北京若生智能科技有限公司
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PT-003

✓ Approved

Pediatrix Therapeutics · 未知 · 未知

什么是 PT-003？

PT-003 是一种未知，由Pediatrix Therapeutics研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Pediatrix Therapeutics
药物类别未知
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Pediatrix Therapeutics

治疗适应症

PT-003 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMedJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2026-09-10

Current clinical applications and future developments of platinum-based anticancer drugs.

Kamusheva Maria S MS, Varbanov Hristo P HP

The study evaluated the current patterns of guideline-recommended clinical use, real-world utilization trends, and translational development of platinum-based (Pt-based) drugs through a comparative analysis of national and international pharmacotherapeutic guidelines, national drug utilization data, clinical trials, and emerging research directions. Cisplatin, carboplatin and oxaliplatin continue to play central roles across multiple malignancies and remain widely incorporated into recommended treatment protocols. Across all five guideline sources evaluated, Pt-based therapies were recommended in more than half of the 18 ICD-O topographic categories, with guideline coverage ranging from 55.6% to 83.3%. Real-world utilization data, using Bulgaria as a case study, indicated sustained and increasing use of Pt-based therapies between 2021 and 2024, with oxaliplatin showing the greatest increase. Current clinical trials focus primarily on optimizing established Pt-based regimens through combinations with immunotherapeutics and emerging drug candidates within increasingly personalized multimodal treatment strategies. In parallel, research efforts are directed toward the development of new Pt complexes, exploring next-generation approaches such as multifunctional Pt(IV) prodrugs and Pt-N-heterocyclic carbene compounds, as well as advanced drug-delivery systems, reflecting continued innovation in the field. Overall, Pt-based drugs remain essential in cancer therapy and continue to represent a dynamic area of research in biological inorganic chemistry and translational oncology.

PMID 42720687
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PubMedThe American journal of sports medicine2026-09-10

Patella Alta and Trochlear Dysplasia as a Determinant of Patellar Tendon Lateralization and Inclination: A Cross-sectional MRI Study in Adolescents With Patellofemoral Instability.

Crippa Marco M, Beltrame Giulia G, Beber Samuel A SA, Matarangas Ariana I AI et al.

Patellofemoral instability (PFI) is traditionally assessed using tibial tubercle-trochlear groove (TT-TG) distance, patellar height indices, and trochlear morphology. However, soft tissue-based measures of patellar tendon orientation may provide complementary insight into patellar containment and extensor mechanism malalignment. Patellar tendon-lateral trochlear ridge distance (PT-LTR) has been proposed as a tendon-based marker of lateralization. The authors introduce the patellar tendon inclination angle (PTIA): a magnetic resonance imaging (MRI)-based parameter designed to quantify the obliquity of the patellar tendon relative to the femoral condyles. To define and validate PTIA and to compare its performance with PT-LTR. Secondary objectives were to assess correlation of PTIA and PT-LTR with established morphologic risk factors for PFI and to evaluate their diagnostic accuracy for identifying PFI. Case-control study; Level of evidence, 3. MRI studies of 284 knees (PFI, n = 142; controls, n = 142) were included in this analysis. PTIA was developed and measured by orthopaedic surgeons, and their agreement was calculated. PT-LTR, sulcus angle, patellar tilt, lateral patellofemoral angle, TT-TG distance, and Caton-Deschamps index (CDI) were measured for all knees as well. Correlations between PT-LTR/PTIA and other classic measurements were assessed to evaluate the relationship of these novel tendon-based parameters. Subgroup analyses examined the effect of abnormal TT-TG distance (>16 mm), patella alta (CDI ≥ 1.3), and trochlear dysplasia (sulcus angle ≥ 145°). Receiver operating characteristic curves were used to determine diagnostic accuracy. Patients with PFI demonstrated significantly higher PT-LTR (mean ± SD, 9.76 ± 7.66 mm) and PTIA (22.76°± 11.22°) as compared with controls (P < .001). PT-LTR and PTIA were significantly positively correlated with patellar tilt, CDI, and sulcus angle. Patella alta significantly increased PT-LTR (P < .001). Receiver operating characteristic analysis demonstrated excellent diagnostic performance for PT-LTR (area under the curve, 0.903; optimal cutoff, 4 mm) and PTIA (area under the curve, 0.866; optimal cutoff, 16°). PT-LTR and PTIA are reliable MRI-based markers of PFI in adolescents. Although both correlate with established risk factors, including TT-TG distance, patella alta, and trochlear dysplasia, they remain informative even in the setting of normal TT-TG values. PTIA, introduced as a novel parameter, complements PT-LTR by quantifying tendon obliquity and providing additional information on patellar tendon alignment.

PMID 42717417
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PubMedSmall methods2026-09-10

Facile Synthesis of Pt-O-Ni Interfacial Sites on MOF-Derived Carbon Nanomaterials for Efficient Alkaline Hydrogen Evolution.

Liu Hui H, Lin Rong R, Fu Yuting Y, Li Nan N et al.

Developing efficient and durable electrocatalysts for the alkaline hydrogen evolution reaction (HER) is critical for sustainable hydrogen production. In this work, one type of nitrogen-doped carbon nanosheet derived from a nickel-based metal-organic framework (MOF) of Ni-BTC-bpy has been prepared, which enables atomic-scale anchoring of platinum clusters. Subsequently, low-temperature oxidation is carried out to create well-defined Pt-O-Ni interfacial sites for efficient alkaline HER. This optimized catalyst of NBP-NC-Pt-O achieves a low overpotential of 28 mV at a current density of 10 mA cm-2 in 1.0 M KOH, and demonstrates accelerated reaction kinetics compared to the commercial Pt/C. Meanwhile, it also exhibits satisfactory long-term electrocatalytic stability, maintaining 94.3% of its initial activity even after 100-h electrolysis. Furthermore, theoretical calculations indicate that the designed Pt-O-Ni interface connected by oxygen bridges not only reduces the energy barrier for water dissociation and subsequent hydrogen desorption, but also precisely regulates the electronic structure of the active sites to realize an almost optimal hydrogen adsorption free energy. Finally, this strategy can be widely applied to a series of Ni-based coordination polymers (e.g., Ni-ABDC, NiOF-1, and Ni-BTC) and shows excellent alkaline HER performance. This study establishes a general and scalable strategy for designing and synthesizing active, low-platinum catalysts by leveraging synergistic metal-support interactions in MOF-derived architectures, with broad implications for sustainable energy conversion technologies.

PMID 42717703
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PubMedChemical communications (Cambridge, England)2026-09-10

Ordered PtCu3 intermetallic enables superior and cost-effective hydrogen evolution in PEM electrolyzers.

Liang Rongshuo R, Li Linsen L, Huang Shan S, Jiang Zhao Z et al.

We report an ordered L11-PtCu3@C intermetallic catalyst that achieves exceptional Pt mass activity of 15 A mgPt-1 for the hydrogen evolution reaction (HER), outperforming most state-of-the-art Pt-based intermetallics. When integrated into a proton exchange membrane (PEM) electrolyzer, this catalyst enables highly efficient and durable hydrogen production with favorable economic viability, demonstrating its potential as a cost-effective and high-performance electrocatalyst for practical green hydrogen generation.

PMID 42717757
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PubMedBMC sports science, medicine & rehabilitation2026-09-10

Effects of plyometric training on explosive power and swimming performance in adolescent swimmers: a systematic review and meta-analysis with dose-response analysis.

Jin Rangxi R, Finlay Mitchell James MJ, Cuenca-Fernández Francisco F, Huang Wei W

Adolescent swimmers depend heavily on lower-limb power during critical phases such as the block start, wall turn, and sprints, with the circa-peak height velocity (PHV) period representing a sensitive window for neuromuscular development. Plyometric training (PT), utilizing the stretch-shortening cycle, is a key component of long-term athletic development, yet evidence stratified by maturation stage is lacking. This systematic review and meta-analysis searched PubMed, Web of Science, Embase, EBSCO, Cochrane Library, and CNKI for controlled trials in swimmers aged 10-18 years, following PRISMA 2020. Effect sizes were pooled using Hedges' g in a random-effects model, dose-response relationships were evaluated via meta-regression, methodological quality assessed with RoB 2.0 and PEDro, and evidence certainty rated by GRADE. Findings suggest that PT may be associated with moderate-to-large positive point estimates for dry-land explosive power and short-distance swimming performance (with positive effect sizes oriented so that faster swim times yield positive g), with point estimates that appeared larger around the circa-PHV stage; however, none of the pooled estimates reached statistical significance under the primary Hartung-Knapp analysis, the confidence intervals were wide, and all findings should therefore be read as preliminary and hypothesis-generating rather than as confirmation that PT significantly improves these outcomes. Transfer to longer distances was smaller in magnitude. The results provide a provisional basis for tailoring PT programmes by developmental stage that requires confirmation in larger studies.

PMID 42717379
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-10

The GPX3-VCAM1 Axis Gates Pro-Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy.

Qi Yunfei Y, Zhao Qiang Q, Lve Yue Y, Yuan Yaming Y et al.

Hyperuricemia is a major driver of chronic kidney disease, yet the underlying intrarenal mechanisms remain unclear. Here, we establish a genetically defined, multi-hit mouse model that recapitulates the sustained hyperuricemia, metabolic dysregulation, and progressive fibrosis of human disease. Using this model, we demonstrate that soluble uric acid activates the renal NLRP3 inflammasome and that its inhibition attenuates kidney injury. Single-nucleus RNA sequencing revealed a distinct pro-inflammatory and pro-fibrotic proximal tubule cell population (Profib PT) marked by high VCAM1 expression, which is conserved in human kidney disease. Direct VCAM1 neutralization with antibodies attenuated renal fibrosis, validating its functional role. Mechanistically, we identify glutathione peroxidase 3 (GPX3) as a master regulator restraining precursor cell differentiation into Profib PT cells. GPX3 expression is suppressed in hyperuricemia, licensing this pathogenic transition; conversely, dietary selenium supplementation restored GPX3 activity, blocked Profib PT differentiation and VCAM1-dependent macrophage adhesion, and ameliorated renal fibrosis. Our findings define the GPX3-VCAM1 axis as a central regulatory node in hyperuricemic nephropathy and identify nutritional selenium repletion as a novel therapeutic strategy to intercept fibrosis.

PMID 42717509
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