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PT-003

✓ Approved

Pediatrix Therapeutics · 未知 · 未知

什么是 PT-003？

PT-003 是一种未知，由Pediatrix Therapeutics研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Pediatrix Therapeutics
药物类别未知
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Pediatrix Therapeutics

治疗适应症

PT-003 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMedThe new microbiologica2026-07-27

TAK-003 Dengue Vaccine Administration in People with HIV, an Observational Study.

Moschetta Nicolò N, Lolatto Riccardo R, Capra Nicolò N, Raccagni Angelo Roberto AR et al.

With its rising incidence, dengue is a growing global health concern. This retrospective observational study evaluated short-term safety of the dengue vaccine TAK-003 in people with asymptomatic HIV infection and no evidence of impaired immune function that have received at least one dose of TAK-003 at the Travel Medicine Clinic of the Infectious Diseases Unit of San Raffaele Scientific Institute, Milan, Italy, from January 2024 to December 2025. Globally, 12/20 (60%) participants did not report any adverse event after both doses. Seven (35%) experienced mild general or local disorders after dose 1, one reported local disorders after D2. In each case, adverse events resolved spontaneously after 1-3 days. No severe AEs were reported. HIVRNA, CD4+ count and percentage did not significantly vary after both doses of TAK-003. TAK-003 was well tolerated, with adverse events being generally mild, self-limiting and comparable to those observed in the general population. Individuals of ≥60 years of age did not report any adverse events. No significant changes in HIVRNA, CD4+ count and percentage were observed after vaccination.

PMID 42507126
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PubMedACS applied materials & interfaces2026-07-27

Effect of Strain Induced by Varying Bottom Electrode Thicknesses on Ferroelectric Properties of Pt/Al0.7Sc0.3N/Pt Capacitors.

Fang Yuan Y, Li Xiaoxi X, Li Jiawei J, Xu Haiwen H et al.

Aluminum scandium nitride (Al1-xScxN) has emerged as a promising candidate for next-generation nonvolatile memories owing to its excellent large remanent polarization (Pr), high Curie temperature, and CMOS compatibility. However, its ferroelectric characteristics are highly sensitive to strain, which limits device scalability. Herein, we systematically investigate the effect of the relative vertical strain, modulated via the bottom electrode thickness, on the ferroelectric behavior of Pt/Al0.7Sc0.3N/Pt capacitors. The X-ray diffraction analysis reveals that increasing the Pt thickness from 10 to 50 nm reduces the relative vertical strain from 0.27 to -0.26%. The optimized 50 nm Pt electrode yields a lower coercive field (Ec = 4.38 MV/cm) and enhanced remanent polarization (2Pr = 287.72 μC/cm2). First-principles calculations indicate that the reduced relative vertical strain decreases the energy barrier for polarization reversal, accounting for the lower Ec. Meanwhile, the temperature-dependent leakage analysis and theoretical modeling show that the smaller relative vertical strain decreases the trap energy level and the nitrogen-vacancy formation energy, resulting in the increased leakage. These findings establish a clear correlation between electrode-induced strain and ferroelectric properties in AlScN, providing guidance for strain engineering in high-density ferroelectric memory integration.

PMID 42504418
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PubMedInorganic chemistry2026-07-27

Sensitive and Reversible Detection of SF6 Decomposition Gases in GIS: A DFT Study of Pd/Pt-Modified Mo2TiC2O2.

Gui Yingang Y, Su Chunhua C, Zhang Guojiang G, Tao Jiagui J et al.

This work systematically investigates the adsorption behaviors and gas-sensing performances of Pd and Pt single-atom modified Mo2TiC2O2 toward SF6 decomposition gases (H2S, SO2, SOF2, and SO2F2) using first-principles calculations. Key parameters including adsorption energy, charge transfer, density of states, band structure, molecular orbitals, work function, and recovery time are calculated. Pd and Pt favor the hollow and bridge sites, respectively. Both substrates exhibit the strongest adsorption toward H2S (-1.440 to - 1.644 eV), but the excessively long recovery times at room temperature preclude reversible detection. SO2 and SOF2 show moderate adsorption energies (-0.964 to -1.157 eV) with considerable charge transfer, and their recovery times reach the second-to-millisecond scale at 398-498 K. SO2F2 exhibits the weakest adsorption and response. Electronic structure analyses reveal that Pd/Pt modification opens a small band gap (0.019-0.055 eV) in the metallic pristine substrate; H2S and SO2 further reduce the gap (Pt-H2S reaching 0 eV), whereas SO2F2 widens it. Work function and orbital distributions confirm the electron donor/acceptor behavior and hybridization differences among gases. Considering all factors, SO2 and SOF2 are the most suitable target gases with a recommended operating temperature of 398-498 K. This study provides a theoretical basis for single-atom modified MXene-based gas sensors.

PMID 42503781
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PubMedNano letters2026-07-27

Conductive Mechanism of Low-Pt-Coated Porous Transport Layers at Key Interfaces in Proton Exchange Membrane Water Electrolyzers.

Liu Yun Y, Meng Lingda L, Ma Yilin Y, Yang Kaikai K et al.

Proton exchange membrane water electrolyzers (PEMWEs) are key for renewable hydrogen production, featuring two critical charge transport interfaces: porous transport layer/catalyst layer (PTL/CL) and PTL/flow field (PTL/FF). To study interface charge transport, three Pt-loaded PTL anodes were combined with a normal or low-loading membrane electrode. Normal loading: optimized Pt boosts catalyst use; low loading: thinnest coating removes PTL/CL passivation. Notably, at low loading and low current density (<0.3 A cm-2), when charge barriers exist at the PTL/CL interface, an uneven Pt coating fails to improve PTL/FF conductivity and instead introduces additional barriers─an effect that diminishes with optimized coating or increased current density. The charge barrier at the PTL/CL interface amplifies the negative effects at the PTL/FF interface; this effect can be mitigated by applying a uniform coating or increasing the current. These findings provide guidance for optimizing platinum-coated PTLs and for studying charge transport at the PTL/FF interface.

PMID 42504557
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PubMedChemical communications (Cambridge, England)2026-07-27

A Pt(IV) prodrug for cancer chemo-photodynamic therapy preventing skin photosensitivity via in situ PpIX generation.

Wang Xiaorui X, Wang Yongyong Y, Ren Jianing J, Yang Zhenyu Z et al.

A Pt(IV) prodrug DPH was synthesized by the complexation of cDDP with a photosensitizer precursor, 5-aminolaevulinic acid (ALA), and a clinically used ion chelator, deferasirox (DFX). Leveraging cancer-specific metabolism of ALA, DPH enabled selective chemo-photodynamic therapy in vitro and in vivo via in situ PpIX generation, while avoiding skin photosensitivity.

PMID 42504784
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PubMedPeerJ2026-07-27

The effects of plyometric training on adolescent sports performance: a systematic review and meta-analysis.

Yuan Song S, Chai Yunmei Y, Tan Zhijun Z, Cui Zhibo Z et al.

Plyometric training (PT) is a popular method of improving explosive power, speed, and agility in adolescent athletes. Nevertheless, earlier reviews have been mainly based on individual performance domains, individual sports or general youth groups. It is therefore not clear whether the effects of PT differ based on sex, type of sport, frequency of training or duration of intervention. This meta-analysis and systematic review investigated the impact of PT on jumping, sprinting, and agility performance in adolescents. PubMed, Web of Science, and Embase were searched from database inception to 1 January 2025, with an updated search on 30 January 2026. Randomized controlled trials that included healthy adolescents aged 10-19 years were included. Conventional random-effects models were used to pool the effects of PT on jumping, sprinting, and agility performance as standardized mean differences (SMDs) with 95% confidence intervals (CIs). To account for multiple effect sizes contributed by the same study, dependency-adjusted analyses were additionally conducted using three-level random-effects models with CR2 cluster-robust variance estimation. A total of 63 studies were included. Conventional random-effects analyses showed that PT significantly improved jump performance (SMD = 0.648, 95% CI [0.523-0.772]; P < 0.001), sprint performance (SMD = -0.496, 95% CI [-0.609 to -0.383]; P < 0.001), and agility performance (SMD = -0.659, 95% CI [-0.851 to -0.467]; P < 0.001). Dependency-adjusted analyses confirmed the robustness of these findings for jump performance (SMD = 0.613, 95% CI [0.447-0.779]; P < 0.001), sprint performance (SMD = -0.414, 95% CI [-0.583 to -0.245]; P < 0.001), and agility performance (SMD = -0.595, 95% CI [-0.796 to -0.394]; P < 0.001). Benefits were more consistent with longer intervention durations, whereas sex- and sport-specific subgroup findings remained exploratory because of small subgroup sizes and heterogeneity. PT seems to be effective in enhancing jumping, sprinting, and agility performance among adolescents, especially when the interventions are continued at least 10 weeks. However, between-study heterogeneity, testing protocol variability, and small sample sizes in some sex- and sport-specific studies limit the generalizability of subgroup results. Future randomized controlled trials should use standardized outcome measures, report training dose and adherence in detail, and have a higher proportion of female participants. PROSPERO registration: CRD42024627316.

PMID 42504251
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