北京若生智能科技有限公司
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YY

YY-3110 (YY 3110 / YY3110)

✓ Approved

YuYu Pharma · 小分子 · 小分子

什么是 YY-3110？

YY-3110 是一种小分子，由YuYu Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名YY 3110, YY3110
公司YuYu Pharma
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, YuYu Pharma

治疗适应症

YY-3110 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersThrombosis✓ Approved

相关研究文献

PubMedClinical science (London, England : 1979)2026-09-10

How lipid ingestion is sensed: the mechanisms underlying intestinal hormone secretion.

Santos-Hernández Marta M, Gribble Fiona M FM, Reimann Frank F

Dietary lipids are potent stimulators of intestinal hormone secretion, which plays a central role in the regulation of digestion, appetite, glucose homeostasis, and lipid metabolism. Following digestion in the intestinal lumen, lipid-derived molecules are detected through complementary mechanisms involving lipid transporters, nutrient-sensing receptors, intracellular metabolic pathways, and bile acid signaling. These pathways couple nutrient availability to the secretion of enteroendocrine hormones, including glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), cholecystokinin (CCK), ghrelin and serotonin, thereby coordinating local and systemic metabolic responses. In the small intestine, CD36 contributes to lipid uptake and sensing, while intracellular lipid processing and chylomicron formation influence hormone secretion. Bile acids facilitate lipid digestion and absorption and further regulate enteroendocrine function through receptor-mediated signaling pathways. This review examines the cellular and molecular mechanisms underlying intestinal lipid sensing, with particular emphasis on the roles of CD36, chylomicron formation, bile acid signaling, and nutrient-sensing receptors in the regulation of enteroendocrine hormone secretion.

PMID 42719962
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PubMedJournal of pediatric endocrinology & metabolism : JPEM2026-09-10

Physical development, hormonal and peptide status in preschool and school-age children born to mothers with obesity.

Firsova Liudmila L, Novikova Valeria V, Evdokimova Nina N, Gurina Olga O et al.

To determine features of physical development and hormonal status in preschool- and school-age children born to mothers with obesity. A case-control single-center study included a group of 69 children (29 aged 5-6 years; 40 aged 14-16 years) born to mothers with body mass index (BMI)≥30 kg/m2 before and during pregnancy (MO group). The control group included 61 children (27 aged 5-6 years; 34 aged 14-16 years) born to mothers with steady normal BMI (18.5-24.9 kg/m2). Anthropometric measurements were analyzed using the World Health Organization (WHO) AnthroPlus program. In 59 children, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), peptide YY (PYY), serotonin, leptin, and ghrelin levels were evaluated using enzyme-linked immunosorbent assay. Statistical analysis was performed. We did not find any differences in height among children aged 5-6 years (p=0.42) and 14-16 years (p=0.12). Children in the MO group had higher weight Z-score and BMI Z-score (p<0.001). In children aged 5-6 years in the MO group, serum leptin was higher (p=0.03) and had a positive correlation with body weight and BMI. Ghrelin level was higher in adolescents of the MO group (p=0.03); however, there were no correlations with body weight (p>0.05). IGF-1, IGF-2, serotonin, and PYY did not show significant differences between the two groups (p>0.05). Children born to mothers with obesity are more likely to suffer from obesity. However, more comprehensive studies on hormonal profiles are needed, incorporating an analysis of additional factors.

PMID 42720320
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PubMedPeerJ2026-09-08

Associations between gut microbiota on carcass traits and meat quality in Neijiang pigs, Yorkshire pigs, and their hybrids.

Hao Ziling Z, Yang Yiting Y, Yan Zhijuan Z, Du Yong Y et al.

This study was designed as an exploratory analysis to compare carcass performance, meat quality traits, and gut microbiota of Neijiang pigs (NN), Yorkshire pigs (YY), and Yorkshire × Neijiang hybrid pigs (YN), with the goal of generating testable hypotheses regarding potential links between gut microbial composition and production phenotypes. Compared with NN pigs, YN hybrids exhibited improved carcass performance while inheriting the favorable meat quality characteristics of Neijiang pigs. The results of 16S rRNA sequencing analysis showed that the relative abundance of the microbiota was similar to that of NN pigs. LDA effect size (LEfSe) results showed that Streptococcus, Treponema, probable_genus_10 and Fibrobacter were the differentially enriched taxa in YN pigs (p < 0.05). Correlation analysis was performed on carcass, meat quality and intestinal microbiota screened out by LEfSe. The results showed that Akkermansia tended to positively associate with body length and oblique length in YN pigs; Dialister correlated positively with dressing rate and pH45min; Treponema showed positive trends with a*45min and a*24h (p < 0.05). Finally, the correlation network model preliminarily mapped associations among production traits, gut microbiota, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for exploratory screening. Nine core microbial taxa exhibited close correlations with phenotypic indicators, which implied that these microbes might modulate metabolic pathways to shape pig performance. Overall, hybrids inherited superior parental carcass and meat quality but harbored unique gut microbial communities relative to purebreds-these preliminary correlative observations generate new hypotheses that gut microbiota may contribute to heterosis-associated phenotypic advantages, which require further targeted validation.

PMID 42708027
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PubMedClinical nutrition (Edinburgh, Scotland)2026-09-04

Postprandial metabolic responses to a glycomacropeptide-based protein substitute in different meal contexts - Implications for phenylketonuria (PKU).

Rodrigues Catarina C, Jácome-Pacheco Dúnio D, Barreiros-Mota Inês I, Ismael Shámila S et al.

Casein glycomacropeptide supplemented with amino acids (CGMP-AA) is used in the treatment of phenylketonuria (PKU). However, its acute metabolic effects when consumed with other foods remain poorly understood. This study investigated the impact CGMP-AA consumed alone or with two low-protein meals providing carbohydrates with either fibre or fat. In this randomised crossover trial, fifteen healthy adults (27.0 ± 7.9 y; 7 females) consumed: A) CGMP-AA alone; B) CGMP-AA with low-protein bread and unpeeled apple; or C) CGMP-AA with low-protein bread and olive oil. Blood samples were collected over 120 min to assess glucose, insulin, C-peptide, amino acids, and appetite-related hormones (glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and peptide YY (PYY)). Co-ingestion with low-protein foods had limited effects on total essential and large neutral amino acid concentrations over 120 min, but increased Tyr incremental area under the curve (iAUC(0-120min)) and peak concentration (Cmax) compared with CGMP-AA alone. Meal B elicited the highest glucose, insulin, and C-peptide iAUC(0-120min) and Cmax, followed by meal C, whereas meal A induced minimal glycaemic and insulinaemic excursions. Meal C produced the greatest GIP response, whereas GLP-1 and PYY did not differ between test meals. In healthy adults, CGMP-AA elicited distinct acute postprandial responses depending on whether it was consumed alone or with low-protein foods. CGMP-AA consumed with food is not metabolically equivalent to CGMP-AA consumed alone, and carbohydrate-with-fibre and carbohydrate-with-fat meal contexts affect distinct aspects of the postprandial response. These findings should be confirmed in individuals with PKU before being translated into dietary recommendations.

PMID 42696856
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PubMedJournal of ethnopharmacology2026-09-01

Yunpi Xiaoji Formula Restores Gut-Brain Axis Homeostasis in Infantile Anorexia by Targeting the SCFAs-GPR43 Signaling Pathway.

Zhao Binyuan B, Tian Wenxia W, Chen Jing J, He Yuezhen Y et al.

Infantile anorexia (IA) represents a complex feeding disorder with limited therapeutic options currently available. The traditional Chinese medicine (TCM) formula Yunpi Xiaoji Formula (YPXJF) has demonstrated clinical efficacy in ameliorating IA symptoms; however, its underlying mechanisms, particularly those associated with the gut-brain axis, remain to be systematically elucidated. This study aimed to determine the association between anorexia and the SCFAs-GPR43-PYY/GLP-1 pathway, to investigate whether YPXJF ameliorates IA via modulation of this pathway, and to elucidate its role in gut-brain axis crosstalk. The phytochemical profile of YPXJF and its absorbed serum constituents was characterized using UHPLC-MS. An integrative approach combining in vivo IA rat models and in vitro cell systems was employed. Interventions included the GPR43 agonist 4-CMTB and antagonist GLPG0974. Genetic techniques involved GPR43 knockdown and overexpression in GLUTag L-cells. Gut-brain axis communication was modeled using a Transwell co-culture system of GLUTag L-cells and POMC neurons. Analytical methods comprised H&E staining, immunohistochemistry, immunofluorescence, Western blotting, RT-PCR, and ELISA. A total of 883 compounds were detected in YPXJF, with 130 absorbed constituents (82 prototypes and 48 metabolites) identified in serum, primarily phenolic acids, alkaloids, and flavonoids. The pathogenesis of IA was driven by aberrant activation of the gut-brain axis. In IA rats, elevated levels of fecal SCFAs (acetate, propionate, and butyrate) activated G protein-coupled receptor 43 (GPR43) on colonic L-cells, leading to excessive secretion of the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). These hormones subsequently acted on the hypothalamus to upregulate anorexigenic POMC/CART neurons and downregulate orexigenic NPY/AGRP neurons, ultimately resulting in anorexia. YPXJF treatment effectively reversed this dysregulation by normalizing fecal SCFA profiles and downregulating colonic GPR43 expression, which reduced GLP-1 and PYY secretion. Consequently, YPXJF suppressed hypothalamic POMC neuronal activity and enhanced NPY neuronal activity, restoring appetite and body weight. These findings were confirmed by molecular assays showing that YPXJF efficacy was blunted by GPR43 overexpression or agonist co-administration. YPXJF ameliorates IA by modulating the SCFAs-GPR43 pathway and restores gut-brain axis homeostasis by attenuating pathological anorexigenic signaling and restoring physiological appetite regulation. This study provides a mechanistic basis for YPXJF's clinical application and identifies GPR43 as a promising therapeutic target.

PMID 42680126
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PubMedMicroorganisms2026-08-27

Contrasting the Microbial Communities in Rhizosphere and Bulk Soils Across Different Eucommia ulmoides Planting Sites and Their Soil Chemical Driving Mechanisms.

Liu Panfeng P, Wang Huaxiang H, Lin Furong F, Du Hongyan H et al.

Soil multifunctionality (SMF) is a core indicator of plantation soil ecological function, and microbial diversity plays a vital role in sustaining it. However, cross-site rhizosphere and bulk SMF disparities and their microbial driving mechanisms remain unclear in Eucommia ulmoides plantations. Here, we collected rhizosphere and bulk soils from three typical sites (Mengzhou, MZ; Liangyuan, LY; and Yuanyang, YY). Soil chemical properties, extracellular enzymes, microbial alpha diversity, community composition and cross-kingdom network topology were measured. Correlation heatmaps, random forest, Redundancy analysis (RDA) and Partial least path modeling (PLS-PM) were adopted to quantify SMF predictors and regulatory pathways. Rhizosphere soils possessed significantly higher alkaline hydrolyzable nitrogen (AN), available phosphorus (AP) and available potassium (AK) than bulk soils at all sites. LY rhizosphere showed the greatest soil organic carbon (SOC), total potassium (TK), available nutrients and enzyme activities, while YY had higher total nitrogen (TN) and AP, yet the lowest enzyme levels. Rhizosphere bacterial and fungal alpha diversity was consistently higher across locations. SMF varied distinctly by site and compartment: LY had substantially higher SMF than MZ and YY in both rhizosphere and bulk soils, with rhizosphere SMF being consistently greater than bulk values across all sites. The PLS-PM (GOF = 0.70) indicated that soil chemical properties regulated SMF via dual pathways: they directly promoted microbial co-occurrence networks and indirectly modified network structure by altering fungal diversity, while suppressing bacterial diversity. Total effect analysis identified soil chemical properties and microbial co-occurrence networks as the core drivers of SMF variation. This work clarifies that rhizosphere effects and soil chemical properties jointly drive SMF by regulating microbial diversity and co-occurrence networks, offering theoretical guidance for sustainable soil management in E. ulmoides plantations.

PMID 42655197
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