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calcitonin (Fortical)

✓ Approved

Unigene · CALCR · 重组蛋白

什么是 calcitonin？

calcitonin 是一种重组蛋白，由Unigene研发。该药已获批，用于治疗相关适应症，给药途径：Inhaled。

药物档案

商品名Fortical
公司Unigene
药物类别重组蛋白
分子靶点CALCR
给药途径Inhaled
状态Approved
来源： ClinicalTrials.gov, Unigene

作用机制

分子靶点

calcitonin 作用于 1 个分子靶点：

CALCRcalcitonin receptor (CT-R, CTR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcitonin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedClinical chemistry and laboratory medicine2026-09-10

Pre-analytical and analytical validation of calcitonin measurement in fine needle aspiration cytology washout.

Mater Amber A, Heijboer Annemieke C AC, Boelen Anita A, de Graaf Pim P et al.

Current guidelines advise calcitonin measurements in washout from fine needle aspiration cytology (FNAC) upon inconclusive cytological examination of medullary thyroid cancer (MTC). (Pre-)analytical validation studies of calcitonin measurements in FNAC washout are however missing. In this study, we examined (pre-)analytical aspects of calcitonin measurements using three washout solvents, aiming to provide insights for implementation of calcitonin measurements in FNAC washout as a supplementary test for diagnosing and monitoring patients with MTC. Validation studies were performed using CytoLyt, NaCl and MultiDiluent as washout solvents. Precision (intra- and inter-assay coefficients of variation (CV)), accuracy (linearity and recovery) and storage stability of each solvent were assessed after spiking with calcitonin standard. Calcitonin measurements were performed using the serum CALCT immunoassay (Siemens, Atellica). Decision criteria were set based on CLSI and manufacturer's manual. Measurements of calcitonin in MultiDiluent met all decision criteria: intra- and inter-assay CVs were ≤5.5 % and ≤9 %, serial dilutions were linear (R2=0.997) and median recovery was 148 % with limited variation. Furthermore, calcitonin concentrations remained stable (<10 % change) after storage. Measurements in CytoLyt were precise and accurate, but unstable upon storage. Measurements in NaCl only met the criteria for intra-assay CV and linearity. This study showed that MultiDiluent was the optimal solvent to use for calcitonin measurements in a non-serum matrix using the Atellica calcitonin immunoassay. CytoLyt performed suboptimal, while the performance of NaCl was poor. Further research is needed to validate the recommended work-up using patient-derived material.

PMID 42720008
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PubMedThe Journal of craniofacial surgery2026-09-10

Subcutaneous Hemangioma on Nasal Dorsum Treated With Rhinoplasty: Literature Review.

Alzamil Abdullah A, Almutairi Abdulaziz B AB, Alsudays Ali M AM, Almuhaya Reham R

Vascular anomalies, including hemangiomas, which have slow blood flow, can develop anywhere on the body. They are mostly isolated lesions and are more common in women. The deformity does not regress on its own. A rare variety, known as subcutaneous hemangioma, grows aggressively and occasionally recurs after excision. In this report, we present a case of a 44-year-old female who experienced a slowly growing, painful nasal hump as a result of nasal trauma she sustained 7 years ago. She denied any associated symptoms apart from pain. Physical examination revealed a palpable, soft, nonmobile mass measuring ∼1 cm by 0.5 cm over the nasal dorsum. There was mild tenderness, and the skin appeared normal. Imaging workup with a CT scan showed a destructive process in the cortex of the left nasal bone, with soft-tissue density noted in the anterior left nasal cavity abutting the anterior nasal septum. Furthermore, an MRI study showed a well-defined, rounded, isointense lesion on T1 FSE images under the nasal bridge and hyperintense on T2 FSE images. Ultimately, the patient underwent open rhinoplasty. According to the histopathology results, there was reactive bone with skeletal muscle fibers, fibrosis, and dilated vascular channels. Atypia, mitosis, and necrosis were not present. The patient was doing well postoperatively with no complications and was scheduled for routine clinic follow-ups.

PMID 42720602
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PubMedOTO open2026-09-10

Anatomical Feature of Nasal Cavity for Endoscopic Endonasal Skull Base Surgery in Patients With GHoma.

Suzuki Tomoharu T, Komune Noritaka N, Miyamoto Yusuke Y, Kuga Daisuke D et al.

Endoscopic endonasal skull base surgery (EESS) is widely performed for pituitary tumors. In growth hormone-secreting adenomas (GHomas), the procedure is technically more demanding than for other pituitary neuroendocrine tumor (PitNET) subtypes due to restricted instrument maneuverability. Few studies have evaluated the influence of nasal cavity morphology on this difficulty. To identify anatomical factors contributing to the technical challenges of EESS for GHomas by comparing nasal cavity structures between GHoma and non-GHoma PitNET patients. Retrospective chart review. Tertiary referral center with a collaborative skull base team of neurosurgery and otolaryngology. Computed tomography (CT) images of 28 GHoma and 104 non-GHoma PitNET patients who underwent EESS between August 2018 and April 2024 were analyzed. Measurements included inter-vidian canal distance, nasolacrimal duct opening width, inferior turbinate width, piriform aperture width, sphenopalatine foramen width, inter-carotid artery distance, skull base-to-hard palate distance, anterior nasal spine-to-clivus distance, and anterior sphenoid wall-to-clivus distance. Comparisons were performed using Student's t-test. GHoma patients showed significantly greater nasolacrimal duct opening width, piriform aperture width, and anterior nasal spine-to-clivus distance (P < .05). Vertical-to-horizontal ratios did not differ significantly. However, the inter-carotid artery distance and the ratios of inter-carotid distances to the anterior nasal spine-to-clivus distance were significantly smaller in GHomas. GHoma patients possess generally larger sinonasal dimensions, yet a narrower paraclival inter-carotid space limit surgical maneuverability. These CT-based anatomical differences may have potential implications for preoperative anatomical assessment in patients with GHomas. IV.

PMID 42719243
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PubMedThe Laryngoscope2026-09-10

Reference Equations for Peak Nasal Inspiratory and Expiratory Flow: A Cross-Sectional Study.

de Oliveira Gardênia Maria Martins GMM, Laporta Gabriel Zorello GZ, Sabiá Joao Paulo Duarte JPD, Ferreira Joao Marcos JM et al.

To develop reference equations for peak nasal inspiratory flow (PNIF) and peak nasal expiratory flow (PNEF) in healthy adults using easily measurable anthropometric variables. This cross-sectional study included 239 clinically healthy adults (123 women and 116 men) aged 20-55 years with normal spirometry and no clinically relevant nasal obstruction symptoms. PNIF and PNEF were measured using standardized techniques. Generalized linear models were constructed using sex, height, weight, and age as candidate predictors. Model selection was based on the corrected Akaike information criterion (AICc). Model m14 demonstrated the best fit and parsimony for both PNIF and PNEF. The final reference equation for PNIF was PNIF (L/min) = exp (3.370356 + 0.633324 × height (m) + 0.004086 × weight (kg) + 0.130967 × sex). The reference equation for PNEF was PNEF (L/min) = exp (2.799532 + 1.062786 × height (m) + 0.005143 × weight (kg) + 0.133738 × sex). Sex was coded as 0 for female and 1 for male. Height and weight showed significant positive associations with both outcomes. Age did not improve model performance. Reference equations for PNIF and PNEF were established in clinically healthy adults. Compared with PNEF, PNIF demonstrated greater homogeneity and lower residual variability, suggesting potential value as a complementary tool for interpreting objective nasal airflow measurements. These internally validated equations require external validation before broader clinical application. N/A.

PMID 42717813
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PubMedNature2026-09-10

Nasal vaccines could stop pandemics before they begin.

King Anthony A

PMID 42717071
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PubMedGeneral physiology and biophysics2026-09-10

Cornuside attenuates inflammatory response injury in mice with ovalbumin-induced allergic rhinitis.

Wang Hui H, Huang Linghan L

Allergic rhinitis (AR) is characterized by inflammation of the nasal mucosa caused by an allergic reaction. Cornuside has been reported to possess anti-allergic properties. This study aims to investigate whether cornuside can suppress AR. Mice were induced by ovalbumin (OVA) to establish AR models. The AR symptoms including sneezing and nasal rubbing were recorded, and the eosinophils in mouse mucosal tissues were analyzed by hematoxylin and eosin staining. Total leucocytes in nasal lavage fluid (NLF) were quantified under a hemocytometer. Wright's Giemsa staining was utilized to quantify eosinophils, lymphocytes, and neutrophils in NLF. Enzyme-linked immunosorbent assay was conducted to detect histamine, serum cytokines (OVA-specific IgE, OVAspecific IgG1, interleukin-4, and leukotriene C4), and serum inflammation cytokines (tumor necrosis factor-α, interleukin-6, interleukin-13, and interleukin-17). Cornuside administration significantly reduced sneezing and nasal rubbing behaviors in mice with AR. Mice with AR exhibited more inflammatory cells and higher levels of histamine, serum cytokines, and inflammatory cytokines in the blood or NLF than the control group. However, these upregulations were all reversed by the administration of cornuside. In addition, we found that cornuside treatment improved the inflammatory condition of mice with AR dose-dependently Cornuside can attenuate the inflammatory response in mice with AR.

PMID 42717790
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