (5-HT) interactions. Adult male Wistar rats, weighing 250-350 g, were treated with the recombinant FGF2, selective inhibitors of FGFR1 (PD173074), FGFR2 (lirafugratinib), FGFR4 (BLU9931), or corresponding vehicle. The excitability of the noradrenergic neurons of the locus coeruleus (LC) and serotonergic (5-HT) neurons of the dorsal raphe nucleus (DRN) was assessed using the single-unit in vivo electrophysiology under chloral hydrate anesthesia. We found that FGF2 stimulated the burst firing of noradrenergic neurons and inhibited the burst firing of 5-HT neurons. PD173074 decreased the density of the spontaneously active noradrenergic neurons in the locus coeruleus, whereas BLU9931 had a stimulatory effect on the burst activity of 5-HT neurons. The psychoactive effects of the FGF2 might be mediated, at least in part, via its interaction with the central monoaminergic circuits. The FGF2-catecholaminergic interactions are putatively mediated via FGFR1, and FGF2-5-HT-crosstalk-via FGFR4. These two receptors can be thus potential targets for the future CNS drugs.

PMID 42499486
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PubMedACS omega2026-07-24

Hydrates-Based Separation of CH4/N2 Gas Using Copper Foam and Chemical Promoters.

Wang Lanyun L, Lv Zecheng Z, Mu Shifang S, Xu Yongliang Y et al.

Hydrate-based gas separation (HBGS) offers a safe and promising route for capturing low-concentration coalbed methane (CH4). Herein, the formation behavior of CH4 hydrates promoted by 1,3-dioxolane (1,3-DIOX) and porous copper foam (CF) was systematically investigated. Experimental results demonstrated that the combined use of CF (60 PPI) and 5.56 mol % 1,3-DIOX under a coupled spraying-stirring mode markedly accelerates hydrate formation, yielding a maximum gas storage capacity of 0.1733 mol CH4 per mole H2O at 3.0 MPa, which is 10.1 times higher than that of the static pure water system. At 4.0 MPa, the maximum capacity is 0.1244 mol CH4/mol H2O, which is 3.7 times higher than that of the static pure water system. Furthermore, due to the higher thermodynamic driving force, the induction time for the 10% CH4 system is shorter than that of the 5% system. Specifically, the induction time with 0.3 wt % l-leucine was 21.31%-40.38% shorter than that of the combined CF and 1,3-DIOX system. After single-stage separation, the CH4 content was effectively enriched from 5% to 8.0%-10.25% and from 10% to 17.9%-21.7%. Compared to l-leucine, the system containing sodium lignosulfonate demonstrated a higher CH4 concentration in the hydrate phase, indicating superior selectivity. The CH4 recovery rates for the feeding gas systems with 10% and 5% CH4 were approximately 40% and 50%, respectively. Comparing to the reported results in smaller reactors of 58-1000 mL, the comparable CH4 recovery here is realized in a much larger scale reactor of 3927 mL, which is really a great improvement. These findings confirm that the proposed CF/1,3-DIOX system is an effective strategy for the enrichment of low-concentration CBM, providing a viable technical route for multistage industrial separation processes.

PMID 42495277
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PubMedEFSA journal. European Food Safety Authority2026-07-24

Assessment of the feed additive consisting of zinc chelate of amino acids hydrate (3b606) for all animal species for the renewal of its authorisation (Zinpro Animal Nutrition (Europe), Inc.).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa Roberto Edoardo RE, Azimonti Giovanna G, Bonos Eleftherios E et al.

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of zinc chelate of amino acids hydrate as a feed additive for all animal species. The applicant has provided data demonstrating that the additive currently in the market complies with the conditions of authorisation. There is no new evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the FEEDAP Panel concludes that the additive remains safe for the target species and consumers. Regarding user safety, the additive is an eye irritant. It is also considered a skin and respiratory sensitiser. Exposure of users by any route is considered a risk and should be minimised. The FEEDAP Panel is not in a position to conclude on the environmental safety of the additive. The conclusions of the forthcoming opinion on the environmental risk assessment of trace elements are expected to be directly applicable to the present assessment and will inform the final evaluation. There is no need to assess the efficacy of the additive in the context of the renewal of the authorisation.

PMID 42494835
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