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fentanyl citrate (OX20 / Rapinyl / EN 3267)

✓ Approved

Kyowa Kirin Co., Ltd. · 小分子 · 小分子

什么是 fentanyl citrate？

fentanyl citrate 是一种小分子，由Kyowa Kirin Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal、Topical。

药物档案

商品名OX20, Rapinyl, EN 3267
公司Kyowa Kirin Co., Ltd.
药物类别小分子
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal, Topical
状态Approved
来源： ClinicalTrials.gov, Kyowa Kirin Co., Ltd.

治疗适应症

fentanyl citrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Cancer pain✓ Approved

相关研究文献

PubMedPacing and clinical electrophysiology : PACE2026-10-26

The Effectiveness and Safety of Deep Sedation Protocols for Pulsed Field Ablation of Atrial Fibrillation.

Zhao Yize Y, Li Fadong F, Wang Jue J, Zhou Le L et al.

Deep sedation (DS) is increasingly utilized during pulsed field ablation (PFA) for atrial fibrillation (AF), but the optimal electrophysiologist-led sedation regimen remains unclear. To compare sedative effectiveness and safety of three electrophysiologist-led DS protocols. In this prospective, single-center study, AF patients undergoing focal-form PFA received (1) midazolam + fentanyl (Midazolam group), (2) flurbiprofen axetil + midazolam + fentanyl (Flurbiprofen group), or (3) dexmedetomidine + fentanyl (Dexmedetomidine group). The primary endpoint was the achievement of the target sedation level at ablation initiation (Ramsay Sedation Score ≥3). Secondary endpoints included intraoperative pain, sedation difficulty, operator satisfaction, and sedation-related adverse events. 166 patients (mean age, 62.2 ± 10.8 years; 62.7% male; 48.2% with paroxysmal AF) were enrolled, with 53, 67, and 46 patients included in the Midazolam, Flurbiprofen, and Dexmedetomidine groups, respectively. The primary outcome occurred more frequently in the Flurbiprofen (73.1%) and Dexmedetomidine (82.6%) groups compared to Midazolam (47.2%) (overall p < 0.001); Flurbiprofen and Dexmedetomidine group did not differ significantly. Intraoperative pain scores were lowest with Dexmedetomidine (overall p < 0.001). Both Flurbiprofen and Dexmedetomidine groups showed lower sedation difficulty and higher operator satisfaction than the Midazolam group (both overall p < 0.001). Dexmedetomidine was associated with more intraoperative hypotension (overall p = 0.047). Electrophysiologist-led DS protocols with Flurbiprofen and Dexmedetomidine were associated with higher target sedation attainment than the specific low-dose Midazolam regimen during PFA, but Dexmedetomidine is linked to higher hypotension rates, warranting caution.

PMID 42929317
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PubMedAddiction science & clinical practice2026-10-26

Leveraging fourier-transform infrared spectroscopy for community drug checking to bridge clinical care and harm reduction services: case report.

Znamierowski Elizabeth E, Hill Katherine K, Butner Jenna L JL, Stouffer Anna A et al.

The opioid overdose crisis parallels the rise of numerous adulterants in the unregulated drug supply. Harm reduction programs have responded by expanding drug checking services, which chemically analyze street-based drugs. Using a clinical report, we demonstrate the utility of Fourier-transform infrared spectroscopy (FTIR) for engaging people who use drugs in simultaneous, tailored harm reduction and clinical services based on their drug-checking results. A woman with a history of fentanyl use (primarily fentanyl via inhalation) was found to be tachycardic during a follow-up visit at an addiction recovery clinic. The patient's provider suggested she utilize local FTIR drug checking, which revealed that her substance contained a large amount of caffeine, and several other active components. Over the next month, the patient submitted six suspected fentanyl drug samples for testing. The patient shared the information with her partner and ultimately requested different drugs from her supplier. Additionally, FTIR results were communicated with the clinical team at the addiction recovery clinic and incorporated into ongoing discussions around the patient's treatment plan. This case study suggests that low-barrier FTIR drug analysis serves as a valuable tool at the intersection of harm reduction and clinical care. Point-of-care drug checking allows clinicians to engage patients in discussion around etiology of wounds, complications of polysubstance use, and more. By equipping individuals who use drugs with real-time information regarding their substance(s), FTIR restores individual decision-making agency and autonomy. Additionally, drug checking fosters peer knowledge sharing-potentially leading to upstream changes to the unregulated drug supply.

PMID 42928326
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PubMedPacing and clinical electrophysiology : PACE2026-10-26

Sedation Versus General Anesthesia During Pediatric Electrophysiology Studies: A Paired Comparison.

Kucuker Hakan H, Genc Abdusselam A, Akesen Selcan S, Turkmen Hasan H et al.

Anesthetic strategy may influence tachycardia inducibility during pediatric electrophysiology studies, but direct paired comparisons between sedation and general anesthesia remain limited. This prospective paired-comparison study included 51 pediatric patients aged 5-21 years with supraventricular tachycardia undergoing electrophysiology study under both procedural sedation and general anesthesia during the same session. Procedural sedation consisted of midazolam, fentanyl, and supplemental propofol boluses as needed. General anesthesia was induced with propofol and fentanyl and maintained with sevoflurane. Tachycardia inducibility and electrophysiological parameters were compared between anesthetic conditions using paired analyses. Overall tachycardia inducibility was higher during sedation than during general anesthesia (40/51 [78.4%] vs. 29/51 [56.9%], p = 0.007). No significant differences were observed in atrial effective refractory period, ventricular effective refractory period, atrioventricular nodal Wenckebach point, jump, echo interval, or ventriculoatrial block duration. In patients with atrioventricular nodal reentrant tachycardia, inducibility decreased from 84.0% during sedation to 60.0% during general anesthesia (p = 0.109). In the Wolff-Parkinson-White/atrioventricular reentrant tachycardia subgroup, inducibility decreased from 73.1% to 53.8% (p = 0.063), and the accessory pathway effective refractory period, measured by extrastimulus pacing, was prolonged under general anesthesia (p = 0.018). Procedural sedation was associated with greater overall tachycardia inducibility than general anesthesia during pediatric electrophysiology studies. The AVNRT and WPW/AVRT subgroups showed numerically lower inducibility under general anesthesia in the same direction as the overall finding, although these subgroup differences did not reach statistical significance. These findings support individualized anesthetic planning that considers the arrhythmia substrate, the need to preserve inducibility for mapping and post-ablation validation, and patient-specific requirements for procedural stability.

PMID 42929424
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants.

Liu Xiyu X, Zhang Wen W, Liu Lunxin L, Gui Lan L et al.

Defective endothelial regeneration constitutes a fundamental barrier to durable vascular repair. By integrating single cell RNA-sequencing data from rat carotid balloon injury with ultrastructural and histological evidence from rabbit stented arteries, we identified mitochondrial disorganization and dysfunction as common features of injured endothelial cells. Guided by these findings, we developed a poly(citrate-polyglycol-procyanidin) (PCGP) nanoshield to couple mitochondrial protection with anticoagulant and immunoregulatory functions for cardiovascular devices. PCGP preserved mitochondrial integrity, restored endothelial metabolic homeostasis, and rescued the regenerative phenotype of endothelial cells under oxidative stress. In rabbit arterial stent models, this intervention reactivated the PI3K/AKT/eNOS-nitric oxide axis, accelerated functional re-endothelialization, and markedly suppressed neointimal hyperplasia. Collectively, these findings support restoration of endothelial mitochondrial homeostasis as an important mechanistic axis associated with vascular repair.

PMID 42928428
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PubMedParasites, hosts and diseases2026-10-26

Molecular diagnosis of a case of Dibothriocephalus nihonkaiensis infection in Suzu City, Ishikawa Prefecture, Japan.

Kawabata Kohei K, Shimosaki Rin R, Ikku Ryosuke R, Saito Hiroaki H et al.

In this study, we intended to report a case of Dibothriocephalus nihonkaiensis infection diagnosed in Suzu City, Ishikawa Prefecture, Japan. A 23-year-old man from Aichi Prefecture moved to Suzu City, one of the most severely destroyed areas by the 2024 Noto Peninsula earthquake, to engage in reconstructive works. He visited the internal medicine department of Suzu General Hospital by the passage of long slender worm in his stool. Numerous operculated helminth eggs were detected from his stool samples, and a tapeworm strobila with the scolex was found after the treatment of praziquantel (10 mg/kg). Magnesium citrate was administered before and after praziquantel treatment, and stool samples were collected from the patient. The expelled tapeworm measured approximately 1.7 m in length. Morphological examination revealed a relatively small scolex with 2 suckling grooves, suggesting an immature adult specimen. Phylogenetic analysis of the mitochondrial 16S rRNA and cox1 genes identified the parasite as Dibothriocephalus nihonkaiensis. This case highlights the importance of integrating morphological and molecular approaches for accurate species identification in cases with complex epidemiological backgrounds.

PMID 42928461
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PubMedClinics and practice2026-10-26

Delayed Emergence Due to Prolonged Mivacurium Blockade in a Child with Markedly Reduced Butyrylcholinesterase Activity: A Case Report.

Saburova Daniela D, Rocans Rihards Peteris RP, Evansa Irina I, Barzdina Arta A et al.

Background: Delayed emergence after general anesthesia in pediatric patients is uncommon and requires prompt evaluation of pharmacological, metabolic, and neurological causes. Residual neuromuscular blockade remains an important reversible cause, particularly when short acting neuromuscular blocking agents dependent on plasma cholinesterase metabolism are used. Case report: We report the case of a previously healthy three-year-old boy who underwent elective adenoidectomy, tonsillotomy, and tympanostomy under general anesthesia with fentanyl, propofol, sevoflurane, and mivacurium. Following the procedure, the patient failed to regain spontaneous breathing, purposeful movements, or response to painful stimuli. In response, neostigmine was administered to reverse possible residual neuromuscular blockade; however, no immediate clinical improvement was observed, and mechanical ventilation was continued. Quantitative neuromuscular monitoring was unavailable. Therefore, residual blockade could not be objectively assessed, and the depth of blockade at the time of neostigmine administration remained unknown. The patient was transferred to a tertiary pediatric center for further evaluation. Several hours later, spontaneous breathing and motor activity recovered, and the patient was successfully extubated. Retrospective family history revealed prolonged recovery after anesthesia in the patient's grandfather. Subsequent laboratory testing demonstrated markedly reduced plasma butyrylcholinesterase activity (2493 U/L; reference range 7000-19,000 U/L), raising a strong suspicion of inherited butyrylcholinesterase deficiency. Conclusions: This case highlights the importance of considering residual neuromuscular blockade in delayed emergence after pediatric anesthesia, maintaining airway protection, and obtaining relevant family history to guide future management.

PMID 42930372
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