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alternaria allergen SLIT

✓ Approved

HAL Allergy Group · 治疗药物

什么是 alternaria allergen SLIT？

alternaria allergen SLIT 是一种治疗药物，由HAL Allergy Group研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。

药物档案

公司HAL Allergy Group
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, HAL Allergy Group

治疗适应症

alternaria allergen SLIT 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMedFrontiers in allergy2026-09-10

Taming pet allergens: strategies to make furry cats less allergenic.

Guillet Carole C, Lüthi Alessia A, Šošić Lara L, Paolucci Marta M et al.

Much research on allergy to furry animals focuses on diagnosis and treatment of the human patients. However, this review will explore strategies aimed at reducing the allergenic potential of the furry animals themselves. A primary focus is vaccination of cats to induce allergen-specific IgG and IgA antibodies. These antibodies can bind the major allergens, potentially prevent their shedding, or neutralise them when exposure occurs. By consequence, neutralising antibodies can reduce IgE-mediated reactions in humans. Two key studies by Thoms et al. (PMID: 32155887; 31056187) provide proof-of-concept for this approach. After vaccination of cats, these produced anti-Fel d 1 IgG and IgA and the cat owners experienced improved tolerance to their pets. Complementary strategies include physical removal of allergens from furry animals through grooming methods such as combing, bathing, or using wipes and enzymatic washing agents, which can reduce the allergen load in the environment. Finally, selective breeding and choice of animal breeds with inherently lower allergen production or reduced shedding may further mitigate exposure. Together, these interventions represent a shift from exclusively human-targeted allergy therapies toward integrated approaches that manage allergen sources at their origin. This review will discuss current evidence, practical implications, and future directions for allergen-reducing strategies in furry animals.

PMID 42719600
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PubMedPhysical chemistry chemical physics : PCCP2026-09-10

Dyads of Au nanoparticles and carbon nanodots confined in plasmonic nanoslits for fluorescence enhancement.

Bagra Bhawna B, Bukari Sherif S, Tukur Frank F, Ji Zuowei Z et al.

Considerable efforts have been made to enhance the fluorescence of carbon nanodots (CNDs) through surface engineering or functionalization. However, these methods often alter the intrinsic properties of the CNDs. Although only a few studies have reported such plasmonic enhancement for CNDs, the rational engineering of plasmonic platforms to modulate light-matter interactions has become a powerful alternative for enhancing emitter performance without altering the emitter. Herein, we offer a simple strategy in which CNDs and gold nanoparticles (AuNPs) are first hybridized and then immobilized within the cavities of a gold nanoslit array to enhance the fluorescence signal of CNDs. For a better understanding of the plasmonic effects, finite difference time domain (FDTD) simulation was conducted for different sizes of AuNPs inside the Au nanoslit. The light intensity and fluorescence measurements correlate with the simulated results and show a fluorescence enhancement factor of 3.7 ± 0.2 for the CND-AuNP dyads confined in the nanoslit, defined relative to pristine CNDs measured on glass under identical illumination and collection conditions (2.2 ± 0.1 relative to the same dyads outside the slit). Controls on CNDs alone with and without the nanoslit, on bare AuNPs and on the empty array establish that dyad formation and slit confinement contribute sequentially, and that the measured enhancement exceeds the product of the two separately measured contributions by a factor of 1.4 ± 0.1, which identifies the architecture as cooperative rather than merely cumulative. The excitation-wavelength dependence of the enhancement, together with the spectral positions of the CND absorption and emission bands relative to the plasmon resonances of the hybrid, indicates that the amplification is dominated by an increased excitation rate in the plasmonic near field, with a smaller emission-side (plasmon-exciton) contribution; the ∼7 nm metal-to-metal gap defined by the self-assembled monolayer and the CND itself keeps the emitters out of the strong non-radiative quenching regime. Comparison with the flat-gold-film reference measured previously on the same platform shows that the glass reference used here is the conservative choice. This study presents a plasmonic platform with the potential to significantly enhance the optical performance of emitters for biosensing and biomedical applications.

PMID 42719949
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PubMedPhysical chemistry chemical physics : PCCP2026-09-10

Ultra-high CD terahertz chiral metasurface absorber for polarization discrimination and sensing.

Zhang Yanpeng Y, Sun Xuehong X, Qin Guoche G, Liu Liping L et al.

Terahertz (THz) chiral metasurfaces can discriminate between left- and right-handed circularly polarized (LCP/RCP) waves and are therefore promising for polarization-resolved detection and chiral spectroscopy; however, naturally occurring dielectrics typically exhibit only weak circular dichroism (CD). Here, we numerically demonstrate a reflective metal-insulator-metal (MIM) chiral metasurface absorber composed of a gold-patterned asymmetric dual-slit elliptical split-ring resonator, a polyimide spacer, and a gold ground plane. By breaking in-plane mirror symmetry, the unit cell supports chirality-dependent resonances, giving rise to a pronounced spin-selective absorption peak at 1.648 THz: the absorptance reaches 99.85% for right-handed circularly polarized (RCP) incidence, whereas it remains 3.67% for left-handed circularly polarized (LCP) incidence, corresponding to an absorptance contrast of CD = 0.9618 (CD = AR - AL). Oblique-incidence analysis shows that the high CD is preserved over a wide angular range, with CD > 0.9 maintained up to 55.8° and CD > 0.8 up to 70.5°. Near-field and current-distribution analyses indicate that the ultrahigh CD originates from spin-dependent mode matching, which enhances field localization and ohmic dissipation for the target spin state while suppressing coupling for the opposite spin. In addition, by dimerizing the unit cell and introducing an extra dielectric layer, dual-band spin-selective absorption and high-Q narrowband resonances are achieved. Leveraging the high-Q resonance, the structure enables THz refractive-index sensing with a sensitivity of 394 GHz/RIU (with the analyte thickness fixed at 30 µm), suggesting a compact route toward polarization-selective THz components and resonance-based sensing platforms.

PMID 42720044
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PubMedInternational medical case reports journal2026-09-10

When Immune System and Herpes Virus Infection Collide: A Case of Severe Stromal Herpetic Keratitis in a Patient with Rheumatoid Arthritis Under Methotrexate.

Corda Claudia C, Lixi Filippo F, Budroni Antonio A, Tomi Mara-Ioana MI et al.

To report a case of refractory herpes simplex virus keratitis (HSVK) complicated by keratolysis and severe stromal thinning in a patient with rheumatoid arthritis (RA) under treatment with methotrexate (MTX). A 79‑year‑old patient with a history of HSVK and RA, treated with weekly MTX, presented with pain and photophobia in the right eye. Best‑corrected visual acuity (BCVA) was limited to counting fingers. Slit‑lamp examination revealed a supero-nasal corneal ulcer (area of 2.98 mm2) with deep stromal involvement and keratolysis. A recurrent episode of HSVK was diagnosed, and treatment with 3 times daily oral acyclovir, 4 times daily 0.15% ganciclovir ophthalmic gel, and 3 times daily 0.15% topical dexamethasone was started. After one week, the picture worsened with corneal thinning (corneal thinnest point [CTP] 82 µm) and anterior chamber fibrin. Cycloplegic therapy 3 times daily was added. Considering the refractory course, the history of recurrent HSVK, and the concomitant systemic immunomodulation, the MTX injection scheduled for the subsequent weeks was interrupted. After 2 weeks, conjunctival hyperemia improved (Efron grade II) and a progressive increase of corneal thickness (CTP 199 µm) was documented. Two months later, complete healing was achieved with no signs of active inflammation or recurrence; BCVA improved to 0.4 LogMAR, with mild residual stromal thinning and opacity (CTP 231 µm). This case underscores how systemic immunomodulatory treatment may play a clinically relevant role in patients with recurrent HSVK. In selected cases, a conservative, surgery‑sparing approach through the optimization of systemic therapy can help promoting viral load control and corneal healing.

PMID 42719413
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PubMedHemoglobin2026-09-10

Ocular Complications Among Patients with Beta-Thalassemia Major and Intermedia Patients: A Comparative Study from Pakistan.

Saeed Amber A, Naheed Farah F, Ullah Saif S, Ullah Asad A et al.

Beta-thalassemia is associated with systemic complications from chronic anemia, iron overload, and long-term transfusion therapy, which may also affect ocular structures. This study aimed to compare the frequency and patterns of ocular complications between patients with β-thalassemia major and β-thalassemia intermedia. This comparative cross-sectional study included 30 patients (60 eyes) with β-thalassemia major or β-thalassemia intermedia, recruited via convenience nonprobability sampling. All participants underwent comprehensive optometric and ophthalmic evaluation, including assessments of visual acuity, intraocular pressure, stereopsis, tear break-up time, visual field testing, and slit-lamp examination of the anterior and posterior segments. Serum ferritin levels were also recorded, and statistical analysis was performed using SPSS version 21. The mean age of participants was 20. 20.67 ± 7. 44 years, and 60% were female. Serum ferritin levels were significantly higher in patients with β-thalassemia major than in those with β-thalassemia intermedia (4056. 47 ± 2415. 28; p < 0. 001). Uncorrected visual acuity and superior visual field extent were significantly better in the intermedia group (0. 913 ± 0. 196 decimal and 52. 67 ± 7. 74 degrees, respectively; p < 0. 05). Tear break- up time was significantly longer in the major group (9. 87 ± 4. 25 seconds) than in the intermedia group (6. 27 ± 3. 91 seconds; p < 0. 005). Patients receiving chelation therapy for more than 5 years had significantly lower tear break-up time values (p = 0. 04). Lenticular abnormalities were observed in 10% of eyes in both groups, whereas vitreous condensations and peripheral fundus atrophic changes were more frequent in β-thalassemia intermedia. In conclusion, patients with β-thalassemia major have higher serum ferritin levels and poorer visual function, whereas certain posterior segment changes appear more prevalent in β-thalassemia intermedia. These findings highlight the importance of regular ophthalmic screening in patients with thalassemia.

PMID 42717806
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PubMedFrontiers in immunology2026-09-09

Low-dose allergen targeting to cDC2 induces long-term protection associated with induction of regulatory-like IL-10+ Foxp3- CD8+ T cells in mice.

Aintablian Arpa A, Cyran Laura L, Helal Moutaz M, Lehmann Christian H K CHK et al.

The prevalence of allergic diseases is rising worldwide. Desensitizing immunotherapy is currently the only available treatment, but it is often ineffective for certain allergies, underscoring the need for new treatments. This study tested in an Ovalbumin (OVA)-mediated allergy mouse model whether direct allergen targeting to DC subsets can induce desensitization. A Standard desensitization protocol was compared with an antibody-OVA fusion protein targeting the conventional cDC1 or cDC2 subsets via their respective receptors CD205 (CD205-Fp) or DCIR2 (DCIR2-Fp). Allergen targeting to cDC2 provided long-lasting protection for up to 56 days after desensitization with only nanogram doses of allergen, whereas the Standard therapy protected for only 20 days, requiring microgram doses and repeated injections with Alum adjuvant. CD205-Fp showed no protective effect. Blocking IL-10 either before administering DCIR2-Fp or before allergen challenge completely abolished protection. Standard therapy had moderate effects on CD4+ T cells, with early expansion of IL-10+ Foxp3- T regulatory type-1 cells (Tr1), followed by an increase in both IL-10+ and IL-10- Foxp3+ regulatory T cells (Foxp3+ Treg). DCIR2-Fp therapy initially expanded IL-10+ and IL-10- Foxp3+ Treg, but these levels returned to baseline. On day 80, we identified Foxp3- CD44high Treg-like CD8+ as the primary source of IL-10. Overall, our data suggest that cDC2 allergen targeting in allergic mice offers a potent, long-lasting IL-10-dependent desensitizing effect.

PMID 42712968
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