北京若生智能科技有限公司
Drug Database
HY

hydroquinone (Tanit)

✓ Approved

Vinas · 小分子 · 小分子

什么是 hydroquinone？

hydroquinone 是一种小分子，由Vinas研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Tanit
公司Vinas
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Vinas

治疗适应症

hydroquinone 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersSkin hyperpigmentation✓ Approved

相关研究文献

PubMedGels (Basel, Switzerland)2026-10-26

Research Progress of Polyacrylamide Gels for Oilfield Applications: A Systematic Review.

Dong Ruiqiang R, Chen Guanyu G, Li Daoyong D, Cui Xinyue X et al.

In the middle-to-late stage of reservoir development, widespread high-permeability channeling exacerbates ineffective water circulation and impairs crude oil recovery. This work explores polyacrylamide (PAM) gels intended for oilfield profile control and water shut-off. It comprehensively compares gelation behaviors and performance metrics of diverse cross-linking and modification strategies, and pinpoints critical unresolved research gaps. Four representative PAM-gel systems are analyzed in detail, including organic-crosslinked, metal-crosslinked, nano-composite-modified, and delayed-crosslinker formulations. The results show that polyethyleneimine (PEI) cross-linked gels achieve a storage modulus of 780 kPa at 110 °C, which is superior to the conventional hydroquinone-hexamethylenetetramine (HQ-HMTA) system. Metal-crosslinked gels are prone to syneresis and structural instability above 70 °C. Nanocomposite modification significantly enhances gel comprehensive properties: nano-silica improves thermal resistance to 155.5 °C; modified nano-graphite doubles storage modulus (G'), shortens gelation time by half, and maintains 76.5% of initial modulus after 60-day aging at 130 °C; TOCN-reinforced gels preserve structural integrity under high-salinity environments at 140 °C for 108 h. Delayed-release cross-linkers can extend gelation time up to 17 days to meet the demands of deep in situ profile control. Furthermore, the emerging data-driven paradigm of artificial-intelligence-assisted gel optimization is also reviewed, together with its current limitations. Future research priorities cover intelligent responsive gel materials, environmentally benign cross-linkers, and unified evaluation specifications for heterogeneous reservoirs. This paper reviews over 100 core publications from 2000 to 2026 based on the Web of Science and Engineering Village databases. Different from existing studies, this work emphasizes the molecular crosslinker mechanisms, nanomodification reinforcement, and field performance variations of PAM gel systems, and concludes the major technical bottlenecks for their application in harsh reservoirs. Meanwhile, it quantitatively compares the performance of modified PAM gel formulations and clarifies the applicable temperature ranges of different crosslinker schemes, providing technical references for the development of PAM plugging agents for complex oil reservoirs.

PMID 42929937
阅读全文 →
PubMedGels (Basel, Switzerland)2026-10-26

Turmeric-Loaded Type A Gelatin Hydrogels: In Vitro Assessment for Oral Wound Management Applications.

Gutierrez-Jimenez Yareth Idalia Ayerim YIA, Garcia-Contreras Rene R, Serrano-Diaz Paloma Netzayeli PN, Flores-Arriaga Juan Carlos JC et al.

Oral surgical wounds may benefit from local biomaterials capable of delivering bioactive compounds while remaining compatible with gingival cells. This study evaluated type A gelatin hydrogels containing turmeric powder (1.5, 3.1, or 12.5 mg per preparation) and a separate series prepared with a 25 mg/mL turmeric stock in dimethyl sulfoxide (DMSO). The hydrogels were assessed for macroscopic integrity, supernatant absorbance, MTT responses in human gingival fibroblasts (HGFs), prostaglandin E2 (PGE2), and exploratory microbial response against Staphylococcus aureus and Candida albicans. Powder-loaded matrices lost macroscopic integrity within approximately 45 min in PBS and 30 min in trypsin. Powder-loaded formulations generally produced MTT signals near control values, whereas several DMSO-stock formulations showed lower signals at later exposures. PGE2 did not show consistent dose-dependent suppression after normalization of the corresponding MTT-derived relative metabolic signal. Agar diffusion showed an approximate 2.4 mm clearance beyond the specimen edge against S. aureus for the 1.5 mg formulation and none against C. albicans; the gelatin control also showed visible clearance, and higher turmeric loadings did not produce measurable zones. Colony recovery decreased across the DMSO-stock formulations, but most plate counts were below the conventional countable range and were therefore interpreted descriptively. Overall, the findings provide an early in vitro characterization of rapidly disintegrating gelatin-turmeric hydrogels and identify matrix stability and assay limitations as major constraints that require further validation.

PMID 42929961
阅读全文 →
PubMedBiotech (Basel (Switzerland))2026-10-26

Micropropagation of Lisianthus (Eustoma grandiflorum (Raf.) Shinn.) Using Meta-Topolin.

Ramírez-Mosqueda Marco A MA, Armenta-Medina Alma A, Baltazar-Bernal Obdulia O, Bautista-Aguilar José Roberto JR et al.

Lisianthus (Eustoma grandiflorum) is an ornamental species of high commercial value due to its diverse flower colors and prolonged vase life. However, lisianthus propagation by seed is limited by its low germination rates and high genetic variability, compromising plant uniformity and production timelines. This study evaluated the effect of meta-Topolin (mT) and of 6-benzylaminopurine (BAP), aromatic cytokinins, on the in vitro micropropagation of lisianthus, aiming to develop an efficient protocol for mass propagation. In vitro established shoots were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations of mT and BAP (0, 0.5, 1.0, or 1.5 mg L-1). The parameters assessed were shoot proliferation, shoot length, leaf number, root formation, and root length. Significant differences were observed among treatments. The highest proliferation rate (59.20 shoots per explant) was achieved with 0.5 mg L-1 mT, representing a 37-fold increase over the control. With the addition of BAP to the culture medium, the results were inferior. Higher mT concentrations promoted rooting and improved acclimatization success, with the highest survival rate (95%) recorded for plants from the 1.5 mg L-1 mT treatment. Low mT concentrations enhanced shoot multiplication but limited root formation, affecting nursery survival. Results demonstrated that meta-Topolin induces a higher shoot number during lisianthus micropropagation, and at higher concentrations, it enables in vitro rooting of the shoots generated during the proliferation stage. This provides a practical alternative for large-scale commercial propagation of this ornamental species.

PMID 42930070
阅读全文 →
PubMedDentistry journal2026-10-26

The Oral-Gut Microbiome Axis: Microbial Transit, Ectopic Colonization, Systemic Associations, Salivaomics, and Clinical Control Points.

Cannon Mark L ML, Peldyak John J, Vigerust David J DJ

The oral cavity is a continuous microbial source for the gastrointestinal tract. Adults swallow approximately 0.5-1.5 L of saliva each day, carrying a large and variable bacterial load. Gastric acidity removes most ingested organisms, but survival increases with food buffering, acid tolerance, mucin or biofilm protection, and proton-pump inhibitor use. Oral taxa are therefore repeatedly detected in stool, intestinal mucosa, and diseased tissues. The strongest mechanistic evidence concerns Fusobacterium nucleatum in colorectal cancer and Porphyromonas gingivalis in inflammatory and metabolic pathways, although detection alone does not prove stable colonization or causality. This narrative review summarizes microbial transit, key taxa, salivaomics, systemic associations, and practical oral control points. It also identifies clinical control points, including probiotics and polyols such as xylitol, as selective microbiome-modulating adjuncts at varying stages of evidence. The evidence suggests a strong clinical message: treat oral dysbiosis for established dental reasons, while paired oral and gut studies determine when downstream systemic benefits are achieved.

PMID 42930391
阅读全文 →
PubMedNature communications2026-10-26

High-sensitivity deep shortwave infrared organic photodetectors enabled by selenium-integrated quinoidal molecular semiconductor.

Wei Wenkui W, Yin Bingyan B, Wang Yeye Y, Wang Jing J et al.

Developing organic photodetectors (OPDs) that can detect in deep shortwave infrared (deep-SWIR) region (1.2-1.6 μm) is technologically important. Yet, the performance of the state-of-the-art deep-SWIR OPDs remains substantially limited. Herein, we report a selenium-integrated quinoidal small molecular acceptor, SeBz-4Cl, enabling highly sensitive deep-SWIR photodetection. Selenium incorporation enhances quinoidal character along the conjugated backbone of the molecules, thus expanding absorption approaching 1.5 μm. Moreover, SeBz-4Cl with strengthened intermolecular interactions led to an ideal film morphology, which reduced Urbach energy and favored charge dynamics. Under -1 V voltage bias, the SeBz-4Cl-based OPD achieved a low dark current density of 2.97 × 10-7 A cm-2 and an external quantum efficiency (EQE) of 7.8% at 1310 nm, together with a high specific detectivity (D*) exceeding 1011 Jones across 500-1400 nm, representing advanced deep-SWIR OPD performance. Furthermore, an optical communication system and a flexible imager under 1.2 μm illumination were demonstrated, highlighting potential of these deep-SWIR OPDs for information electronics and next generation optoelectronic applications in future.

PMID 42928368
阅读全文 →
PubMedPeerJ2026-10-26

Fracture resistance of mandibular molar endocrown with different preparation designs: an in vitro study.

Awang Iskanderdzulkarnein Pengiran Muhammad Badi'uzzaman PMB, Raja Mohd Noorhayati N, Ahmad Ubaidillah Anas Hakimee AH, Noor Zari Muhammad Aliff Ikram MAI et al.

Endocrowns have gained popularity as a conservative option for restoring endodontically treated molars because their success rates are comparable to those of conventional crowns. However, there is limited evidence on the effectiveness of different endocrown marginal designs, particularly concerning their fracture resistance and failure modes under axial and oblique loading. This in vitro study aimed to evaluate the fracture resistance and failure modes of three different endocrown marginal designs on mandibular molars and compare them with endocrowns under axial and oblique loading. Sixty-four extracted mandibular molars were root-treated and lined with flowable composite (1.5 mm thickness) before being embedded in epoxy resin blocks. The samples were divided into four groups (n = 16): three endocrown groups with different preparation designs (butt-joint, 0.8 mm chamfer, and 1.0 mm shoulder) and one group with conventional crowns. Crown preparations were performed with a high-speed handpiece mounted on a modified milling device, targeting a 2.0 mm anatomical occlusal reduction for conventional crowns and a 4.0 mm central chamber depth with a 2.0 mm axial wall height (ferrule) for endocrowns (except the butt-joint design, which had no ferrule preparation). Restorations were fabricated using the Chairside Economical Restoration of Esthetic Ceramics (CEREC) Computer-Aided Design and Computer-Aided Manufacturing (CAD/CAM) system with lithium disilicate (IPS e.max CAD; minimum occlusal thickness: 1.5 mm) as the restorative material and cemented with the RelyX Ultimate dual-cure resin adhesive. After 1,500 thermocycling cycles, the samples were divided into two subgroups (n = 8) for axial and oblique loading tests. The fracture resistance was tested using a universal testing machine at a crosshead speed of 0.5 mm/min, applying a load of up to 5,000 N until fracture. Failure modes were examined using a stereomicroscope at 5x magnification and categorized as catastrophic or non-catastrophic. The mean fracture resistance was compared using one-way Analysis of Variance (ANOVA) with Bonferroni post-hoc tests, and Fisher's exact test was used to assess the association between preparation designs and failure modes (p < 0.05). Endocrowns with shoulder margins showed significantly higher fracture resistance (3,042.83 ± 850.76 N) than conventional crowns (1,908.28 ± 635.82 N) under axial loading (p = 0.02). No significant differences were found under oblique loading between the preparation designs. The preparation design significantly influenced the failure mode under axial loading (p = 0.049). Endocrowns exhibited a higher rate of catastrophic fractures than conventional crowns, regardless of loading direction. Endocrowns provide a conservative alternative to conventional crowns, offering a higher fracture resistance under axial loading. Further research is needed to evaluate the endocrown performance under oblique loading.

PMID 42928894
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多hydroquinone