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Oxalyt-C

✓ Approved

Rottapharm Madaus · 小分子 · 小分子

什么是 Oxalyt-C？

Oxalyt-C 是一种小分子，由Rottapharm Madaus研发。该药已获批，用于治疗相关适应症。

药物档案

公司Rottapharm Madaus
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Rottapharm Madaus

治疗适应症

Oxalyt-C 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersCalculus urinary✓ Approved

相关研究文献

PubMedDiabetes, obesity & metabolism2026-10-26

Estimated sdLDL-C/LDL-C Discordance Is Associated With Advanced Cardiovascular-Kidney-Metabolic Syndrome, Incident Cardiovascular Disease and Mortality: Evidence From Two Population-Based Cohorts.

Sun Honglin H, Cui Ruixiang R, Jiang Lanxuan L, Liu Jia J et al.

sdLDL-C is a more atherogenic subfraction of LDL particles. We aimed to investigate the associations of sdLDL-C and its discordance with LDL-C with advanced stages, incident cardiovascular disease (CVD) and mortality among adults across the cardiovascular-kidney-metabolic (CKM) syndrome spectrum. This study included adults from two cohorts: 16 992 participants from the National Health and Nutrition Examination Survey (NHANES, 1999-2018) and 8252 from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2020) across CKM Stages 0-4. sdLDL-C was estimated (E-sdLDL-C) via Sampson's equation. Discordance was defined as an absolute E-sdLDL-C/LDL-C percentile difference of ≥ 10 percentiles. Logistic regression assessed advanced CKM, and Cox models evaluated associations with incident CVD in CHARLS and mortality in both cohorts. Survey-weighted analyses were applied in NHANES, and CHARLS models were fitted with community-level cluster-robust standard errors. Higher E-sdLDL-C at a given level of E-lbLDL-C and greater E-sdLDL-C/LDL-C discordance were each associated with increased advanced CKM prevalence across both cohorts (discordantly high vs. low in NHANES: OR: 2.89, 95% CI: 2.39-3.50). E-sdLDL-C at a given level of E-lbLDL-C was positively associated with incident CVD risk in CHARLS, whereas the discordance associations were attenuated after adjustment for baseline CKM stage. Each SD increment in discordance was associated with 15% higher all-cause and 20% higher cardiovascular mortality in NHANES, and 23% higher all-cause mortality in CHARLS. E-sdLDL-C and its discordance with LDL-C are associated with advanced CKM, incident CVD and mortality, suggesting that E-sdLDL-C/LDL-C discordance may reflect LDL-related lipid heterogeneity associated with adverse CKM outcomes.

PMID 42928050
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PubMedCell communication and signaling : CCS2026-10-26

Rhythmic-phasic c-di-AMP signaling: a new paradigm for bacterial growth synchronization governed by a pseudo-phosphodiesterase and modifiable diadenylate cyclase.

Adhikari Suraj S, Ghods Shirin S, Seelan Ratnam S RS, Hamidi Masoud M et al.

Cyclic di-adenosine monophosphate (c-di-AMP) is an essential bacterial second messenger that regulates bacterial physiology, survival, and pathogenesis. While current models describe c-di-AMP regulation as a linear synthesis-degradation paradigm through opposing activities of diadenylate cyclases (DACs) and c-di-AMP-specific phosphodiesterases (PDEs), they fail to capture the temporal complexity of c-di-AMP signaling dynamics in coordination with discrete growth-phase transitions, metabolic state, and redox homeostasis. In Porphyromonas gingivalis, a key Gram-negative proteolytic oral pathobiont relevant to oral and systemic disease, measurable canonical c-di-AMP degradation is absent, suggesting that c-di-AMP signaling operates through an atypical regulatory architecture mediated by the atypical phosphodiesterase PDEPg. Here, we identify rhythmic-phasic c-di-AMP signaling scheme in which PDEPg plays a critical role by coordinating with bacterial growth phase, metabolism, and cell cycle progression. We employed an integrated experimental and structural modeling framework that combined bacterial genetics, growth-phase-resolved nucleotide profiling, whole membrane fraction biochemical assays, untargeted metabolomics, transcriptomics, proteomics, post-translational modification profiling, ultrastructural transmission electron microscopy, structural modeling, and molecular dynamics simulations to dissect the pseudoenzymatic-controlled c-di-AMP regulatory module in P. gingivalis. This study demonstrates that growth phase synchronization in P. gingivalis requires rhythmic-phasic c-di-AMP signaling, characterized by coordinated depletion-replenishment episodes of intracellular c-di-AMP during growth-phase transitions. This regulatory network is orchestrated by two key components: the atypical HD-domain PDE homolog, PDEPg, and the conserved serine residue (Ser-226) within the DACPg SEE loop. PDEPg maintains c-di-AMP homeostasis through a noncanonical regulatory mechanism rather than through measurable PDE-mediated hydrolysis. Disruption of PDEPg profoundly remodels bacterial physiology, resulting in altered c-di-AMP dynamics, impaired peptide-dependent metabolic adaptation, disrupted ATP homeostasis, and widespread post-translational remodeling, including condition-specific phosphorylation of the c-di-AMP cyclase DACPg at the conserved Ser226 residue. Functional genetic analyses demonstrate that Ser226 is required for proper coordination of rhythmic-phasic c-di-AMP signaling and metabolic adaptation, while pantothenate-mediated rescue further supports the contribution of metabolic homeostasis to these processes. Along with structural modeling and molecular dynamics simulations, these findings support a model in which noncanonical regulatory protein (pseudoenzymatic function) PDEPg coordinates rhythmic-phasic c-di-AMP signaling and physiological adaptation in P. gingivalis. Together, our findings establish a new paradigm in bacterial second messenger signaling, showing that pseudoenzymatic scaffolds coordinate rhythmic c-di-AMP dynamics that synchronize nutrient acquisition, redox metabolism, and cell-cycle progression, with broad implications for microbial physiology and pathogenesis.

PMID 42928305
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PubMedJournal of materials chemistry. B2026-10-26

A self-powered Zn/C micro-galvanic electrospun membrane enhances osteoimmunomodulation and accelerates cranial defect regeneration.

Nie ZhiJun Z, Chen Jing J, Gao Dejian D, Chenzun et al.

The repair of critical-sized cranial defects remains challenging because passive membranes provide limited biochemical and bioelectrical cues. In this study, we fabricated a spatially patterned P/C-Zn/C electrospun membrane comprising a Zn-containing central region and a carbon-containing peripheral ring. During 28 days of immersion, the membrane exhibited time-dependent Zn release, limited pH variation in the tested medium, morphological changes, and retained a measurable voltage-generating capability. Additional in vitro groups comprising P/C with exogenous Zn2+ and P/C subjected to external electrical stimulation were evaluated separately to examine the contributions of the two cues. The complete P/C-Zn/C membrane produced the greatest osteogenic response and the strongest shift toward an M2-associated macrophage marker profile among the tested groups. In a rat critical-sized calvarial defect model, P/C-Zn/C was associated with an increased proportion of F4/80+CD206+ cells, a pro-regenerative tissue gene-expression profile, increased bone volume and BV/TV, and improved defect bridging and collagen deposition. These findings support complementary ionic and electrical contributions to the osteogenic and immunomodulatory performance of the membrane, while direct in vivo electrical measurements and temporal immune profiling remain necessary.

PMID 42930319
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PubMedRomanian journal of internal medicine = Revue roumaine de medecine interne2026-10-26

Achieving Risk-Specific Absolute LDL-C Threshold with PCSK9 Inhibitors: A Real-World, Single-Center Analysis.

Ciobanu Dana Mihaela DM, Berchișan Antonia A, Mălan Cosmina C, Rusu Adriana A et al.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors emerged as an effective treatment for hypercholesterolemia in clinical trials, however real-world evidence shows considerable heterogeneity. We aimed to assess the effectiveness and safety of injectable PCSK9 inhibitors in real-world patients. Our retrospective analysis included 45 consecutive adults, 18 (40%) men, mean age 57.4 years, inadequately controlled on, or intolerant to, statins and/or ezetimibe, and newly initiated on alirocumab 75 mg or 150 mg, evolocumab 140 mg, or inclisiran 284 mg. Biochemical parameters and adverse events were recorded at baseline and when LDL-C reached the risk-specific absolute threshold or the lowest LDL-C closest to it after starting PCSK9 inhibitors (<55 mg/dL very high, <70 mg/dL high cardiovascular risk, per European Society of Cardiology). LDL-C was also assessed at standardized time points (3, 6, 12, 18, 24 months). At 3 and 6 months, LDL-C decreased by a median of 54.4% and 59.2% (both p < 0.001), with 52.4% and 50.0% of patients below threshold. The best LDL-C reduction was 66.9% (from 145 mg/dL to 50 mg/dL; p < 0.001) at a median time to first documented threshold attainment of 5 months. In an exploratory analysis, no significant association was detected between LDL-C reduction and sex, diabetes, statin intensity or ezetimibe use. No clinically relevant hepatic or muscular toxicity was attributed to PCSK9 inhibitors. In real-world patients aiming to achieve the absolute LDL-C threshold on PCSK9 inhibitors, treatment was associated with marked LDL-C reduction after a median of 5 months.

PMID 42928644
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PubMedEuropean journal of investigation in health, psychology and education2026-10-26

Validation of the Brief Pathological Narcissism Inventory and Its Association with Cyber Intimate Partner Violence in Portuguese Emerging Adults.

Rego Mónica M, Caridade Sónia S

Cyber intimate partner violence (C-IPV) refers to abusive and controlling behaviors enacted through digital technologies toward a current or former intimate partner. Previous research suggests that pathological narcissism may be associated with C-IPV. This study examined the psychometric properties of the Brief Pathological Narcissism Inventory (B-PNI), the frequency of self-reported C-IPV perpetration and related behaviors, and the association between C-IPV perpetration and pathological narcissism among emerging adults. The sample comprised 371 participants aged 18-25 years (M = 21.52, SD = 1.97), of whom 78.7% were female. Confirmatory factor analysis provided support for the a priori two-factor model of the B-PNI (CFI = 0.982, TLI = 0.965, RMSEA = 0.076), comprising grandiose and vulnerable narcissism. The B-PNI showed satisfactory internal consistency and theoretically expected associations with psychopathological symptoms and broader personality dimensions. Overall, 79.5% of participants reported at least one C-IPV behavior, with 61.5% reporting online control, 62.0% online jealousy, and 31.5% online intrusive behaviors. C-IPV perpetration was positively and significantly associated with both grandiose and vulnerable narcissism, although the associations were small in magnitude. The findings provide preliminary support for the use of the B-PNI among Portuguese emerging adults and indicate that pathological narcissism is associated with C-IPV perpetration. Given the modest magnitude of these associations, narcissistic traits should be considered as one of multiple individual and relational factors potentially involved in C-IPV.

PMID 42930218
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PubMedChemSusChem2026-10-26

Sustainable Electron Donor-Acceptor Complex-Mediated Decarboxylative C─C Coupling of Cinnamic Acids.

Tambe Akash Balu AB, Tang Yihan Y, Eun Jin

Developing catalyst-free photochemical transformations that efficiently harness visible light remains an important challenge in sustainable organic synthesis. Herein, we report a visible-light-induced decarboxylative C─C coupling of readily available cinnamic acids with aryl diazonium salts for the stereoselective synthesis of stilbene derivatives. The reaction proceeds under transition-metal- and photosensitizer-free conditions using ethanol as a green solvent and K2CO3 as an inexpensive base, providing a broad range of stilbenes in good to excellent yields with excellent E-selectivity. Remarkably, simply changing the irradiation wavelength enables access to the corresponding Z-stilbenes as the major stereoisomer, providing a convenient wavelength-controlled stereodivergent protocol. The synthetic utility is further enhanced by gram-scale synthesis and chromatographic purification-free product isolation through simple recrystallization. Experimental studies combined with DFT calculations support an electron donor-acceptor (EDA)-complex-mediated photoinduced single-electron-transfer process that generates alkenyl and aryl radicals for subsequent radical-radical coupling. This work demonstrates the potential of EDA-complex photochemistry as a practical and sustainable platform for catalyst-free C─C bond formation.

PMID 42929407
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