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ceftriaxone sodium + tazobactam sodium (Citrafen)

✓ Approved

Bharat Serums and Vaccines Limited · 小分子 · 小分子

什么是 ceftriaxone sodium + tazobactam sodium？

ceftriaxone sodium + tazobactam sodium 是一种小分子，由Bharat Serums and Vaccines Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名Citrafen
公司Bharat Serums and Vaccines Limited
药物类别小分子
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Bharat Serums and Vaccines Limited

治疗适应症

ceftriaxone sodium + tazobactam sodium 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsStreptococcal infection✓ Approved

相关研究文献

PubMedZhonghua yi xue za zhi2026-07-27

[The impact of dietary sodium intake on therapeutic efficacy and short-term renal injury in patients after treatment for primary aldosteronism].

Deng Q R QR, Du Y Y, Zhong Z T ZT, Chen Z X ZX et al.

Objective: To evaluate the impact of dietary sodium intake on therapeutic efficacy and short-term renal injury in patients after treatment for primary aldosteronism(PA). Methods: A retrospective study was conducted on PA patients admitted between May 2017 and November 2024. Sodium intake was assessed via 24 h urinary sodium excretion before treatment. Patients were categorized into normal sodium (<6 g/d) and moderate-to-high sodium (≥6 g/d) groups. The baseline clinical characteristics of the two groups were compared. Spearman correlation analysis was used to analyze the correlations between sodium intake and baseline clinical indicators. The efficacy and renal function indicators were compared after 6 months of mineralocorticoid receptor antagonist (MRA) therapy or adrenalectomy. Restricted cubic spline model were used to analyze the nonlinear correlations between sodium intake and post-treatment urinary albumin-to-creatinine ratio (UACR). Results: A total of 239 patients were enrolled, including 122 males and 117 females with the age of (49.0±11.3) years. Among them, 72 patients were categorized into the normal sodium intake group and 167 into the moderate-to-high sodium intake group. Levels of UACR, urinary albumin excretion rate (UAER), 24 h urinary protein and 24 h urinary potassium were significantly higher in the moderate-to-high sodium intake group relative to the normal sodium intake group (all P<0.05). Spearman correlation analysis demonstrated that daily sodium intake was positively correlated with systolic blood pressure (SBP) (r=0.180), 24 h urinary potassium (r=0.375), UACR (r=0.224) and UAER (r=0.150) in patients with primary aldosteronism (all P<0.05). Following MRA pharmacotherapy, patients in the moderate-to-high sodium intake group exhibited higher SBP [130.0(120.0, 140.0) vs 120.0(119.0, 130.0) mmHg(1 mmHg=0.133 kPa), P=0.026] and a lower proportion of normotensive cases [65.6%(40/61) vs 90.9%(30/33), P=0.010] compared with the normal sodium intake group. After surgical intervention, the moderate-to-high sodium intake group achieved a greater reduction in SBP [-17.3(-26.5, -9.5) vs -7.0(-24.7, 1.7) mmHg, P=0.023], alongside a more prominent decline in UACR [-11.15(-35.75, 4.75) vs 0.10(-7.28, 7.33) mg/g, P=0.008] than the normal sodium intake group. Restricted cubic spline analysis revealed a "J-shaped" nonlinear association between baseline sodium intake and postoperative UACR. When sodium intake was ≥6.65 g/d, postoperative UACR increased progressively along with rising sodium intake. Conclusions: Moderate-to-high sodium intake is detrimental to blood pressure control and renal protection in patients with PA, while surgical treatment can partially alleviate the negative effects of moderate-to-high sodium intake on their blood pressure and kidneys. Sodium intake restriction should be an important component of comprehensive management for PA.

PMID 42503920
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PubMedArtificial organs2026-07-27

Disparity in Molar Conductivity Among Ions: Implications for Conductivity Monitoring in Hemodialysis.

Petitclerc Thierry T

Conductivity monitoring during hemodialysis allows for online estimation of patient's natremia and enables the hemodialysis machine to automatically adjust the dialysate sodium. It is based on the premise that the conductivity is proportional to sodium concentration or, more precisely, to ionic osmolality. Given the actual disparity in molar conductivity among ions, this premise is not entirely justified, and it is important to consider its implications. Explain why the disparity in molar conductivity: (1) results in a discrepancy between the plasma conductivity calculated from conductivity measurements in the dialysate or the ultrafiltrate and its actual value; (2) affects the accuracy of software designed to automatically adjust the dialysate sodium. (1) Despite a part of cations (primarily sodium) retained in plasma due to the Gibbs-Donnan effect, the ionic osmolalities of the dialysate at equilibrium with plasma and of the ultrafiltrate are virtually equal to that of plasma. (2) Plasma conductivity calculated from conductivity measurements in the dialysate or the ultrafiltrate is higher than its actual value. (3) Conductivity kinetic models carry a risk of inaccuracy. Since software designed to automatically adjust the dialysate sodium is based on the inaccurate assumption that conductivity is strictly proportional to ionic osmolality, corrective adjustments are necessary.

PMID 42504516
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PubMedJournal of agricultural and food chemistry2026-07-27

Journal of Agricultural and Food Chemistry Structural and Functional Characterization of the Heterodimeric Voltage-Gated Sodium Channel in the Green Peach Aphid Myzus persicae.

Liu Kaiyang K, Wang Qinglong Q, Xie Yuran Y, Qiu Xingyao X et al.

Voltage-gated sodium channels (VGSCs) are primary targets of pyrethroid insecticides, yet aphids possess a unique architecture with gene fission and a noncanonical DENS selectivity filter. Here, the VGSC of Myzus persicae was characterized using heterologous expression, electrophysiology, structural modeling, and molecular docking. Individual channel fragments failed to produce sodium currents, whereas linker concatenation partially restored activity with reduced amplitude, indicating impaired interdomain coupling. Despite the DENS motif, sodium selectivity was retained, indicating that ion discrimination can be maintained despite alterations in the canonical selectivity filter sequence. Molecular docking predicted genotype-dependent differences in pyrethroid binding modes among variants carrying mutations at positions 918 and 1014, suggesting potential effects on the local binding environment. These findings reveal an evolutionarily distinct functional organization of aphid VGSCs and provide a framework for future investigations into their interactions with pyrethroid insecticides.

PMID 42504526
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PubMedAntibiotics (Basel, Switzerland)2026-07-27

Evaluation of Short Versus Long Course of Tobramycin Combined with Piperacillin/Tazobactam Against Antibiotic-Resistant Pseudomonas aeruginosa in a Hollow Fibre Infection Model.

Wale Yalew M YM, Roberts Jason A JA, Won Hayoung H, Reghu Sheethal S et al.

Aminoglycosides are commonly partnered with β-lactam antibiotics for empirical treatment of severe Gram-negative bacterial infections, including those caused by Pseudomonas aeruginosa. However, the optimal duration of aminoglycoside therapy when co-administered with β-lactam antibiotics remains poorly defined. This study compared the antibacterial efficacy of short (one-day, three-day) versus long course (seven-day) of tobramycin therapy, co-administered with piperacillin/tazobactam, against piperacillin/tazobactam-resistant clinical isolates of P. aeruginosa in a hollow fibre infection model (HFIM). A broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the antibiotics. The HFIM experiments were performed using two piperacillin/tazobactam-resistant clinical isolates, CTAP-32 and CTAP-72 (both with piperacillin/tazobactam MICs > 128 mg/L). The clinical dose of tobramycin (10 mg/kg/day IV) was simulated for one, three, and seven days, each in combination with piperacillin/tazobactam (4.5 g every six hours infused over 30 min). In the HFIM, the one-day, three-day, and seven-day courses of tobramycin administered with piperacillin/tazobactam resulted in comparable bacterial kill with ~3log10 CFU/mL bacterial density reduction within the first 8 h of treatment against the CTAP-32 bacterial isolate. Similarly, these three combination regimens resulted in equivalent bacterial killing effects against the CTAP-72 isolate with a ~5log10 CFU/mL bacterial reduction during the initial treatment period. However, despite this early decline, comparable bacterial regrowth was observed thereafter with the short versus the long course of tobramycin co-administered with piperacillin/tazobactam. In conclusion, short-course and long-course tobramycin therapy, when combined with piperacillin/tazobactam, achieved comparable antibacterial efficacy against P. aeruginosa isolates in the HFIM. However, these findings warrant further validation in clinical studies.

PMID 42505648
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PubMedThe Journal of clinical endocrinology and metabolism2026-07-27

Low-renin hypertension: a distinct phenotype enabling mechanism-based treatment.

Shah Sonali S SS, Fuller Peter J PJ, Young Morag J MJ, Yang Jun J

Low-renin hypertension is increasingly recognized as a common and clinically important form of hypertension. Expanded screening for primary aldosteronism has revealed many individuals with suppressed renin who do not meet the diagnostic criteria for aldosterone excess, yet exhibit features consistent with sodium retention or increased mineralocorticoid activity. This review synthesizes evidence from targeted literature searches on the epidemiology, mechanisms, diagnostic challenges, and treatment of low-renin hypertension. Early studies proposed renin, in the presence of hypertension, as a marker of excess sodium retention and volume expansion, suggesting that renin could guide individualized therapy. Adoption of a renin-guided treatment approach was historically limited by assay variability and concerns regarding adverse effects from high-dose mineralocorticoid receptor antagonists. However, improvements in renin assay performance, increased accessibility and use of renin testing, and the availability of lower-dose and better-tolerated mineralocorticoid receptor antagonists have renewed interest in this strategy. Low-renin hypertension encompasses primary aldosteronism, conditions that mimic mineralocorticoid excess, and disorders of renal tubular sodium transport. Across this spectrum, patients respond more favorably to therapies targeting sodium retention: mineralocorticoid receptor antagonists, epithelial sodium channel inhibitors, or thiazide diuretics, than to agents directed primarily at vasoconstriction. Recognition of low-renin hypertension as a distinct phenotype enables mechanism-based therapy and may improve blood pressure control, reduce medication burden, and mitigate long-term cardiovascular risk.

PMID 42504137
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

Biomass Precursors for Hard Carbon Anodes in Sodium-Ion Batteries: Structural Characteristics and Performance Relationships.

Kang Man M, Huang Luyao L, Zhang Yuxuan Y, Wang Fei F et al.

Sodium-ion batteries (SIBs) have become a crucial supplementary technology for large-scale energy storage due to abundant sodium resources and their low cost. Biomass-derived hard carbon materials have been considered as one of the most promising anode materials for commercial SIBs. However, the inherent structures of different biomass materials vary significantly, which directly affects the electrochemical performance of the resulting hard carbon anode materials. In this review, raw materials are classified into four types based on the natural structure characteristics of biomass: fibrous, granular, dense, and special. This review highlights the structural characteristics of each biomass type and their influence on sodium storage performance. The carbonization process, including the treatment of raw materials before carbonization, the parameter control during the carbonization process, and the surface optimization after carbonization, is proposed as an effective strategy for regulating the structure of biomass-derived hard carbon. The existing structural deficiencies in current carbon materials are also analyzed. Finally, the selection of biomass precursors and the structural regulation strategies for commercial SIBs are discussed.

PMID 42506512
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