若生智能
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Oxalyt-C

✓ Approved

Rottapharm Madaus · 小分子 · 小分子

什么是 Oxalyt-C？

Oxalyt-C 是一种小分子，由Rottapharm Madaus研发。该药已获批，用于治疗相关适应症。

药物档案

公司Rottapharm Madaus
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Rottapharm Madaus

治疗适应症

Oxalyt-C 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersCalculus urinary✓ Approved

相关研究文献

PubMedJournal of cardiovascular development and disease2026-07-27

Incremental Predictive Value of the Non-HDL-C/HDL-C Ratio for Cryptogenic Stroke in Patients with Patent Foramen Ovale.

Yildirim Tarik T, Hekim Mehmet Tolga MT, Kiris Tuncay T

Background: The non-high-density lipoprotein cholesterol (non-HDL-C) / high-density lipoprotein cholesterol (HDL-C) ratio has emerged as a marker of residual vascular risk; however, its role in patent foramen ovale (PFO)-associated cryptogenic stroke (CS) remains unclear. We investigated the association between the non-HDL-C/HDL-C ratio and CS in patients with PFO and evaluated its incremental predictive value beyond the Risk of Paradoxical Embolism (ROPE) score. Methods: This retrospective study included 316 patients with confirmed PFO, including 56 patients with CS. Multivariable logistic regression, restricted cubic spline analysis, ROC analysis, net reclassification improvement (NRI), integrated discrimination improvement (IDI), decision curve analysis, and bootstrap internal validation were performed. Results: Patients with CS had significantly higher non-HDL-C/HDL-C ratio levels than those without CS (p < 0.001). In multivariable analysis, the non-HDL-C/HDL-C ratio remained independently associated with CS (OR: 1.881, 95% CI: 1.310-2.700, p < 0.001). Restricted cubic spline analysis demonstrated a significant nonlinear association between the non-HDL-C/HDL-C ratio and CS risk (overall p = 0.001; nonlinear p = 0.015). Addition of the non-HDL-C/HDL-C ratio to the ROPE score improved discrimination, increasing the AUC from 0.781 to 0.819 (DeLong p = 0.010), and significantly improved risk reclassification (continuous NRI: 0.555, p = 0.002; IDI: 0.057, p = 0.002). Internal validation demonstrated stable model performance with minimal optimism. Conclusions: The non-HDL-C/HDL-C ratio was independently associated with CS and demonstrated potential incremental predictive value beyond the ROPE score in patients with PFO. These findings suggest that metabolic lipid burden may contribute to thromboembolic susceptibility and may improve individualized risk stratification in PFO-related stroke.

PMID 42505890
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PubMedJournal of neurogastroenterology and motility2026-07-27

The Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet Is Effective in Irritable Bowel Syndrome With Constipation: A Single Center Tertiary Care Clinical Practice Evaluation.

Martin Lee David LD, Fragkos Konstantinos C KC

: The low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet is a well-researched treatment for diarrhea-predominant irritable bowel syndrome (IBS-D), but its value for constipation-predominant IBS (IBS-C) is uncertain. Clinicians may hesitate to recommend it for IBS-C, fearing it could worsen constipation or offer little relief. This study aims to assess the diet's effectiveness across all IBS subtypes, specifically investigating its impact on stool patterns in IBS-C and the correlation with symptom relief. : This prospective service evaluation involved 294 IBS patients (84% female, mean age 44.6) attending dietitian-led group sessions on FODMAP restriction (baseline) and reintroduction (follow-up). The primary outcome was "satisfactory relief of gut symptoms" via the global symptom question; secondary outcomes included changes in stool consistency, IBS subtype, and gastrointestinal symptoms. : At baseline, 23.8% (70/294) had IBS-C and 35.7% IBS-D (105/294). All subtypes except IBS-M showed significant symptom relief at follow-up (P < 0.001), with no statistically significant difference between IBS-C (50.7%, 35/69) and IBS-D (44.8%, 47/105) (P = 0.158). After FODMAP restriction, 50.7% (35/69) IBS-C remained IBS-C, while 44.9% (31/69) shifted to unclassified IBS (IBS-U). Those who shifted (IBS-C to IBS-U) reported greater relief (74.2%, 23/31 vs 45.7% 16/35, P = 0.019) and reduced pain (P = 0.006), unlike those who remained IBS-C (P = 0.180). : IBS-C and IBS-D showed similar symptom relief after FODMAP restriction. Notably, 44.9% of IBS-C patients shifted to normal stool consistency (IBS-U), with greater symptom relief and reduced pain. FODMAP restriction does not necessarily exacerbate constipation in IBS-C and remains a viable treatment option in real world clinical practice.

PMID 42504656
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PubMedOrganic letters2026-07-27

Trisulfur Radical Anion (S3•-)-Promoted Defluorotrisulfuration-Cyclization of Allylic gem-Difluoromethylenes with Elemental Sulfur through C-F and C-H Bond Functionalization.

Zhang Li-Dan LD, Wang Xiao X, Ma Qin Q, Zhu Hao-Ning HN et al.

A defluorotrisulfuration-cyclization reaction of allylic gem-difluoromethylenes with elemental sulfur via sequential C(sp3)-F and C(sp2)/C(sp3)-H bond functionalization has been developed for the synthesis of structurally significant 1,2-dithiole-3-thiones. The success of this transformation arises from the dual roles of sulfur: (1) acting as a commercially available, low-cost, nontoxic, bench-stable, and easy-to-handle sulfurating reagent that enables the construction of three C-S/C═S bonds under mild reaction conditions and (2) serving as a defluorinating promoter via in situ generation of a reactive trisulfur radical anion. Moreover, the distinct reactivity profiles of a series of allylic haloalkyl alkenes are first demonstrated. The one-pot synthesis of the anethole dithiolethione drug is achieved, and the resulting product can be transformed into high-value heterocycles.

PMID 42503854
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PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Effects of Temperature on Growth, Pathogenicity, and Fungicide Sensitivity of Two Coniella Species Causing Grape White Rot.

Yuan Lifang L, Liu Bo B, Li Tinggang T, Yin Xiangtian X et al.

Grape white rot, primarily caused by Coniella diplodiella and Coniella vitis, is a major fungal disease threatening grape production worldwide, with C. vitis more prevalent in China. Temperature is a critical environmental factor influencing pathogen development and disease outbreaks, but how temperature influences the biological characteristics, pathogenicity, and fungicide sensitivity of these two pathogens remains limited. This study aimed to evaluate the effects of temperature on mycelial growth, conidial germination, extracellular enzyme activity, pathogenicity, and fungicide sensitivity of C. diplodiella 2019 and C. vitis GP1. The growth, conidial germination, extracellular enzyme production, pathogenicity, and fungicide control efficacy against the two pathogens were systematically evaluated under different temperature conditions (5, 15, 25, 35, and 45 °C). Results showed temperature significantly affected all investigated traits in both species. Optimal mycelial growth, conidial germination, and pathogenicity occurred at moderate temperatures (25 °C), whereas extreme temperatures (5 °C and 45 °C) significantly markedly inhibited fungal development and disease severity. C. vitis GP1 showed greater adaptability and consistently higher pathogenicity than C. diplodiella 2019 across the tested temperature range. Fungicide sensitivity also differed between the two species, and the inhibitory activity of difenoconazole was significantly reduced under temperature extremes, indicating that fungicide performance is influenced by environmental temperature. These findings demonstrate that temperature regulates both fungal development and fungicide efficacy, providing new insights into the temperature-dependent epidemiology of grape white rot and a scientific basis for optimizing disease management under changing environmental conditions.

PMID 42506296
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PubMedBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis2026-07-27

Coagulation profiles and bleeding tendency in 12 patients with factor X deficiency: first report of a homozygous p.Gln249Pro mutation.

Wang Jianru J, Tang Ning N, Cao Weiliang W

To analyze the coagulation function and bleeding tendency in 12 patients with Factor X (FX) deficiency. Activated partial thromboplastin time (APTT), prothrombin time (PT), and FX activity (FX:C) were measured. F10 gene mutations were identified via Sanger sequencing. Clinical data and bleeding tendency were assessed using the ISTH-BAT score. Among the 12 patients, 10 had hereditary FX deficiency and 2 had acquired deficiency. Four patients with FX:C of 40-50% and heterozygous c.746A>C (p.Gln249Pro) mutations had no bleeding tendency. Five patients with F.X:C of 30-50% and heterozygous mutations (c.452G>A, c.871C>T, or c.1252G>A) showed mild bleeding. One patient with severe bleeding (FX:C <1.0%) had a homozygous c.746A>C (p.Gln249Pro) mutation - representing the first global report of this genotype. Two acquired cases had FX:C of 9% and 3%, with mild and moderate-severe bleeding, respectively. Severe bleeding in FX deficiency is associated with FX:C <5%, while milder deficiencies often present minimal symptoms. The novel homozygous p.Gln249Pro mutation causes a severe phenotype, highlighting the importance of genetic diagnosis.

PMID 42506896
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PubMedJournal of the American Chemical Society2026-07-27

Sulfilimines Are Azide Alternatives for Nitrene-Mediated Aromatic C-to-N Transmutation.

Puriņš Mikus M, Hwang Jeongyeon J, Levin Mark D MD

C-to-N atom transmutation reactions present the opportunity to conduct nitrogen scans in a direct fashion, but adoption of these methods has been hindered by the requirement for azide precursors, which impose hazards related to toxicity and energetic properties. Herein, we report sulfilimines as alternative, photoactivatable nitrene precursors, which serve as drop-in replacements across three mechanistically distinct, recently reported C-to-N transmutation reactions. Compared to azide-based protocols, sulfilimine-mediated reactions proceed with comparable or superior efficiency, with reduced reaction times and improved scalability. The requisite precursors can be prepared from a variety of functional handles, including those accessible through C-H functionalization, enabling C-to-N replacement on complex scaffolds. These results establish sulfilimines as a practical, azide-free platform for C-to-N skeletal editing and should facilitate the broader implementation of atom transmutation methods in practice.

PMID 42503822
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