若生智能
Drug Database
AL

alternaria allergen SLIT

✓ Approved

HAL Allergy Group · 治疗药物

什么是 alternaria allergen SLIT？

alternaria allergen SLIT 是一种治疗药物，由HAL Allergy Group研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。

药物档案

公司HAL Allergy Group
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, HAL Allergy Group

治疗适应症

alternaria allergen SLIT 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMediMeta2026-07-27

Dietary fiber-based oral nanovaccine promotes gut-to-nose trafficking of regulatory cells and drives antigen-specific tolerance to relieve airway allergy.

Qin Yuting Y, Wang Zeming Z, Zong Yuru Y, Lu Zefang Z et al.

Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen-specific immune tolerance. Here, we developed an oral nano-dietary fiber (NDF) platform that integrates allergen delivery with microbiota-driven immunomodulation, using dextran as both an antigen carrier and a fermentable substrate for intestinal bacteria. NDF enabled coordinated allergen release and sustained short-chain fatty acid (SCFA) production in the gut, promoting SCFA-FFAR2-dependent expansion of regulatory B and T cells and their trafficking to the nasal mucosa. In murine models, NDF slowed disease progression, improved airway function, and reduced allergen-specific IgE levels. Together, these findings establish NDF as an oral tolerogenic vaccine that provides durable protection against allergic airway disease through the gut-nasal axis.

PMID 42504168
阅读全文 →
PubMedImmunity, inflammation and disease2026-07-27

Clinical Feasibility and Safety of Nasal Allergen Provocation Testing in Pediatric Allergic Rhinitis.

Wang Mei-Lan ML, Low Terese Huiying TH, Li Zheng-Cai ZC, Bi Xian-Yun XY et al.

Nasal allergen provocation testing (NAPT) has been shown to be a safe and reproducible test in adults; however, pediatric data are limited. This study aims to investigate the clinical applications, feasibility, reproducibility and safety of NAPT in the pediatric population. In this prospective study, 294 patients (4.16-14.25 years old, mean of 7.33 years), with symptoms and medical history of allergic rhinitis (AR) and IgE-mediated sensitization to Dermatophagoides pteronyssinus and Dermatophagoides farinae were recruited. Participants underwent NAPT with negative control and with increasing concentrations of crude Dermatophagoides farinae (50 µg/ml, 500 µg/ml, and 5000 µg/ml) at 15 min intervals. Pre- and post-test subjective symptom scores and objective active anterior rhinometry measurements were analyzed. Among the 245 participants (83.3%) with a positive NAPT, the majority (n = 193, 78.8%) tested positive at 500 µg/ml or less. They (n = 226, 92.2%) were diagnosed based on an increase in total nasal symptoms score (TNSS) ≥ 5 points. The remaining 7.8% (n = 19) required objective measurements to fulfill the criteria for a positive result. Five participants were unable to fully comply with the instructions provided. There were no adverse events recorded during the study. The group which tested positive on NAPT recorded higher sIgE levels than that which tested negative. Furthermore, those with higher serum sIgE levels tested positive on NAPT at lower allergen concentrations. The baseline visual analog scale (VAS) was significantly higher in the group testing positive on NAPT at the lowest allergen concentration, compared with the other groups. Our study demonstrates that NAPT is safe and feasible to be conducted on the pediatric population.

PMID 42504668
阅读全文 →
PubMedBiosensors2026-07-27

Magnetic Beads-Based Electrochemical Label-Free DNA-Bioassay for the Detection of Peanut Allergen Ara h2 in Food Matrices.

Hervás-Pérez Juan Pablo JP, Izcara Sergio S, Sánchez-Paniagua Marta M

The reliable detection of the peanut allergen Ara h2 in processed foods remains a major challenge, since thermal and high-pressure treatments can alter protein structure and limit the performance of immunoassays. DNA-based methods provide a robust alternative to this approach. In this work, a highly sensitive label-free electrochemical genoassay for Ara h2 DNA detection was developed using streptavidin-coated magnetic beads (MBs). A biotinylated capture probe (CP) immobilized on the MBs' surface enabled specific target recognition through a sandwich hybridization strategy with a secondary probe, allowing for direct electrochemical detection without enzymatic labels. Two transduction strategies were evaluated: (i) electrochemical impedance spectroscopy (EIS) with ferri/ferrocyanide as a redox probe, and (ii) differential pulse voltammetry (DPV) using methylene blue. The ferri/ferrocyanide-based EIS approach showed the best sensitivity and discrimination between hybridized and non-hybridized states. A linear dependence was observed with the concentration of the synthetic Ara h2 target over the 0.05 to 20 nM range, with a detection limit of 0.025 nM. CP-MBs showed good stability for at least 20 days. Applicability was demonstrated in soy beverages, rice beverages, and low-fat cow's milk, with recoveries close to 100% and negligible matrix effects.

PMID 42505463
阅读全文 →
PubMedTranslational vision science & technology2026-07-27

Leakage-Aware Visit-Level Benchmarking Reveals Representational Overlap in Deep Learning for Bacterial Versus Fungal Keratitis Classification.

Jeong Wonjong W, Jeong Jinho J

The purpose of this study was to benchmark deep learning for bacterial versus fungal keratitis classification from slit-lamp photographs under a leakage-aware, visit-level framework, and to characterize embedding-space geometry as a potential performance ceiling. This retrospective single-center study included white-light slit-lamp photographs from 101 patients with culture-confirmed bacterial or fungal keratitis (258 visits; 658 images), using strict patient-disjoint five-fold cross-validation with the clinical visit as the primary prediction unit. Image-level classifiers, multiple instance learning (MIL), and DINOv2-based retrieval were compared under three preprocessing strategies: full-frame, corneal region of interest (ROI), and lesion-centered MedSAM crops. Embedding geometry was analyzed using Uniform Manifold Approximation and Projection (UMAP). Pairwise visit-level model comparisons were performed using patient-cluster paired bootstrap on aligned out-of-fold (OOF) visit-level predictions, and probability calibration was assessed using expected calibration error (ECE) and Brier score. At the image level, the highest area under the receiver operating characteristic curve (AUROC) was 0.691. At the visit level, convolutional neural network (CNN)-based MIL models achieved the highest AUROC (0.677), followed by retrieval-based approaches (0.661). However, MIL models showed larger generalization gaps, whereas DINOv2 lesion-crop retrieval remained stable (-0.014). Lesion-centered preprocessing was the dominant performance determinant within the retrieval paradigm. Embedding analysis revealed extensive class overlap, with 90.9% of fungal visits within the bacterial convex hull. Under leakage-aware, visit-level evaluation, all paradigms converged to modest discrimination, consistent with representational overlap within this single-center cohort. CNN-based MIL achieved higher AUROC but greater overfitting; retrieval-based models provided more stable generalization and superior probability calibration. Whether this ceiling is task-intrinsic or site-specific requires multicenter validation. Leakage-aware visit-level benchmarking supports realistic evaluation and calibrated decision support.

PMID 42506962
阅读全文 →
PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Sonoplasma Technology for Water Treatment Against Phytopathogenic Fungi: Responses of Melanized and Hyaline Species.

Fedoseeva Elena V EV, Sergeeva Yulia D YD, Patsaeva Svetlana V SV, Kamler Anna V AV et al.

Sonoplasma treatment (SPT), which combines hydrodynamic cavitation with low-temperature plasma discharge in water, has been proposed as an advanced oxidation process for reducing biological contamination. By generating physical stressors and reactive oxygen species, including hydrogen peroxide (HP), SPT may inactivate microorganisms, but its effects on stress-resistant filamentous fungi remain insufficiently characterized. We examined two phytopathogenic fungi with contrasting pigmentation: melanized Alternaria alternata and hyaline Fusarium solani. Spore suspensions were exposed to direct and indirect SPT at 30 kHz, and viability, biomass accumulation, conidial production, allelopathic activity, and pigmentation-associated spectral responses were assessed immediately after treatment and after storage. Fungus F. solani showed greater susceptibility, with reduced colony-forming capacity and suppressed biomass production, although surviving propagules showed increased sporulation. In contrast, A. alternata maintained viable growth under the tested conditions and showed stimulation of growth-related and reproductive endpoints, together with darker colony pigmentation. These responses are consistent with pigmentation-associated tolerance to SPT-induced physical and oxidative stress, but do not establish melanin as the sole causal mechanism. SPT efficacy against filamentous fungi is therefore species-dependent and may be limited when resistant melanized taxa are present.

PMID 42506249
阅读全文 →
PubMedFood science and technology international = Ciencia y tecnologia de los alimentos internacional2026-07-27

Allergenic protein behavior, parvalbumin (PA) contained in skipjack tuna (Katsuwonus pelamis) during the fish sauce processing stage.

Amalia Ulfah U, Romadhon Romadhon R, Purnamayati Lukita L

Parvalbumin (PA) is a major muscle allergen in fish capable of triggering immunoglobulin E-mediated hypersensitivity reactions in fish-allergic individuals. This study investigated the degradation and allergenic behavior of PA in skipjack tuna (Katsuwonus pelamis) sauce during a 60-day fermentation process, sampled at 20-day intervals. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting were used to monitor PA profiles and immunoglobulin G (IgG)-binding ability, which revealed a thin, undetectable band of PA and low IgG-binding ability by immunoblotting with the progress of fish sauce manufacturing. Additionally, because skipjack tuna belongs to the Scombridae family, histamine levels, pH, total acidity, and total soluble peptides were analyzed to ensure food safety and monitor proteolysis. The results demonstrated that PA bands became progressively thinner and undetectable by day 60, which strongly correlated with a marked decrease in IgG-binding ability. Fermentation also triggered significant peptide solubilization, while histamine content showed a strong correlation with changes in pH and total acidity. These findings demonstrate that traditional fish sauce processing effectively degrades the allergenic protein PA, highlighting fermentation as a viable method to reduce allergenicity in scombroid fish products while maintaining standard quality markers.

PMID 42506887
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多alternaria allergen SLIT