北京若生智能科技有限公司
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Oxalyt-C

✓ Approved

Rottapharm Madaus · 小分子 · 小分子

什么是 Oxalyt-C？

Oxalyt-C 是一种小分子，由Rottapharm Madaus研发。该药已获批，用于治疗相关适应症。

药物档案

公司Rottapharm Madaus
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Rottapharm Madaus

治疗适应症

Oxalyt-C 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersCalculus urinary✓ Approved

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PubMedComparative cytogenetics2026-09-10

First karyotype description of the Indochinese shrew Crocidura indochinensis Robinson et Kloss, 1922 (Mammalia, Eulipotyphla, Soricidae) from Yunnan, China.

Jin Jiayu J, Dai Jing J, Ye Jianping J

The small-sized Crocidura horsfieldii (Tomes, 1856) species complex, comprising C. watasei (Kuroda, 1924), C. tadae (Tokuda et Kano, 1936), C. kurodai (Jameson et Jones, 1977), C. wuchihensis (Wang, 1966), and C. indochinensis (Robinson et Kloss, 1922), has long been the subject of taxonomic confusion in the literature. Here, we report for the first time the karyotype of female C. indochinensis from Yongde Snow Mountain, based on conventional Giemsa staining and the GTG-banding technique. C. indochinensis has 2n = 38 and FN = 56. The autosomes consist of four metacentric or submetacentric pairs, four subtelocentric pairs, and ten acrocentric pairs, whereas the X chromosome is a medium-sized submetacentric. Our results demonstrate that the karyotype of C. indochinensis differs markedly in 2n and FN from those of C. horsfieldii, C. watasei, C. tadae and C. kurodai, providing further evidence for the distinct species status of C. indochinensis within this complex. Furthermore, comparative analysis of the G-banded chromosomes of C. indochinensis and C. dsinezumi revealed a high degree of karyotypic homology, with their karyotypes differing primarily by a single fusion/fission event and a centromeric shift or a pericentric inversion, thereby enhancing our understanding of karyotype evolution within the genus Crocidura Wagler, 1832.

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PubMedOphthalmic genetics2026-09-10

Novel mutations of PIKFYVE identified in 322 sporadic cataract patients.

Ni Jinglan J, Cui Yubo Y, Mei Shaoyi S, Hou Ziyi Z et al.

PIKFYVE, a novel pathogenic gene causing congenital cataract, its association with sporadic cataracts has not been systematically investigated. This study aimed to explore PIKFYVE mutation profiles in major sporadic cataract subtypes. We enrolled 322 sporadic cataract cases including 240 age-related cataract cases, 63 diabetes mellitus cataract cases and 19 high myopic cataract cases. One hundred seventy non -cataract individuals were enrolled as controls. PIKFYVE variants were initially screened using FastTarget region sequencing and validated by Sanger sequencing. Pathogenic impacts of variants were assessed using SIFT, PolyPhen-2, MutationTaster, ClinPred, ACMG and gnomAD databases, as well as Protein Three-Dimensional Structure Prediction and protein-protein interaction analysis. Eight PIKFYVE variants were identified in these cataract cases, including two novel variants (c.881T > A and c.4027C > T), and six known variants (c.1051-4G > T; c.1654A > G; c.2795C > G; c.5335G > T; c.5399A > C; and c.5594C > T). Among these variants, three variants (c.2795C > G; c.4027C > T; and c.5335G > T) were predicted to be in silico predicted deleterious on PIKFYVE protein function and alter normal protein conformation. We identified two novel variants and three in silico predicted deleterious variants on PIKFYVE gene in sporadic cataract patients. These findings expand the PIKFYVE mutation spectrum and indicate that PIKFYVE variants may potentially contribute to sporadic cataract pathogenesis.

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Comparative analyses on the structure, composition, and gene expression in seed coat of hulled and hull-less lines in Cucurbita moschata.

Shen Qiong Q, Liu Jiangtao J, Meng Hongyu H, Liu Yanan Y et al.

The escalating demand for hull-less Cucurbita moschata seeds, driven by a thorough comprehensive understanding of their functional properties and the global trade in pumpkin seeds, emphasizes the necessity to expedite the breeding of hull-less varieties to satisfy market requirements. Existing knowledge regarding hull-less seeds in pumpkins primarily stems from studies on C. pepo, where the lignin pathway is considered a significant factor; however, its significance in C. moschata remains unexplored. This study aims to investigate anatomical, compositional, and gene expression alterations in the seed coat of one hulled wild type (RHS-1) and three hull-less mutant recombinant inbred lines (RHLS-2, RHLS-3 and RHLS-4) at 20 DPA (days post anthesis) and 50 DPA in C. moschata. The anatomical changes in the seed coat of hulled and hull-less lines in C. moschata during seed coat development were comparable to those observed in C. pepo, with five distinct seed coat layers appearing in the hulled wild type but a papery thin layer (composed of the epidermis and sclerenchyma) in the hull-less mutants. However, compositional changes in pectin content in the seed coat of hulled and hull-less lines in C. moschata differed from those in C. pepo. Specifically, the seed coat of hull-less mutants exhibited higher pectin levels than that of hulled wild type. Additionally, the expression of three lignin biosynthesis genes (CmoC4H, Cmo4CL, and CmoCCR) was upregulated at 50 DPA, which was contrary to the patterns observed in C. pepo. In summary, our results revealed both conserved and distinct features of the seed coat development between C. moschata and C. pepo. These correlative findings provide comparative features of seed coat development in hulled and hull-less C. moschata lines and provide candidate genes for future functional studies.

PMID 42717307
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PubMedMovement disorders clinical practice2026-09-10

Lipid-Related Metabolic Dysregulation Affects Survival in Idiopathic Normal Pressure Hydrocephalus.

Bissacco Jacopo J, Mascioli Davide D, Simonetta Clara C, Mancini Maria M et al.

Idiopathic normal pressure hydrocephalus (iNPH) is associated with increased mortality and vascular-metabolic comorbidity, but prognostic biomarkers are lacking. To assess the triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio, an insulin resistance (IR) marker, and its associations with MRI glymphatic markers and mortality in iNPH. We conducted a dual-center longitudinal study including 67 iNPH patients and 37 matched controls. Baseline lipid profiles were assessed, enlarged perivascular spaces (EPVS) were rated on 3 T MRI in a subgroup, differences were tested by ANCOVA, and mortality associations by adjusted Cox models. iNPH patients showed higher triglycerides and TG/HDL-C and lower HDL-C. High-grade centrum semiovale (CSO)-EPVS were associated with higher TG/HDL-C. TG/HDL-C showed the strongest mortality association. A model combining TG/HDL-C with CSO-EPVS showed the best fit, suggesting synergy. iNPH exhibits a lipid profile associated with IR linked to glymphatic alterations and mortality. Moreover, despite requiring large-scale validation, combined-marker models are promising.

PMID 42717528
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PubMedVirulence2026-09-10

Coxiella burnetii establishes a small cell variant (SCV)-like persistent form to survive adverse intracellular conditions.

Asghar Faiza F, Hayek Inaya I, Bachmann Elke E, Berens Christian C et al.

Coxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Infections can be either acute or chronic. Of note, chronic Q fever can develop months or years after primary infection without clinical symptoms, suggesting bacterial persistence. Yet, information about the induction, regulation, and/or location of C. burnetii persistence is rare. We have shown that during infection of primary macrophages, hypoxia-induced citrate limitation results in inhibition of C. burnetii replication without affecting viability. Here, primary murine macrophages were infected with C. burnetii under normoxic (21% O2) and hypoxic (0.5% O2) conditions to clarify how C. burnetii survives this environmental stress condition. Our data suggest that under hypoxic conditions, C. burnetii does not undergo the stringent response, but instead enters an SCV-like form, which is smaller in size, possesses condensed chromatin material and a thicker cell wall. These changes have functional consequences, as the SCV-like persistent form of C. burnetii is more infectious, more tolerant to antibiotics and less sensitive to clearance by IFNγ activated macrophages. Hence, the development of the SCV-like persistent form of C. burnetii prevents elimination of the pathogen, which in turn allows the pathogen to thrive once the conditions again change in its favor.

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PubMedNature communications2026-09-10

Ti doping-induced strain engineering boosts low-temperature NH3-SCR deNOx performance and H2O/SO2 resistance of Ce8MnOx.

Guo Xuewen X, Hu Yongji Y, Wu Xiaoyi X, Shen Yuesong Y

H2O and SO2 poisoning of cerium-manganese oxide catalysts remains a critical challenge for low-temperature selective catalytic reduction of nitrogen oxides by NH3. Here we show that Ti doping of CeO2 induces lattice contraction and structural distortion, promoting the generation of oxygen vacancies, active oxygen species, and stable Ce-O-Ti interfaces. These strain-engineered structural modifications enhances surface Lewis acidity and triggers a downshift of the d-band center, collectively improving low-temperature catalytic activity and resistance to H2O/SO2 poisoning. The optimized Ce8MnTi2.5Ox catalyst achieves over 90% nitrogen oxides removal across a 150-335 °C temperature range. Under 5 vol.% water and 100 ppm SO2, it maintains over 98% efficiency for 12 h at 210 °C. Furthermore, during stepwise heating from 150 °C to 240 °C with 5 vol.% H2O and 200 ppm SO2, initial activity suppression below 180 °C is fully reversed at or above 210 °C, demonstrating temperature-driven regeneration. This study introduces a strain-engineering strategy for designing robust catalysts for low-temperature nitrogen oxides removal.

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