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telmisartan + amlodipine (Micamlo BP / Onduarp / Micamlo AP)

✓ Approved

Astellas Pharma · AGTR1 · 小分子

什么是 telmisartan + amlodipine？

telmisartan + amlodipine 是一种小分子，由Astellas Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Micamlo BP, Onduarp, Micamlo AP
公司Astellas Pharma
药物类别小分子
分子靶点AGTR1, CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Astellas Pharma

作用机制

分子靶点

telmisartan + amlodipine 作用于 2 个分子靶点：

AGTR1angiotensin II receptor type 1 (HAT1R, AT1)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

telmisartan + amlodipine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Molecularly Engineered Nitrate Double Perovskites with Elevated Ferroelectric Phase Transition Temperature and Large Piezoelectric Response.

Ye Le L, Hu Guang-Yuan GY, Duan Yarou Y, Lin Yutong Y et al.

Conventional ABX3 perovskites place organic species at A-sites or as X-site linkers, where the B-site is reserved for metals. Molecular double perovskites with a general formula A2BIBIIIX6 possess higher tunability and distinct BI-sites that can accommodate small cations, further regulating lattice connectivity and physical properties. Here, we introduce a new family of BI-site-organic nitrate double perovskites, (RM3HQ)2BIEu(NO3)6 (RM3HQ = (R)-N-methyl-3-hydroxyquinuclidinium), forming compounds 1-4 with BI = ammonium, methylammonium, formamidinium, and dimethylammonium, respectively. Compounds 1 and 2 adopt mixed corner-/face-sharing non-perovskite structures, whereas 3 and 4 form double perovskites. This structural variation raises the ferroelectric phase-transition temperature to 349 K in 4 and 414 K in 3, much higher than that of the inorganic analogue (Tc = 285 K). This further widens the temperature margin for stable room-temperature piezoelectric responses, as demonstrated in 3 by ferroelectric hysteresis loops, ferroelastic domains, and a large piezoelectric coefficient (|d33| ≈ 56 pC N-1). During these phase transitions, the Eu3+ photoluminescence intensity ratio (616 nm/ 592 nm) increases from 0.32 to 2.92 in 3 and from 0.37 to 4.59 in 4, reflecting transition-related changes in the ligand field. This work highlights the BI-site as an effective handle for tuning ferroelectric phase-transition temperatures and tunable Eu3+ photoluminescence.

PMID 42929189
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PubMedEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026-10-26

Persistent RNA signatures suggestive of Mycobacterium leprae viability detected by qRT-PCR in multibacillary leprosy patients after one year of WHO-MDT: clinical and histopathological correlation.

Sharma Rahul R, Singh Itu I, Gupta Saurabh S, Lavania Mallika M et al.

Multidrug therapy (MDT) has significantly reduced the global burden of leprosy; however, emerging evidence suggests that viable Mycobacterium leprae may persist in high BI cases of leprosy even after completion of treatment, posing a risk for relapse and continued transmission. This study aimed to longitudinally quantify RNA transcripts of genes associated with viability M. leprae in high bacteriological index multibacillary leprosy patients during and after MDT and to correlate these findings with histopathological and clinical outcomes. Slit skin smear (SSS) samples were collected from 180 newly diagnosed multibacillary (MB) patients at recruitment (BI >3+), 125 patients at 6 months, and 60 patients at 12 months. DNA and RNA were extracted from SSSs, followed by reverse transcription to cDNA, and subjected to qPCR. Standard curves were generated using 10-fold serial dilutions of purified amplicons of all the genes to quantify the copy numbers. DNA was used for RLEP qPCR for normalization of RNA for 16S rRNA, hsp18 and esxA gene. We performed molecular viability assessment of M. leprae using real-time quantitative PCR targeting three viability associated genes: 16S rRNA, hsp18, and esxA. Statistical analysis was performed using ANOVA with Tukey's multiple comparison tests. Histopathological analysis was done in a subset of patients (n = 5) who showed presence of viable bacilli after 12 months of treatment. We observed that a significant proportion of patients show persistent expression of all three gene targets after one year of completion of MDT. When patients were released from treatment (RFT) at 12 months, gene expressions of 16S rRNA, esxA and hsp18 were detected in 40%, 45%, and 46.6% of high BI MB leprosy patients. Notably, copy numbers of genes either remained constant or increased over time in a subset of patients. Histopathological analysis corroborated molecular findings, showing presence of active granulomas and acid-fast bacilli in biopsies from such RFT patients. Statistical analysis confirmed a highly significant difference in gene expression between baseline and 12th month of MB MDT. Our findings demonstrate persistent RNA signatures associated with M. leprae viability in a subset of high-BI MB patients after completion of the standard 12-month WHO-MDT regimen. These molecular findings are suggestive of persistent bacterial viability but cannot definitively distinguish viable, replication-competent bacilli from residual RNA. The use of molecular viability markers (16S rRNA, hsp18, esxA) provides a sensitive tool for monitoring treatment response and supports the need to re-evaluate current fixed-duration therapy, especially for high-BI cases.

PMID 42928317
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PubMedHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026-10-26

A Practical Treatment Platform Version 3.0 for Using Angiotensin Receptor Blocker-Based Single-Pill Combinations in Patients With Hypertension.

Tocci Giuliano G, Burnier Michel M, de la Sierra Alejandro A, Grassi Guido G et al.

Elevated blood pressure (BP) is the leading cause of cardiovascular disease and a major contributor to mortality, affecting almost one third of the adult population worldwide. Despite strong scientific evidence, guidelines and multiple therapeutic options, many patients remain undertreated or uncontrolled, largely due to poor medication adherence and medical inertia. Complexity of multi-pill regimens contributes significantly to non-adherence, whereas single-pill combinations (SPCs) improve adherence and persistence, accelerate BP control, and promote better long-term outcomes than multiple combinations. Appropriate selection of SPC in individual hypertensive patients may be a difficult though very important task for physicians. Thus, development of tools that may facilitate use of SPC in clinical practice is desirable. Among renin-angiotensin system blockers, olmesartan (OM) has demonstrated sustained efficacy, favourable tolerability, both as monotherapy and in SPCs with amlodipine and/or hydrochlorothiazide, which are available in multiple dosages. The present OM-based platform builds on earlier frameworks and incorporates guidelines' updates complemented by a systematic review of available literature. This "3.0" proposal expands patient categorization to include comorbidities or complications often overlooked in clinical practice guidelines, providing a practical, evidence-based approach to support individualized hypertension management complementing guideline recommendations.

PMID 42928416
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PubMedHealth informatics journal2026-10-26

Accurate classification of intracranial hemorrhage using transfer learning and combined spatial and channel attention modules.

Rahimi Parnian P, Naderan Marjan M, Jamshidnezhad Amir A, Rafie Shahram S

PurposeIntracranial hemorrhage (ICH), as a severe brain injury, requires immediate treatment and is usually being diagnosed from Computed Tomography (CT) scans in clinical settings. This task is considered a challenging procedure due to interpretation variability between experts, imaging modality limitations, time sensitivity, and heterogeneous presentations. Recent studies have utilized deep neural networks to overcome limitations such as overfitting and poor generalization across scanners, for ICH diagnosis which requires heavy processing (in terms of Graphical Processing Units (GPUs)) and accurate detection in a time-sensitive period.ApproachThis paper presents deep learning models with attention mechanisms for the purpose of detecting and classifying acute ICH in CT scans. Some pre-processing is needed before inserting the images into the models, which include data splitting, normalization, resizing and augmentation. The proposed approaches combine Channel and Spatial Attention methods with two Convolutional Neural Network (CNN) architectures to extract features and make initial predictions. Furthermore, PCA is used followed by a Bi-LSTM network to reduce the number of features for faster classification and finally, it is concatenated with the initial prediction to produce the final accurate result. This integration particularly benefits ICH classification since Bi-LSTM better understands temporal relations between CT neighboring slices, attention modules focus on hemorrhagic regions, and the PCA method reduces the feature space for less computation.ResultsResult of experiments show that the proposed methods outperform baselines on the RSNA dataset for six classes in most evaluation metrics, including an average accuracy and an average F1 score of 97.8% and 73.3%, respectively. The Grad-CAM technique is also applied to visualize the important parts of images in the detection process of the model.ConclusionsAccording to the results, using attention modules together with pre-trained models can improve the accuracy of detection and classification for ICH. In addition, Grad-CAM results were approved by the medical team as a supporting analysis, especially in critical situations where the hemorrhaged region could not be identified by physicians which shows interpretation models can help the physicians for more reliability in the detection process.

PMID 42929378
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PubMedNature communications2026-10-26

Identification of substrates of the human mitochondrial ClpXP protease and its implications for Perrault syndrome.

Aljghami Mazen E ME, Morey Trevor M TM, Mabanglo Mark F MF, Meyrick Jonathan J JJ et al.

The ClpXP ATP-dependent unfoldase-protease complex plays important roles in maintaining protein homeostasis in the mitochondria. Pathogenic variants of CLPP have been identified in patients with Perrault syndrome type 3 (PRLTS3), a rare recessive mitochondrial disease characterized by sensorineural hearing loss, ovarian dysfunction, and neurological abnormalities. However, it remains unclear how these ClpP variants cause this disease. Here we identify three cellular substrates of ClpXP using proteomic analysis of PRLTS3 patient-derived fibroblasts, with follow up studies using induced pluripotent stem cells (iPSCs) and iPSC-derived neural progenitor cells, alongside in vitro biochemical assays. These substrates are: CHCHD2, a bi-organellar regulator of oxidative phosphorylation and mitochondrial stress responses; ALAS1, which catalyzes the rate-limiting step in heme biosynthesis; and TFAM, an essential mitochondrial transcription factor. Efficient degradation of these substrates by ClpXP requires the adaptor protein PDIP38. We propose that dysregulated cellular levels of these substrates might contribute to the etiology of PRLTS3.

PMID 42928091
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PubMedThe Journal of cell biology2026-10-26

Slender lobes is a spindle matrix protein regulated by spindle envelope kinase Greatwall in oocytes.

Kaade Rayane R, Peat Emma E, Repton Charlotte C, Niziol Julia J et al.

Chromosome segregation is mediated by microtubule-based machinery, the spindle. Microtubule-independent structures, often called the spindle matrix or the spindle envelope, have been reported to embed or surround the spindle, respectively. The concepts have been around for several decades, but they still remain enigmatic. Here, we show the spindle matrix and the spindle envelope form one functional unit crucial for spindle structure and function in oocytes. We found that in Drosophila oocytes, Slender lobes (Sle) protein is an integral component of the spindle matrix, which has a composition different from that in mitotic cells. We further found that Greatwall (Gwl) kinase localizes to the spindle envelope tightly surrounding the Sle spindle matrix in oocytes. Gwl promotes assembly of the Sle spindle matrix, which in turn determines the location of the Gwl spindle envelope. sle silencing in oocytes resulted in spindle abnormalities. Cosilencing experiments revealed that Sle buffers the impacts of compromised kinetochore-microtubule interaction on centromere bi-orientation in meiotic metaphase I.

PMID 42929796
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