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unspecified allergy vaccine (Staloral)

✓ Approved

Stallergenes · 治疗药物

什么是 unspecified allergy vaccine？

unspecified allergy vaccine 是一种治疗药物，由Stallergenes研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Oral (PO)、Subcutaneous Injection、Sublingual (SL)/Oral Transmucosal。

药物档案

商品名Staloral
公司Stallergenes
给药途径Injectable (Others), Oral (PO), Subcutaneous Injection, Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, Stallergenes

治疗适应症

unspecified allergy vaccine 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

相关研究文献

PubMedVaccines2026-07-27

Yellow Fever Vaccination in an Individual with Confirmed Egg Protein Allergy: A Case Report.

Otte Nelly N, Kahaki Amir Maleki AM, Wurpts Gerda G, Kraus Thomas T et al.

Yellow fever vaccination is recommended for travelers visiting endemic regions in South America and Africa. The live-attenuated vaccine (Stamaril®, Sanofi Pasteur) is produced in embryonated chicken eggs and contains residual ovalbumin, posing a challenge for individuals with egg protein allergy. We report the case of a 35-year-old male disaster relief worker with confirmed egg protein allergy and moderate sensitization but no history of anaphylaxis. Under normal circumstances, a statement confirming that vaccination is not possible would be sufficient for entry. However, due to his work-related duties and the relevant guidelines from his employer, there was an urgent need for vaccination despite his egg protein allergy. A comprehensive allergy work-up including skin prick testing, serum-specific IgE, and oral provocation testing revealed a moderate allergy without systemic reactions. Following informed consent and risk assessment, a fractional dose (0.1 mL) of the reconstituted yellow fever vaccine was administered under close monitoring. The patient developed a localized dermal reaction without systemic symptoms. Post-vaccination neutralization testing confirmed seroconversion indicating protective immunity. Although yellow fever vaccination is considered contraindicated in individuals with severe egg protein allergy, the literature supports its cautious use in selected cases. Fractional dosing has emerged as an effective dose-sparing strategy. Studies show that even in egg protein-allergic individuals, adverse events are rare. In this case, a fractional yellow fever vaccination was safe and an effective option for an egg-allergic individual in a high-risk occupational setting, supporting a personalized approach based on clinical risk assessment and current evidence.

PMID 42506643
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PubMediMeta2026-07-27

Dietary fiber-based oral nanovaccine promotes gut-to-nose trafficking of regulatory cells and drives antigen-specific tolerance to relieve airway allergy.

Qin Yuting Y, Wang Zeming Z, Zong Yuru Y, Lu Zefang Z et al.

Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen-specific immune tolerance. Here, we developed an oral nano-dietary fiber (NDF) platform that integrates allergen delivery with microbiota-driven immunomodulation, using dextran as both an antigen carrier and a fermentable substrate for intestinal bacteria. NDF enabled coordinated allergen release and sustained short-chain fatty acid (SCFA) production in the gut, promoting SCFA-FFAR2-dependent expansion of regulatory B and T cells and their trafficking to the nasal mucosa. In murine models, NDF slowed disease progression, improved airway function, and reduced allergen-specific IgE levels. Together, these findings establish NDF as an oral tolerogenic vaccine that provides durable protection against allergic airway disease through the gut-nasal axis.

PMID 42504168
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PubMedCells2026-07-27

The Basophil Activation Test in Allergy Diagnostics: Clinical Applications, Methodological Challenges, and Proposed Clinical Frameworks.

Izmailovich Marina M, Kabyldina Aizhan A, Seilkhan Zamira Z, Zhussip Aruzhan A et al.

The basophil activation test (BAT) is a modern in vitro functional assay used for the diagnosis of immunoglobulin E-mediated allergic reactions. The method is based on flow cytometric assessment of activation marker expression on peripheral blood basophils after stimulation with specific allergens. BAT has gained increasing clinical relevance in allergology, particularly in patients with anaphylaxis risk, polysensitization, drug hypersensitivity, and inconclusive skin or serological test results. This narrative review summarizes current evidence on the diagnostic performance and clinical applications of BAT in food allergy, drug hypersensitivity, Hymenoptera venom allergy, latex sensitization, and allergen immunotherapy monitoring. The review discusses the immunological mechanisms of basophil activation, the role of CD63 and CD203c, methodological aspects of the assay, sensitivity and specificity data, and advantages and limitations compared with conventional diagnostic approaches. Particular attention is given to protocol standardization, interpretation criteria, and the problem of non-responder patients. Current evidence indicates that BAT demonstrates high specificity and provides functional assessment of clinically relevant allergic reactions. In addition, this review proposes practical clinical frameworks for integrating BAT into allergy diagnostic pathways and for managing inconclusive or non-responder BAT results. Further standardization, multiplex formats, and automated analytical approaches may expand its role in personalized allergy diagnostics.

PMID 42505351
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PubMedVaccines2026-07-27

Untangling the Roots of HPV Vaccine Acceptance in West Virginia: How Hesitancy and Misinformation Shape Parental Decisions.

Guidry Jeanine P D JPD, Laestadius Linnea I LI, Engbersen-Severijns Yil Y, Miller Carrie A CA et al.

West Virginia is of particular concern regarding HPV vaccine hesitancy, currently ranking 45th among U.S. states in HPV vaccine uptake. General vaccine hesitancy and HPV- and HPV vaccine-specific misinformation, both associated with lower vaccination, have increased in recent years, complicating efforts to identify key drivers of HPV vaccine acceptance and effective intervention targets. This study used a Qualtrics survey of n = 330 parents of children aged 0-14 in West Virginia. Measures included parental HPV vaccine acceptance for their youngest child (reflecting either completed vaccination or intention to vaccinate), general vaccine hesitancy measured using the Vaccine Hesitancy Scale (VHS), and endorsement of nine common HPV- and HPV vaccine-specific misinformation statements. Misinformation items were summed and demonstrated good internal reliability (Cronbach's α = 0.868). Hierarchical logistic regression analyses indicated significant racial/ethnic differences across all model steps, with non-White parents less likely to report HPV vaccine acceptance for their child (p < 0.001). In Step 2, lower levels of general vaccine hesitancy predicted higher HPV vaccine acceptance (p < 0.001). In the final model, higher endorsement of HPV- and HPV vaccine-specific misinformation was associated with lower HPV vaccine acceptance (p = 0.035). These findings underscore the independent and additive influence of general vaccine hesitancy and HPV- and HPV vaccine-specific misinformation on parental HPV vaccine acceptance in West Virginia. Community-engaged public health strategies should prioritize strengthening vaccine confidence and directly addressing HPV- and HPV vaccine-specific misinformation, particularly among underserved populations.

PMID 42506645
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PubMedThe Journal of asthma : official journal of the Association for the Care of Asthma2026-07-27

Genetically predicted gut microbiota and risk of pediatric asthma and food allergy in East Asian populations: a two-sample Mendelian randomization study.

Han Zaimeng Z, Zang Caihong C, Zhang Chunjuan C, Di Wanpeng W et al.

To investigate the genetically predicted associations between gut microbiota composition and the risk of pediatric asthma and food allergy in East Asian populations using a bidirectional two-sample Mendelian randomization (MR) approach. We performed bidirectional two-sample MR analyses using summary-level genome-wide association study (GWAS) data. Genetic instruments for 500 gut microbial taxa were obtained from the 4D-SZ cohort, which included 3,432 Chinese individuals who underwent whole-metagenome shotgun sequencing. Outcome GWAS summary statistics for pediatric asthma (547 cases and 161,803 controls; GCST90018675) and food allergy (3,777 cases and 165,939 controls; GCST90018625) were derived from the Biobank Japan project. All participants were of East Asian ancestry. The primary MR analysis was conducted using the inverse-variance weighted (IVW) method, with MR-Egger, weighted median, and weighted mode analyses used as complementary approaches. Sensitivity analyses included Cochran's Q test for heterogeneity, the MR-Egger intercept test for horizontal pleiotropy, and MR-PRESSO for outlier detection. The IVW analysis identified nine gut microbial taxa with nominally significant associations with pediatric asthma risk (p < 0.05). Among them, Subdoligranulum showed a suggestive protective association (OR = 0.91, 95% CI: 0.83-0.99), whereas Solobacterium showed a suggestive risk association (OR = 1.08, 95% CI: 1.00-1.16). For food allergy, eighteen taxa were nominally associated with disease risk (p < 0.05). Bacteroides helcogenes showed a suggestive protective association (OR = 0.96, 95% CI: 0.94-0.98), whereas Alistipes shahii showed a suggestive risk association (OR = 1.03, 95% CI: 1.00-1.05). Sensitivity analyses yielded generally consistent results. Reverse MR analyses did not identify significant genetically predicted effects of pediatric asthma or food allergy on gut microbiota composition. This exploratory MR study provides suggestive evidence that specific gut microbial taxa may be associated with pediatric asthma and food allergy in East Asian populations. These findings offer preliminary support for the role of the gut microbiota in allergic diseases and underscore the importance of population-specific research. Further large-scale studies with stricter multiple-testing correction are needed to validate these associations.

PMID 42506917
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PubMedVaccines2026-07-27

Human Papillomavirus Vaccine Intent and Associated Factors Among the Unvaccinated University Freshmen in the Largest University Town in China.

Yao Hongcen H, Lu Hongmei H, Zhu Qi Q, Shen Jinhua J et al.

Background: Human papillomavirus (HPV) vaccine has been proven a safe, necessary, and effective measure against HPV infection. However, HPV vaccine uptake remains limited among university students in China. This study investigated HPV vaccine intent among university freshmen in the largest university town in China. Methods: A cross-sectional online survey was conducted among unvaccinated female and male freshmen attending seven universities in Songjiang University Town, Shanghai, during 2024-2025. The questionnaire collected sociodemographic characteristics, HPV and HPV-vaccine-related knowledge, awareness, and vaccine intent. Factors associated with HPV vaccine intent were determined. Results: A total of 3397 valid questionnaires were collected, including female (60.02%) and male (39.98%) university freshmen. Overall, 76.12% were aware of HPV, 80.98% were aware of the HPV vaccine, and 84.31% expressed vaccine intent, with significantly higher rates among females than males (each p < 0.001). Socioeconomics, knowledge, awareness, sexual behavior, and HPV testing history were significantly associated with vaccine intent (each p < 0.05). The most common reason for no intent was perceived low risk of HPV-related diseases (40.53%). The most expected improvement measures were regulatory confirmation of vaccine safety and effectiveness (37.71%) and healthcare professionals' recommendations (37.71%), with no gender difference (each p > 0.05). Notably, 4.00% refused HPV vaccination, regardless of improvement measures. Additionally, most respondents preferred financial supporting policies, regardless of gender or vaccine intent (each p > 0.05). Conclusions: University freshmen showed the disparity between high awareness/intent and low knowledge. Financial considerations may influence HPV vaccination decisions. Thus, improving knowledge, particularly among males, and providing financial support may enhance HPV vaccine intent.

PMID 42506658
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