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sumatriptan succinate (Zelrix / NP101 / Zecuity)

✓ Approved

Nupathe Inc. · HTR1D · 小分子

什么是 sumatriptan succinate？

sumatriptan succinate 是一种小分子，由Nupathe Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Topical、Transdermal。

药物档案

商品名Zelrix, NP101, Zecuity
公司Nupathe Inc.
药物类别小分子
分子靶点HTR1D
给药途径Topical, Transdermal
状态Approved
来源： ClinicalTrials.gov, Nupathe Inc.

作用机制

分子靶点

sumatriptan succinate 作用于 1 个分子靶点：

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sumatriptan succinate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersMigraine✓ Approved

相关研究文献

PubMedArchiv der Pharmazie2026-10-26

TPGS-Transferrin Functionalized Polydopamine Nanocarriers Potentiate the Pharmacokinetics, Antioxidant, and Anti-Inflammatory Activity of Carvacrol.

Mahata Rumi R, Modak Mrinmoyee M, Malakar Rimpa R, Karan Gouri G et al.

Poor aqueous solubility and rapid systemic clearance limit the therapeutic translation of carvacrol (CVC). Herein, we report the fabrication of carvacrol loaded, transferrin (Tf) and d-α-tocopheryl polyethylene glycol succinate (TPGS) functionalized polydopamine nanoparticles (PDA NPs). We recently demonstrated the therapeutic efficacy of CVC-PDA-TPGS-Tf against breast cancer. In the present study, we evaluated the in vivo pharmacokinetic (PK) and biodistribution analysis of this nanoconjugate in Swiss albino female mice. The results of PK and biodistribution analyses revealed markedly increased area under the curve (AUC) (1858 vs. 31,797 ng·min/mL) and maximum serum concentration (Cmax) (318 vs. 715 ng/mL), compared with free CVC. Biodistribution studies demonstrated preferential accumulation in the liver and kidneys with minimal penetration into the brain and spleen. The nanoconjugate displayed superior in vitro free radical scavenging activity against hydroxyl, superoxide, and nitric oxide species and an in vivo antioxidant effect relative to free CVC, and significantly attenuated inflammation in a murine paw edema model. Molecular docking suggested strong interactions of CVC with inflammation- and oxidative stress-related protein targets, consistent with the observed bioactivity. Collectively, these results demonstrate that TPGS-Tf-modified PDA nanocarrier effectively modulates the biological behavior of CVC, offering a promising nanoplatform for improving the pharmacological performance of hydrophobic phenolic therapeutics.

PMID 42929738
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PubMedChemistry & biodiversity2026-10-26

Design, Synthesis, and Antifungal Structure-Activity Relationship of Hydrazide Derivatives Containing a Cyclopropyl Group Against Phytopathogenic Fungi.

Yang Shanshan S, Wang Xinyuan X, Yin Bixi B, Yan Weiting W et al.

To discover novel antifungal agents with unique scaffolds for crop protection, a series of 23 hydrazide derivatives containing a cyclopropyl group, including 14 new chemical entities, were designed, synthesized, and evaluated for their antifungal activity against eight phytopathogenic fungi. The in vitro bioassay results at 50 µg/mL revealed that most target compounds exhibited moderate to excellent antifungal activities. Notably, three compounds (4, 6, 7) displayed the most potent broad-spectrum activity with inhibition rates of 95.0%-100.0% against all eight tested fungi. Their EC50 values were below 10 µg/mL against most fungi. SEM analysis revealed that the parent compound 1 caused pronounced morphological alterations in A. alternata mycelia, including shrinkage, collapse, and irregular distortion, providing a preliminary indication of the cellular effect of the series. Molecular docking of compound 1 with succinate dehydrogenase (SDH) generated a plausible binding model, suggesting SDH as a potential target candidate for this series, pending direct enzymatic validation. SAR analysis demonstrated that the phenyl ring was consistently associated with high activity, and para-substitution with halogen atoms is favorable for enhancing antifungal activity. These findings suggest that cyclopropyl-containing hydrazide derivatives, particularly compounds 4, 6, and 7, represent promising lead candidates for the development of novel antifungal agents.

PMID 42929290
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PubMedAging cell2026-10-26

Metabolomic Signatures of Longevity in Bivalves Reveal Reorganization of TCA Cycle and Amino Acid Metabolism.

Bertrand Pauline P, Chevret Clément J L CJL, Rodríguez Enrique E, Lemieux Hélène H et al.

Mitochondria are central regulators of cellular metabolism, integrating energy production, redox balance, and signaling pathways that shape aging trajectories. If mitochondrial organization contributes to lifespan divergence, exceptionally long-lived species should exhibit distinctive metabolic signatures reflecting adaptations promoting long-term cellular maintenance. Comparative approaches across species with extreme lifespan variation provide a powerful framework for identifying potential metabolic strategies underlying longevity. We conducted targeted metabolomic profiling of five marine bivalve species spanning a lifespan gradient from approximately 30 to more than 500 years, including the exceptionally long-lived ocean quahog, Arctica islandica. Fifty metabolites were quantified in gill and mantle tissue to determine whether lifespan variation is associated with coordinated changes in metabolic organization. Lifespan emerged as a dominant axis of metabolomic variation across species. Long-lived bivalves exhibited a distinct metabolic phenotype characterized by a global reduction in free amino acid pools and coordinated changes in metabolites associated with mitochondrial metabolism. Longevity was associated with increased succinate-to-fumarate ratios, reduced fumarate and malate concentrations, and reduced engagement of pyruvate-derived anaerobic pathways under basal conditions. Although these patterns varied in magnitude across tissues, they converged on a common longevity-associated metabolic signature. Together, these patterns suggest that exceptional longevity is associated with a distinct organization of mitochondrial-related metabolism and a more selective allocation of metabolic resources, rather than a generalized suppression of metabolism. Our findings identify metabolomic signatures associated with exceptional longevity across the bivalve species studied and support the hypothesis that long lifespan is characterized by a distinctive metabolic architecture favoring long-term cellular maintenance.

PMID 42928049
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PubMedTalanta2026-10-25

Unified alcoholysis-GC-MS/MS for simultaneous differentiation and quantification of polyester microplastics in water.

Wu Qin Q, Wang Yu Y, Li Jing J, Tian Xike X et al.

Environmental waters now carry complex mixtures of polyester microplastics that vary in origin and biodegradability, including fossil-based and biodegradable polyesters, yet no method can simultaneously distinguish and individually quantify them. We present a unified alcoholysis method coupled with GC-MS/MS to quantify four polyester microplastics (PEMPs) in a single workflow. By selectively cleaving ester bonds in an alcohol medium, the method converts polylactic acid, polyethylene terephthalate, polyhydroxybutyrate and polybutylene succinate into four distinct, stable monomers. These monomers are directly determined by GC-MS/MS without derivatization. Under unified conditions (190 °C, 5 h), depolymerization efficiencies range from 15% to 90%. We calibrate directly between polymer mass and monomer signal intensity. Detection limits are 0.0462 μg/L for polylactic acid (PLA), 0.103 μg/L for polyethylene terephthalate (PET), 2.92 μg/L for polyhydroxybutyrate (PHB), and 0.695 μg/L for polybutylene succinate (PBS). Spiked recoveries in lake water are 90-115%. In six lake samples, PLA constitutes over 75% of total PEMPs. This fingerprint points to consumer packaging as the dominant source. By circumventing particle morphology constraints and delivering polymer-specific mass concentrations, the method opens a direct route for source apportionment of coexisting fossil-based and biodegradable polyester microplastics.

PMID 42927722
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PubMedEndocrine oncology (Bristol, England)2026-10-25

Germline Pathogenic Variants in Succinate Dehydrogenase Genes: Implications from a Single Institution Study.

Awasty Sanjana S SS, Fisher Carly C, Brock Pamela L PL, Kirschner Lawrence S LS

Germline pathogenic variants (PVs) in the succinate dehydrogenase (SDHx) genes are associated with inherited pheochromocytoma-paraganglioma (PPGL). Because of the high incidence of germline PVs, genetic testing is recommended for all cases of PPGL; relatives may thus be found through cascade testing. PPGL-associated genes are also included on cancer genetics panels, which may lead to variant identification related to other tumors. After PV detection, screening recommendations entail biochemical/radiologic testing and frequent surveillance. To assess the consequences and impact of these approaches in a cohort of individuals with germline PVs in the SDHx genes. Natural history study. Single academic medical centerPatients or Other Participants: 156 patients with SDHx PVs collected over 10 years. None. We report distribution of PVs; rationale for genetic screening; tumor incidence, and second genetic variants. Of 156 patients with variants in the SDHx genes, PVs in SDHB were the most common. In probands tested for non-PPGL tumors, SDHA PVs were the most common, whereas SDHD cases were never detected in this manner. We also identified individuals with variants in a second cancer-associated gene. For individuals not found to have a tumor at initial presentation, the rate of tumor development was <5%. SDHx PVs may be more common than expected and there are gene-specific patterns of ascertainment. Future research is needed to evaluate the role of modifier variants on tumor risk. Reconsideration of surveillance guidelines may be appropriate given the low frequency of new lesions in tumor-free carriers.

PMID 42925006
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PubMedAmerican journal of translational research2026-10-25

Resveratrol improves asthenozoospermia by mitigating oxidative stress-induced mitochondrial dysfunction.

Wang Yanan Y, Zhao Yu Y, Yang Huailiang H, Zhang Bin B et al.

To investigate the protective effects and mechanisms of resveratrol against oxidative stress-induced sperm dysfunction in vitro and cyclophosphamide-induced asthenozoospermia in vivo. An H2O2-induced sperm oxidative stress model was established to evaluate the dose-dependent effects of resveratrol on viability, motility, reactive oxygen species (ROS), lipid peroxidation, antioxidant enzymes, mitochondrial function, and apoptosis. A cyclophosphamide-induced asthenozoospermic mouse model was used to assess in vivo efficacy on sperm quality and testicular antioxidant capacity. Resveratrol significantly improved sperm viability, total motility, and progressive motility in a dose-dependent manner. It reduced ROS generation and malondialdehyde (MDA) levels while enhancing antioxidant enzyme activities. Mitochondrial function was enhanced, as evidenced by maintained membrane potential, increased Adenosine Triphosphate (ATP) production, elevated succinate dehydrogenase activity, and preserved mitochondrial ultrastructure. Furthermore, resveratrol suppressed mitochondrial-mediated apoptosis by modulating B-cell Lymphoma 2 (Bcl-2) family protein ratios. In vivo, resveratrol treatment markedly improved sperm parameters and testicular antioxidant capacity in asthenozoospermic mice. Resveratrol protects sperm against oxidative damage through multiple mechanisms, including antioxidative, mitochondria-preserving, and anti-apoptotic pathways. These findings support its potential as a therapeutic candidate for male infertility associated with oxidative stress.

PMID 42923682
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