北京若生智能科技有限公司
Drug Database
SA

saxagliptin (Bessin)

✓ Approved

Sino Biopharmaceutical Co., Ltd · DPP4 · 小分子

什么是 saxagliptin？

saxagliptin 是一种小分子，由Sino Biopharmaceutical Co., Ltd研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Bessin
公司Sino Biopharmaceutical Co., Ltd
药物类别小分子
分子靶点DPP4
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sino Biopharmaceutical Co., Ltd

作用机制

分子靶点

saxagliptin 作用于 1 个分子靶点：

DPP4dipeptidyl peptidase 4 (CD26, DPPIV)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

saxagliptin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved

相关研究文献

PubMedFrontiers in psychiatry2026-09-10

Tai Chi modulates resting alpha and theta EEG rhythms in female individuals with amphetamine-type stimulant dependence during compulsory detoxification.

Wang Ruzhen R, Chen Jingyi J, Zhu Dong D

Amphetamine-type stimulants (ATS), primarily methamphetamine, are currently the most frequently abused illicit drugs in China, causing profound neurotoxicity and cognitive impairment, particularly in women. While exercise-based rehabilitation such as Tai Chi has shown benefits for sleep, mood, and executive function, its specific neurophysiological mechanisms in addiction recovery remain unclear. Thirty-two female individuals with ATS dependence from a compulsory rehabilitation center were randomly assigned to a Tai Chi group (n=16) or a matched-intensity control group (routine physical rehabilitation; n=16). The intervention lasted 6 months (three 60-min sessions/week). Resting-state electroencephalography (EEG) was recorded pre-intervention, post-intervention, and immediately after a 20-min acute exercise bout. Alpha (7.5-12.5 Hz) and theta (4-7.5 Hz) power were analyzed across 15 scalp electrodes. Of the 32 randomized participants, 25 completed the full 6-month intervention (Tai Chi: n=14; Control: n=11), and 24 participants (Tai Chi: n=13; Control: n=11) provided usable EEG data at all assessment points and were included in the primary neurophysiological analyses. After the 6-month intervention, both groups exhibited significant reductions in resting alpha and theta power across multiple cortical regions (p<0.05), indicating a general modulation and reduction of cortical oscillatory activity. Acutely, however, Tai Chi elicited significantly higher alpha and theta power in widespread frontal, parietal, temporal, and occipital regions compared to treadmill exercise (p ≤ 0.05). Notably, these acute comparisons reflect post-exercise group differences rather than within-group changes from an acute pre-exercise baseline, as no pre-exercise EEG was recorded immediately before the acute bout. Long-term moderate-intensity exercise effectively modulates resting EEG rhythms among female individuals with ATS dependence. Furthermore, an acute bout of Tai Chi is associated with a distinct pattern of EEG changes consistent with greater cortical relaxation and internal focus compared to conventional exercise. These findings suggest that Tai Chi serves as a neurophysiologically meaningful, low-cost adjunctive therapy for cognitive and emotional rehabilitation in compulsory detoxification settings. However, the absence of a non-exercise control group, healthy normative data, and immediate pre-exercise EEG recordings precludes causal attribution of these changes solely to Tai Chi or definitive claims of physiological 'normalization'.

PMID 42719036
阅读全文 →
PubMedAAPS PharmSciTech2026-09-10

Correlative Spectroscopic and Structural Imaging for Resin-Embedded Extended-Release Morphine Sulfate Pellets.

Zaker Yeakub Y, Ahmed Snober S, Tian Li L, Yilmaz Huzeyfe H et al.

Correlative spectroscopic and structural imaging provides a powerful approach for characterizing the microstructure of complex pharmaceutical formulations. Laser direct infrared (LDIR) spectroscopy is an emerging, rapid spectroscopic imaging technique that complements traditional approaches by enabling non-destructive chemical and morphological analysis over large sample surfaces within minutes. In this study, the capabilities of LDIR imaging were evaluated alongside Raman mapping, SEM-EDS, laser microscopy, and micro-CT as part of a correlative workflow to characterize the microstructure and chemical composition of pharmaceutical pellets. Resin embedding enabled consistent handling and structural preservation of extended-release pharmaceutical pellets across all imaging modalities. Two commercially available morphine sulfate ER pellets (ER-1 and ER-2) with different excipient compositions were used as model systems. Laser microscopy revealed distinct differences in surface topography, while micro-CT performed before milling confirmed inherent structural features. ER-1 displayed a smooth, intact core, whereas ER-2 exhibited internal cracks and cavities. Hyperspectral LDIR imaging successfully identified major components in both formulations (hit-quality index, HQI ≥ 0.83) with strong concordance to Raman mapping (HQI ≥ 0.85). The spatial distribution of the active pharmaceutical ingredient (API) revealed a layered structure in ER-1 and a homogeneous core in ER-2. This correlative workflow, combining resin embedding with multiple imaging modalities, underscores the value of LDIR and complementary techniques for comprehensive physicochemical characterization of complex drug products. These findings highlight the utility of correlative imaging for regulatory assessment and quality control of complex extended-release formulations.

PMID 42717169
阅读全文 →
PubMedCrystal growth & design2026-09-10

Enhanced Solubility of Famotidine through Salification.

Eilers Jane M JM, Seo Payton P, Ma Liulei L, Kelley Steven P SP et al.

Famotidine (FMT) is an active pharmaceutical ingredient that exhibits poor aqueous solubility and poor permeability. Molecular electrostatic potential and pK a calculations were used to guide a salification strategy for FMT and afforded five salts featuring carboxylic acid-containing coformers. All solids feature charge-assisted hydrogen bonds between the guanidinium group of FMT and carboxylate of the coformer. All salts exhibited good thermal and benchtop stability, and a six- to 20-fold increase in aqueous solubility was achieved, depending on the coformer used. The best performing salts include coformers on the FDA's generally recognized as safe list, making the solids promising for pharmaceutical applications.

PMID 42719395
阅读全文 →
PubMedAAPS PharmSciTech2026-09-10

Real-Time Monitoring of Tablet API Concentration and Bioavailability via Dissolution Kinetics in Simulated Stomach Fluid by T-Ray Transmission Technique.

Rahman Anis A, Islam Rafiq R, Michniak-Kohn Bozena B

This paper introduces a real-time, separationless method for monitoring Active Pharmaceutical Ingredient (API) concentration and dissolution kinetics in oral tablets using terahertz radiation (T-ray) transmission kinetics within simulated stomach fluid. Unlike conventional techniques such as High-Performance Liquid Chromatography (HPLC), which produce only discrete data points and require labor-intensive sample preparation, the T-ray approach offers continuous, quantitative measurement and monitoring. By leveraging the unique transmission and absorption characteristics of APIs in the T-ray region, this technique enables precise, real-time quantification of API concentration without physically separating excipients from the sample. The technique captures comprehensive kinetic profiles, providing deeper insights into dissolution processes and underlying molecular interactions. Its application can enhance Process Analytical Technology (PAT) by facilitating immediate, real-time quality control and supporting continuous manufacturing in the pharmaceutical industry. Additionally, the data generated can strengthen the modeling of in vitro-in vivo correlations (IVIVC), which is crucial for drug development and bioavailability assessment. Overall, the T-ray transmission technique represents a robust, efficient, and sustainable analytical tool for pharmaceutical research and production, offering significant advantages over traditional methods in both accuracy and operational speed.

PMID 42717175
阅读全文 →
PubMedTransactions of the Royal Society of Tropical Medicine and Hygiene2026-09-10

Intersectional analysis of patient information leaflets for neglected tropical diseases in Argentina.

Bongioanni Agustina A, Gomez Camila C, Palma Santiago D SD, Saletti-Cuesta Lorena L

Neglected tropical diseases (NTDs) disproportionately affect vulnerable populations in Argentina, yet the equity dimensions of patient information leaflets (PILs) for NTD treatments remain unexplored. This study analysed PILs of drugs available in Argentina for treating NTDs from an intersectional and health equity perspective using the PROGRESS-Plus framework. A systematic documentary analysis was conducted on 139 PILs covering 13 endemic NTDs in Argentina, identified through official pharmaceutical databases (March-December 2024). A double-entry matrix recorded the presence or absence of equity content across adapted PROGRESS-Plus dimensions. Data were analysed using descriptive statistics in Python. Critical equity gaps were identified across all PROGRESS-Plus dimensions. Religion, education, menopause and transgender individuals were entirely absent from all PILs. Only 5% included race and ethnicity considerations and 14% provided sex-disaggregated clinical data. Contradictory information on pregnancy and breastfeeding was identified across manufacturers for identical drugs. Disability considerations appeared in <1% of PILs. Only 62.5% of World Health Organization essential medicines for selected NTDs were commercially available in Argentina. PILs for NTD treatments in Argentina lack intersectional perspectives, creating barriers to equitable healthcare access. Regulatory reform of Argentina's PIL provisions and adoption of PROGRESS-Plus-informed standards are urgently needed to ensure that pharmaceutical communications serve all populations affected by NTDs.

PMID 42717840
阅读全文 →
PubMedPhysical chemistry chemical physics : PCCP2026-09-10

Elucidation of hydrogen bonding networks in theophylline cocrystals by 1H-detected 17O and 14N solid-state NMR spectroscopy.

Bequette Joseph P JP, Riemersma Kipper K, Carnahan Scott L SL, Paterson Alexander L AL et al.

Determining hydrogen bonding networks and proton positions in pharmaceutical cocrystals remains challenging, particularly for microcrystalline materials and systems involving strong hydrogen bonds and partial proton transfer. Here, we demonstrate a strategy that combines fast magic-angle spinning (MAS) solid-state NMR with 1H-detected 17O → 1H and 1H{14N} heteronuclear correlation experiments to directly probe hydrogen bonding interactions in theophylline-carboxylic acid cocrystals. Facile 17O enrichment of carboxylic acid coformers (benzoic, oxalic, maleic, and malonic acids) was achieved by isotope exchange with 17O-enriched water under mild conditions. Isotope exchange reactions can be easily monitored by 17O solution NMR spectroscopy. Two-dimensional 17O → 1H D-RINEPT and 1H{14N} D-HMQC spectra recorded with variable dipolar recoupling times enable assignment of overlapping 1H resonances and provide site-specific identification of intermolecular hydrogen bonds between theophylline and carboxylic acid coformers. High magnetic field SSNMR experiments (up to 25.8 T) further enhance 17O spectral resolution and enable resolution of overlapping 17O resonances associated with distinct hydroxyl, carbonyl, and dynamically exchanging oxygen environments. Complementary 1H spin-diffusion and dipolar double-quantum experiments corroborate intermolecular contacts and confirm cocrystal formation. Experimental 17O and 14N solid-state NMR parameters are in good agreement with Gauge Including Projector Augmented Wave (GIPAW) density functional theory (DFT) calculations. Together, these results establish a practical multinuclear SSNMR approach for identifying hydrogen bonding networks in pharmaceutical cocrystals and other multicomponent organic solids.

PMID 42717882
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多saxagliptin