若生智能
Drug Database
GE

Gensci-004 (PEG rhGH / Gensci 004 / PEG Somatropin)

✓ Approved

GeneScience Pharmaceuticals Co., Ltd. · GHR · 小分子

什么是 Gensci-004？

Gensci-004 是一种小分子，由GeneScience Pharmaceuticals Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名PEG rhGH, Gensci 004, PEG Somatropin
公司GeneScience Pharmaceuticals Co., Ltd.
药物类别小分子, 重组蛋白
分子靶点GHR,
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, GeneScience Pharmaceuticals Co., Ltd.

作用机制

分子靶点

Gensci-004 作用于 2 个分子靶点：

GHRgrowth hormone receptor (GHBP, GHIP)
(TERG_01127)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Gensci-004 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersGrowth hormone deficiency✓ Approved

相关研究文献

PubMedJournal of cutaneous medicine and surgery2026-07-27

Psychodermatologic Features of Hand Dermatitis in Adolescents With and Without Obsessive-Compulsive Disorder.

Turan Serkan S, Kamberoğlu Turan Işıl I

Hand dermatitis (HD) in adolescence is a multifactorial inflammatory condition in which repetitive cleansing behaviors, emotional distress, and psychodermatologic factors may be associated with disease persistence and clinical burden. To compare dermatologic severity, clinical characteristics, neurocognitive functioning, and emotional-behavioral features among adolescents with obsessive-compulsive disorder (OCD), HD, or their co-occurrence. A total of 139 adolescents were categorized into HD only, OCD + HD, and OCD only. Standardized measures assessed premorbid functioning, neurocognition, and emotional-behavioral symptoms. Group differences were examined using ANOVA/ANCOVA and chi-square tests, and logistic regression identified predictors of OCD comorbidity among adolescents with HD. The OCD + HD group demonstrated a significantly shorter onset-diagnosis interval than both comparison groups. Global functioning was highest in the HD-only group, while OCD groups showed better verbal learning and fluency. Anxiety, depressive symptoms, and OCD severity were higher in OCD groups. Hand Eczema Severity Index scores were significantly higher in the OCD + HD group, which also demonstrated more frequent fissuring, xerosis, and recurrent irritant-pattern lesions during dermatologic examination. Exploratory logistic regression analyses indicated that shorter onset-diagnosis interval (OR = 0.79, P = .013), poorer premorbid peer functioning (OR = 2.22, P = .003), and longer treatment duration (OR = 1.21, P = .004) were associated with OCD comorbidity among adolescents with HD. Adolescents with comorbid OCD and HD may represent a clinically distinct psychodermatologic subgroup characterized by greater dermatologic severity and elevated emotional symptom burden. Recognition of behavioral and psychiatric features in adolescents with recurrent or treatment-resistant HD may support earlier multidisciplinary intervention.

PMID 42505060
阅读全文 →
PubMedClinical lung cancer2026-07-26

Poor Performance Status Associated With Inferior Tarlatamab Outcomes in a Large, Multi-institution Real-World Database of Patients With 2L + ES-SCLC.

Barsouk Adam A AA, Yaskolko Maxim M, Sussman Jonathan H JH, Sun Lova L et al.

Tarlatamab is approved for 2L + extensive-stage small cell lung cancer. In previously published retrospective studies, tarlatamab resulted in inferior survival compared to that observed in the DeLLphi-304 trial. To better understand real-world outcomes with tarlatamab, we examined a much larger, multi-institutional dataset. Utilizing the US-based, de-identified Flatiron Health Research Database, patients treated with tarlatamab between March 2024 and September 2025 were identified. Baseline characteristics, treatment history, and clinical outcomes were summarized. Median time to treatment discontinuation (mTTD), real-world progression-free survival (mPFS), and overall survival (mOS) from the start of tarlatamab were estimated via Kaplan-Meier methods. Effects of baseline patient characteristics were estimated via log-rank analysis and Cox regression. Of 204 patients identified, 90 (44%) were female. Sixty-two (30%) patients were ECOG PS 0, 86 (42%) were ECOG 1, and 48 (24%) were ECOG ≥ 2. 75 (37%) received tarlatamab in 2 L, 64 (32%) in 3 L, and 65 (31%) in 4L + . mPFS was 3.8 months(m), mTTD was 2.3 m, and mOS was 11.2 m. Patient sex, race (Black vs. White), and age (<65 vs. ≥ 65 years old) were not associated with TTD, PFS, or OS. ECOG PS ≥ 2 compared to ECOG 0-1 was associated with shorter mPFS (2.1 vs. 4.5; P = .004); mTTD (1.6 vs. 2.8; P = .001) and mOS (3.2 vs. 13.4; P < .001). In the largest retrospective analysis to date, mTTD, mPFS, and mOS in patients with intact PS (0-1) appeared similar to outcomes reported in DeLLphi-304. By contrast, ECOG PS ≥ 2 was associated with shorter TTD, PFS, and OS, which may account for inferior real-world outcomes compared to the trial. Line of therapy in our cohort was not associated with outcomes; nor was race, sex, or age.

PMID 42501611
阅读全文 →
PubMedArthroscopy, sports medicine, and rehabilitation2026-07-25

Influence of Psychiatric Comorbidities on Postoperative Outcomes Following Pediatric Medial Patellofemoral Ligament Reconstruction.

Arif Haad A HA, Lane Pearce P, Elliott Shamar T ST, Momaya Amit A et al.

To compare postoperative complications, rehabilitation outcomes, and health care utilization in children undergoing primary medial patellofemoral ligament reconstruction for patellofemoral instability with and without a pre-existing mental illness. The TriNetX U.S. Collaborative Network was queried to identify patients younger than 18 years old undergoing medial patellofemoral ligament reconstruction for patellar instability in the United States between 2000 and 2020. Patients were then separated into those with a pre-existing mental illness (PMI Group) and those without (Control Group). After propensity score matching for patient demographics, chronic pain, and obesity, postoperative complication rates, rehabilitation outcomes, and health care utilization of both groups were compared across 1 year. After propensity score matching, each group consisted of 223 patients for a total cohort of 446 patients. The PMI Group showed significantly greater rates of postoperative knee pain (51.5% vs 41.0%, P = .004, risk ratios (RR): 1.40), opioid analgesic use (42.2% vs 31.4%, P = .018, RR: 1.34), nonopioid analgesic use (34.5% vs 22.0%, P = .006, RR: 1.27), emergency department visits (22.0% vs 4.9%, P < .001, RR: 4.46), and physical therapy treatment sessions (61.4% vs 51.1%, P = .028, RR: 1.20). Children with pre-existing mental illness exhibit significantly greater rates of persistent knee pain, higher opioid consumption, and increased health care utilization following medial patellofemoral ligament reconstruction. Level III, retrospective comparative study.

PMID 42500160
阅读全文 →
PubMedNutrition research (New York, N.Y.)2026-07-25

Skin carotenoid scores are a valid approximation of fruit and vegetable intake among adults with obesity.

Jilcott Pitts Stephanie B SB, Wu Qiang Q, Gates Elizabeth E, Laska Melissa N MN et al.

Skin carotenoid score (SCS) as measured using pressure-mediated reflection spectroscopy has been validated among adults with normal and overweight body mass index, with little validation research among adults with obesity. Therefore, the purpose of this exploratory study was to examine the validity of SCS as an approximation of fruit and vegetable intake among adults with obesity. We used samples from adults with obesity from three prior studies: The first study examined the validity of SCS among 213 adults, 34 with obesity; the second, examined sensitivity of SCS to a β-carotene-rich juice intervention among 162 adults, 14 with obesity; the third examined changes in inflammatory markers in a 3-week lycopene-rich juice intervention, among 25 participants with obesity. Correlations between SCS and plasma carotenoids, and between SCS and self-reported FV and carotenoid intake were calculated using SAS 9.4. There was a positive association between SCS and plasma carotenoids (r = 0.30, P = .009), and between SCS and self-reported FV (r = 0.33, P = .004) and total carotenoid (r = 0.44, P < .001) intake in adults with obesity. In this small, secondary data analysis, the association between SCS and self-reported total FV intake among adults with obesity was similar to that among normal- and overweight adults in prior studies. The correlation between SCS and total plasma carotenoid concentrations among adults with obesity was weaker than that among normal- and overweight adults in prior studies. More work is needed to understand the associations between SCS and plasma carotenoid concentrations among adults with obesity.

PMID 42497489
阅读全文 →
PubMedMedicine2026-07-25

Risk factors of cerebrospinal fluid leakage following posterior lumbar interbody fusion for lumbar degenerative disease: A retrospective observational study of 684 patients.

Wang Hongwei H, Yuan Hong H, Zheng Bin B, Wang Xiaoying X et al.

This study holds the primary objective of confirming the risk factors for cerebrospinal fluid leakage (CSFL) following posterior lumbar interbody fusion for lumbar degenerative disease. The 684 patients who received posterior lumbar interbody fusion for lumbar degenerative disease at our hospital from 2017 to 2023 fell into the CSFL group (n = 115) or the control group (n = 569). We retrospectively recorded demographic, surgical, and radiographic data for the examination of the independent risk factors related to CSFL. Univariate and multivariate logistic regression analyses were conducted to more thoroughly measure their significance. The incidence of CSFL was 16.8% (115/684 patients). According to multivariate analysis, elderly individuals (age ≥ 60 years; odds ratio [OR], 1.601; 95% confidence interval [CI], 1.004-2.554; P = .048), patients with fusion levels ≥ 4 (OR, 3.665; 95% CI, 1.523-8.818; P = .004), patients with scoliosis (OR, 5.213; 95% CI, 1.380-19.698; P = .015), patients with spondylolisthesis (OR, 2.229; 95% CI, 1.382-3.595; P = .001), and patients with a duration of operation ≥ 250 minutes (OR, 8.586; 95% CI, 1.114-66.172; P = .039) could independently indicate the risk of CSFL. For patients with CSFL, obvious increases in postoperative drainage, lengths of stay, hospitalization costs, and frequency of blood transfusions, all with P < .001, were detected. Elderly age (≥60 years), fusion level ≥ 4, scoliosis, spondylolisthesis, and operative duration ≥ 250 minutes were identified as independent predictive factors for the risk of CSFL. CSFL patients had significantly more postoperative drainage, longer lengths of stay, higher hospitalization costs, and more frequent blood transfusions.

PMID 42499087
阅读全文 →
PubMedMedicine2026-07-25

The effect of family integrated care based on Swanson theory of caring on premature infants: A non-randomized cohort study.

Chen Lili L, Zhu Huijie H

Preterm birth significantly impacts neonatal growth and development, and the family integrated care (FICare) nursing model offers several benefits. This study investigated the impact of FICare on preterm infants, based on Swanson caring theory. This theory includes 5 core processes (knowing, being with, doing for, enabling, and maintaining belief) that guide person-centered care. A non-randomized cohort study was conducted. A total of 52 preterm infants (28-36 weeks of gestation) were enrolled, 33 in the intervention group (FICare nursing model based on Swanson caring theory) and 19 in the control group (traditional care). The primary outcomes were the length, weight, and head circumference of preterm infants at corrected ages of 1, 3, and 6 months. Additionally, parental anxiety levels and the Parenting Sense of Competence scale were assessed. The intervention group demonstrated a shorter transitional feeding period (P = .015), a higher breastfeeding rate (P = .007), and a significantly lower rate of unplanned rehospitalization (P = .004). Infants in the intervention group had significantly greater body length (P = .041) and weight (P = .002) at corrected ages. Parental state and trait anxiety decreased, and Parenting Sense of Competence scores were increased (P < .001). No significant differences were observed in the duration of oxygen therapy, total enteral feeding period, length of hospital stay, or weight at discharge from hospital. FICare based on Swanson caring theory was associated with improved feeding transition, reduces unplanned readmissions, promotes growth within 6 months corrected age, alleviates parental anxiety, and enhances parenting competence. The findings are limited by the non-randomized design and baseline imbalance in birth weight.

PMID 42499060
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多Gensci-004