若生智能
Drug Database
SU

sultosilic acid piperazine (Mimedran)

✓ Approved

Esteve · LPL · 小分子

什么是 sultosilic acid piperazine？

sultosilic acid piperazine 是一种小分子，由Esteve研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Mimedran
公司Esteve
药物类别小分子
分子靶点LPL
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Esteve

作用机制

分子靶点

sultosilic acid piperazine 作用于 1 个分子靶点：

LPLlipoprotein lipase (HDLCQ11, LIPD)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sultosilic acid piperazine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHyperlipidaemia✓ Approved

相关研究文献

PubMedACS nano2026-07-27

Synergistic Water Enrichment-Evaporation in Patterned Covalent Organic Framework Janus Membranes Enables Resilient Ultrahigh-Permeance Desalination.

Wu Xinlei X, Yang Tianxiang T, Zhao Zhenyi Z, Wang Zhi Z et al.

Sustainable water management demands efficient hypersaline treatment and salt recovery. Membrane distillation (MD) is promising but limited by the trade-off between permeability and wetting resistance in conventional hydrophobic membranes. Herein, we report a patterned covalent organic framework (COF) Janus membrane with a hydrophilic-hydrophobic architecture. This membrane is fabricated via trimesoyl chloride-triggered interfacial reassembly, enabling defect-free formation of a hydrophilic terephthaldehyde-piperazine COF layer with subnanometer pores on a hydrophobic polytetrafluoroethylene (PTFE) substrate. This structure leverages a synergistic "water enrichment-evaporation" mechanism, where confined pores and the patterned hydrophilic surface reorganize the hydrogen-bond network of water, dramatically accelerating transport and evaporation. The COF Janus membrane achieves >99.99% NaCl rejection and an ultrahigh water flux of 121.7 L m-2 h-1, a 72% improvement over the PTFE membrane. It also exhibits robust resistance to surfactant-induced wetting and oil fouling, ensuring long-term stability under harsh conditions. This work resolves the permeability-wetting trade-off in MD and establishes a versatile platform for next-generation high-performance desalination membranes.

PMID 42503855
阅读全文 →
PubMedACS applied materials & interfaces2026-07-27

Engineering Polyamide Networks via Synergistic Surfactant Regulation and Solvent Treatment for Efficient Ion Separation.

Lin Wan-Ting WT, Chen Xiaohong X, Luo Xiao-Wei XW, Li Wan-Long WL et al.

Separating monovalent ions from divalent ions remains a central challenge in resource recovery. While the classic poly(piperazine-amide) nanofiltration membrane exhibits superior rejection of divalent anion, the application in cation separation is constrained by the strongly negatively charged surface and limited size-sieving precision. To address this limitation, we propose a solvent treatment-induced optimization strategy for surfactant-tailored polyamide networks. The surfactant-assisted interfacial polymerization yields a dense and uniform nascent polyamide network that can withstand solvent treatment while preserving its cross-linked structure. Subsequent solvent treatment selectively removes oligomers trapped within the network, thereby refining the polyamide network architecture. This strategy facilitates the formation of a thinner polyamide selective layer that exhibits an attenuated negative surface charge and a more uniform pore size distribution. The optimized membrane achieves a dual enhancement in performance, exhibiting high mono-/divalent ion selectivity (Li+/Mg2+ selectivity of 96.1 and Cl-/SO42- selectivity of 1351) coupled with a high water permeance of 14.9 L m-2 h-1 bar-1. This work provides a straightforward and effective method to refine surface properties and internal architecture of polyamide networks for efficient mono-/divalent ion separation.

PMID 42504470
阅读全文 →
PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Transporter Engineering for Enhancing Citric Acid Production in Aspergillus niger.

Li Jie J, Li Mingyang M, Song Yan Y, Xu Zeyu Z et al.

The efficient industrial production of citric acid by A. niger requires overcoming the limitations of substrate uptake and citrate export on the citrate synthesis efficiency. This study addresses these obstacles using a transporter engineering strategy, modifying the endogenous high-affinity glucose transporter MstF and citrate exporter CexA. The "push-pull" strategy was used to improve citric acid production by increasing glucose import and citrate export. A single overexpression of mstF improved citric acid production, reaching 179.35 g/L in the H7 strain. However, cexA high expression impaired dense mycelium pellet formation and affected the expression of key genes, resulting in reduced citric acid production. For balancing intracellular accumulation and secretion of citrate, simultaneous overexpression of mstF and cexA increased citric acid production and efficiency. In a 30 L fermenter, strain A5 achieved a citric acid titer of 185.91 g/L, a productivity of 3.21 g/h/L, and a shortened fermentation cycle. Collectively, these results provide a reference for the industrial production of citric acid and other organic acids.

PMID 42506234
阅读全文 →
PubMedAnatolian journal of cardiology2026-07-27

Composite Uric Acid Index for Prediction of Significant Coronary Stenosis on Computed Tomography Angiography.

Çamkıran Volkan V, Us Gediz Doğay GD, Aksoy Eray E, Kılıç Şahhan Ş et al.

A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomography (CT) angiography and compared its diagnostic performance with serum uric acid. In this retrospective, single-center study, 258 adults who underwent coronary CT angiography between January 2023 and December 2024 were included. Coronary calcification was scored using the Agatston method by 2 cardiologists. Clinical, demographic, and laboratory data were collected. The uric acid index was calculated as Ln [triglycerides × uric acid × glucose/2]. Univariable and hierarchical multiple logistic regression analyses were performed. Seventy-one patients (27.5%) showed ≥50% stenosis. Those with stenosis were older and had higher Agatston scores, creatinine, uric acid, glucose, HbA1c, and lower high-density lipoprotein cholestrol (HDL-C). In the final multiple models adjusted for age, sex, creatinine and Agatston score, the uric acid index remained a strong independent predictor of ≥50% stenosis (odds ratio [OR] = 1.988, P = .019, 95% confidence interval [CI] = 1.117-3.538). The index demonstrated significant incremental predictive value over the base model, with a Net Reclassification Improvement (NRI) of 0.500 (P < .05) and an Integrated Discrimination Improvement (IDI) of 0.029. The area under the curve for the uric acid index (0.688) exceeded that of uric acid (0.664). In a real-world coronary CT angiography cohort, the composite uric acid index independently predicted significant coronary stenosis. Its incremental predictive value requires validation in larger, prospective studies.

PMID 42505007
阅读全文 →
PubMedAIDS (London, England)2026-07-27

Altered bile acid metabolism in people with HIV correlates with systemic and intestinal inflammation.

Irwin Sophie S, Elliott Julie J, Li Fan F, Ruiz Paola P et al.

To examine associations between plasma bile acids, systemic and gut inflammation, and intestinal bile acid receptor expression in people with HIV (PWH). Retrospective case-control study using paired plasma and colorectal biopsy samples from adults with and without HIV. Samples from 31 PWH and 21 people without HIV (PWOH) were analyzed. Plasma bile acids were quantified by targeted liquid chromatography-mass spectrometry (LC-MS) and cytokines by multiplex assays. Bile acid receptors farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) were quantified in gut tissue by quantitative reverse-transcriptase (qRT)-PCR, and immunohistochemistry with digital image analysis to localize receptor expression. Intestinal inflammation was assessed by histopathology. Group comparisons, multivariable regression, and Pearson correlations were used to evaluate relationships among bile acids, inflammation, and receptor expression. Decreased levels of the primary bile acid chenodeoxycholic acid [P < 0.001, false discovery rate (FDR) = 0.002] as well as decreased levels of conjugated secondary bile acids glycochenodeoxycholic acid (P < 0.001, FDR=0.001), and taurochenodeoxycholic acid (P = 0.007, FDR = 0.02), and glycoursodeoxycholic acid (P = 0.008, FDR = 0.02) were observed in PWH. Antiretroviral therapy may also be a contributor to bile acid alterations with decreased glycodeoxycholic acid (P = 0.02, FDR = 0.19). There was no difference in FXR expression in the gut, but PWH had higher TGR5 expression (P < 0.001), which correlated with intestinal inflammation histopathology scores (r = 0.56, P = 0.004). PWH had decreased plasma primary and secondary bile acids. In addition, PWH had higher TGR5 expression in the gut, which correlated with intestinal inflammation. Reduced anti-inflammatory bile acid signaling may be one potential mechanism contributing to ongoing inflammation in HIV.

PMID 42504576
阅读全文 →
PubMedGels (Basel, Switzerland)2026-07-27

A Coupled Model of Acid Transport, Gel Cleanup, and Fracture Propagation in Prepad Acid Fracturing.

Zhang Weiyou W, Sun Yongpeng Y, Meng Xianghua X, Dou Rutong R

In conventional hydraulic fracturing of low-permeability sandstone reservoirs, polymer-gel leak-off creates low-permeability filter cakes that impair productivity. This study proposes a prepad acid fracturing technique using a fluoroboric acid (HBF4) pre-flush to dissolve gel residues and mineral fines. A fully coupled mathematical model integrates HBF4 hydrolysis kinetics, multi-mineral surface reactions, porosity-permeability evolution via the Panda-Lake model, and dynamic leak-off coefficient feedback. Simulations show HBF4 decreases monotonically along the fracture while HF peaks at 40-60 m from wellbore. Acid concentration in the leak-off zone decays exponentially, defining a gel-dissolution zone within 0.5 m of the fracture wall. Acid dissolution increases near-wall porosity to 12-15% and permeability to 2.5-3.5 mD (3- to 4-fold). The leak-off coefficient varies dynamically: high in the acid-dominated zone (1.5-2.2 × 10-3 m/√min) favoring gel dissolution, and low in the gel-dominated zone (≈0.8 × 10-3 m/√min) promoting fracture extension. Compared with conventional polymer gel fracturing, the proposed method achieves a 15.9% higher stimulation ratio and 22.5% higher productivity after 100 days, despite slightly shorter fractures. The core advantage is restoring leak-off zone permeability from 0.45 mD to 0.85 mD and increasing gel filter cake permeability from 8 × 10-4 mD to 0.1 mD, with an average relative error of 8.2% against experimental data. These findings provide theoretical guidance for optimizing prepad acid fracturing in gel-damaged low-permeability sandstones.

PMID 42505304
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多sultosilic acid piperazine