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Factor VIII (Factor VIII, Ipsen / Hyate C / Hyate)

✓ Approved

Sanofi S.A · F8 · 细胞治疗

什么是 Factor VIII？

Factor VIII 是一种细胞治疗，由Sanofi S.A研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Factor VIII, Ipsen, Hyate C, Hyate
公司Sanofi S.A
药物类别细胞治疗
分子靶点F8, VWF
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

作用机制

分子靶点

Factor VIII 作用于 2 个分子靶点：

F8coagulation factor VIII (AHF, FVIII)
VWFvon Willebrand factor (VWD, F8VWF)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Factor VIII 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

相关研究文献

PubMedBone research2026-09-10

WDR23 prevents bone loss by promoting autophagic degradation of TRAF6 in osteoclastogenesis.

Park Hye-Won HW, Yu Jungeun J, Yu Jiyeon J, You Jinseon J et al.

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a pivotal adaptor molecule in the receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) signaling pathways, which are essential for osteoclastogenesis. In this study, we identified WD40 repeat-containing protein 23 (WDR23), also known as DDB1-CUL4 associated factor 11 (DCAF11), as a novel binding partner of TRAF6. Our findings demonstrate that WDR23/DCAF11 acts as a negative feedback regulator of RANK/RANKL-induced osteoclastogenesis by promoting the autophagy-dependent degradation of TRAF6. Notably, RANKL induced the upregulation of WDR23 expression during osteoclastogenesis. WDR23 physically interacted with the TRAF domain of TRAF6 via the WD40 repeat domains 1 and 2 of WDR23, resulting in reduced TRAF6 protein stability by its autophagy-dependent degradation during osteoclastogenesis. By modulating TRAF6 protein levels, WDR23 attenuated RANKL signaling cascades, including nuclear factor-κB and mitogen-activated protein kinases, thereby downregulating the expression of osteoclastogenic markers, such as nuclear factor of activated T-cell c1, tartrate-resistant acid phosphatase, dendritic cell-specific transmembrane protein, V-ATPase subunit d2 and cathepsin K. Conversely, WDR23 knockdown or deficiency enhanced RANKL-induced osteoclastogenesis by preventing the autophagy-dependent degradation of TRAF6. WDR23-deficient mice exhibit an osteoporotic bone phenotype characterized by elevated osteoclast formation and reduced bone mass. Collectively, these results establish WDR23 as a key negative feedback regulator of RANKL-induced osteoclastogenesis via autophagy-mediated TRAF6 degradation and underscore its potential as a therapeutic target for bone disorders associated with aberrant osteoclast formation and function.

PMID 42717193
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PubMedEating disorders2026-09-10

Psychometric properties of a Greek translation of the intuitive eating Scale-3 (IES-3) in adults from Greece.

Argyrides Marios M, Maïano Christophe C, Tylka Tracy L TL, Reppa Glygeria G et al.

The Intuitive Eating Scale-3 (IES-3) is a new, 12-item measure of intuitive eating, which is recognised as a protective factor of disordered eating. Given its recency, there has been limited evaluation of the psychometric properties of the IES-3 in diverse national and linguistic contexts. Therefore, we report on the translation and psychometric evaluation of a novel Greek version of the IES-3 in Greek adults. A total of 1,138 women and 712 men completed the Greek IES-3 alongside additional measures selected to assess validity. Exploratory factor analysis with a first split-half subsample showed that the original 4-factor model fit the data well. In a second split-half subsample, a bifactor-exploratory structural equation model (B-ESEM) with a G-factor and four S-factors fit the data and demonstrated superior fit compared to alternative models. Across subsamples, the 4-factor and B-ESEM models demonstrated gender invariance and did not show measurement bias in terms of age and body mass index. Validity analyses revealed that intuitive eating was associated with higher positive body image and psychological well-being and lower disordered eating and psychological distress. These results indicate that the Greek IES-3 has robust psychometric properties.

PMID 42717485
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PubMedRegenerative biomaterials2026-09-10

Synergistic effects of berberine and adipose stem cells in a silk fibroin-PEG hydrogel for diabetic wound healing via macrophage polarization modulation.

Hu Xiaohao X, Xu Jia J, Zhong Yanping Y, Zheng Weihao W et al.

Diabetic wound repair remains a considerable clinical challenge, largely due to the limited efficacy of current therapies. Herein, we engineered a novel silk fibroin (SF)-polyethylene glycol (PEG) hydrogel (SPB) incorporated with berberine (BBR) and adipose-derived stem cells (ASCs) to synergistically promote diabetic wound healing. By optimizing the physicochemical properties of SPB, we found that a 7:3 SF:PEG ratio provided an ideal balance of pore size (25.83 ± 3.94 μm), mechanical strength (32.33 ± 4.07 kPa) and sustained BBR release. In vitro, SPB significantly enhanced ASC paracrine function, promoting the production of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2), stromal cell-derived factor 1 (SDF-1), platelet-derived growth factor-BB (PDGF-BB), and transforming growth factor beta (TGF-β). Accordingly, SF-based hydrogel system (SPBA) markedly stimulated fibroblast proliferation and migration and enhanced endothelial cell angiogenesis. Moreover, SPBA effectively modulated macrophage repolarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype, thereby suppressing inflammation. In vivo, SPBA demonstrated remarkable therapeutic efficacy in diabetic rat full-thickness skin wounds, accelerating wound closure, promoting re-epithelialization, collagen deposition and neovascularization, while reducing local inflammation. These results highlight SPBA as a highly efficient and promising biomaterial strategy for diabetic wound treatment.

PMID 42719899
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PubMedSubstance use & misuse2026-09-10

Development and Validation of the Stress Burden of Electronic Cigarette Smoking Scale (SBECSS) Among Adult Dual Users.

Jo Duckhyun D, Mayorga Nubia A NA, Smit Tanya T, Robison Jillian J et al.

The present study aimed to develop and evaluate the preliminary validity of the Stress Burden of Electronic Cigarette Smoking Scale (SBECSS), a new measure designed to assess the level of stress burden associated with the co-occurring perceptions of electronic cigarette (e-cigarette) use and efforts to quit within an individual. To achieve this, 400 adult dual users of combustible cigarettes and e-cigarettes (52.8% female; 90% non-Hispanic White; Mage = 37.8, SD = 9.7) participated in an online survey. Items were developed in accordance with the operational definition, reviewed by field experts, and evaluated post-data collection for inter-item correlations and theoretical alignment. Confirmatory factor analysis was conducted to compare the unidimensional, two-factor correlated, second order, and bifactor models. Factor analysis supported a unidimensional factor structure (X2[170] = 343.557, p < 0.001; RMSEA = 0.051 [90% CI: 0.043, 0.059], p = 0.413; CFI = 0.970; SRMR = 0.021), and measurement invariance was supported across sex. The SBECSS demonstrated construct validity with measures of e-cigarette related and affective processes. These findings suggest that the SBECSS is a reliable and valid tool for measuring and understanding the stress burden of using or quitting e-cigarettes among dual tobacco users.

PMID 42720193
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PubMedJournal of ginseng research2026-09-10

Traditional Chinese medicine ginseng regulates neurotrophic factors to improve neurodegenerative diseases: A potential strategy for Alzheimer's disease treatment.

Huang Qucheng Q, Xie Yining Y, Zhang Xiaojun X, Zuo YuanYuan Y et al.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory impairment and progressive cognitive decline. Its core pathological mechanisms include β-amyloid deposition, abnormal tau phosphorylation, neuroinflammation, and decreased levels of neurotrophic factors. In recent years, the deficiency of neurotrophic factors has been recognized as a key driver of impaired neuronal survival and synaptic dysfunction. Consequently, restoring or enhancing neurotrophic factor signaling has emerged as a major therapeutic target for AD. As a traditional medicinal plant, ginseng exhibits multi-targeted, multi-level neuroprotective effects. Its active components-including ginsenosides, ginseng polysaccharides, and ginseng proteins-have been demonstrated to promote neuronal survival, inhibit apoptosis, and enhance synaptic plasticity by upregulating signaling pathways such as BDNF/TrkB and NGF/TrkA. Additionally, ginseng suppresses inflammatory responses and oxidative stress, thereby indirectly correcting neurotrophic factor imbalances and demonstrating significant neuroprotective potential. This review summarizes recent advances in ginseng's regulation of neurotrophic factor levels and signaling pathways, focusing on its molecular mechanisms for improving neuronal dysfunction and delaying AD progression. It also outlines future research strategies and prospects for clinical translation. In summary, ginseng's neuroprotective effects achieved through regulating the neurotrophic factor network offer a potential natural drug intervention strategy for AD treatment.

PMID 42719334
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PubMedBMC pediatrics2026-09-10

Psychometric properties of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) scale.

Bolacali Edanur Tar ET, Bolacali Memiş M

Childhood obesity in preschool years is strongly influenced by modifiable parental attitudes and behaviors. This study examined the validity and reliability of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) Scale, which assesses parental attitudes related to childhood obesity during the preschool period. This methodological study was conducted with 460 parents of children aged 2-6 years from seven preschools in Central Anatolia, Türkiye. Data were collected using a family and child information form and the PRELSA Scale. The adaptation process included forward-backward translation, expert review, face validity assessment, and psychometric evaluation. Data were analyzed using exploratory and confirmatory factor analyses, Cronbach's alpha, test-retest reliability, and intraclass correlation coefficients (ICC). The Turkish version comprised 39 items across 13 subscales. The overall Cronbach's alpha coefficient was 0.887. Exploratory factor analysis explained 58.5% of the total variance, with factor loadings ranging from 0.353 to 0.890. Confirmatory factor analysis indicated acceptable model fit (χ²/df = 1.434, RMSEA = 0.031, SRMR = 0.046, CFI = 0.904, IFI = 0.907, GFI = 0.911, TLI = 0.888). Test-retest reliability was high (r = 0.911), and the ICC was 0.865 (95% CI: 0.738-0.933), indicating good temporal stability. The Turkish PRELSA Scale is a valid and reliable instrument for assessing parental attitudes toward eating behaviors, physical activity, screen use, and sleep routines in early childhood.

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