北京若生智能科技有限公司
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PT

PT-003

✓ Approved

Pediatrix Therapeutics · 未知 · 未知

什么是 PT-003？

PT-003 是一种未知，由Pediatrix Therapeutics研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Pediatrix Therapeutics
药物类别未知
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Pediatrix Therapeutics

治疗适应症

PT-003 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

The Potential of Zero Charge: An Interfacial Descriptor Governing Hydrogen Evolution Reaction on Bulk Metal Electrodes.

Zhang Yuefei Y, Xue Yufei Y, Zhang Yang Y, Liu Xuefei X et al.

While the Sabatier-based volcano plots guide catalyst design for Hydrogen Evolution Reaction (HER), the purely thermodynamic hydrogen binding energy descriptor fails to capture experimental HER trends accurately due to the omission of kinetic contributions. Herein, we combine the fixed-potential method with our developed continuous proton supply/consumption model to establish an extra kinetic descriptor for metal-based electrodes (Pt, Pd, Au, Ag, and their bimetallic alloys) under practical working conditions. The potential of zero charge (PZC) is demonstrated to be the interfacial descriptor, which modulates surface charge density and thereby tunes the kinetic proton enrichment within the EDL. Building on this insight, the PZC is integrated with hydrogen binding energies to establish a new two-dimensional volcano plot for HER. The updated volcano plot derived from the dual descriptors effectively matches the experimental results, which provides an additional guiding parameter for rational catalyst design.

PMID 42928057
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PubMedGeriatrics (Basel, Switzerland)2026-10-26

Function-Specific Profiles of Chronic Low Back Pain in Middle-Aged and Older Patients and Their Association with Standing Sagittal Spinopelvic Alignment: A Cross-Sectional Study.

Morimoto Toru T, Ikemoto Tatsunori T, Arai Young-Chang YC, Hirasawa Atsuhiko A et al.

Background/Objectives: Chronic low back pain (LBP) in older adults is usually quantified as a single global score, which may not reflect the activities in which pain actually limits the patient. This study described function-specific LBP profiles in middle-aged and older patients and examined their cross-sectional association with standing sagittal spinopelvic alignment. Methods: This cross-sectional, retrospective observational study evaluated 102 patients with chronic LBP, categorized into Group M (under 75 years; n = 51) and Group O (75 years or older; n = 51). Visual Analog Scale (VAS) scores were assessed during rest, getting up, rolling over, and walking (gait). An exploratory index, the proportional pain contribution (VAS%), was derived by expressing each phase as a percentage of the sum of the four scores; because the four values sum to 100% by definition, VAS% was interpreted only as a descriptor of the within-patient distribution of pain and always alongside the absolute scores. Lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), sacral slope and PI minus LL (PI-LL) were measured on standing radiographs. Results: Group M reported higher absolute pain than Group O at rest, on getting up and on rolling over (all p < 0.001), whereas absolute gait pain did not differ between the groups (p = 0.730). As a consequence of this pattern, Gait VAS% was higher in Group O (median 59.8% vs. 27.3%, p < 0.001). Group O had lower LL (p = 0.001) and a larger PI-LL (p = 0.005); PI and PT did not differ significantly. Gait VAS% correlated with age (τ = 0.33) and PI-LL (τ = 0.29). In exploratory multivariable models, age and PI-LL were retained in the final model for Gait VAS% and were independently associated with it (β = 0.37 and 0.30 respectively; R2 = 0.29). Conclusions: In this sample, the older patients reported less pain at rest and during postural transitions but similar pain during walking, so that walking accounted for a larger share of their total reported pain burden. This proportional pattern was associated with a larger standing PI-LL mismatch, although the association was modest. The findings are descriptive and hypothesis-generating, and suggest that asking separately about pain during walking may add information that a single global score does not capture.

PMID 42930023
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Synergistic Charge Scavenging in Pt/C-Polyoxometalate Systems for Scalable Biomass Power Generation via Super-Reduced Electrolytes.

Lee Hojin H, Lee Hyeong-Jin HJ, Lee Jongseo J, Han Sang-Soo SS et al.

Direct electrochemical conversion of unrefined biomass waste into electricity offers a sustainable pathway for decentralized energy generation, yet its practical implementation has been fundamentally hindered by low power densities and limited scalability. A fundamental bottleneck lies in the intrinsic recalcitrance of biomass, which restricts electron harvesting to shallow oxidation pathways and confines redox mediators to low reduction states. Here, we demonstrate a scalable biomass flow fuel cell (BFFC) enabled by a super-reduced polyoxometalate (POM) electrolyte that overcomes the long-standing electron-harvesting ceiling. By employing a catalytic oxidative degradation strategy that promotes extensive cleavage of recalcitrant C─C linkages in the lignocellulosic matrix, we unlock deep multi-electron reduction of POM, achieving an electron transfer capacity exceeding four electrons per molecule. As a result, the single-cell device delivers a record-breaking power density of 218.6 mW cm- 2. Beyond laboratory-scale demonstrations, we constructed a 10-cell stack prototype, producing 59.2 Wh over 15.6 h of stable operation directly from raw biomass.

PMID 42928433
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PubMedInorganic chemistry2026-10-26

A Dichalcogenide-Protected Pt@Au12@Ag8 Nanocluster.

Chiu Tzu-Hao TH, Pillay Michael N MN, Kahlal Samia S, Saillard Jean-Yves JY et al.

Precise control over the location of heterometal atoms in alloy nanoclusters is essential for understanding how metal distribution governs superatomic structure and properties. Herein we show that PtAg20[S2P(OPr)2]12 (PtAg20) can serve as a structurally defined precursor for constructing a PtAu12 superatom copassivated by ligands and Ag atoms through redox-mediated Au-for-Ag exchange. Treatment of PtAg20 with an excess of Au(I) affords PtAu12Ag8[S2P(OPr)2]12 (PtAu12Ag8), in which substitution of Ag by Au occurs exclusively on the PtAg20 icosahedral core. Single-crystal X-ray diffraction reveals a compact PtAu12 core encapsulated by two Ag4(dtp)6 (dtp = dithiophosphate) units. Unlike all the known silver-rich isoelectronic nanoclusters featuring a centered icosahedron protected by a Ag8(dtp)12 outer shell that adopt C3-type or C3-derived shell arrangements, PtAu12Ag8 displays a C2 geometry. Spectroscopic and mass-spectrometric measurements support the formation of the Au-rich cluster, while DFT calculations identify the [PtAu12]4+ core as an eight-electron superatom with a closed-shell 1S21P61D0 electronic configuration. This work demonstrates that selective replacement of the icosahedral cage can generate not only a new trimetallic superatomic core but also an unusual reconstruction of the surrounding Ag-ligand passivating layer.

PMID 42929643
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PubMedPhysical chemistry chemical physics : PCCP2026-10-26

Review of the design and development of MXene-based electrocatalysts for the oxygen reduction reaction.

Wu Zixuan Z, Sit Patrick H-L PH

The oxygen reduction reaction (ORR) is a critical half-reaction in fuel cells, but its slow kinetics demand the use of efficient and durable electrocatalysts. MXenes, a novel class of two-dimensional materials, have emerged as highly promising catalyst supports for the oxygen reduction reaction (ORR) due to their high electrical conductivity, abundant anchoring sites, adjustable surface properties, and excellent durability. This review offers an overview of recent advancements in the design and development of MXene-based electrocatalysts for the ORR. We first introduce common synthesis methods, structural characteristics, and electronic properties of MXenes. Then, we summarize research progress on noble metal catalysts (particularly Pt) using MXenes as supports, as well as non-noble metal catalysts composed of MXenes combined with metal oxides, M-N-C structures, or carbon nanotubes. Moreover, we specifically discuss the theoretical studies of MXene-based single-atom catalysts, which allow efficient activity screening and reaction mechanism elucidation. The application of machine learning in the study of MXene-based ORR electrocatalysts is further reviewed, focusing on how data-driven methods accelerate catalyst discovery and reveal hidden structure-property relationships. Finally, we highlight the major challenges and future research directions, particularly the need to successfully integrate experimental and theoretical studies with machine learning predictions to efficiently explore a broader space of MXene-based electrocatalysts.

PMID 42929712
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PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-10-26

Arthroscopic Delivery of Particulated Juvenile Articular Cartilage Allografts Provides Durable Outcomes for Full-Thickness Chondral Lesions of the Knee.

Dragoo Jason L JL, Constantine Evangelia P EP, Whitney Kaitlyn E KE, McCartney Carolynn M CM et al.

To evaluate patient outcomes after arthroscopic particulated juvenile articular cartilage implantation for full-thickness cartilage lesions in the knee with a minimum 24-month follow-up. This was a retrospective case series of patients aged ≥15 years with International Cartilage Repair Society grade IV chondral lesions with exposed subchondral bone treated with primary arthroscopic particulated juvenile articular cartilage implantation between 2016 and 2023. All included patients had a minimum of 24 month follow-up. Knee Injury and Osteoarthritis Outcome Score and Western Ontario and McMaster Universities Osteoarthritis Index subscales were compared between baseline and a minimum of 24 months postoperatively using Wilcoxon signed-rank tests. Linear mixed-effects models with random intercepts for patients were constructed a priori to evaluate longitudinal associations between outcomes and prespecified covariates (age, sex, body mass index [BMI], smoking exposure, lesion area and compartment, and common concomitant procedures). Thirty-four patients (16 women, 18 men; mean age 43.5 ± 10.2 years; mean BMI 27.9 ± 5.2) with mean lesion area of 2.98 ± 1.50 cm2 were included. Mean follow-up was 3.9 years (range: 2.1-9.5). All outcome subscales improved significantly from baseline to 24 months (all P < .003), with 71% to 82% of patients achieving clinically meaningful improvements (54% for Western Ontario and McMaster Universities Osteoarthritis Index Stiffness). In mixed-effects models, higher BMI was the only covariate associated with worse outcomes, with approximately 1.2-point lower Knee Injury and Osteoarthritis Outcome Score scores for each 1 increase in BMI. No acute graft displacements occurred, and 1 patient (2.9% of the cohort) experienced late graft delamination requiring revision 2.3 years postoperatively. Arthroscopic particulated juvenile articular cartilage transplantation provided significant 24-month improvements across all outcome domains for high-grade knee lesions. Outcomes were not associated with lesion size, location, or demographics, though higher BMI was associated with worse results. No acute graft complications occurred. Level IV, retrospective case series.

PMID 42928438
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