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SC-001 (SP009 / SC001)

✓ Approved

Declion Pharmaceuticals · · 多肽类

什么是 SC-001？

SC-001 是一种多肽类，由Declion Pharmaceuticals研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intradermal Injection。

药物档案

商品名SP009, SC001
公司Declion Pharmaceuticals
药物类别多肽类
给药途径Injectable (Others), Intradermal Injection
状态Approved
来源： ClinicalTrials.gov, Declion Pharmaceuticals

作用机制

分子靶点

SC-001 作用于 1 个分子靶点：

()
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

SC-001 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresBotulinum toxin injection✓ Approved

相关研究文献

PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Sophocarpine Inhibits Proliferation and Triggers Apoptosis in Breast Cancer Cells by Modulating the miR-21/PTEN/AKT and ERK1/2 Signaling Networks.

Shahin Yasmin R YR, Elguindy Nihal M NM, Ghareeb Doaa A DA, Elabd Seham S et al.

Background: Sophocarpine (SC), a tetracyclic quinolizidine alkaloid, has shown antitumor potential, yet its activity and underlying mechanisms in breast cancer remain unexplored. This study aimed to investigate the anticancer effects of SC and the molecular mechanism, focusing on the involvement of microRNA-21 (miR-21) and AKT/mTOR and ERK1/2 signaling networks. Methods: In MDA-MB-231 and T-47D breast cancer cells, SC cytotoxicity and growth-inhibitory effects were evaluated using MTT viability, colony formation, migration assays, and flow cytometry for cell cycle and apoptosis analysis. RT-qPCR analysis, Western blotting, and immunofluorescence staining were performed to measure RNA and protein expression, respectively. Molecular docking analysis was performed to explore SC's interaction with the miR-21 precursor. Results: SC treatment effectively inhibited the proliferation, survival, and migration of breast cancer cells. It also induced cell cycle arrest and triggered apoptosis in both cell lines. Mechanistically, SC downregulated oncogenic miR-21 transcription, thereby enhancing tumor suppressors PTEN and PDCD4 and suppressing AKT/mTOR and ERK1/2 signaling. Interestingly, restoration of miR-21 reversed SC's effects on PTEN and PDCD4, confirming SC's miR-21 dependency. Docking analysis suggested that SC may bind the miR-21 precursor and interfere with its maturation. SC also increased long noncoding RNA GAS5 while reducing miR-196a-5p and HIF-1α transcripts. It shifted the Bcl2/Bax/Bad/caspases balance toward apoptosis. Conclusions: These findings identify SC as a potential structural scaffold exhibiting preliminary anti-tumor activity against breast cancer cells, at least in part, through modulating miR-21 and inhibition of the AKT/mTOR/ERK1/2 survival network.

PMID 42943210
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PubMedAnimals : an open access journal from MDPI2026-10-27

Pharmacokinetics of Doramectin After Subcutaneous and Intramuscular Administrations in Siamese Freshwater Crocodiles (Crocodylus siamensis).

Leksansern Arin A, Poapolathep Saranya S, Klangkaew Narumol N, Phaochoosak Napasorn N et al.

Doramectin (DRM) is a broad-spectrum macrocyclic lactone antiparasitic agent widely used in veterinary medicine. Its pharmacokinetics in reptiles, particularly Siamese freshwater crocodiles (Crocodylus siamensis), remain limited. This study aimed to characterize the pharmacokinetic profiles of DRM following subcutaneous (SC) and intramuscular (IM) administration in Siamese crocodiles. Twenty clinically healthy male crocodiles were randomly allocated into four groups (n = 5 per group) and administered a single dose of DRM at 0.2 or 0.3 mg/kg body weight (b.w.) via either the SC or IM route. Blood samples were collected from pre-dose to 60 days after administration, and plasma DRM concentrations were quantified using a validated high-performance liquid chromatography method with fluorescence detector. Pharmacokinetic parameters were determined by non-compartmental analysis. Plasma DRM concentrations remained quantifiable through day 60 in 19 of 20 animals. Geometric mean maximum plasma concentrations (Cmax) were 14.73 and 20.28 ng/mL following SC administration at 0.2 and 0.3 mg/kg, respectively, and 24.48 and 36.34 ng/mL following IM administration. Significantly higher Cmax values were observed at 0.3 mg/kg for both routes (p < 0.05). Median Tmax values were 11 and 9 days following SC administration and 3 and 4 days following IM administration at 0.2 and 0.3 mg/kg, respectively. The geometric mean terminal elimination half-lives (T1/2λz) were 5.37 and 9.73 days for SC administration and 7.38 and 9.97 days for IM administration at 0.2 and 0.3 mg/kg, respectively. Systemic exposure increased with dose. The geometric mean AUC0-last increased numerically from 368.84 to 491.87 ng × day/mL following SC administration and significantly from 372.45 to 643.97 ng × day/mL following IM administration (p < 0.05). Intramuscular administration resulted in higher Cmax and more rapid attainment of peak plasma concentrations than SC administration. These findings demonstrate prolonged systemic persistence and dose-related pharmacokinetic changes in DRM in freshwater crocodiles and provide species-specific information to support further evaluation of dosage regimens.

PMID 42939220
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PubMedAnalytical chemistry2026-10-27

Nanoscale Chemical Imaging of Soot and Brown Carbon Components in Individual Atmospheric Particles.

Sharpe Steven A L SAL, Olayemi Temitope E TE, Ese Julius J, Koloski Seth S et al.

Biomass-burning aerosols contain complex mixtures of soot carbon (SC), brown carbon (BrC), organic carbon (OC), and inorganic (IN) constituents whose spatial distributions within individual particles strongly influence aerosol optical properties, atmospheric chemistry, and climate impacts. Scanning transmission X-ray microscopy (STXM) coupled with near-edge X-ray absorption fine structure spectroscopy (STXM/NEXAFS) is widely used to characterize the composition and mixing state of individual particles; however, existing approaches cannot explicitly distinguish SC from BrC because both exhibit strong aromatic π*C═C absorption at 285.4 eV. Here, a novel X-ray spectromicroscopic method at the carbon K-edge is introduced to resolve SC and BrC at the nanoscale within individual particles. The approach exploits differences between the aromatic π*C═C transition at 285.4 eV and the soot-specific σ*Graphitic-like(GL) transition at 307.0 eV. Analysis of STXM/NEXAFS spectra of biomass-burning particles, laboratory-generated BrC proxies, tar balls, and soot reference particles demonstrates that the relative intensities of these transitions provide a robust basis for differentiating SC and BrC. An integrated peak ratio and a simplified four-energy Soot Index (SI) were developed to classify particle components and generate spatially resolved maps of SC, BrC, OC, and IN at the nanoscale. The SI reproduces classifications obtained from full spectral deconvolution while enabling rapid, pixel-resolved chemical imaging. Application of this method reveals substantial variability in the internal distributions of SC and BrC within biomass-burning particles and demonstrates that conventional STXM mapping approach frequently classifies BrC-rich regions as elemental carbon. The new analytical framework expands the capabilities of X-ray spectromicroscopy for atmospheric aerosol characterization and provides improved particle-resolved constraints on aerosol composition, mixing state, and morphology.

PMID 42937342
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PubMedACS nano2026-10-27

Marine-Inspired Synergistic Adhesion Enables Highly Efficient and Atraumatic Macromolecular Transdermal Delivery on Dynamic Skin.

Song Minwoo M, Kim Minjin M, Son Jihun J, Hwang Gui Won GW et al.

Effective transdermal drug delivery (TDD) demands both the ability to bypass the stratum corneum (ST) and the robustness to sustain delivery efficiency under real-life conditions. Despite advances in nanocarriers, microneedles, and electrostimulation, many TDDS strategies face limitations due to cytotoxicity, invasiveness, device dependence, and poor performance for large molecules in real-world conditions. In this study, we present a marine-inspired TDDS patch (PDA@SC) that integrates adhesion strategies from marine organisms to achieve stable skin attachment and atraumatic macromolecular delivery, even on dynamic skin surfaces. The suction-cup (SC) structure, inspired by octopus' suckers, generates negative pressure upon preload-induced deformation, promoting temporary mechanical modulation for nanolevel control of the ST barrier and enhancing drug delivery without external power. Simultaneously, the mussel-inspired polydopamine (PDA) coating modifies hydrophobic surfaces into high surface energy interfaces capable of chemical bonding, thereby ensuring intimate adhesion and minimizing drug leakage. Experimental findings confirmed that the delivery of the high molecular weight compound was enhanced on deformed skin, showing a 600% improvement compared to conventional topical application. In addition, preliminary human evaluation demonstrated that PDA@SC effectively improved key dermatological parameters. Collectively, these results highlight the potential of PDA@SC as a platform that can drive technological progress in wearable therapeutics and cosmetics.

PMID 42937558
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PubMedGenes2026-10-27

Metabolomic Profiling Screening for Molecular Level Associations Related to Cashmere Quality Related Phenotypic Types in Liaoning Cashmere Goats.

Zhou Nan N, Sun Meng M, Liu Huiying H, Wang Chunqiang C et al.

Background/Objectives: Distinct cashmere-related traits are observed between long cashmere short wool (LC-SW) and short cashmere long-hair (SC-LW) Liaoning cashmere goats. Yet metabolic differences associated with these phenotypes remain poorly characterised. This study explored skin metabolic divergence between two specific farm-raised maternal families that consistently exhibit LC-SW and SC-LW phenotypes, providing preliminary references for improving cashmere traits. Considering experimental limitations, phenotype is confounded by maternal family genetic background; therefore, this work does not aim to uncover universal mechanisms underlying breed-wide LC-SW/SC-LW subtypes. Methods: 120 healthy adult female Liaoning cashmere goats from two independent maternal families were used for phenotypic measurement. Among them, six animals from each family (total n = 12) were randomly selected for untargeted metabolomic analysis of skin tissue using GC-TOF-MS. Results: The two maternal families differed significantly in body weight, cashmere yield and cashmere fibre length (p < 0.05), whereas cashmere fibre diameter showed no significant difference. In total, 89 nominally associated candidate metabolites were mapped to the following KEGG pathways: amino acid biosynthesis, ABC transporters, and central carbon metabolism in cancer (KEGG database annotations for core carbon-related metabolites; no cancer-related physiology is implied). The LC-SW family showed higher relative abundances of metabolites associated with glycolysis/TCA-related metabolism, as well as multiple amino acid-related metabolites. These energy-related and keratin precursor-related metabolites exhibit higher relative abundance in the LC-SW-related maternal family. The SC-LW family exhibited reduced levels of γ-aminobutyric acid and glutamate, indicating metabolite-level differences that warrant further investigation into links with cashmere length traits. Conclusions: This study characterises skin metabolomic profiles of two phenotype-divergent maternal families. These findings offer preliminary data for cashmere trait research, but cannot be generalised to all LC-SW and SC-LW goats. Further validation using materials from multiple unrelated families is required.

PMID 42938414
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PubMedJournal of clinical medicine2026-10-27

Autonomic Changes During an Adaptive Cognitive Task.

Lachowicz Maciej M, Wilk Iwona I, Hrehorowicz Igor I, Bałamucki Szymon S et al.

Background/Objectives: This study examined between-participant associations of task-minus-baseline heart rate (HR) and skin conductance (SC) changes with performance during the adaptive Determination Test (DT), in which performance influences subsequent task demand. Methods: This exploratory secondary analysis included 48 young adults. Accuracy was the study-defined proportion correct/(correct + incorrect + omitted), calculated from exported counts. Ten Pearson correlations formed the primary analytical family. Complementary fractional-logit and linear models included the corresponding baseline physiological value and the exported stimulus count (DT_Stimuli). Tonic skin conductance level and skin conductance response (SCR) frequency and amplitude were also examined. Benjamini-Hochberg (BH) adjustment was applied separately to the defined analytical families. Results: Mean HR increased by 19.99 bpm and mean SC by 4.65 µS. The HR-accuracy Pearson estimate was r = 0.338 (95% CI 0.060 to 0.568; p = 0.019; BH q = 0.187), compared with Spearman ρ = 0.192. In the model including baseline HR and DT_Stimuli, the average marginal association was 1.42 percentage points per 10 bpm (95% bootstrap CI 0.13 to 2.65; p = 0.033; BH q = 0.306). Neither the primary correlation family nor the 15 complementary model tests met q < 0.05. Direct comparisons did not establish different HR and SC correlations. Conclusions: HR and SC increased during adaptive DT performance. A possible HR-accuracy association depended on analytical specification. Adjustment for aggregate stimulus count did not identify the direction of the performance-demand-physiology relationship. These findings support prospective testing with time-resolved task exposure.

PMID 42941581
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