北京若生智能科技有限公司
Drug Database
IM

ImoVax rabies (Imovax)

✓ Approved

Servier · 疫苗 · 疫苗

什么是 ImoVax rabies？

ImoVax rabies 是一种疫苗，由Servier研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intradermal Injection、Intramuscular (IM) Injection。

药物档案

商品名Imovax
公司Servier
药物类别疫苗, 大分子
给药途径Injectable (Others), Intradermal Injection, Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Servier

治疗适应症

ImoVax rabies 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsRabies✓ Approved

相关研究文献

PubMedVeterinary world2026-10-26

Knowledge, attitudes, and preventive behaviors toward rabies among urban residents in Bangkok, Thailand: Implications for targeted One Health rabies elimination strategies.

Luenglertamorn Kittithat K, Borvornpadungkitti Taksaporn T, Luangyawee Rapee R, Choksuchat Siwat S et al.

Rabies remains a fatal zoonotic disease and an important public health concern despite substantial reductions in human cases in Thailand. Continued circulation of rabies among animal populations highlights the need to strengthen public awareness and preventive behaviors. This study aimed to assess knowledge, attitudes, and preventive behaviors regarding rabies among Bangkok residents, identify sociodemographic factors associated with these outcomes, and examine relationships among knowledge, attitudes, and preventive behaviors to support urban rabies prevention and control strategies. A cross-sectional online survey was conducted among Bangkok residents between December 2024 and August 2025 using a structured, content-validated questionnaire. Of 262 respondents, 258 met the eligibility criteria and were included in the analysis. Descriptive statistics summarized participant characteristics and knowledge, attitudes, and preventive behaviors. Binary logistic regression identified factors associated with these domains, while Pearson's chi-square test evaluated associations among knowledge, attitudes, and preventive behaviors. Overall, 58.9% of participants demonstrated sufficient knowledge, whereas attitudes and preventive behaviors were generally favorable. Correct responses were highest for rabies transmission (97.7%), clinical signs in dogs (98.8%), and animal vaccination (96.9%), whereas only 36.1% correctly identified the recommended observation period following a bite incident. Participation in rabies awareness activities was limited (26.7%), although 73.6% reported routine pet rabies vaccination. Multivariable logistic regression showed that private sector employees were less likely to demonstrate sufficient knowledge (adjusted odds ratio [AOR] = 0.268, 95% confidence interval [CI]: 0.148-0.483; p < 0.001) and positive attitudes (AOR = 0.337, 95% CI: 0.186-0.610; p < 0.001) than students/unemployed participants. Participants aged 26-40 years had lower odds of appropriate preventive behaviors (AOR = 0.338, 95% CI: 0.173-0.657; p = 0.001), whereas participants whose pets had received rabies vaccination were more likely to report appropriate preventive behaviors (AOR = 2.512, 95% CI: 1.413-4.465; p = 0.002). Significant positive associations were identified between knowledge and attitudes and between knowledge and preventive behaviors (both p < 0.001). Although participants generally demonstrated favorable rabies-related knowledge, attitudes, and preventive behaviors, important gaps persisted regarding post-bite animal observation and participation in rabies awareness activities. Occupation and age were important determinants of knowledge, attitudes, and preventive behaviors, while responsible pet vaccination was positively associated with preventive practices. These findings support targeted, culturally appropriate educational interventions, workplace- and community-based awareness programs, and stronger One Health collaboration to advance urban rabies prevention and support Thailand's progress toward the WHO "Zero by 30" rabies elimination goal.

PMID 42928789
阅读全文 →
PubMedJournal of virology2026-10-25

Engineering a low cytotoxicity recombinant rabies virus neurotracer via N-gene recoding.

Hu You Y, Wang Qinghan Q, Sun Kangyixin K, Li Li L et al.

Viral-vector-based tracers have proven invaluable for mapping neural circuits. Rabies virus (RV)-based retrograde trans-monosynaptic tracers have been widely used for depicting the input neural circuit of targeted neuronal populations. However, the cytotoxicity of the RV tracer limits its application. Here, we employed the synthetic attenuated virus engineering technology to recode the N gene of the RV SAD-B19 strain by codon pair deoptimization to generate attenuated RV tracers. The characteristics of the recoded RV tracers were tested both in vitro and in vivo. The full-length recoded N gene abolished viral rescue, whereas the partial recoded N gene supported successful viral recovery. Compared to its parent, the recoded RV trans-monosynaptic tracer exhibited lower cytotoxicity and labeled more input neurons. It can also robustly express proteins to visualize the neuronal morphology and manipulate the neural circuit activity. Collectively, our work generated a new retrograde trans-monosynaptic tool, which complements existing neural circuit tracers. Viral vectors play an important role across multiple fields in biomedicine. In the neuroscience community, rabies virus (RV)-based retrograde trans-monosynaptic tracers have been widely used to map the input neural circuits of targeted neuronal populations. However, the inherent cytotoxicity of RV-based tracers limits their broader application. In this study, we utilized synthetic attenuated virus engineering technology to recode the RV N gene, generating an attenuated neurotracer that will significantly benefit future neuroscience research.

PMID 42925086
阅读全文 →
PubMedNeural regeneration research2026-10-25

Membrane targeted rabies virus labeling system: Brain-wide single-neuron mapping of target-specific and intersectionally defined neuronal circuits.

Yuan Xinyu X, Zhang Jianchao J, Liu Yunmiao Y, Jin Lin L et al.

Elucidating neural circuit organization at single-neuron resolution is a core goal of modern neuroscience. Brain-wide input connectivity maps underpin the mammalian connectome, but systematic and comprehensive whole-brain input mapping with resolved single-neuron anatomy for defined brain regions remains a formidable technical challenge. Here, we developed a membrane-targeted rabies virus labeling system using mClover3 as the fluorescent reporter, which features high compatibility with fluorescence micro-optical sectioning tomography imaging and enables complete visualization of fine neuronal morphology across the entire brain. Validation in the mouse primary somatosensory cortex barrel field confirms robust full-morphology labeling and faithful reconstruction of brain-wide input neurons, revealing diverse projection patterns with distinct axonal targets. We further generated a dual-recombinase dependent TVA reporter mouse line to enable anatomical interrogation of intersectionally defined neuron populations via EnvA-pseudotyped membrane-targeted rabies virus, allowing specific targeting and single-neuron reconstruction of PV+/vGlut2+ L5b pyramidal neurons in the primary somatosensory cortex barrel field. These neurons exhibited a pathway-conserved population-level projection profile likely representing a subset of pyramidal tract neuron projections, while showing pronounced cellto-cell diversity in axonal target specificity. Overall, this work delivers a robust, versatile toolkit for brain-wide single-neuron mapping of target-specific and intersectionally defined neuronal circuits, with strong potential to advance brain connectomics.

PMID 42927475
阅读全文 →
PubMedNeural networks : the official journal of the International Neural Network Society2026-10-25

Tempered fractional rabies dynamics with deep neural surrogate modeling: Analysis, computation, and prediction.

Sallami Mohamed Nidhal MN, Fredj Ouissem Ben OB, Agarwal Praveen P, Naifar Omar O

Rabies is a fatal zoonotic disease for which domestic dogs constitute the main reservoir; its long and variable incubation period motivates transmission models that account for memory effects. This paper proposes a tempered fractional rabies model in which the classical time derivative is replaced by the left tempered Caputo derivative of order ξ ∈ (0, 1] and tempering parameter λ ≥ 0, so that the dynamics remain nonlocal while the influence of past states decays exponentially. We first establish the qualitative properties of the model: solutions remain nonnegative for nonnegative initial data, total populations are bounded on finite time intervals, and a unique continuous solution exists, which we prove by combining an exponential transformation with a contraction argument. We further derive the basic reproduction number R0 by the next-generation-matrix approach and prove local asymptotic stability of the disease-free equilibrium whenever R0<1, uniformly in the fractional order and the tempering parameter. A predictor-corrector product-integration scheme is then developed for the tempered system, and a mesh-refinement study confirms an empirical convergence order close to one. To accelerate repeated simulations, we train a deep neural surrogate that maps a short history window of log-transformed states to log-state increments, using a two-stage procedure consisting of one-step pretraining followed by differentiable rollout fine-tuning. Ablation experiments show that the logarithmic state representation and the increment-based targets are the decisive design choices, while rollout fine-tuning further improves worst-case robustness of free-running predictions. The selected surrogate attains high one-step accuracy (RMSE 0.4121, MAE 0.1303, R2=0.999998) and, in fully free-running closed-loop mode, reproduces unseen tempered test scenarios with mean R2=0.9990 (mean RMSE 3.32) on the benchmark cases and R2=0.9973±0.0031 over a random evaluation suite of 18 unseen tempered scenarios; accuracy degrades only in the near-untempered long-memory limit λ → 0, which we characterize explicitly. Parameter-matched LSTM and GRU baselines trained under the identical protocol do not outperform the proposed feed-forward surrogate, and in batched operation the surrogate is about two orders of magnitude faster than the numerical solver. The resulting framework provides a fast, accurate, and stable proxy of the tempered fractional rabies model that supports rapid parameter sweeps and forecasting-oriented scenario analysis.

PMID 42925622
阅读全文 →
PubMedResearch square2026-10-25

Distinguishing True Spillover Trends from Surveillance Bias in Detected Cases.

Gilbertson Kendra K, Holmes Iris I, Bento Ana A, Sun Yining Y et al.

Claims that zoonotic spillover is rising globally have shaped research priorities for decades, but this apparent rise can be a statistical artifact of changing detection effort, not a genuine biological signal. Methodological correction alone cannot resolve the ambiguity: closing the gap requires investment in surveillance infrastructure, not modeling. Testing three approaches-generalized linear models, generalized additive models, and double machine learning-against simulated data spanning detection-bias and prevalence conditions, we find trend direction is recoverable under simple bias but not under oscillating or shared-driver detection, and all methods risk false increases when true rates are stable. Applied to 27 years of bovine rabies surveillance in South Africa, independent methods agreed on the declining trend direction but produced magnitude estimates differing more than threefold, showing model disagreement is informative. We translate these findings into reporting guidelines: prioritize direction over magnitude, disclose method reliability, treat cross-model disagreement as signal, and flag high-risk detection regimes.

PMID 42922706
阅读全文 →
PubMedBiochemistry. Biokhimiia2026-10-25

Transferrin Receptor as a Target for Regulation of Ferroptosis and Some Viral Infections.

Sokolov Alexey V AV, Elizarova Anna Yu AY, Bogoslovskaya Tatyana Yu TY

This review is devoted to molecular mechanisms of ferroptosis, a type of programmed cell death dependent on lipid peroxidation and limited by iron influx, mediated by the transferrin receptor (TfR1 or CD71). In addition to the iron-saturated transferrin, ligands of transferrin receptor also include its homologues lactoferrin and melanotransferrin, as well as heavy-chain ferritin and heme complex with human serum albumin. Activation of ferroptosis, including by increasing the labile pool of iron in tumor cells, is considered a promising strategy for combating cancer. However, a number of pathogenic human viruses, including influenza virus, SARS-CoV-2 coronavirus, and rabies virus, use binding with TfR1 to infect cells and affect ferroptosis. The review summarizes information on natural and synthetic TfR1 regulators, including the mechanisms of their influence on the development of ferroptosis and the prospects for their use as antiviral agents.

PMID 42927747
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多ImoVax rabies