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Livact Jelly (Livact Jelly)

✓ Approved

Ajinomoto · 治疗药物

什么是 Livact Jelly？

Livact Jelly 是一种治疗药物，由Ajinomoto研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Livact Jelly
公司Ajinomoto
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Ajinomoto

治疗适应症

Livact Jelly 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Hepatobiliary disordersHepatic cirrhosis✓ Approved
Metabolism and nutrition disordersHypoalbuminaemia✓ Approved

相关研究文献

PubMedPakistan journal of pharmaceutical sciences2026-10-26

Stability studies and characterization of nanoemulgel containing gallic acid.

Awan Hina H, Khan Hira H, Haq Rizwan Ul RU, Fatima Nighat N et al.

Gallic acid is a natural phenolic compound with excellent antioxidant, antimicrobial and anti-inflammatory activity and good skin penetration. Gallic acid demonstrates both stability and solubility problems in topical formulations. A nanoemulgel combines an emulsion for enhanced solubility with a gel base for improved physical stability. The main objective of this study is to characterize and assess the stability of a gallic acid-containing nanoemulgel. Various gallic acid nanoemulsions (GNE) were prepared using optimized ratios of oil, surfactants, gallic acid and water and evaluated for stability. Finally, stable GNE-19 was characterized for particle size and converted to nanoemulgel (GNEG-19). Nanoemulgel was subjected to short-term and accelerated stability studies and characterized for pH, viscosity, spreadability, occlusion effect, FTIR, in-vitro drug release and in-vitro pharmacological activities. The results showed that formulation GNEG-19 showed optimum thermodynamic stability, having no phase separation and color change. The droplet size of freshly prepared GNE and after 28 days was 175.43nm and 183.23nm, respectively. The pH was slightly acidic but still within the human skin range (3.9-4.5). No interaction was found between the gallic acid and other components of nanoemulgel following FTIR analysis. The viscosity of freshly prepared GNEG-19 was 2127.1 cP and after 90 days, it was 2102.3 cP, which showed its stability. The percent drug release of gallic acid from nanoemulgel after 24 hrs was 93.12%. GNEG-19 also showed effective occlusion properties when compared with gel base and petroleum jelly. In-vitro pharmacological activities showed that GNEG-19 had antioxidant activity of 63.77% and a zone of inhibition (ZOI) of 11.4 mm compared to pure gallic acid (9.5 mm). In conclusion, nanoemulgel containing gallic acid showed good physical and chemical stability and was pharmacologically active.

PMID 42929401
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PubMediScience2026-10-25

Design and validation of a GMP-compliant manufacturing platform of extracellular vesicles from mesenchymal stromal cells.

Courageux Yvan Y, Monguió-Tortajada Marta M, López-Fernández Alba A, Schoch Leonie L et al.

There is growing interest in mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) as key components in the development of next-generation regenerative cell-free therapies; however, their clinical translation remains limited by a lack of validated clinical-grade manufacturing platforms. Thus, we have established a good manufacturing practice (GMP)-compliant, semi-automated, mid-scale manufacturing workflow that couples the single-use stirred-tank bioreactor expansion of Wharton's jelly-derived MSCs with tangential flow filtration and automated size-exclusion chromatography, featuring in-line monitoring of critical process parameters. The MSC-EV-based product meets pre-specified critical quality attributes (CQAs), co-expresses parental-cell- and EV-specific markers, and complies with standardized quality and safety regulations. Moreover, the final product CQAs-including CD73-associated immunomodulatory activity-remained within acceptable limits for 12 months of storage in PlasmaLyte 148 at -80°C. Overall, our integrated platform yields MSC-EVs with high batch-to-batch reproducibility, in alignment with current GMP and regulatory standards, thereby providing a robust foundation supporting their potential clinical applicability.

PMID 42926845
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PubMedResearch square2026-10-25

Exploring the interaction between extracellular matrix components of bone marrow and prostate cancer cells in a novel 3D model.

Yang Jianhui J, Veldhuizen Peter Van PV, Awad Hani H, Miyamoto Hiroshi H et al.

Our study aims to investigate the interaction between disseminated prostate cancer (PC) cells and the extracellular matrix (ECM) of the bone marrow microenvironment (BMM) using a 3Dimensional (3D) in vitro model, which biochemically resembles the stromal ECM part of the hematopoietic stem cell niche. Wharton's Jelly (WJ) was processed and lyophilized to produce a decellularized WJ matrix (DWJM). PC cell lines DU145 and PC-3 were seeded on the DWJM to assess chemosensitivity, cell dormancy, and cancer stemness. CD133, a key marker of PC stem cells (PCSC), was used to evaluate the stemness of the PC cell lines by conventional and imaging flow cytometry. Our results demonstrated that both DU145 and PC-3 cells cultured on DWJM exhibited chemoresistance to Docetaxel and entered a dormant state. Additionally, a small population (~5%) of CD133(+) DU145 cells was detected after 7 days of culture on DWJM. These CD133(+) cells displayed the development of characteristics of epithelial-to-mesenchymal transition. Moreover, limited dilution assay in vivo revealed that DWJM-induced CD133(+) DU145 cells were significantly more tumorigenic than parental DU145 cells. Our findings suggest that PCSCs may be induced in DU145 cells but not in PC-3 cells when PC cells cultured on DWJM.In conclusion, we have developed a 3D in vitro model that effectively mimics the interaction between disseminated PC cells and the ECM of BMM,which may inform the development of therapies targeting metastatic cells in BMM.

PMID 42922696
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PubMedCureus2026-10-25

Rapidly Progressive Peritoneal Carcinomatosis Originating From Mucinous Appendiceal Adenocarcinoma: A Case Report.

Verble Cole C, Powers Verble Kalyn K

Malignant neoplasms of the appendix are rare. These neoplasms can be further delineated into either colonic or cystic types. A cystic type appendiceal tumor is often referred to as an appendiceal mucocele due to its production of jelly-like mucus. Mucinous appendiceal adenocarcinoma (MAA) is a malignant appendiceal mucocele associated with nonspecific symptoms and often found incidentally when other abdominal work-up is performed. If the appendix ruptures, the peritoneal cavity and organs are coated with mucus-producing cells, leading to the complication pseudomyxoma peritonei (PMP). If found late in the disease progression, it can further develop into peritoneal carcinomatosis, which is typically treated with cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC). A 28-year-old male with no past medical history arrived at the emergency department for longstanding constipation. Upon workup, he was found to have stage IV MAA with dissemination into the peritoneal cavity leading to PMP and peritoneal carcinomatosis. The mucin in his abdominal cavity had proliferated and solidified to the point where CRS/HIPEC was unable to be performed. He received multiple rounds of palliative chemotherapy; however, it failed to shrink any tumors or lessen mucin burden in order to receive CRS/HIPEC.  This case demonstrates the importance of early detection of MAA. It also illustrates that even in healthy young adults, advanced peritoneal carcinomatosis may impede CRS/HIPEC from being performed. In the current literature, most patients with peritoneal carcinomatosis, unless contraindicated, are able to receive CRS/HIPEC.

PMID 42921477
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PubMedFrontiers in oncology2026-10-22

Ultrasonic manifestations of diffuse pericardial mesothelioma masquerading as pericardial effusion: a case report.

Zhu Shuxu S, Zhou Yibo Y

Primary pericardial mesothelioma (PPM) is an exceedingly rare, highly invasive cardiac neoplasm with insidious onset and non-specific clinical symptoms. Due to the lack of typical early manifestations and effective routine diagnostic methods, PPM is often misdiagnosed and missed, resulting in delayed treatment and poor prognosis. A 42-year-old male presented with 6 months of recurrent chest tightness and pain, worsening over 2 months, and two prior admissions for unexplained pericardial effusion. On admission, he had tachycardia, distant heart sounds, bilateral lower extremity edema, and a 3×2 cm hard, fixed left supraclavicular lymph node. Imaging confirmed pericardial effusion with abnormal pericardial lesions. Ultrasound-guided pericardiocentesis yielded only a small amount of red jelly-like material, with cytology suggesting epithelioid neoplastic cells. Supraclavicular lymph node biopsy confirmed metastatic malignant mesothelioma. Nivolumab immunotherapy showed no improvement. Pericardial tumor resection revealed diffuse, fish-flesh-like tumor invading the myocardium and great vessels. Final pathology confirmed epithelioid-type PPM. Patients with recurrent unexplained pericardial effusion and atypical sonographic features, such as flocculent echoes and irregular pericardial thickening, should raise suspicion for PPM. Early recognition of these signs and timely pathological confirmation are critical to avoid diagnostic delays and may improve outcomes.

PMID 42903210
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PubMedFood chemistry2026-10-18

Current trends in the analysis of mycotoxins in bee products: Occurrence, extraction, and determination.

Brugnerotto Patricia P, Fuente-Ballesteros Adrián A, Antunes Ana Clara Nascimento ACN, Ares Ana M AM et al.

Bee products, including honey, bee pollen, propolis, and royal jelly, are increasingly valued for their nutritional and bioactive properties. However, these matrices may also be contaminated by mycotoxins, toxic secondary metabolites produced by fungi under inadequate agricultural and storage conditions. Although mycotoxin contamination has been extensively investigated in cereals and animal feed, studies involving bee products remain limited, despite their increasing consumption and commercial relevance. This review is the first to comprehensively compile and critically discuss current methodologies for the extraction and determination of mycotoxins specifically in bee products. Emphasis is placed on advances reported over approximately the last five years, including improvements in sample preparation and the application of chromatographic and mass spectrometric techniques. Additionally, occurrence data are examined in light of analytical performance, limitations, and emerging challenges. The implementation of sensitive and robust analytical strategies is essential to ensure product safety, support regulatory monitoring, and preserve the functional quality of bee-derived foods within the global food system.

PMID 42892026
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