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ibuprofen + arginine (Spedifen / Zafen / Espedifen)

✓ Approved

Zambon · PTGS1 · 小分子

什么是 ibuprofen + arginine？

ibuprofen + arginine 是一种小分子，由Zambon研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Spedifen, Zafen, Espedifen
公司Zambon
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Zambon

作用机制

分子靶点

ibuprofen + arginine 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ibuprofen + arginine 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Hepatobiliary disordersHepatitis✓ Approved

相关研究文献

PubMedFrontiers in cellular and infection microbiology2026-10-27

The arginine repressor ArgR controls virulence factors of adherent-invasive Escherichia coli strains.

Bonet-Rossinyol Queralt Q, Martinez-Medina Margarita M, Fernández-Coll Llorenç L

Adherent-invasive Escherichia coli (AIEC) has been related to the physiopathology of Crohn's disease, yet its pathogenic mechanisms are not completely understood. Arginine biosynthesis genes are upregulated in AIEC strains compared to non-AIEC strains present in the supernatant of infected intestinal epithelial cells, suggesting that arginine biosynthesis may be involved in AIEC pathogenicity. To test this hypothesis, the argR gene, encoding the transcriptional repressor ArgR, was deleted in the AIEC strains AIEC16 and LF82, and in E. coli Nissle 1917 and K-12 C600, leading to increased expression of arginine biosynthesis genes. Phenotypic assays and transcriptomic analyses were conducted to assess differences between mutants (ΔargR) and wild-type (WT) strains. The absence of ArgR led to a more invasive and motile AIEC LF82 strain. No differences in invasion were found for AIEC16 and the mutation led to reduced motility and biofilm formation in this strain. Transcriptomic analysis was in line with the phenotypic observations and further revealed that ArgR regulates the expression of multiple virulence-associated genes. Acid resistance genes (gad operon) were upregulated in ΔargR strains, indicating a repressive role of ArgR. Conversely, genes involved in adhesion, lipopolysaccharide biosynthesis, and iron uptake were downregulated in mutant strains, suggesting that ArgR functions as an activator for these pathways. These findings highlight ArgR as a potential modulator of multiple virulence traits, influencing the invasive and adaptive capabilities of AIEC.

PMID 42935828
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PubMedNutrients2026-10-27

Effects of Oral L-Arginine on Everyday Persistent Fatigue, Sleep, and Post-Exercise Lactate Recovery in Community-Dwelling Working-Age Adults: A Double-Blind, Placebo-Controlled Randomized Trial.

Kang Eun-Bum EB, Hong Seong-Bong SB, Yoon Namkyu N, Lee Namju N et al.

The evidence for nutritional interventions against fatigue is limited; we evaluated whether L-arginine reduces fatigue in working-age adults. In this 8-week randomized, double-blind, placebo-controlled trial, 120 community-dwelling working-age adults aged 30-59 years with persistent fatigue (Fatigue Severity Scale [FSS] total ≥ 27) received oral L-arginine 3 g/day, 6 g/day, or placebo. The primary endpoint was FSS change; secondary endpoints included the Checklist Individual Strength (CIS), Pittsburgh Sleep Quality Index (PSQI), and blood lactate kinetics during a standardized submaximal treadmill run (~70% VO2max, 30 min). Data from 119 participants were analyzed, with Holm adjustment for multiplicity. At Week 8, FSS decreased more with 6 g/day than with placebo (-6.41 vs. -2.23; Holm-adjusted p = 0.024), whereas 3 g/day did not differ from placebo. The 6 g/day CIS improvement did not survive multiplicity adjustment. PSQI scores improved nominally at both doses (3 g/day, p = 0.007; 6 g/day, p = 0.045). With 6 g/day, the total lactate area under the curve (Holm-adjusted p = 0.041) and 15-min recovery lactate (Holm-adjusted p = 0.002) were lower than with the placebo, whereas the resting plasma nitrite did not differ. No serious adverse events occurred. L-arginine supplementation at 6 g/day for 8 weeks reduced fatigue severity relative to placebo and was well-tolerated; however, mean FSS scores remained above the enrollment threshold, indicating a reduction in, rather than resolution of, persistent fatigue.

PMID 42942946
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PubMedFrontiers in immunology2026-10-27

Dried blood spot IP-10 as a biomarker of tuberculosis severity and treatment responses: results from a phase IIb trial of adjunctive acetylsalicylic acid and ibuprofen.

Høgbakk Edlund Iselin I, Alonso-Rodriguez Noelia N, Sopegno Chiara C, Farrés Judith J et al.

Host-directed therapies may improve tuberculosis (TB) outcomes by modulating immune responses and attenuating hyperinflammation, yet accessible biomarkers remain limited. We hypothesized that interferon-γ-inducible protein 10 (IP-10/CXCL10) measured in dried blood spot (DBS), a low-threshold and field-adapted sampling method, has potential as a biomarker for treatment response in pulmonary TB. Accordingly, we assessed IP-10 levels in patients receiving adjunctive acetylsalicylic acid (ASA) or ibuprofen (IBU) alongside TB standard therapy. IP-10 levels were quantified longitudinally in DBS from 120 pulmonary TB patients enrolled in the SMA-TB clinical trial (NCT04575519) at two sites in South Africa. Samples collected at baseline, week 2, week 8, and week 24 were analyzed by the enzyme-linked immunosorbent assay (ELISA). Associations with disease severity and treatment response were assessed, and the predictive value of IP-10 for microbiological, clinical, and radiological outcomes was evaluated. IP-10 levels correlated with TB disease severity, with higher concentrations observed in patients with elevated clinical and radiological scores and positive sputum acid-fast-bacilli staining. This association was reflected in treatment response, as patients with good clinical outcomes exhibited an earlier decline in IP-10 (week 8, p=0.0005), whereas those with poor outcomes showed a delayed decline (week 24, p<0.0001). Overall, IP-10 levels decreased during treatment irrespective of intervention or HIV status, with no significant differences between treatment arms at week 24. Notably, IP-10 levels at week 2 predicted rapid sputum culture conversion in the IBU arm, as well as in HIV-negative patients in the ASA arm (AUC: ASA 0.79; IBU 0.76). IP-10 levels measured in DBS are associated with disease severity and treatment response and may serve as a biomarker for therapy monitoring and early prediction of microbiological outcomes in TB, irrespective of adjunctive host-directed therapies. These findings require validation in larger patient cohorts before the method can be implemented in clinical practice.

PMID 42935866
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PubMedMetabolites2026-10-27

Ligustrazine Combined with Sinomenine Alleviates Central Sensitization in CCI-Induced Neuropathic Pain in Rats by Restoring Metabolic Homeostasis in the Spinal Dorsal Horn.

Yuan Zhaoyue Z, Gao Chang C, Zhao Xiaoliang X, Wang Jingyi J et al.

Neuropathic pain (NP) is a chronic pain condition caused by a lesion or disease of the somatosensory nervous system. Its development and persistence are closely associated with peripheral nociceptive input, central sensitization, neuroimmune dysregulation, and remodeling of the local metabolic microenvironment. Our previous studies demonstrated that combined treatment with ligustrazine and sinomenine ameliorates early sciatic nerve pathological damage and systemic metabolic disturbances in rats with chronic constriction injury (CCI). However, whether this combination modulates central sensitization in NP remains unclear. This study aimed to evaluate the effects of combined ligustrazine and sinomenine treatment on pain-related behaviors and motor function during the maintenance phase of CCI-induced neuropathic pain and to investigate the potential mechanisms underlying its attenuation of central sensitization, with particular emphasis on metabolic remodeling, neurotransmitter homeostasis, and associated regulatory molecules in the spinal dorsal horn. A rat model of CCI was established, and animals were treated with ligustrazine combined with sinomenine (12.5 + 12.5, 25 + 25, or 50 + 50 mg/kg) for 7 consecutive days. Mechanical withdrawal threshold, cold hypersensitivity, and gait behavior were assessed. A multiplex assay was used to profile 12 plasma inflammatory cytokines and pain-related mediators. Integrated transcriptomic and metabolomic analyses of the spinal dorsal horn were subsequently performed to identify key altered pathways. Oxylipin profiling, targeted neurotransmitter analysis, and quantification of metabolites associated with the arginine-polyamine pathway were further conducted to characterize alterations in the local metabolic microenvironment associated with central sensitization. Finally, quantitative real-time PCR (qRT-PCR) and Western blotting were used to evaluate molecules related to polyamine metabolism, redox homeostasis, and central sensitization. Combined ligustrazine and sinomenine treatment improved pain-related behaviors and gait dysfunction in CCI rats and partially normalized systemic inflammatory dysregulation. The ipsilateral-to-contralateral maximum contact-area ratio decreased from 102.8 ± 9.0% in the Sham group to 53.1 ± 9.7% in the Model group and recovered to 85.5 ± 4.4% in the high-dose group. Metabolomic and transcriptomic analyses identified 54 differential metabolites and 130 differentially expressed genes, respectively, following treatment. Integrated multi-omics analysis highlighted arginine-related metabolic pathways, together with alterations in neurotransmitter, polyamine, oxylipin, and redox homeostasis.

PMID 42941193
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PubMedFood chemistry: X2026-10-27

Quality deterioration characteristics and metabolomic analysis of nano-packaged Venus Golden apples under dynamic temperature fluctuations.

Zheng Xiaodong X, Pan Shaoxiang S, Wang Zhen Z, Guo Qi Q et al.

Temperature fluctuations are a major cause of apple quality deterioration during distribution, but their effects on nano-packaging performance and fruit metabolism remain unclear. Long-term cold-stored Venus Golden apples (VG) were evaluated using quality, physiological, and untargeted metabolomic analyses. Different packaging treatments were compared, and NPF-packaged fruit was stored at constant 10 °C, constant 20 °C, or fluctuating 10-20 °C. NPF effectively delayed changes in color, texture, sugars, organic acids, and antioxidant capacity. However, temperature fluctuations weakened its preservation efficacy and intensified browning, softening, and oxidative damage. Metabolomic analysis revealed disturbances in alanine, aspartate and glutamate metabolism, galactose metabolism, and arginine biosynthesis, accompanied by accelerated depletion of sugars, organic acids, and amino acids. Nine candidate biomarkers of quality deterioration, including L-glutamic acid, γ-aminobutyric acid, and D-sorbitol, were identified. These findings provide insights for cold-chain temperature management, nano-packaging optimization, and metabolite-based quality monitoring.

PMID 42935827
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PubMedBiology2026-10-27

Metabolomics Reveals Differences in Muscle Metabolite Profiles Between Daweishan Mini Chickens and Tegel Broilers at Marketable Age.

Huang Wei W, Ran Jinshan J, Wu Shangwen S, Li Jing J et al.

Metabolic differences are an important factor influencing the quality of chicken meat. To investigate the differences in muscle flavor precursors between Daweishan mini chickens and Tegel broilers, integrated metabolomics analyses were used to compare the muscle metabolite profiles of the two breeds at marketable age (150-day-old Daweishan mini chickens and 45-day-old Tegel broilers). The differential metabolites (DMs) were significantly enriched in aminoacyl-tRNA biosynthesis; glycine, serine and threonine metabolism; glutathione metabolism; alanine, aspartate and glutamate metabolism; arginine biosynthesis; purine metabolism; pantothenate and CoA biosynthesis; cysteine and methionine metabolism; glycerophospholipid metabolism; and D-glutamine and D-glutamate metabolism, which contributed to the quality differences between the two breeds. Moreover, 3-methylhistidine, L-carnosine, L-anserine, DL-lactate, choline, L-phenylalanine, and L-ascorbic acid were present at higher relative abundances in the muscle of Daweishan mini chickens at marketable age. This study provides basic data on the mechanisms underlying the meat quality of local chickens and a reference for the development and utilization of local chicken breeds and the selective breeding of high-quality broilers.

PMID 42939405
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