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telmisartan + amlodipine (Micamlo BP / Onduarp / Micamlo AP)

✓ Approved

Astellas Pharma · AGTR1 · 小分子

什么是 telmisartan + amlodipine？

telmisartan + amlodipine 是一种小分子，由Astellas Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Micamlo BP, Onduarp, Micamlo AP
公司Astellas Pharma
药物类别小分子
分子靶点AGTR1, CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Astellas Pharma

作用机制

分子靶点

telmisartan + amlodipine 作用于 2 个分子靶点：

AGTR1angiotensin II receptor type 1 (HAT1R, AT1)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

telmisartan + amlodipine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedFrontiers in psychology2026-09-10

Media amplification, model source cues, and expectancy violation in public acceptance of generative AI: evidence from a health-consultation experiment.

Liu Zhiyue Z, Zhang Zhongchao Z

Generative artificial intelligence (GenAI) is increasingly used for health-information seeking, where evaluations may depend on prior media amplification, the model identity presented, and expectancy violation. We conducted a 2 (media amplification: benefit vs. risk) × 2 (model source: general-purpose vs. professional) × 2 (expectancy violation: positive vs. negative) between-subjects online experiment with 491 participants. Participants read prior-user reports of better- or worse-than-expected performance without using the AI or observing a response. Type III factorial models tested attitude toward use (ATT), behavioral intention (BI), and perceived risk (PRISK). A secondary analysis estimated conditional indirect associations between expectancy violation and BI through PRISK. Media amplification increased PRISK but did not change ATT or BI on average. Professional model-source cues and positive expectancy violation produced favorable average effects across all three outcomes. In the primary Type III models, the three-way interactions reached significance for ATT, BI, and PRISK (partial η2 = 0.008-0.009). Sensitivity support was strongest for the PRISK interaction; the ATT and BI terms varied across specifications. Conditional indirect associations between expectancy violation and BI through lower PRISK were observed in three of the four conditions, while the joint-moderation index included zero. In this health-consultation vignette, media amplification most clearly altered perceived risk, while model source and expectancy violation shaped prospective acceptance across communication conditions. The three-way evidence was most consistent for perceived risk.

PMID 42718575
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PubMedBone & joint research2026-09-10

Effect of robotic arm-assisted bi-unicompartmental knee arthroplasty versus total knee arthroplasty on objectively measured physical activity: secondary outcomes of a randomized controlled trial.

Kanakala Sree S, Brkljac Miloš M, Banger Matthew M, Doonan James J et al.

Bi-unicompartmental knee arthroplasty (Bi-UKA) is a bone-conserving, cruciate-sparing alternative to total knee arthroplasty (TKA). Patient-reported outcome measures (PROMs) do not differ between procedures. Conflicting data exist on gait preservation, and little is known about physical activity (PA) outcomes. PA is understudied in arthroplasty, despite its links with all-cause mortality. We compared PA volume and intensity in patients randomized to Bi-UKA or TKA. We analyzed 38 TKA and 31 Bi-UKA patients from a prospective randomized controlled trial. A triaxial accelerometer was worn on the surgical thigh for seven days, with a three-day minimum wear criterion. Data were collected preoperatively, and at one and two years postoperatively. Outcomes were PA energy expenditure (PAEE), moderate-to-vigorous intensity PA (MVPA), light-intensity PA (LPA), and sedentary time (ST), plus proportional PAEE by intensity. Group differences were assessed with mixed-effects models including baseline PA and biphasic gait as covariates. Spearman's rank correlation between PROMs and PA was performed. Preoperative characteristics were comparable. Activity levels were higher following surgery, but postoperative differences in PAEE, MVPA, LPA, or ST between groups failed to reach statistical significance. Baseline PAEE (β =+ 0.27, p = 0.037) and MVPA (β =+ 0.25, p = 0.024) were associated with improvements in postoperative activity. Postoperative correlations between PROMs and objective PA were weak across groups, and appeared to diminish over time. Although free-living PA improved following Bi-UKA and TKA, differences between groups failed to reach statistical significance. Across both procedures, habitual and behavioural factors appear to be stronger determinants of postoperative PA than surgical procedure, as reflected by the limited correlation between PROMs and objective PA. Larger, long-term randomized studies are needed to confirm these findings.

PMID 42717773
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PubMedMaterials & design2026-09-10

Engineering bi-directional microstructural heterogeneity through mechanical surface treatment.

Oranli Erencan E, Heydari Astaraee Asghar A, Novelli Marc M, Grosdidier Thierry T et al.

By integrating regions with distinct mechanical properties, heterogeneous materials can offer a wide range of mechanical properties and may even surpass the mechanical and functional properties observed in their homogeneous counterparts. Impact-based mechanical surface treatments have proven highly effective in generating microstructural heterogeneity by introducing severe plastic deformation at the surface and subsurface layers, resulting in gradient grain refinement and microstructural modifications while preserving the original properties of the core material. Herein, we employed a strategically modulated ultrasonic shot peening (USP) technique to engineer materials exhibiting bi-directional heterogeneity, i.e., both planar (across the specimen surface) and transversal (in-depth), specifically by creating gradients in both grain size and geometrically necessary dislocation (GND) density. The innovative localized treatment uses masks of various geometric patterns to selectively shield or expose designated regions of the specimens during USP treatment. Tensile tests performed on the USPed specimens evidenced modulated material strengthening, supported by site-specific variations in microstructural features, microhardness, and residual stress distribution. The findings indicate that this novel USP strategy can be implemented to enable engineering materials with heterogeneous structures and tailored mechanical characteristics.

PMID 42719138
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PubMedBMC plant biology2026-09-10

Evolutionary dynamics of the chloroplast genome in Abutilon (Malvoideae, Malvaceae).

Abdullah, Yan Rushan R, Sammad Abdul A, Vallada Atinga A et al.

The genus Abutilon Mill. (Malvaceae) comprises approximately 178 species distributed across tropical and subtropical regions, many of which hold significant ornamental, economic, and medicinal value; yet its taxonomic classification remains challenging. In this study, six species were sequenced from herbarium specimens, and the chloroplast (cp.) genomes of ten additional species were assembled de novo from publicly available raw data. Three previously reported cp. genomes were also incorporated to characterise cp. genome structure, identify polymorphic loci, and perform phylogenetic analyses. The cp. genomes ranged from 159,458 to 160,454 bp and exhibited the typical quadripartite structure, with each genome containing 112 unique genes (78 protein-coding, 30 tRNA, and 4 rRNA) that showed conserved content and organisation. These genomes exhibited high similarity in GC content, inverted repeat boundaries, relative synonymous codon usage, amino acid frequencies, and substitution patterns. However, notable variation was observed in the total number of simple sequence repeats, ranging from 70 to 97 per genome. Selection analyses indicated predominant purifying selection, with evidence of episodic positive selection detected in rpoC2, rbcL, and ycf1. Two codons in rbcL were clade-specific and provided phylogenetic signal distinguishing Australian and Old World pantropical species. Nucleotide diversity analysis identified six highly polymorphic intergenic spacers (trnH-psbA, rps19-rpl2, psbT-pbf1, psaC-ndhD, trnR-atpA, and ndhJ-ndhK) that may be suitable for taxonomic studies. The phylogeny from maximum likelihood (ML) and Bayesian inference (BI) resolved two major clades: one comprising an exclusively Australian lineage occurring predominantly in arid and semi-arid environments, and the other a pantropical lineage spanning multiple continents. Abutilon grandifolium was recovered as sister to the remaining sampled Abutilon taxa in both ML and BI analyses, although no biogeographic origin inference can be drawn from this placement pending broader taxon sampling and integration of nuclear genomic data. These findings provide insights into the evolutionary dynamics of the cp. genome in Abutilon and offer a foundational genomic framework for refining Abutilon taxonomy.

PMID 42717316
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PubMedCureus2026-09-10

From Dyspnea to Suspected Breast Cancer: A Post-traumatic Hematoma as a Diagnostic Pitfall.

Cohen Osnat O, Carême Nicolas N, Van Steen Roanne R, Verslegers Inge I et al.

Post-traumatic breast hematomas are uncommon but clinically relevant, as they may closely mimic breast cancer on both clinical examination and imaging. These hematomas may be large and persistent, particularly in patients receiving anticoagulant therapy. Conversely, breast cancer itself may present with hematoma formation, creating a diagnostic pitfall. With the increasing use of cross-sectional imaging for non-breast indications, incidental breast findings are detected with growing frequency. Although many of these findings are benign, their imaging appearance can occasionally mimic malignancy, often necessitating further diagnostic evaluation. We report the case of a 76-year-old woman who presented with progressive dyspnea, leading to a chest computed tomography (CT) for pulmonary evaluation. This examination revealed an incidental breast mass-like lesion. The patient reported a recent fall with subsequent ecchymosis of both breasts while on chronic anticoagulant therapy with apixaban. Clinical examination six months after the fall still demonstrated a large palpable mass measuring 60 x 50 mm with associated skin retraction in the right breast. The lesions in the left breast had resolved completely. Mammography, ultrasound, and magnetic resonance imaging (MRI) resulted in a Breast Imaging Reporting and Data System (BI-RADS) IV classification. The clinical examination in combination with the breast imaging was suggestive of locally advanced breast cancer. A core biopsy showed benign findings consistent with an organizing hematoma. It could, however, not rule out a malignant lesion. Following a multidisciplinary team meeting discussion, it was decided to repeat the clinical examination, imaging, and biopsy after two months. After two months, the deformation of the breast had increased, and the image was still BI-RADS IV, but the repeated core biopsy confirmed a complex organized hematoma without evidence of carcinoma. This case illustrates the diagnostic challenges associated with post-traumatic breast lesions. In this patient, clinical examination and imaging were unable to reliably distinguish an organized hematoma from breast cancer despite a clear history of trauma and anticoagulant therapy. Histological confirmation was therefore required. Persistent clinical-radiological discordance required a multidisciplinary approach. The decision to repeat the assessment after an appropriate follow-up was essential to ensure diagnostic safety and avoid both delayed cancer diagnosis and unnecessary overtreatment.

PMID 42719434
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PubMedJACC. Case reports2026-09-10

Early Coronary Atherosclerosis in Homozygous Familial Hypercholesterolemia: The Importance of Aggressive Lipid Lowering.

Zachariah Don D, Thomas Anjana A, Nkheli Lindinkululeko L, Mansfield Brett B et al.

Homozygous familial hypercholesterolemia (HoFH) causes severe lifelong low-density lipoprotein-cholesterol (LDL-C) elevation and accelerated atherosclerosis from childhood. A 10-year-old boy presented with extensive tuberous xanthomas and was diagnosed with HoFH due to bi-allelic pathogenic variants in the low-density lipoprotein receptor gene. Baseline LDL-C was 663 mg/dL (17.14 mmol/L). Treatment with atorvastatin, followed by rosuvastatin and ezetimibe, reduced LDL-C to 235 mg/dL (6.08 mmol/L) with marked regression of xanthomas. One year later, he developed exertional chest pain. Coronary angiography and intravascular ultrasound demonstrated early coronary atherosclerosis with a nonobstructive 28% stenosis of the right coronary artery. This case provides an opportunity to discuss the role and limitations of currently available lipid-lowering therapies in HoFH. We review current lipid-lowering therapies and the challenges of achieving LDL-C targets in patients with HoFH, particularly in resource-limited settings. Early recognition and aggressive LDL-C lowering are essential in HoFH to prevent atherosclerosis.

PMID 42720648
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