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alternaria allergen SLIT

✓ Approved

HAL Allergy Group · 治疗药物

什么是 alternaria allergen SLIT？

alternaria allergen SLIT 是一种治疗药物，由HAL Allergy Group研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。

药物档案

公司HAL Allergy Group
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, HAL Allergy Group

治疗适应症

alternaria allergen SLIT 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMedTurkish journal of ophthalmology2026-10-26

Anatomopathological Aspects and Clinical Correlation of Conjunctival Bleb Fibrosis Following Encapsulation of a Biodegradable Collagen Matrix Implant in Glaucoma Surgery.

Castro-Roger Luisa L, Labay-Tejado Sara S, Suárez Xavier X, Lop Gros Joan J et al.

This study reports a case series of glaucoma patients in whom a biodegradable collagen-glycosaminoglycan implant (Ologen®) failed to prevent fibrosis after non-penetrating deep sclerectomy (NPDS) and describes the associated histopathological findings. This single-centre retrospective study included four patients with progressive glaucoma and inadequate intraocular pressure (IOP) control despite maximal medical therapy. All underwent NPDS with implantation of a collagen-glycosaminoglycan matrix and adjunctive mitomycin C. Postoperative follow-up included IOP monitoring, slit-lamp examination, and photographic documentation. Patients with bleb failure required surgical revision, and excised tissue, including the implant and surrounding Tenon's capsule, was analysed histologically. All cases developed progressive bleb fibrosis. The implants remained intact, encapsulated by dense fibrotic tissue ("ring-of-steel" appearance), with minimal fibroblast infiltration, extensive collagen deposition, and no significant degradation for up to three years. These findings highlight variability in tissue response and suggest a potential role of patient-specific fibrotic predisposition in surgical outcomes.

PMID 42929100
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PubMedCells2026-10-26

Bet v 1 Allergen Is the Main Driver of Disease in Patients with Pollen Allergy in Belgium.

Pirson Françoise F, Lopez Esmeralda Fraille EF, Hupin Cloé C, Sohy Carine C et al.

Birch pollen-sensitized patients co-sensitized to Bet v 1 and Bet v 2 allergens present more frequent and severe respiratory or plant-related food allergy symptoms (PFASs). This study analyzed the relevance of Bet v 1 and profilin sensitization in the clinical phenotype of pollen-allergic patients in Belgium. Ten patients allergic to birch pollen (BPA), 31 to grass pollen (GPA) and 33 to both pollens (MPA), with rhino-conjunctivitis with/without asthma (ARRC), were evaluated by means of questionnaire, skin-prick tests and specific IgE assays. Half of GPA were co-sensitized to birch pollen, and no BPA were sensitized to profilin. The prevalence of asthma and pollen-related food allergy syndrome (PFAS) was higher in BPA than in MPA or GPA, with a higher severity of PFAS in asthmatic BPA. GPA with PFAS were more frequently sensitized to Bet v 1, with higher levels of rBet v 1-IgE. The prevalence of PFAS, together with the duration of rhinitis and PFAS tended to increase in profilin-polysensitized vs. mono- and un-sensitized GPA, regardless of Bet v 1-IgE and the severity of symptoms.

PMID 42929879
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PubMedEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026-10-26

Persistent RNA signatures suggestive of Mycobacterium leprae viability detected by qRT-PCR in multibacillary leprosy patients after one year of WHO-MDT: clinical and histopathological correlation.

Sharma Rahul R, Singh Itu I, Gupta Saurabh S, Lavania Mallika M et al.

Multidrug therapy (MDT) has significantly reduced the global burden of leprosy; however, emerging evidence suggests that viable Mycobacterium leprae may persist in high BI cases of leprosy even after completion of treatment, posing a risk for relapse and continued transmission. This study aimed to longitudinally quantify RNA transcripts of genes associated with viability M. leprae in high bacteriological index multibacillary leprosy patients during and after MDT and to correlate these findings with histopathological and clinical outcomes. Slit skin smear (SSS) samples were collected from 180 newly diagnosed multibacillary (MB) patients at recruitment (BI >3+), 125 patients at 6 months, and 60 patients at 12 months. DNA and RNA were extracted from SSSs, followed by reverse transcription to cDNA, and subjected to qPCR. Standard curves were generated using 10-fold serial dilutions of purified amplicons of all the genes to quantify the copy numbers. DNA was used for RLEP qPCR for normalization of RNA for 16S rRNA, hsp18 and esxA gene. We performed molecular viability assessment of M. leprae using real-time quantitative PCR targeting three viability associated genes: 16S rRNA, hsp18, and esxA. Statistical analysis was performed using ANOVA with Tukey's multiple comparison tests. Histopathological analysis was done in a subset of patients (n = 5) who showed presence of viable bacilli after 12 months of treatment. We observed that a significant proportion of patients show persistent expression of all three gene targets after one year of completion of MDT. When patients were released from treatment (RFT) at 12 months, gene expressions of 16S rRNA, esxA and hsp18 were detected in 40%, 45%, and 46.6% of high BI MB leprosy patients. Notably, copy numbers of genes either remained constant or increased over time in a subset of patients. Histopathological analysis corroborated molecular findings, showing presence of active granulomas and acid-fast bacilli in biopsies from such RFT patients. Statistical analysis confirmed a highly significant difference in gene expression between baseline and 12th month of MB MDT. Our findings demonstrate persistent RNA signatures associated with M. leprae viability in a subset of high-BI MB patients after completion of the standard 12-month WHO-MDT regimen. These molecular findings are suggestive of persistent bacterial viability but cannot definitively distinguish viable, replication-competent bacilli from residual RNA. The use of molecular viability markers (16S rRNA, hsp18, esxA) provides a sensitive tool for monitoring treatment response and supports the need to re-evaluate current fixed-duration therapy, especially for high-BI cases.

PMID 42928317
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PubMedbioRxiv : the preprint server for biology2026-10-25

Circadian and Sex-Specific Responses to Alternaria alternata in Allergic Airway Inflammation.

Duraisamy Santhosh Kumar SK, Mainzer Joanna J, Prasad Chandrashekar C, Haworth Steven S et al.

Asthma severity and immune responses are regulated by circadian rhythms, yet the role of circadian timing in fungal allergen-induced airway inflammation remains poorly defined. Alternaria alternata , a clinically relevant fungal allergen, is strongly associated with severe asthma exacerbations and persistent airway dysfunction. Using a preclinical mouse model, we investigated whether pulmonary responses to Alternaria exposure are influenced by time of day and sex. We demonstrate that Alternaria induces allergic airway inflammation, airway hyperresponsiveness (AHR), and epithelial barrier disruption in a circadian- and sex-dependent manner. Female mice exhibited enhanced eosinophilic, neutrophilic, interstitial macrophage, and dendritic cell infiltration predominantly at Zeitgeber Time 0 (ZT0), whereas males showed stronger inflammatory responses at ZT12. Alternaria exposure increased IL-33 release and promoted ILC2 and Th2 cell accumulation, with distinct temporal patterns between sexes. Cytokine and chemokine profiling revealed robust Th2, proinflammatory, and Th17 responses that varied with exposure time, with higher responses at ZT12 in females and ZT0 in males. Markers of tissue injury, including lactate dehydrogenase and uric acid, followed similar circadian-dependent trends. Functionally, Alternaria -exposed mice displayed greater AHR during the resting phase, particularly in males. Additionally, Alternaria disrupted epithelial junctional proteins (E-cadherin and ZO-1) and altered expression of core circadian clock proteins CLOCK, BMAL1, and REV-ERBα. Mechanistically, peak inflammation coincided with enhanced STAT1, STAT3, and STAT6 activation. Collectively, these findings identify circadian timing and sex as key determinants of fungal allergen-induced airway inflammation and suggest chronotherapeutic approaches may improve asthma outcomes.

PMID 42926388
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PubMedAllergology international : official journal of the Japanese Society of Allergology2026-10-25

TLR4 agonists as emerging adjuvants for sublingual allergen immunotherapy: Preclinical evidence and future perspectives.

Oka Tatsuya T, Kobayashi Hiroyuki H

Sublingual immunotherapy (SLIT) is a safe and convenient treatment for allergic diseases, but it usually requires several years to achieve sufficient clinical benefit. Therefore, effective adjuvants are needed to enhance its efficacy and shorten the time required to achieve a therapeutic response. In this review, we summarize the rationale for using Toll-like receptor 4 (TLR4) agonists as adjuvants for SLIT and describe our recent preclinical findings with synthetic TLR4 agonist derivatives. We established a mouse model of sublingual administration using a small administration volume and a defined retention period after administration. Several TLR4 agonist derivatives enhanced allergen-specific serum IgG responses when administered with allergen. The adjuvant activity of one derivative was abolished in TLR4-knockout mice, indicating that its activity was dependent on TLR4 signaling. A selected derivative was further evaluated in combination with Japanese cedar pollen (JCP) extract. Co-administration of the derivative with JCP extract increased Cry j 1-specific IgG and IgA levels in serum and IgA levels in nasal lavage fluid. It also enhanced allergen-induced IL-10 production without substantially increasing IFN-γ or IL-4 production. Moreover, IgG from mice treated with the derivative and JCP extract more effectively inhibited allergen-induced mast cell degranulation than IgG from mice treated with JCP extract alone. These findings suggest that synthetic TLR4 agonists may enhance SLIT by promoting functional allergen-specific antibody responses. Further studies are needed to confirm their safety and clinical efficacy in humans.

PMID 42926171
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PubMedOrganic & biomolecular chemistry2026-10-25

New abscisic acid analogues produced via genome mining-guided heterologous expression.

Liu Guowei G, Ge Xueping X, Lan Donghe D, Tong Xiaoyang X et al.

Abscisic acid (ABA), a pivotal phytohormone, was traditionally considered to be synthesized via the carotenoid pathway exclusively in plants. In our recent work, a dedicated ABA biosynthetic gene cluster (ablt) was discovered from the marine-derived fungus Alternaria alternata JJY-32 by genome mining. Heterologous expression of the ablt cluster in Aspergillus nidulans A1145 led to the production of two new analogues of ABA, designated as abaterpene A (1) and abaterpene B (2), along with six known sesquiterpenes. Further step-wise gene co-expression analysis demonstrated that ablt3 and ablt5 are necessary and sufficient for the production of compounds 1 and 2. The structures were determined using comprehensive 1D and 2D NMR data and assisted by ECD calculations.

PMID 42924436
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