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HE

Hep A-Vi (ViATIM / ViVAXIM)

✓ Approved

Sanofi S.A · 疫苗 · 疫苗

什么是 Hep A-Vi?

Hep A-Vi 是一种疫苗,由Sanofi S.A研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名ViATIM, ViVAXIM
公司Sanofi S.A
药物类别疫苗, 大分子
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved

治疗适应症

Hep A-Vi 针对 2 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsTyphoid fever✓ Approved
Surgical and medical proceduresAntiviral prophylaxis✓ Approved

相关研究文献

PubMedBiosensors2026-07-27

A Deep Learning Framework for EEG-Based Decoding of Visually Imagined Arrows with Different Colors and Directions.

Alazrai Rami R, Hatahet Oula O, Qaadan Sahar S, Alothman Youssef Y et al.

Brain-computer interface (BCI) systems have demonstrated significant potential across medical, educational, and entertainment domains. Recently, visual imagery (VI) has emerged as an alternative to traditional motor imagery (MI) paradigms, offering a broader spectrum of control signals for dexterous assistive devices. In this study, we propose a novel BCI framework for classifying visually imagined arrows defined by different colors and directions. The proposed framework employs the Choi-Williams time-frequency distribution (CW-TFD) to construct a joint time-frequency-spatial representation (TFSR) of EEG signals. The resulting TFSR is converted into grayscale images and provided as input to a newly designed convolutional neural network (CNN), which performs 16-class decoding of visually imagined arrows defined by combined color and direction attributes. A new EEG dataset was collected from 16 subjects who imagined 16 distinct arrows comprising four colors and four directions. The framework achieved an average classification accuracy of 95.05% and a Cohen's kappa score of 0.947 across the 16 classes. To comprehensively evaluate the proposed approach, three comparative analyses were conducted. First, multiple time-frequency representations were assessed for VI-based EEG decoding. Second, the proposed CNN architecture was benchmarked against several state-of-the-art pre-trained deep learning models. Third, the framework was compared with conventional machine learning classifiers using handcrafted features. Results demonstrate that the constructed CWD-based TFSR combined with the proposed CNN consistently outperforms alternative representations and classification models. These findings demonstrate the feasibility of decoding an expanded set of visually imagined color-direction arrow commands in a subject-specific EEG-based BCI setting, supporting further development of calibrated VI-based BCI systems for assistive and interactive applications.

PMID 42505459
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PubMedMedical sciences (Basel, Switzerland)2026-07-27

Evaluating the Acceptability and Pilot Diagnostic Accuracy of a Visually Independent Test Battery of Neurocognition (VISION-Cog).

Yee Hiromi H, Ho Aricia Xin Yi AXY, Wong Chiew Meng Johnny CMJ, Tan Wei Lin WL et al.

Cognitive impairment (CI) may be overdiagnosed in individuals with vision impairment (VI) due to the vision-dependent design of current cognitive assessment tools. This cross-sectional study evaluated the acceptability and diagnostic accuracy (pilot) of the Visually Independent Test Battery of Neurocognition (VISION-Cog) protocol, against gold-standard neurologist diagnosis. Community-dwelling older adults with near binocular presenting VI (near visual acuity [NVA] ≥ 0.2 logarithm of the minimum angle of resolution [LogMAR] units) were recruited from the Population Health and Eye Disease Profile in Elderly Singaporeans (PIONEER) study. Participants underwent VISION-Cog and the Singapore-validated Montreal Cognitive Assessment (MoCA-SG) testing and were referred for neurologist evaluation based on standardized referral protocols. The acceptability of the VISION-Cog was assessed through study completion rates, test duration, and the qualitative feedback. Vision-Cog's diagnostic accuracy (pilot) against neurologist evaluation was analyzed using binary logistic regression and C-statistics to estimate area under the receiver operating curve (AUC) with corresponding sensitivity and specificity. Out of forty-five participants (mean age [SD]: 73.8 [6.1 years]; mean NVA [SD]: 0.47 [0.14] LogMAR; and 54.1% female), 37 (82.2%) completed the protocol. The mean VISION-Cog completion time [SD] was 59 m 57 s (7 m 18 s). Qualitatively, participants found the testing time acceptable. The VISION-Cog achieved an AUC of 0.930 against neurologist diagnosis, with 100.0% sensitivity and 78.0% specificity. The VISION-Cog demonstrated satisfactory preliminary diagnostic accuracy and good acceptability indices in older Asian adults, supporting the need of larger studies to confirm its diagnostic accuracy of CI and clinical utility in those with VI.

PMID 42506313
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PubMedCureus2026-07-27

Early Six-Month Functional and Radiological Outcomes of Expert Tibia Nailing in Intra-articular Tibial Plateau Fractures: A Prospective Study.

Kumar Vishal V, Kothale Jayant J, Sharma Ravi R, Azlam Mohamed P MP

Background and objective Intra-articular tibial plateau fractures present significant management challenges. Traditional plating can compromise soft tissues, whereas Expert Tibia Nailing provides minimally invasive fixation with multidirectional locking capabilities. This study aimed to evaluate the early functional and radiological outcomes of Expert Tibia Nailing, with an a priori comparison between simple (Schatzker I-IV) and complex (V-VI) tibial plateau fractures. Methods This prospective observational study included 36 patients treated with Expert Tibia Nailing at the Department of Orthopaedics, Netaji Subhash Chandra Bose Medical College, Jabalpur, from May 2022 to June 2024. The cohort comprised 29 males (80.6%) and seven females (19.4%), with a mean age of 41.6 ± 11.5 years. The primary outcome was the Knee Society Score (KSS) at six months. Secondary outcomes included time to weight-bearing, radiological union, and complications. Categorical variables were analyzed using the chi-square test or Fisher's exact test, and continuous variables were analyzed using the Mann-Whitney U test. Results Road traffic accidents accounted for injuries in 27/36 patients (75.0%), while falls accounted for 9/36 cases (25.0%). Schatzker type II, type IV, and type V fractures were each observed in 7/36 patients (19.4%). The mean time to partial weight-bearing was 8.11 ± 1.8 weeks, and the mean time to radiological union was 15.83 ± 2.9 weeks. At six months, KSS outcomes were rated as excellent in 10/36 patients (27.8%), good in 16/36 (44.4%), fair in 4/36 (11.1%), and poor in 6/36 (16.7%). Excellent-to-good outcomes were achieved in 26/36 patients (72.2%). Patients with Schatzker types I-IV demonstrated significantly better outcomes than those with types V-VI (20/23, 87.0% vs. 6/13, 46.2%; p = 0.007). Complications occurred in 14/36 patients (38.9%), including knee stiffness in 7/36 (19.4%), condylar collapse in 6/36 (16.7%), superficial infection in 3/36 (8.3%), and malunion in 1/36 (2.8%). No cases of nonunion, deep infection, compartment syndrome, implant failure, or neurovascular injury were observed. Conclusions Expert Tibia Nailing yielded satisfactory early functional and radiological outcomes in this prospective series of tibial plateau fractures, with low rates of deep infection, nonunion, and neurovascular complications. However, the technique demonstrated poorer results and a higher complication burden in bicondylar fractures; therefore, its use should be limited to carefully selected unicondylar patterns. Larger multicenter studies with longer follow-up periods are needed to confirm its role relative to plate-based fixation.

PMID 42504333
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PubMedBriefings in bioinformatics2026-07-27

Screening of cell-type-specific meta-programs for drug repurposing in Alzheimer's disease.

Zhang Chunlong C, Zhang Yuxi Y, Wu Zhiyi Z, Zhang Yuting Y et al.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder driven by complex cellular changes. To identify transcriptional signatures involved in AD pathology, we first analyzed nine single-cell/nucleus RNA-seq datasets from 67 high-pathology cases (Braak stages V/VI), generating an atlas of 363 243 cells. Using a multi-sample integration strategy, we identified 51 cross-sample meta-programs (MPs) across seven cell types that collectively capture key AD-related processes, including synaptic dysfunction and neuroinflammation. By screening bulk transcriptomes from 1208 ad and 725 normal samples, we found that 26 MPs (13 pathogenic and 13 protective) displayed differential activity in AD, characterized by up-regulation of microglia MPs and down-regulated of neuron MPs. Furthermore, spatial transcriptomics revealed that these MPs form spatially coherent communities associated with distinct cellular neighborhoods. Finally, we performed an integrative drug repurposing screen to identify candidate drugs predicted to regulate pathogenic MPs. In conclusion, we conducted an integrated multi-omics study to identify AD cell-type-specific MPs, and this framework can be applied to deconvolve cellular heterogeneity and screen candidate drugs for AD.

PMID 42506875
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

Recent Developments in Graphene-Based Adsorbents for Environmental Applications.

Pintea Stelian S, Stegarescu Adina A, Lung Ildiko I, Chiș Anda Maria AM et al.

Graphene and its derivatives have attracted sustained research interest as adsorbent materials for environmental applications, driven by their large surface area, chemically tunable surface, and compatibility with a wide range of functional modifications. This review covers recent developments in the use of graphene-based materials for water, air, and soil remediation, focusing primarily on work published over the last five years. A concise overview of graphene, its derivatives, and other carbon nanostructures, such as carbon nanotubes and fullerenes, is also provided. The main graphene derivatives are briefly described (graphene oxide, reduced graphene oxide, graphene nanoribbons, and graphene quantum dots) together with a comparative overview of the principal synthesis methods, from mechanical exfoliation and chemical vapor deposition to liquid-phase exfoliation, oxidation/reduction, and flash Joule heating. The discussion then turns to how surface functionalization and composite formation affect adsorption performance in practice. In water treatment, the results are most developed: functionalized composites have reached adsorption capacities of 484.3 mg g-1 for organic dyes and 157.23 mg g-1 for Cr(VI). Air purification is a smaller but growing area, with plasma-treated graphene aerogels achieving CO2 capture capacities of 3.3 mmol g-1 and retaining performance over 40 cycles. Soil remediation remains the least explored compartment, though arsenic immobilization efficiencies of up to 99.3% have been reported. Remaining challenges around scalability, behavior in real environmental matrices, and long-term ecotoxicological impact are identified and discussed.

PMID 42506517
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PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Chemo-Diversity and Secondary Metabolite Content in Corticolous Crustose Lichens (Fam. Arthoniaceae, Graphidaceae, Pyrenulaceae) from Remnants of Colombian Tropical Dry Forests.

España-Puccini Pierine P, Muñoz-Acevedo Amner A, Llanos-López Natalia A NA, Stadler Marc M et al.

Colombia ranks third among South American countries in terms of fungal diversity (including lichens); however, the lichen diversity of tropical dry forest ecosystems, particularly those in the Caribbean region, remains relatively understudied. The typical lichens found in tropical dry forest are crustose/corticolous microlichens (adapted to the xerophytic environments), which produce certain secondary metabolites that act as protective agents against ultraviolet radiation/decomposition/depredators; nonetheless, secondary metabolites of most of these lichens have not yet been described. This study focused on the compositional analysis and the extrolite content of seven lichens: Cryptothecia sp., Cryptothecia scripta, Graphis dendrogramma, Leucodecton occultum, Helminthocarpon leprevostii, Pyrenula ochraceoflava, and Allographa seminuda, using thin-layer chromatography, high-performance liquid chromatography-diode array detector, liquid chromatography-electrospray-mass spectrometry and/or liquid chromatography-tandem mass spectrometry. The main findings were: (i) two Cryptothecia spp. contained 2'-O-methylperlatolic acid (97%) or ovoic/gyrophoric acids (67%/28%); (ii) two specimens of G. dendrogramma had stictic/norstictic acids (33-60%/40%); (iii) three samples of L. occultum were characterized by norstictic acid (42-82%); (iv) schizopeltic/3-O-methylschizopeltic acids (58%/32%) were found in one specimen of H. leprevostii; (v) one sample of P. ochraceoflava was represented by unidentified xanthone-type metabolite/7-chloroemodin/ (26%/24%); and, (vi) the extrolite content in one specimen of A. seminuda was negligible. Finally, 10 of the 11 lichen specimens studied from the Department of Atlántico within Colombia contained certain secondary metabolites that likely reflect the common types of extrolites, namely, di-/tri-depsides, depsidones, dibenzofurans, and chlorinated anthraquinones/xanthones, which could be hypothetically related to the evolutionary patterns of this type of organism.

PMID 42506287
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