北京若生智能科技有限公司
Drug Database
SU

sumatriptan succinate (Zelrix / NP101 / Zecuity)

✓ Approved

Nupathe Inc. · HTR1D · 小分子

什么是 sumatriptan succinate？

sumatriptan succinate 是一种小分子，由Nupathe Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Topical、Transdermal。

药物档案

商品名Zelrix, NP101, Zecuity
公司Nupathe Inc.
药物类别小分子
分子靶点HTR1D
给药途径Topical, Transdermal
状态Approved
来源： ClinicalTrials.gov, Nupathe Inc.

作用机制

分子靶点

sumatriptan succinate 作用于 1 个分子靶点：

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sumatriptan succinate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersMigraine✓ Approved

相关研究文献

PubMedChemistry & biodiversity2026-09-10

Synthesis and Antifungal Evaluation of Isoquinoline-3-amide Derivatives Containing a Phenoxypyridine Moiety for Plant Protection.

Zhang Jiayao J, Sun Shuaipeng S, Guo Yajing Y, Xu Zhiyuan Z et al.

To discover novel green antifungal candidates, 20 3-acylaminoisoquinoline derivatives were designed and synthesized by introducing the active fragment phenoxypyridine. Their structures were verified by 1H NMR, 13C NMR, and HRMS. The structure of compound X9 was further confirmed via X-ray crystallography. Their antifungal activities against five phytopathogenic fungi were evaluated to develop isoquinoline-based antifungal agents. Among them, compound X6 demonstrated significant antifungal activity against Botrytis cinerea with an EC50 value of 7.55 µg/mL. In vivo assays revealed that compound X6 exhibited strong protective and curative efficacy against B. cinerea with rates of 77.86% and 45.45% at a concentration of 100 µg/mL. Molecular docking studies confirmed that isoquinoline amide compounds possess strong binding affinity to succinate dehydrogenase (SDH). Molecular dynamics (MD) simulations revealed that compound X6 has better pocket spatial compatibility and more stable binding interactions with SDH than boscalid. Furthermore, SDH activity assays showed compound X6 inhibited SDH activity by 66.7% at 4 EC50 concentration, which was comparable to that of the boscalid (75.85%). These findings demonstrated that isoquinoline derivatives incorporating the phenoxypyridine fragment possess potent fungicidal properties for crop safety, with compound X6 emerging as a promising candidate for a novel SDH inhibitor.

PMID 42720078
阅读全文 →
PubMedGeneral physiology and biophysics2026-09-10

Bardoxolone methyl induces mitochondrial dysfunction, activation of the cytosolic stress response, and increased chaperone capacity in SH-SY5Y cells. Focus on mitochondrial protease LONP1.

Hudak Lubos L, Evinova Andrea A, Liskova Monika M, Guzikova Jaroslava J et al.

Our work aimed to study the impact of bardoxolone methyl, 2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me), on mitochondrial function and morphology in SH-SY5Y cells, molecular responses, with a focus on the expression of proteins of mitochondriaspecific unfolded protein response (mtUPR), the endoplasmic reticulum-specific UPR (UPRER), and the cytosolic stress response. Treatment of SH-SY5Y cells with CDDO-Me is associated with decreased relative cell survival associated with gasdermin E cleavage, compatible with pyroptotic cell death features. Treatment of SH-SY5Y cells with CDDO-Me results in decreased ROUTINE respiration, maximal respiration, succinate-driven maximal respiration, ATP-coupled respiration, and spare respiratory capacity. We have not observed significant changes in the expression of proteins that play important roles in both mtUPR (LONP1) and UPRER (HRD1 and SEL1L), whereas expression of cytosolic chaperone HSP70 was significantly increased in response to CDDO-Me. In addition, we have observed increased expression of mitochondrial chaperones HSP60 and GRP75 as well as ER chaperone GRP78. Finally, we have observed the formation of donut-like mitochondria induced by CDDO-Me. Our results, together with previously published data, indicate that mitochondrial dysfunction, activation of cytosolic stress response, and an increase in chaperone capacity elicited by CDDO-Me could be attributed to CDDO-Me's ability to inhibit LONP1 protease.

PMID 42717783
阅读全文 →
PubMedPlant, cell & environment2026-09-09

Mitochondrial Respiratory Metabolism in Salt-Stressed Barley (Hordeum vulgare): TCA Cycle Activation With Limited GABA Shunt Engagement.

Bandehagh Ali A, Taylor Nicolas L NL

Plants maintain energy balance under salinity stress through increased respiration and energy use, processes also associated with reactive oxygen species generation. Although respiration imposes a high energy cost, mitochondrial respiration and the tricarboxylic acid (TCA) cycle activity are vital for ATP production and for providing electron donors that drive ion exclusion and ROS detoxification. This study examined the molecular basis of salinity-induced respiratory responses in barley using physiological, biochemical, metabolomic and proteomic analyses. Salt exposure resulted in sodium accumulation, decreased photosynthesis and biomass, and increased respiration. Metabolite profiling indicated activation of the TCA cycle, while proteomics showed increased abundance of all targeted TCA enzymes, including phosphoenolpyruvate carboxylase isoforms and succinate dehydrogenase. Enhanced pyruvate oxidation and accumulation of downstream metabolites are consistent with a central role for the classical TCA cycle in barley's salinity response. Conversely, reduced levels of 2-oxoglutarate and succinate, together with non-detection of key GABA shunt enzymes (SSADH, GDH), are consistent with limited GABA shunt contribution under the conditions examined, although we cannot exclude dynamic GABA cycling that does not result in net accumulation. The absence of detectable arginine and ornithine, unlike their salt-induced increase in wheat, further suggests that the GABA shunt may contribute less to barley's salinity response under these conditions. Overall, the combined metabolomic and proteomic evidence supports an interpretation that barley preferentially relies on enhanced mitochondrial respiration and the canonical TCA cycle under these experimental conditions, with a lesser contribution from GABA shunt metabolism than in wheat. As neither metabolite pool sizes nor protein abundances measure pathway flux directly, this is presented as an interpretation of the combined datasets rather than a demonstration of the relative fluxes through the two pathways. These results point to a species-specific divergence in respiratory and osmotic adjustment strategies under salinity and invite future investigation into how key compatible solutes such as glycine betaine, an alternative osmolyte with a known relationship to GABA metabolism, contribute to barley's salinity tolerance.

PMID 42713811
阅读全文 →
PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-09

SIRT7-Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis-Associated Cognitive Dysfunction.

Meng Na N, Zhou Jiateng J, Guo Xiaoyu X, Hong Ting T et al.

Sepsis-associated encephalopathy (SAE) is a severe neurological complication of sepsis, yet how metabolic disturbances engage epigenetic regulation in SAE remains unclear. We found that septic mice exhibited hippocampal succinate and succinyl-CoA accumulation, accompanied by enhanced neuronal histone H2BK120 succinylation (H2BK120su). Pharmacological reduction of succinylation alleviated neuronal injury and improved cognitive function. Mechanistically, integrated CUT&Tag and transcriptomic analyses identified Pdcd1 as a downstream gene associated with H2BK120su enrichment. H2BK120su enrichment at the Pdcd1 promoter activated the PD-1/PD-L1 axis, promoted mitochondrial translocation of PD-L1 and its interaction with PINK1, and triggered PINK1/Parkin-dependent mitophagy, leading to mitochondrial dysfunction and neuronal apoptosis. Neutralization of PD-1/PD-L1 or knockdown of Pdcd1 attenuated mitophagy and neuronal injury. We further identified SIRT7 downregulation as a major cause of H2BK120su accumulation in the septic hippocampus. Neuron-specific Sirt7 deletion exacerbated H2BK120su enrichment, PD-1/PD-L1 activation, excessive mitophagy, and cognitive impairment, whereas SIRT7 overexpression reversed these pathological changes. Together, our findings define a SIRT7-H2BK120su-PD-1/PD-L1-PINK1 axis linking metabolic reprogramming to aberrant mitophagy in SAE and suggest SIRT7-dependent succinylation as a potential therapeutic target.

PMID 42711924
阅读全文 →
PubMedNPJ precision oncology2026-09-09

Minigene-based characterization and classification of splice-associated variants in succinate dehydrogenase B.

Köhler Anni A, Baumann Alexandra A AA, Lewis Natasha N, Richter Anja A et al.

Pathogenic germline variants in SDHB predispose to pheochromocytoma and paraganglioma, but limited functional evidence challenges clinical interpretation. To investigate splice-associated SDHB variants, we developed a minigene spanning exons 2-5 and assessed derived SDHB transcripts in HEK293T cells using targeted RNA sequencing. We evaluated 48 variants prioritized by SpliceAI (Δ≥0.42), two negative controls and endogenous SDHB, and compared findings with tumor data (n = 2). Nineteen variants (38%) showed ≥90% wildtype splicing, whereas 17 (34%) exhibited ≥90% aberrant splicing. Across all variants, 73 aberrant transcripts were observed (average of 2.3 per variant, 22 unique transcripts). Using a customized decision framework, RNA-based evidence strengths were assigned to 64 aberrant transcripts (88%). Among 26 classified variants, 10 received PVS1_Strong (RNA) (38%), including eight canonical splice-site variants, one missense variant and one stop-gain variant; two received PVS1_Moderate (RNA) and 14 received BP7_Strong (RNA). Integration of minigene RNA data changed ACMG scores by a mean of 2.7 points and led to reclassification of 13 variants (50%), including 12 downgrades from VUS to likely benign and one downgrade from likely pathogenic to VUS. These findings demonstrate that targeted sequencing of minigene-derived transcripts provides a scalable approach to evaluate splice-associated SDHB variants and improve variant classification.

PMID 42711465
阅读全文 →
PubMedFrontiers in microbiology2026-09-09

Broad-spectrum biodegradation of aliphatic and aliphatic-aromatic polyesters by Papiliotrema laurentii isolated from locust frass.

An Sihyun S, Weon Hang-Yeon HY, Ahn Jae-Hyung JH, Chung Joon-Hui JH et al.

Biodegradable aliphatic and aliphatic-aromatic polyesters, such as poly(butylene adipate-co-terephthalate) (PBAT), polylactic acid (PLA), polycaprolactone (PCL), polybutylene succinate (PBS), and polyhydroxyalkanoates (PHA), are increasingly used as sustainable alternatives to petrochemical plastics. However, their depolymerization outside industrial composting facilities is often incomplete. This study characterized Papiliotrema laurentii strain 62UF-13, isolated from migratory locust frass, for broad-spectrum polyester hydrolysis. Emulsion assays demonstrated hydrolytic activity across all five polymers, with PCL and PBS showing the highest clearance rates. Solid-film assays revealed substantial gravimetric mass loss of PCL, PLA, and PHA cast films, whereas a commercial PBAT-PLA mulch film in minimal medium, underwent progressive fragmentation/disintegration, as assessed by the remaining film area. Incubation with the PBAT-PLA film was accompanied by the release of adipic acid (49.60 mg/L, week 1) and terephthalic acid (maximum 21.62 mg/L, week 4), followed by a decrease to 0.26 mg/L by week 8, coinciding with the emergence of putative 3,4-dihydroxymandelic acid and a putative acetylated derivative. Scanning electron microscopy (SEM) revealed pronounced pitting and erosion, while Fourier-transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) indicated ester-bond scission and changes in crystallinity/melting behavior. Whole-genome sequencing identified eight candidate polyesterases, including cutinases and esterases, with ≥ 60% amino acid identity to known hydrolases active on PCL, PBS, PHA, and PLA. This study is the first report of P. laurentii degrading a broad range of aliphatic and aliphatic-aromatic polyesters, including partial biotransformation of terephthalate moieties from PBAT. Integration of phenotypic assays and genomic evidence positions P. laurentii 62UF-13 as a viable biocatalyst for decentralized management of biodegradable plastic waste under mild environmental conditions.

PMID 42712520
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多sumatriptan succinate