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NIK-127

✓ Approved

Kowa · 小分子 · 小分子

什么是 NIK-127？

NIK-127 是一种小分子，由Kowa研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Kowa
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Kowa

治疗适应症

NIK-127 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersDiarrhoea✓ Approved

相关研究文献

PubMedAntibiotics (Basel, Switzerland)2026-07-27

Prevalence and Genomic Characterization of ESBL-Producing Escherichia coli in Livestock and Farmers in Catalonia, Spain.

Serras-Pujol Marina M, Párraga-Niño Noemí N, Navarro Marian M, Vilamala Anna A et al.

Extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae represent an increasing One Health concern because food-producing animals may act as reservoirs of antimicrobial-resistant bacteria with potential transmission to humans. Therefore, this study aimed to assess the prevalence and genomic characteristics of ESBL- and carbapenemase-producing Enterobacteriaceae in livestock and farmers, and to evaluate genomic overlap between animal and human ESBL-producing Escherichia coli to explore potential shared origins and interspecies transmission. We conducted a cross-sectional study in Osona (Catalonia, Spain), sampling livestock (swine, cattle, poultry, and horses) and farmers. ESBL-, AmpC-, and carbapenemase-producing Enterobacteriaceae were identified and characterized using whole genome sequencing (WGS). Genomic analyses included sequence typing (ST), serotyping, virulence-associated genes, antimicrobial resistance determinants, and plasmid replicon profiling. A total of 945 animals were analysed. ESBL-producing Enterobacteriaceae were predominantly detected in swine, with 63.5% (127/200) of animals testing positive, including four ESBL + AmpC-producing isolates and two carbapenem-resistant Enterobacteriaceae. No ESBL-, AmpC- or carbapenemase-producing isolates were identified in cattle (0/360) or poultry (0/171), and a low prevalence was observed in horses (7.0%, 15/214). A total of 64 farm workers were analysed. ESBL-producing E. coli were detected in 46.7% (7/15) of swine farmers and 8.3% (2/24) of cattle farmers, while no ESBL-producing isolates were found among poultry farmers (0/8) or equine caretakers (0/17). A total of 162 isolates were analyzed by WGS, showing high genetic diversity. Among the 127 Escherichia coli isolates, the most prevalent were ST10 (18/127, 14.2%), followed by ST453 (7/127, 5.5%), ST515 (7/127, 5.5%), and ST10562 (7/127, 5.5%). Virulence-associated gene profiles were heterogeneous, although genes related to stress tolerance and intestinal colonization predominated among ESBL-producing E. coli isolates from swine, including terC (54/127, 42.5%), csgA (41/127, 32.3%), nlpI (41/127, 32.3%), and fimH (39/127, 30.7%). ESBL production among E. coli isolates from swine was primarily mediated by blaCTX-M genes (89/127, 70.1%), with additional contributions from blaSHV (34/127, 26.8%) and blaTEM (40/127, 31.5%). Among swine isolates, IncX1 (100/127, 78.7%), IncFIB(AP001918) (82/127, 64.6%), IncI1-I(Alpha) (69/127, 54.3%), and IncFII (54/127, 42.5%) were the most frequently detected plasmid replicons. Two carbapenem-resistant isolates carrying blaOXA-48 were identified in swine, including E. coli ST58 and K. oxytoca ST145, both associated with IncL plasmids. Swine appear to constitute the primary reservoir of ESBL-producing E. coli. The genomic relatedness observed between animal and human isolates supports shared exposure to a common ecological pool of multidrug-resistant bacteria. The identification of blaOXA-48-producing Enterobacterales associated with IncL plasmids further highlights the public health relevance of livestock-associated antimicrobial resistance. However, the cross-sectional design precludes inference of transmission pathways or transmission directionality. Longitudinal studies are needed to elucidate the dynamics of interspecies transmission.

PMID 42505639
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PubMedJAMA pediatrics2026-07-27

Erythropoietin for Neonatal Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.

Liley Helen G HG, Hunt Rod W RW, O'Connell Rachel L RL, Battin Malcolm R MR et al.

Therapeutic hypothermia (TH) is the standard of care to improve outcomes following neonatal hypoxic-ischemic encephalopathy (HIE), but mortality and morbidity remain high, prompting research into treatment adjuncts. To assess whether erythropoietin (EPO) plus TH improves outcomes in infants with moderate or severe HIE. The PAEAN (Preventing Adverse Outcomes of Neonatal Hypoxic Ischaemic Encephalopathy with Erythropoietin) study was a phase 3, multicenter, double-blinded, placebo-controlled randomized clinical trial conducted in 24 neonatal intensive care units in Australia, New Zealand, and Singapore. Infants 35 weeks' gestation or older, less than 23 hours old, with perinatal depression (umbilical cord arterial pH <7.0 or base excess ≥12 mmol/L or, at 10 minutes, Apgar score ≤5 or still receiving resuscitation), and moderate or severe HIE (modified Sarnat criteria) who had commenced TH within 6 hours of birth were eligible for inclusion. Study recruitment was conducted between May 2016 and March 2021, with data collection completed in September 2024. Data analysis was performed from September 2024 to October 2025. Intravenous EPO, 1000 IU/kg (5 doses over the first week), or placebo. The primary outcome was a composite of death or moderate or severe motor or cognitive disability using standardized neurological and developmental assessments at 2 years. Moderate or severe disability comprised motor deficit (diagnosis of cerebral palsy with Gross Motor Function Classification Scale score ≥2) or moderate or severe cognitive deficit using Bayley Scales of Infant Development, Third Edition. Secondary outcomes included death, disabilities alone, and safety. From 2016 to 2021, 313 infants were randomized (EPO: n = 156; placebo: n = 157). Baseline characteristics (including mean [SD] gestational age at birth: 39.4 [1.7] weeks vs 39.3 [1.6] weeks and ratio of moderate:severe encephalopathy: 78%:22% vs 77%:23%) and loss to follow-up (10.2% overall) were similar across both groups. There were 67 (42.9%) and 59 (37.6%) female infants, respectively. There was no significant difference in the primary outcome (EPO: 47 of 138 [34.1%] vs placebo: 41 of 143 [28.7%]; relative risk, 1.19; 95% CI, 0.84-1.68; P = .33), in secondary outcomes (death: 22 of 146 [15.1%] vs 18 of 149 [12.1%]; P = .45; cerebral palsy: 22 of 120 [18.3%] vs 22 of 127 [17.3%]; motor deficit: 13 of 120 [10.8%] vs 15 of 127 [11.8%]; cognitive deficit: 20 of 113 [17.7%] vs 16 of 118 [13.6%]), or in any safety outcomes. Per the results of this multicenter randomized clinical trial, EPO did not demonstrate any adjunctive effect to hypothermia, but no safety concerns were evident. anzctr.org.au Identifier: ACTRN12614000669695.

PMID 42507461
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PubMedJournal of personalized medicine2026-07-27

Inverse Association of p63 Expression with Hormone Receptor Status in Invasive Breast Cancer.

Lykoudis Panagis P, Papadoliopoulou Maria M, Kozonis Alexios A, Kirkilesis Georgios G et al.

Background/Objectives: Immunohistochemistry is an integral component of the diagnostic approach in breast cancer and remains essential for tumor characterization and therapeutic decision-making. p63 gene expression may have potential diagnostic and prognostic roles in breast cancer patients. Methods: In this study, 127 specimens of invasive breast carcinoma and 50 control cases were evaluated for p63 gene expression and compared to other pathology factors. Results: None of the 50 control cases was assessed as positive for p63 expression. Progesterone and estrogen receptor status were the only factors that demonstrated a statistically significant negative correlation with p63 expression (p = 0.005 and p = 0.017, respectively). Tumor size demonstrated a marginally non-significant correlation with p63 expression (p = 0.051). None of the remaining factors was significantly correlated with p63 expression. Conclusions: In conclusion, p63 expression is inversely correlated with estrogen and progesterone receptor status, and type, size and grade of the tumors are not correlated with the gene's expression, nor is HER2 status. This conclusion might impact genotype-based stratification pertinent to diagnosis and tailored treatment.

PMID 42506085
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PubMedAutism : the international journal of research and practice2026-07-27

Prevalence, Distribution, Co-occurring Neurodevelopmental Conditions, and Associated Factors of Autism Among Children in Northern Uganda.

Simple Ouma O, Estlin Edward John EJ, Okello Kennedy Kosko KK, Okello Morrish Obol MO et al.

Autism is a neurodevelopmental condition characterized by differences in social interaction, communication and behaviour. Despite a global prevalence of one in 127 individuals, autism remains underdiagnosed in low-resource settings. We examined the epidemiology of autism among children aged 2 to 9 years in Northern Uganda. Using multistage sampling, 1,139 children were screened for neurodevelopmental conditions using the validated 23Q screening tool. Children who screened positive underwent clinical assessment, and suspected cases received specialist assessments according to DSM-5-TR criteria. Descriptive statistics and Firth logistic regression were employed for analysis. The mean age was 5.38 years (SD = 2.07), and 51.0% were male. The prevalence of autism was 10.5 per 1,000 children (95% confidence interval [CI] [6.0, 18.5]), of whom 75.0% had co-occurring neurodevelopmental conditions. Autistic children were more likely to have intellectual disability, epilepsy, learning disabilities, global developmental delay, attention-deficit/hyperactivity disorder, dyslexia, cerebral palsy, hearing impairment and speech delay (p < .0045). After adjusting for gender, family history of autism (adjusted odds ratio [aOR] = 6.95, 95% CI [1.60, 30.23]), teenage motherhood (aOR = 8.30, 95% CI [1.30, 53.12]), breech presentation (aOR = 12.23, 95% CI [1.83, 81.64]), and oxygen resuscitation at birth (aOR = 4.56, 95% CI [1.08, 19.33]) were independent predictors of autism. These findings highlight the need to strengthen early identification and targeted services for autistic children in low-resource settings.Lay AbstractAutism affects how people communicate, interact, and process information, and about one in 127 people worldwide are autistic. In low-resource settings, autism is often under-researched and underdiagnosed. We carried out a study in Northern Uganda to estimate how common autism is among children aged 2 to 9 years, to identify co-occurring neurodevelopmental conditions, and to explore factors that may increase likelihood of autism. We enrolled 1,139 children from diverse communities using a multi-step sampling process. After parental consent, one child per household was screened with the 23Q neurodevelopmental screener. Children with possible conditions received further assessment by trained health care workers, and likely cases were confirmed by specialist clinicians using DSM-5-TR diagnostic criteria. Approximately 1 in 95 children were autistic, and none had previously received a diagnosis of autism. The average age of the children diagnosed with autism was about 5 years, and slightly more than half were boys, and most lived in rural areas. Most autistic children (82%) had at least one additional neurodevelopmental condition, such as intellectual disability, learning delays, or epilepsy. Autism was linked to family history, teenage motherhood, and certain birth complications. Improving maternal care, community awareness, and early diagnosis could better support autistic children in Northern Uganda.

PMID 42503632
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PubMedCurrent oncology (Toronto, Ont.)2026-07-27

Outcomes of Inpatient Chemotherapy for Patients with Newly Diagnosed Extensive-Stage Small-Cell Lung Cancer.

Gauthier Sara N SN, Wheatley-Price Paul P, Stewart David J DJ, Brule Stephanie S et al.

Background: Small-cell lung cancer (SCLC) accounts for 15% of lung cancers, with 70% diagnosed at extensive-stage (ES). Systemic therapy is often considered in very unwell patients, although outcomes for inpatients with ES-SCLC are not well understood. Methods: We reviewed patients with de novo ES-SCLC who had an inpatient medical oncology consultation at the Ottawa Hospital between 2013 and 2021. The primary endpoint was overall survival (OS). Secondary endpoints included length of stay (LOS) and tumor lysis syndrome (TLS) incidence. Results: There were 127 patients identified. Median age was 68 years (range 50-87), 58% female, 99% had prior smoking history, 22% had brain metastases, and 64% had liver metastases. Ninety-two (72%) received chemotherapy. Median OS for treated patients was 5.9 months (95% CI, 4.5-7.3 m), and a median LOS of 13 days. Patients in the non-treatment cohort had a median OS of 14 days (95% CI, 0.2-0.7 m), a median LOS of 11 days, and 54% in-hospital death rate. TLS occurred in six of the 76 (8%) evaluated patients, all dying within 7 days of chemotherapy. Conclusions: Chemotherapy was associated with longer survival among inpatients with ES-SCLC. TLS was rare but uniformly fatal, highlighting the need for aggressive prophylaxis among patients with identified risk factors.

PMID 42505190
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PubMedCureus2026-07-27

Comparison of Pre-transfer Risk Assessment Tools Used for Critically Ill Patient Transport: A Retrospective Study.

Poomali Aruvi A, Ambalakkatte Ajay A, Tp Sreelal S, Mohanan Abhijit A et al.

Objective The objective of this study was to compare three scoring systems for pre-transfer risk assessment to enable the efficient utilization of transport infrastructure available while avoiding adverse events during interhospital patient transport. Methods This was a retrospective, cross-sectional study conducted in a tertiary care hospital situated in an aspirational district in Southern India. Trained personnel used three pre-transfer risk assessment tools to stratify the medical records of patients transported from the hospital during the study period. The data were analyzed to assess the sensitivity, specificity, and positive and negative likelihood ratios of the scoring systems. Results A total of 200 patient transports were included in the study. Cardiac emergency was the most common clinical diagnosis. A total of 35 patients had at least one major adverse event during transport. The Risk Score for Transport Patients (RSTP) classified 127 patients as high risk, the Transport Triage Tool (TTT) classified 133 as high risk, and the National Early Warning Score (NEWS2)-based tool classified 123 patients as high risk. Sensitivity and specificity of the RSTP scoring system to predict a major adverse event during transport were 77% and 39%, respectively. It also had a positive likelihood ratio of 1.27. Conclusion While the RSTP scoring system has the highest sensitivity and positive predictive value, further research is required to validate its performance in the Indian context.

PMID 42504371
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