北京若生智能科技有限公司
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Gensci-004 (PEG rhGH / Gensci 004 / PEG Somatropin)

✓ Approved

GeneScience Pharmaceuticals Co., Ltd. · GHR · 小分子

什么是 Gensci-004？

Gensci-004 是一种小分子，由GeneScience Pharmaceuticals Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名PEG rhGH, Gensci 004, PEG Somatropin
公司GeneScience Pharmaceuticals Co., Ltd.
药物类别小分子, 重组蛋白
分子靶点GHR,
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, GeneScience Pharmaceuticals Co., Ltd.

作用机制

分子靶点

Gensci-004 作用于 2 个分子靶点：

GHRgrowth hormone receptor (GHBP, GHIP)
(TERG_01127)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Gensci-004 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersGrowth hormone deficiency✓ Approved

相关研究文献

PubMedNeuro-oncology advances2026-09-10

A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate.

Dirain Carolyn O CO, Grossman Stuart A SA, Ye Xiaobu X, Sambasivan Priya P et al.

Glioblastomas are characterized by the Warburg effect, driven by upregulation of pyruvate dehydrogenase kinase (PDK), which inhibits pyruvate dehydrogenase complex (PDC), leading to lactate accumulation. Dichloroacetate (DCA) is a potent and safe PDK inhibitor that crosses the blood-brain barrier, reverses Warburg metabolism, and reduces lactate levels. This trial (RO1FD007271) evaluated the pharmacodynamics and pharmacokinetics of oral DCA in recurrent glioblastoma patients requiring surgical debulking. The primary endpoint was decreased PDC phosphorylation (p-PDHA1) in resected tumors. Patients received either 1 week of DCA or no DCA prior to surgery. All patients received DCA postoperatively. Enhancing and non-enhancing tumor tissue, and serial plasma DCA and lactate levels were analyzed. 37 patients were enrolled (median age = 60 years). In DCA-treated patients, the contrast-enhancing tumor had lower p-PDHA1, PDK4, HIF1-α, VEGF-α, and PGK1 expression (all P < .05) than non-DCA-treated patients. In non-enhancing tumors, p-PDHA1 and PDK 1-3 expression were not different, but PDK4, PCNA, and PGK1 levels were reduced, and ERK1/2 was increased in DCA-treated patients (all P ≤ .01). At surgery, DCA-treated patients had lower plasma lactate (P = .004) than untreated patients. Postoperatively when all patients received DCA, plasma lactate fell dramatically (P < .001). DCA was well-tolerated but did not delay tumor recurrence. In recurrent glioblastomas, DCA was safe, well-tolerated, and promoted aerobic respiration. It reduced markers of tumor cell proliferation and lowered plasma lactate. Although no clinical benefit was noted, further studies of combination therapy are indicated, given the known association between poor cancer outcomes and elevated PDK expression and lactate levels.

PMID 42719375
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PubMedAnnals of thoracic surgery short reports2026-09-10

The Impact of Preexisting Diabetes Mellitus on Chronic Lung Allograft Dysfunction After Lung Transplantation.

Christopher Kwon Ye In YI, Keller Michael M, Caboti-Jones Holly H, Ambrosio Matthew M et al.

Chronic lung allograft dysfunction (CLAD) remains a major cause of mortality after lung transplantation. Diabetes mellitus (DM) may contribute to CLAD through metabolic dysregulation. We evaluated post-lung transplant outcomes in recipients with DM. Adults undergoing first-time, isolated lung transplant (November 2017 to December 2024) with at least 6 months of follow-up were identified in the United Network for Organ Sharing registry and stratified by DM diagnosis at waitlist registration. CLAD was defined as ≥20% forced expiratory volume in 1 second and/or forced vital capacity decline after >3 months follow-up. Kaplan-Meier and multivariable Cox models assessed survival and CLAD risk, with subgroup analysis by race and ethnicity. Among 18,199 analyzed patients, 3479 (18.3%) had DM. CLAD rates were higher among recipients with DM (21.3% vs 17.4%, P = .003). Grade 3 primary graft dysfunction at 72 hours was more frequent among recipients with DM (20.3% vs 17.1%, P = .03). Additionally, 5-year overall survival was lower in DM patients (55.2% vs 58.7%, P = .003). On multivariate analysis, DM was associated with increased risk of 5-year mortality (hazard ratio, 2.58, P = .004) and CLAD (odds ratio, 1.46, P = .03). Notably, in patients with DM, 5-year survival was significantly decreased among Asian patients (P = .024) compared with other races. Among patients with DM, Asian status was independently associated with increased risk of mortality (hazard ratio, 1.72, P = .002). Recipient DM is associated with reduced long-term survival and CLAD risk after lung transplant. Asian American recipients with DM appear to face disproportionately worse survival, suggesting a potential interaction between race, ethnicity, and metabolic status.

PMID 42719663
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PubMedFoot & ankle specialist2026-09-10

Association of Tarsometatarsal Joint Slippage With Distal Screw Removal After Third-Generation Minimally Invasive Bunion Surgery: A Retrospective Controlled Study.

El Masry Seif S, DiGiovanni Grace M GM, Ammerman Brittany M BM, Palma Joaquín J et al.

BackgroundFollowing Minimally Invasive Bunionectomy (MISB), some patients undergo the removal of hardware (ROH) due to medial-sided pain near the distal metatarsal screw site. Medial pain following MISB has been attributed to multiple factors, including hardware prominence, residual medial bony prominence, and construct-specific considerations. One potential radiographic finding observed postoperatively is medial translation of the first metatarsal base at the tarsometatarsal (TMT) joint, referred to here as "TMT slippage." This study investigated the association between postoperative TMT slippage and subsequent ROH following MISB.MethodsA retrospective analysis identified 38 MISB patients with distal screw ROH and a control group of 40 MISB patients without ROH. Pre- and at least 6-month post-operative anteroposterior (AP) radiographs were measured to obtain transverse TMT slippage, distal and midshaft foot width, hallux valgus angle (HVA), and intermetatarsal angle (IMA). Independent samples t-tests and chi-square analyses compared continuous and categorical characteristics, respectively. Multivariable logistic regression modeling identified ROH risk factors.ResultsInterobserver reliability, measured by intraclass correlation coefficients (ICCs), was high for all measurements (ICC > 0.70). The change in TMT slip was significantly higher in the ROH group compared to the control group (+1.39 vs +0.80, P = .004). A greater decrease in distal foot width (narrower distal width postoperatively) was associated with an increased ROH likelihood (odds ratio [OR] = 0.76), while smaller reductions in HVA and IMA were linked to a higher ROH likelihood (OR = 1.12 and 1.42, respectively). Notably, a larger increase in TMT slip correlated with the highest likelihood of ROH (OR = 2.87).ConclusionWhile midfoot widening was not significantly different between groups, increased TMT slippage and incomplete correction of deformity (lower HVA/IMA change) were associated with higher ROH likelihood. These findings raise the possibility that postoperative TMT slippage may be associated with symptomatic distal screw removal, although causation cannot be inferred.Level of Evidence:Level III, comparative series.

PMID 42720046
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PubMedArthroscopy, sports medicine, and rehabilitation2026-09-10

Non-Weightbearing in Hinged-Knee Braces Locked in High Degrees of Flexion Shows High Hamstring Muscle Activation in Healthy Volunteers.

Athanasian Christian E CE, Schwartz Brendan B, Czerwonka Natalia N, Trofa David P DP et al.

To determine the effect of various postoperative ambulation and bracing protocols on hamstring muscle group activation in healthy volunteers. Hamstring muscle group activation was assessed via Myontec Mbody 3 Shorts. Volunteers ambulated 10 yards in conditions including walking unassisted, flat-foot weightbearing (FFWB), FFWB with a Newport abduction hip brace restricting motion past 90° of flexion, FFWB with an unlocked hinged-knee brace, and non-weightbearing (NWB) in hinged-knee braces locked in 90°, 60°, and 30° of flexion. Data was standardized with the unassisted walking condition as the reference. Each condition was tested on both extremities. Primary outcomes were normalized cumulative hamstring activation and normalized peak hamstring activation on the protected extremity. Analysis of variance and post hoc Tukey tests were performed. Fifteen healthy volunteers with no history of hip or knee surgery were recruited over a 1-year period from June 2023 to June 2024. Analysis of variance testing showed statistically significant differences in both cumulative ipsilateral hamstring muscle activation (P = .002) and peak ipsilateral hamstring muscle activation (P = .004). Post hoc Tukey testing showed significant differences in cumulative ipsilateral hamstring muscle activation between NWB hinged-knee braces locked at 90° compared with 30° (3.38 (standard deviation [SD]: 4.03) vs 1.49 (SD: 2.13), P = .01) and NWB hinged-knee braces locked at 90° compared with FFWB with unlocked hinged-knee braces (3.38 (SD: 4.03) vs 1.54 (SD: 1.15), P = .01). For normalized peak muscle activation, significant differences were noted from NWB hinged-knee braces locked at 60° compared with FFWB (1.12 (SD: 1.21) vs 0.58 (SD: 0.50), P = .02), and NWB hinged-knee braces locked at 60° compared with FFWB with hinged-knee braces unlocked (1.12 (SD: 1.21) vs 0.61 (SD: 0.57), P = .03). Healthy volunteers showed lower levels of cumulative hamstring muscle activation during FFWB with an unlocked hinged-knee brace compared with NWB with hinged-knee braces locked at 90° and NWB with hinged-knee braces locked at 30° compared with NWB with hinged-knee braces locked at 90°. Lower levels of peak hamstring muscle activation were noted during FFWB compared with NWB hinged-knee braces locked at 60° and FFWB with an unlocked hinged-knee brace compared with NWB hinged-knee braces locked at 60°. Level IV, retrospective case series.

PMID 42719857
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PubMedOrthopaedic journal of sports medicine2026-09-10

Generalized Joint Laxity Is an Independent Predictor of Postoperative Resprain Following Anatomic Reconstruction Using Gracilis Tendon Autograft for Patients With Chronic Lateral Ankle Instability.

Liu Haoxuan H, Li Jianhong J, Su Tong T, Jiang Yanfang Y et al.

Generalized joint laxity (GJL) has been reported as a risk factor for poor outcomes following multiligament surgery. However, no previous studies have investigated whether GJL is a risk factor of postoperative resprain following anatomic reconstruction using gracilis tendon autograft. To investigate whether GJL is a risk factor of postoperative resprain in chronic lateral ankle instability (CLAI) patients following anatomic reconstruction using gracilis tendon autograft. Cohort study; Level of evidence, 3. A total of 290 consecutive CLAI patients who underwent anatomic reconstruction using gracilis tendon autograft from January 2018 to September 2023 with a minimum follow-up of 24 months were retrospectively evaluated and were divided into 2 groups according to the presence of GJL (based on age and Beighton score). Clinical outcomes were measured through the presence of postoperative noncontact resprain and recurrent instability, return-to-sport status, and patient-reported outcomes including the visual analog scale (VAS) for pain, Tegner Activity Level scale, and Karlsson-Peterson ankle score (Karlsson score). Risk factors associated with postoperative noncontact resprain were determined using univariate and multivariate logistic regression analysis. Survival outcomes were compared using Kaplan-Meier analysis. A total of 72 patients were included in the GJL group (mean age at surgery, 27.5 ± 9.0 years; male, n = 27; female, n = 45), and 218 patients were included in the non-GJL group (mean age at surgery, 32.8 ± 10.2 years; male, n = 129; female, n = 89). The overall noncontact resprain rate was 6.6%, and the overall recurrent instability rate was 1.7%. There was no significant difference in the postoperative VAS, Tegner, return to recreational sports rate, return to preinjury sports rate, and other surgical complications between the 2 groups. The patients with GJL demonstrated a significantly higher postoperative noncontact resprain rate (15.3% vs 3.7%; P = .001), a significantly higher postoperative recurrent instability rate (6.9% vs 0.0%; P = .001), and a significantly lower postoperative Karlsson score (90.0 ± 6.2 vs 95.6 ± 4.4; P < .001) compared with those without GJL. Multivariate logistic regression analysis revealed that GJL was an independent predictor of postoperative noncontact resprain following anatomic reconstruction using gracilis tendon autograft (P = .004; odds ratio = 4.293; 95% CI, 1.612-11.431). The cumulative success rates of the patients with GJL were significantly lower than those of the patients without GJL (P = .001). GJL is an independent predictor of postoperative noncontact resprain of CLAI patients following anatomic reconstruction using gracilis tendon autograft.

PMID 42719479
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PubMedHolistic nursing practice2026-09-09

The Effect of Music Listening Intervention on Symptom Management and Quality of Life in Patients With Rheumatoid Arthritis: A Randomized Controlled Trial.

Yildiz Cilengiroglu Irem I, Unsar Serap S, Emmungil Hakan H, Ozturk Levent L

Rheumatoid arthritis is a chronic inflammatory disorder severely impacting physical and psychosocial well-being. Alongside pharmacological treatments, nonpharmacological interventions are increasingly sought. This randomized controlled trial aimed to evaluate the efficacy of a music listening intervention on symptom management and quality of life in patients with rheumatoid arthritis. The study included 88 patients at a university hospital. The intervention group listened to standardized Turkish music (maqams) twice daily for 30 days. Data were collected at baseline, day 15, and day 30 using the EuroQol 5-dimensional Quality of Life Scale and Patient Symptom Thermometer. By day 30, the intervention group demonstrated significantly higher overall quality of life (EuroQol 5-dimensional Index and Visual Analog Scale; P < .05) compared with controls. Significant improvements were also observed in pain intensity, fatigue, physical function, depression (all P < .001), and general health status (P = .004). Therapeutic music listening can be an effective, noninvasive, and cost-efficient holistic nursing intervention. Integrating this sustainable strategy into rheumatoid arthritis care yields rapid, significant clinical improvements in multidimensional symptom management and overall quality of life.

PMID 42711766
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