北京若生智能科技有限公司
Drug Database
CI

ciprofloxacin (Aceoto / Cetraxal / Cetraxal Otico)

✓ Approved

Laboratorios SALVAT · 小分子 · 小分子

什么是 ciprofloxacin？

ciprofloxacin 是一种小分子，由Laboratorios SALVAT研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

商品名Aceoto, Cetraxal, Cetraxal Otico
公司Laboratorios SALVAT
药物类别小分子
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Laboratorios SALVAT

治疗适应症

ciprofloxacin 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsOtitis externa✓ Approved
Ear and labyrinth disordersExternal ear inflammation✓ Approved

相关研究文献

PubMedCureus2026-09-10

Bacterial Profile and Antibiotic Susceptibility Patterns of Urogenital Isolates Among Women With Preterm Labor at a Tertiary Hospital in Southwestern Uganda.

Birungi Wilson W, Turanzomwe Stuart S, Byamukama Onesmus O, Bawakanya Stephen S et al.

Pathogenic bacterial colonization of the urogenital tract during pregnancy may lead to infection and inflammation, contributing to adverse obstetric and neonatal outcomes such as preterm labor, preterm premature rupture of membranes, chorioamnionitis, neonatal sepsis, and perinatal mortality. Early identification of bacterial isolates and their antibiotic susceptibility patterns is essential for guiding appropriate antimicrobial therapy, reducing maternal and neonatal morbidity, and informing local treatment guidelines. This study aimed to determine the bacterial isolates colonizing the urogenital tract and their antibiotic susceptibility patterns among women presenting with preterm labor at Mbarara Regional Referral Hospital. This cross-sectional study consecutively enrolled 156 women with preterm labor between November 2022 and April 2023. Midstream urine samples, endocervical swabs, and high vaginal swabs were collected for bacterial culture, identification, and antibiotic susceptibility testing. Data were analyzed descriptively, and bacterial isolates and antibiotic susceptibility patterns were summarized as frequencies and percentages. Bacteria were isolated from urine samples in 43/156 (27.6%) participants and from genital tract specimens in 75/156 (48.1%). The predominant urinary isolates were Klebsiella spp. (20/43, 46.5%) and Staphylococcus aureus (16/43, 37.2%), while Escherichia coli accounted for 4/43 (9.3%) of urinary isolates. In the genital tract, S. aureus was the most frequently isolated organism (43/75, 57.3%), whereas Proteus spp. (1/75, 1.3%) and Pseudomonas spp. (1/75, 1.3%) were the least common. The predominant urinary and genital tract isolates demonstrated high resistance to ampicillin and azithromycin but were generally susceptible to ceftriaxone, gentamicin, and ciprofloxacin. Staphylococcus aureus and Klebsiella spp. were the predominant urogenital bacterial isolates among women with preterm labor. Most bacterial isolates were susceptible to gentamicin, ciprofloxacin, ceftriaxone, and ceftazidime but demonstrated high resistance to ampicillin and azithromycin. These findings highlight the need for routine culture and antibiotic susceptibility testing and may inform future updates of empirical antibiotic treatment guidelines in Uganda.

PMID 42719564
阅读全文 →
PubMedSAGE open medical case reports2026-09-10

Disseminated meningococcal infection presenting with constrictive pericarditis and bilateral septic arthritis without meningitis: A case report.

Binidris Mutasim M, Shehata Menatalla M, Mahfouz Ahmed A, Abousaad Omar O et al.

Invasive meningococcal disease is a life-threatening infection that classically presents as meningitis or meningococcemia. Extra-meningeal manifestations, including pericarditis and septic arthritis, are uncommon and may complicate diagnosis, particularly in the absence of meningeal involvement. A previously healthy vaccinated man in his 50s presented with acute bilateral knee pain and swelling following a short history of fever, productive cough, fatigue, and dyspnea. Blood cultures grew Neisseria meningitidis serogroup W, whereas cerebrospinal fluid, synovial fluid, and pericardial fluid cultures remained negative. Cardiac magnetic resonance imaging demonstrated constrictive pericarditis with circumferential pericardial enhancement and pericardial effusion. The patient was successfully treated with intravenous ceftriaxone, colchicine, ibuprofen, pericardiocentesis, and bilateral knee washout, followed by oral ciprofloxacin. This case adds to the limited literature describing concurrent cardiac and musculoskeletal manifestations of invasive meningococcal disease without meningitis and shows the importance of early recognition, comprehensive investigation and multidisciplinary management of these uncommon presentations.

PMID 42718941
阅读全文 →
PubMedMicrobiologyOpen2026-09-10

Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram-Negative Bacterial Strains.

Freire Talita Vilalva TV, Marques Ana Carolina de Freitas ACF, Gonçalves Valéria Dos Santos VDS, Moslaves Iluska Senna Bonfá ISB et al.

Bacterial resistance to antibiotics represents a critical global health challenge, demanding urgent alternative strategies to manage infections caused by multidrug-resistant (MDR) pathogens such as Acinetobacter baumannii, Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. A promising approach to address this problem involves the use of combination therapies, in which plant-derived natural products represent an important reservoir of bioactive compounds with the potential to act as effective adjuvants, restoring or enhancing antibiotic efficacy. In this study, the ethanolic extract of Mouriri elliptica (EME) leaves was investigated for its antimicrobial and synergistic potential. EME showed moderate inhibitory activity against both standard and MDR strains, with the most significant effect against A. baumannii (MIC 78.1-312.5 µg/mL). Synergistic interactions were observed with conventional antibiotics, particularly ciprofloxacin against K. pneumoniae, reducing MIC values up to fifteen-fold, and with ampicillin against E. coli and S. aureus. The extract also inhibited biofilm formation, with 68% inhibition for E. coli at 500 µg/mL and 72.04% for S. aureus at 250 µg/mL, with atomic force microscopy images corroborating these findings. LC-MS profiling identified 41 compounds, including chlorogenic acid derivatives, flavonoids, ellagic acid derivatives, and triterpenes. Acute toxicity evaluation in mice at 2000 mg/kg revealed no adverse effects. Collectively, these findings support the potential of M. elliptica as a natural antibacterial adjuvant for enhancing the effectiveness of selected antibiotics against MDR pathogens, warranting further chemical, mechanistic, and in vivo investigation.

PMID 42717400
阅读全文 →
PubMedAnalytical methods : advancing methods and applications2026-09-10

Density separation-Raman spectroscopic quantification of microplastic-antibiotic co-contamination and transport in plastic-mulched agricultural soils.

Ren Jia J, Buyong Faeiza F, Wang Yapeng Y, Li Yichao Y et al.

Plastic-mulched soils contain mineral particles, organic matter and weathered polymer fragments that complicate the joint measurement of microplastics and co-occurring antibiotics. We developed a matrix-adaptive workflow combining sequential Fenton-enzymatic digestion, ZnCl2/NaI cascade density separation, silver-membrane collection, µ-Raman chemical imaging and isotope-dilution LC-MS/MS. Performance was evaluated with four agricultural soils, four mulch-relevant polymers, two particle-size fractions, pristine and aged surfaces, and tetracycline, ciprofloxacin and sulfamethoxazole. Across 2304 independent particle-spike observations, mean microplastic recovery was 93.72 ± 3.17% (95% confidence interval, 93.59-93.85%), within-laboratory relative standard deviations were 2.5-3.4%, and Raman classification accuracy was 96.25%. Antibiotic recovery across 432 observations was 95.31 ± 3.61%; matrix effects ranged from -14.2 to 5.3%, while matrix-matched calibration gave R2 values of 0.9995-0.9998. Pyrolysis GC-MS confirmed Raman-derived mass estimates (R2 = 0.9897), with a mean inter-platform bias of 0.022 mg. Aging increased XPS O/C ratios, AFM roughness and BET area and nearly doubled Langmuir capacities; aged polyamide reached 32.66 mg g-1 for tetracycline. In saturated columns, pristine polyethylene slightly advanced breakthrough, whereas aged polyethylene and polyamide shifted the 50% breakthrough point from 2.34 pore volumes without microplastics to 2.86 and 3.22 pore volumes, respectively. Factorial and mixed-effects analyses, multiplicity-controlled contrasts, grouped cross-validation and an uncertainty budget supported the method's cross-matrix robustness. The workflow provides a quantitative basis for linking analytical recovery, particle surface chemistry and contaminant migration in complex agricultural soils.

PMID 42717874
阅读全文 →
PubMedEnvironmental health insights2026-09-10

Salmonella Outbreaks in Low- and Middle-Income Countries over the Last Decade: A Systematic Review and Meta-Analysis of Transmission Dynamics, Clinical Outcomes, and Antimicrobial Resistance.

Appiah Peter Ofori PO, Anita Akuffo A, Owusu Wisdom Boateng WB, Muntala Hafizu H et al.

Salmonella outbreaks persist as a public health burden in low- and middle-income countries (LMICs), yet comprehensive synthesis of their epidemiology over the past decade remains limited. Following PRISMA 2020 guidelines, we searched PubMed, Scopus, Web of Science, and Google Scholar for laboratory-confirmed Salmonella outbreaks in LMICs (1 January 2016-1 January 2026). Random-effects meta-analysis estimated pooled prevalence rates, with statistical heterogeneity quantified using I2 statistic. Given extreme heterogeneity across most outcomes (I2 > 90%), we present individual study ranges alongside pooled estimates. Twenty-four studies from 14 LMICs met inclusion criteria. Salmonella Typhi was the predominant pathogen (70.8% of outbreaks). Waterborne transmission was most frequent (37.5%), predominating in Africa (83.3%), whereas foodborne and fecal-oral routes were common in Asia. Pooled laboratory confirmation rate was 28.02% (95% CI: 12.2-52.1; observed range: 1.5-100%), varying by region: Southeast Asia 54.2% (95% CI: 4.3-96.9), Western Pacific 27.6% (95% CI: 8.0-56.9), and Africa 6.1% (95% CI: 5.3-6.9). The pooled case fatality rate was 7.0% (95% CI: 3.4-13.7; range: 3.6-10.0%). Fever (93.0%), abdominal pain (53.6%), and headache (52.0%) were most common symptoms. Pooled antimicrobial resistance reached 59.3% (95% CI: 26.6-85.4%), highest for trimethoprim-sulfamethoxazole (94.2%) and ciprofloxacin (61.3%). Extreme heterogeneity and wide confidence intervals were observed across some pooled estimates and should be interpreted with caution. Salmonella outbreaks in LMICs are characterized by high S. Typhi prevalence and predominant waterborne transmission. Elevated mortality and widespread first-line antibiotic resistance show the need for improved WASH infrastructure, enhanced real-time outbreak surveillance, and revised empiric treatment protocols.

PMID 42719459
阅读全文 →
PubMedFrontiers in cellular and infection microbiology2026-09-10

EprX associates with concurrent shifts in antimicrobial resistance and virulence in clinical bloodstream E. coli: a putative adaptive node for bacterial fitness.

Wang Afeng A, Guo Yingying Y, Zhu Jichao J, Sun Yuliang Y et al.

Bloodstream infections (BSIs) caused by E. coli represent a growing global threat, driven by escalating antimicrobial resistance (AMR) and sustained virulence. However, the regulatory mechanisms linking these two phenotypes remain poorly understood. Here, we identify EprX, a previously uncharacterized YjbI-type pentapeptide repeat protein (PRP), a locus that our data suggest may influence metabolic and transcriptional profiles in clinical BSI E. coli isolates. Genomic screening of 85 clinical BSI strains reveals that eprX is present in 21.2% of isolates, often within distinct genomic contexts suggestive of mobile acquisition. Using λ-Red recombineering, we constructed eprX knockout mutants. Loss of eprX is associated with altered antimicrobial resistance profiles, increasing susceptibility to gentamicin, ciprofloxacin, and levofloxacin. This phenotype is consistent with upregulation of outer membrane porin genes (ompC, ompF) and downregulation of multidrug efflux pump genes (macB, mdtC, emrB) and two-component regulatory system genes. eprX deficiency also appears to correlate with attenuated virulence in our assays, as evidenced by improved survival of Galleria mellonella larvae (65-95% at 72 h post-infection vs. 40-60% for wild-type strains) and reduced adhesion to and invasion of human HeLa cells. Transcriptomic profiling reveals that eprX carriage is associated with broad, coordinated shifts in the expression of genes involved in LPS transport (lptG/lptF), type ;II secretion system components (gspD/gspE/gspF), autotransporter adhesins (ag43), and flagellar assembly, suggesting potential disruptions in outer-membrane integrity, biofilm formation, and virulence programs. Our data suggests that eprX is a genetic locus whose presence correlates with concurrent shifts in resistance maintenance and virulence traits, representing a putative adaptive node within the E. coli fitness landscape.

PMID 42718476
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多ciprofloxacin