sildenafil citrate (SPO1101D / Vultis / SPO1101)

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants.

Liu Xiyu X, Zhang Wen W, Liu Lunxin L, Gui Lan L et al.

Defective endothelial regeneration constitutes a fundamental barrier to durable vascular repair. By integrating single cell RNA-sequencing data from rat carotid balloon injury with ultrastructural and histological evidence from rabbit stented arteries, we identified mitochondrial disorganization and dysfunction as common features of injured endothelial cells. Guided by these findings, we developed a poly(citrate-polyglycol-procyanidin) (PCGP) nanoshield to couple mitochondrial protection with anticoagulant and immunoregulatory functions for cardiovascular devices. PCGP preserved mitochondrial integrity, restored endothelial metabolic homeostasis, and rescued the regenerative phenotype of endothelial cells under oxidative stress. In rabbit arterial stent models, this intervention reactivated the PI3K/AKT/eNOS-nitric oxide axis, accelerated functional re-endothelialization, and markedly suppressed neointimal hyperplasia. Collectively, these findings support restoration of endothelial mitochondrial homeostasis as an important mechanistic axis associated with vascular repair.

Molecular diagnosis of a case of Dibothriocephalus nihonkaiensis infection in Suzu City, Ishikawa Prefecture, Japan.

Kawabata Kohei K, Shimosaki Rin R, Ikku Ryosuke R, Saito Hiroaki H et al.

In this study, we intended to report a case of Dibothriocephalus nihonkaiensis infection diagnosed in Suzu City, Ishikawa Prefecture, Japan. A 23-year-old man from Aichi Prefecture moved to Suzu City, one of the most severely destroyed areas by the 2024 Noto Peninsula earthquake, to engage in reconstructive works. He visited the internal medicine department of Suzu General Hospital by the passage of long slender worm in his stool. Numerous operculated helminth eggs were detected from his stool samples, and a tapeworm strobila with the scolex was found after the treatment of praziquantel (10 mg/kg). Magnesium citrate was administered before and after praziquantel treatment, and stool samples were collected from the patient. The expelled tapeworm measured approximately 1.7 m in length. Morphological examination revealed a relatively small scolex with 2 suckling grooves, suggesting an immature adult specimen. Phylogenetic analysis of the mitochondrial 16S rRNA and cox1 genes identified the parasite as Dibothriocephalus nihonkaiensis. This case highlights the importance of integrating morphological and molecular approaches for accurate species identification in cases with complex epidemiological backgrounds.

Retraction Note: Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis.

Hasan Mohammad M, Yadav Pooja P, Ansari Mairaj Ahmed MA, Ali Shakir S et al.

Rational construction of an electrophoretic system for the determination of flaxseed lignans by capillary electrophoresis.

Vera-Candioti Luciana L, Negro Emilse E, Bernal Claudio C

A rational strategy was developed for constructing a capillary electrophoretic system for the separation of structurally related flaxseed lignans. Electrophoretic selectivity was sequentially optimized through background electrolyte composition, dynamic capillary modification, and organic modifier content using multivariate experimental design. The selected system consisted of 20 mmol L-1 borate, 7.5 mmol L-1 phosphate, and 2.5 mmol L-1 citrate (pH 11.0), containing 0.20% (w/v) PDADMAC and 20% (v/v) methanol, with separation at -20 kV. The method separated pinoresinol, lariciresinol, matairesinol, secoisolariciresinol, and secoisolariciresinol diglucoside. Quantitative validation was established for secoisolariciresinol and secoisolariciresinol diglucoside, determined at 0.87 ± 0.05 mg g-1 after sequential alkaline-acid hydrolysis and 6.6 ± 0.3 mg g-1 after alkaline hydrolysis, respectively. Field-amplified sample injection was additionally explored for improving detectability, although signal enhancement was accompanied by loss of selectivity for the lariciresinol-matairesinol pair.