北京若生智能科技有限公司
Drug Database
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NIK-127

✓ Approved

Kowa · 小分子 · 小分子

什么是 NIK-127？

NIK-127 是一种小分子，由Kowa研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Kowa
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Kowa

治疗适应症

NIK-127 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersDiarrhoea✓ Approved

相关研究文献

PubMedJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2026-09-10

When sleep advice goes viral: medical reliability of insomnia content on TikTok.

Papadopoulou Styliani S, Karkala Aliki A, Engelshove Ellen E, Testelmans Dries D et al.

The reliability and educational quality of TikTok videos addressing insomnia management remain uncertain. A total of 127 TikTok videos were assessed with Global Quality Score (GQS) for educational value and with Viewing and Engagement Index for popularity. Among these, 66 videos by general users, 20 by physicians, 32 by other healthcare professionals, and 9 by brand-affiliated accounts showed overall poor quality: only 20 videos (15.7%) had high educational value, while another 11 (8.7%) had moderate educational value; only 5 videos received the highest score for consistency with guidelines, only 5 videos recommended consulting a physician, and only 2 included scientific references. Approximately 55% of physicians' videos had GQS ≥ 3, compared with 25%, 18%, and 0% of other healthcare professionals, general users, and brand accounts respectively. GQS was not correlated with engagement metrics. Sponsored videos were associated with lower-quality content. In conclusion, TikTok videos related to insomnia management generally do not provide reliable, guidelines-based information, raising concerns regarding the use of TikTok as a source of insomnia management information.

PMID 42717129
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PubMedInnovation (Cambridge (Mass.))2026-09-10

Quantum evidence of nonlocal consciousness during clinical death.

Escolà-Gascón Álex Á, Drinkwater Kenneth K, Denovan Andrew A, Dagnall Neil N et al.

If consciousness can operate under quantum principles, then the boundaries between life, death, and cognition are far more permeable than current science allows. In the first large-scale, randomized, double-blind, multicenter trial to test this possibility, conducted across 13 hospitals in the UK and Spain, we investigated whether the human mind can access information during clinical death-but only when exposed to auditory stimuli governed by quantum entanglement. The entangled stimulation circuit was implemented and synchronized with the 127-qubit IBM Brisbane quantum supercomputer and delivered during in-hospital cardiopulmonary arrest (CA), beginning 120 s after arrest onset. Quantum entanglement was verified through statistically significant violations of Mermin inequalities. During resuscitation, we measured neurophysiological biomarkers including cerebral oxygenation via near-infrared spectroscopy (NIRS), brain temperature, and blood pH, lactate, and serum concentrations of brain-derived neurotrophic factor (BDNF). After reanimation, 142 survivors completed a forced-choice recall test, near-death experience (NDE) scales, and other clinical control assessments. False memories, hallucinations, and confounding biases were successfully controlled. Notably, recall lucidity increased momentarily as NIRS values dropped, and NDEs positively correlated with neuroplasticity during CA. Biomarker models explained up to 56.8% of the variance in recall. These findings compel a radical rethinking of clinical death: consciousness may persist-quantum bound, detectable, and not yet defeated.

PMID 42719279
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PubMedCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026-09-10

Associations Between Pre-diagnostic Plasma Metabolites and Ovarian Cancer: A Prospective Case-Cohort Analysis in the Cancer Prevention Study-3.

Pfluger Brigitte A BA, Masters Matthew M, Nguyen Nancy B NB, Patel Alpa V AV et al.

Ovarian cancer remains a significant health concern among U.S. women, yet its underlying etiology is not fully understood. Untargeted metabolomics enables comprehensive profiling of small molecules that may provide insight into metabolic alterations associated with ovarian cancer risk. We conducted a case-cohort study within the Cancer Prevention Study-3, measuring pre-diagnostic plasma metabolites via untargeted metabolomics in 127 ovarian cancer cases and a randomly selected sub-cohort of 1,811 women, one of whom was later diagnosed with ovarian cancer. Median follow-up time was 2.4 years (IQR: 1.2-3.6) among ovarian cancer cases and 3.2 years (IQR: 2.5-5.2) in the sub-cohort. Metabolite associations with ovarian cancer risk were estimated using multivariable Prentice-weighted Cox models, and pathway enrichment analyses were performed. False discovery rate (FDR) correction was applied, considering FDR < 0.2 statistically significant. Among 868 plasma metabolites analyzed, none showed statistically significant associations with ovarian cancer risk after FDR correction. In stratified analyses by menopausal status, five metabolites remained statistically significant after FDR correction among postmenopausal women only. Pathway enrichment analyses identified several lipid-related sub-pathways enriched among metabolites associated with ovarian cancer risk (FDR-adjusted p-value < 0.2), with the strongest positive enrichment observed for primary bile acid metabolism and the strongest negative enrichment for sphingomyelins. In this prospective metabolomics analysis, individual pre-diagnostic plasma metabolites were not associated with ovarian cancer risk, but lipid-related pathways and possible differences by menopausal status may warrant additional investigation. These findings contribute to the growing untargeted metabolomics literature on ovarian cancer.

PMID 42720260
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PubMedClinical ophthalmology (Auckland, N.Z.)2026-09-10

Frequency of Risk Factors for Presenile Cataract Among Patients Aged 30-50: A Cross-Sectional Study in Shafa Hospital, Kerman (2024-2025).

Sharifi Ali A, Farajpour Bashir B

This study aimed to determine the frequency and profile of key risk factors for presenile cataract among patients aged 30 to 50 years in Kerman, Iran, a region characterized by high solar exposure and specific socio-behavioral patterns. An analytical cross-sectional study was conducted in 2024 at the Ophthalmology Department of Shafa Hospital. A census sampling method enrolled 245 patients (468 eyes) requiring cataract surgery. Data on demographic, occupational, systemic, and behavioral factors were collected using a structured registration form. Data were analyzed using descriptive statistics, chi-square tests, and ANOVA. The study included 127 (51.84%) male participants with a mean age of 44.42 years (SD 5.78). Posterior subcapsular (PSC) cataract was the most common type, affecting 55.51% of patients. A significant number of patients worked in outdoor or high-exposure occupations, with 50.61% being farmers or drivers. Key risk factors included diabetes (20.82%), opioid use (34.69%), and corticosteroid use. Age significantly influenced cataract type in both eyes (right: P < 0.001; left: P = 0.01). A significant relationship was also found between gender and cataract type, but only in the left eye (P = 0.013). Presenile cataract in this population results from multiple factors, strongly linked to modifiable environmental and behavioral risks. Occupational UV exposure, opioid addiction, and systemic diseases such as diabetes are major contributors. The notable difference in gender association indicates a potential influence from local external factors. Public health strategies should focus on protecting workers' eyes, controlling substance abuse, and managing systemic conditions to reduce the burden of presenile cataract.

PMID 42719059
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PubMedRevista espanola de enfermedades digestivas2026-09-09

Accredited inflammatory bowel disease units are associated with better patient-reported experience: a cross-sectional study.

Calvet Xavier X, Puy Guillén Anna A, Reales Úrsula Ú, Brunet-Mas Eduard E et al.

Comprehensive inflammatory bowel disease (IBD) units have been implemented to improve the quality of care delivered to patients with Crohn's disease and ulcerative colitis. Although accreditation programmes have improved structural and process quality indicators, little is known about their association with patients' healthcare experience. To compare patient-reported experience between patients receiving care in accredited and non-accredited IBD units. Secondary objectives were to compare perceived disease activity and selected organisational quality indicators. Cross-sectional online survey conducted among members of the Associació de Malalts de Crohn i Colitis Ulcerosa de Catalunya. The questionnaire included nine prespecified individual PREM indicators previously developed and used by our group, a global five-point satisfaction score, the Manitoba Index and organisational quality indicators. Hospitals were classified as having or not having an accredited IBD unit according to the official information of the Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa. Comparisons were performed using univariate analyses. A total of 127 valid questionnaires were analysed (95 accredited units; 32 non-accredited units). All nine PREM showed significantly better scores in accredited units. Overall satisfaction was also significantly higher among patients attending accredited units, which also scored better for organisational quality indicators. No statistically significant difference was observed in disease activity measured by the Manitoba Index. Accredited IBD units are associated with substantially better patient-reported experience without statistically significant differences in patient-reported disease activity. These findings provide patient-centred evidence supporting this model of care.

PMID 42714106
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PubMedThe Laryngoscope2026-09-09

When They Stop Coming: Key Factors in Pediatric BCHD Adherence in Microtia Patients.

Chan Sih-Yu SY, Alfonso Kristan K, Drob Jennifer J, Hosek Kathleen K et al.

To analyze the demographic and clinical factors associated with adherence to bone conduction hearing device follow-up care in pediatric patients with microtia and aural atresia. Retrospective chart review of 127 patients in a tertiary care microtia database (2015-2025). Data collected included ethnicity, insurance type, current age, fitting age, unilateral versus bilateral hearing loss, time to first follow-up, annual visit frequency, and daily datalogging hours, each analyzed as components of a composite adherence score (1-9) and as independent variables. Unilateral hearing loss was the strongest predictor of decreased adherence on multivariate analysis (OR = 4.504, p = 0.034). Older age was independently associated with reduced adherence; patients aged ≥ 11 years had significantly higher odds of poor adherence versus those under 6 years (OR = 5.795, p = 0.001). While patients aged 7-10 had 4 times the odds of reduced adherence (OR = 4.391, p = 0.003). Public or no insurance was associated with decreased adherence versus private insurance (p = 0.009). Fitting age was not significant (p = 0.098). Independent analysis of daily datalogging hours confirmed a significant association with adherence tier (p < 0.001); patients logging fewer than 4 h per day had markedly higher odds of decreased adherence on multivariate analysis (OR = 33.39, p = 0.003). Unilateral hearing loss, public or no insurance, and older age are risk factors for poor long-term BCHD adherence in pediatric patients. Reduced daily device wear, as measured by datalogging, is a strong independent predictor and should be routinely monitored.

PMID 42714262
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