prezatide copper acetate (GHK:Cu / vulnerary, ProCyte / Iamin Hydrating Gel)

✓ Approved

ProCyte · 小分子 · 小分子

什么是 prezatide copper acetate？

prezatide copper acetate 是一种小分子，由ProCyte研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名	GHK:Cu, vulnerary, ProCyte, Iamin Hydrating Gel
公司	ProCyte
药物类别	小分子
给药途径	Topical
状态	Approved

来源： ClinicalTrials.gov, ProCyte

治疗适应症

prezatide copper acetate 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域	疾病/病症	分期
Skin and subcutaneous tissue disorders	Decubitus ulcer	✓ Approved
General disorders and administration site conditions	Impaired healing	✓ Approved
Injury, poisoning and procedural complications	Thermal burn	✓ Approved
Skin and subcutaneous tissue disorders	Diabetic foot	✓ Approved

相关研究文献

PubMedACS omega2026-09-10

Determination of Molecular Interactions between Copper Pigments and Soybean Oil Alkyd Resins in Paints: A Spectroscopic Study.

Costa Thiago Guimarães TG, Candeias António José Estêvão Grande AJEG, Gazotto Enzo Gimenes EG, Júnior Feik Amil de Campos FAC et al.

Alkyd paints are widely used in modern painting and can be obtained commercially or prepared from pure materials. Various formulations can be used to obtain these paints. Copper pigments can be found in various works of art and in industrial paints. The use of these pigments in modern resins can be a low-cost alternative for different applications. However, studies must be conducted to ensure safety when applying these paints. In this work, the interaction of Cu-(II) present in malachite, azurite, and copper acetate pigments with soybean oil-based alkyd resins when subjected to heat treatment above 50 °C was characterized. The results show that paintings containing malachite and azurite exhibited colorimetric ΔE values of 2.77 and 3.72, respectively, showing no significant chromatic change during the studied heat period. Fourier transform infrared (FTIR) spectroscopy revealed a decrease in the intensity of ester and phthalic groups in the resin over time, indicating that reactions occurred in these groups during the sample aging process. Raw copper acetate was initially present in the dimeric form; however, when mixed with a binder, monomeric species were formed, and the intensity of dimers decreased with the aging period, leading to the formation of only monomeric species with a color change. Scanning electron microscopy (SEM) analysis showed that the paint layers remained uniform even after the studied aging period. μ-Raman showed signals below 500 cm-1, which are attributed to Cu-O vibrational modes of new structures formed during the aging process of the paints. The chemical transformations do not lead to color changes in the pigments of malachite and azurite, so the results suggest that soybean oil-based alkyd resin could be a viable and cost-effective alternative to be used in the formulation with copper pigments. Furthermore, the data present can help understand the behavior of alkyd paints in the presence of copper pigments, assisting in the advancement of materials for use in painting materials.

PMID 42719401

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PubMedGeroScience2026-09-10

Copper and iron engage distinct metabolic programs for cellular survival.

Naaz Arshia A, Cheng Trishia Yi Ning TYN, Lin Jovian Jing JJ, Gao Mingtong M et al.

Copper and iron are redox-active micronutrients with tightly coupled homeostasis, yet how copper modulates iron-dependent stress responses remains unclear. Using Saccharomyces cerevisiae under nutrient-limited conditions, we uncoupled proliferative growth from long-term survival to dissect metal-dependent adaptation. Copper selectively preserved survival without affecting growth, whereas iron showed similar effects. Iron chelation impaired growth and suppressed electron transport chain gene expression; copper partially rescued these defects but required iron availability for its pro-survival activity. Despite this interdependence, copper and iron engaged distinct signaling programs. Iron-dependent survival required a Target of Rapamycin complex 1 (TORC1)-permissive state and was attenuated by rapamycin, whereas copper remained active under TORC1 inhibition. In contrast, copper promoted survival through AMP-activated protein kinase (AMPK) and antioxidant pathways, while iron exhibited context-dependent AMPK reliance. Together, these findings reveal that copper and iron support cellular survival through distinct metabolic programs and suggest that the consequences of micronutrient availability are shaped by the underlying nutrient-sensing and metabolic state of the cell. This framework provides insight into how alterations in micronutrient homeostasis and metabolic signaling may influence cellular resilience during aging.

PMID 42717163

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PubMedEES batteries2026-09-10

Understanding the reactivity of copper current collectors in lithium batteries - an operando XAS study.

Koronfel M A MA, Omirkhan A A, Yadegari H H, Thornton D D et al.

Copper is used as the anode current collector in lithium-ion batteries, as well as the electrode itself in other types of lithium batteries. It is nominally a stable material in the organic electrolytes under normal battery operating potentials. Copper dissolution in lithium battery electrolytes has been extensively shown to occur at potentials attainable only in over-discharge conditions. However, in this work, copper dissolution is shown to occur even under normal cycling conditions, contrary to thermodynamic prediction. Utilising the high chemical sensitivity of X-ray absorption spectroscopy, copper oxidation state and concentration are quantified in operando. The results raise concerns about the impact of copper on battery efficiency, lifetime and safety, along with resulting implications on battery cycling.

PMID 42719668

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PubMedChemistry & biodiversity2026-09-10

Antioxidant Activities of Pentacyclic Triterpenes From Melipona beecheii Propolis and Their Semisynthetic Derivatives.

Santana-Hernández Aarón A, Yam-Puc Alejandro A, Yah-Nahuat Pamela P, Vargas-Vargas María M et al.

Four principal fractions (I-IV) were obtained from the Melipona beecheii propolis. GC-MS analysis of these fractions allowed us to recognize 11 pentacyclic triterpenes (PTs), fraction I [β-amyrin acetate (1), germanicol acetate (2), moretenol acetate (3) and 24-methylencycloartan-3-ol acetate (4)]; fraction II [marsformosanone (5), β-amyrenone (6), germanicone (7) and lupenone (8)]; fraction III [β-amyrin (9) and, glutinol (10)]; and fraction IV [9 and α-amyrin (11)]. This is the first time that triterpenes 7 and 10 are reported in the propolis of M. beecheii. Three semisynthetic derivatives were prepared: the reduction of fraction II and the acetylation and oxidation of fraction IV. The ethanolic extract of propolis and fraction III presented the highest free DPPH radical scavenging capacity at 53.89 ± 8.39% and 47.77 ± 0.91%, respectively, using a concentration of 10 mg/mL. In contrast, the reducing power of Fe (III) analysis showed a strong reducing power of Fe(III) for all fractions and their derivatives with an EC50 = 0.8-1.0 mg/mL.

PMID 42720076

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PubMedBiomaterials research2026-09-10

Intraperitoneal Copper-Manganese Nanozyme Suppresses Peritoneal Metastasis with Antitumor Immune Activation.

Zhang Jinquan J, Xie Zhenze Z, He Muye M, He Siqi S et al.

Peritoneal metastasis from colorectal cancer (CRC) carries a dismal prognosis, and current surgical and medical therapies achieve limited efficacy with high recurrence rates. Here, we developed a copper-manganese-based nanozyme (CM) that integrated MnO2-mediated Fenton-like catalysis with copper-induced cuproptosis for intraperitoneal treatment of CRC peritoneal metastasis. Composed of CuO and Cu2(OH)3Cl crystalline domains embedded in amorphous MnO2, the nanozyme has a hydrodynamic diameter of ~140 nm and displays peroxidase-like, glutathione oxidase, catalase, and Fenton-like activities that amplify reactive oxygen species (ROS) under tumor-mimicking conditions. CRC cells efficiently internalize the nanozyme, which penetrates 3-dimensional spheroids and induces strong, selective cytotoxicity via ROS amplification and cuproptosis. Intraperitoneal delivery of CM achieves prolonged peritoneal retention, marked reduction of peritoneal tumor burden and ascites, and remodeling of the local immune microenvironment with activation of antitumor immune responses. This study provides an effective cavity-confined therapeutic approach for CRC peritoneal metastasis based on Fenton-like ROS amplification and cuproptosis.

PMID 42719306

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PubMedFrontiers in nutrition2026-09-10

Preparation, characterization, stability, and application in curcumin of the emulsion gels stabilized with coconut cake albumin modified by ultrasonication and carboxymethylation.

Yang Yong Y, Gong Meiling M, Duan Jiapeng J

Curcumin has applications in food and medical industries, but its stability and bioaccessibility are poor. Coconut cake albumin (CCA) has potential as a component of the curcumin-loading system; however, relative data are scare. Herein, emulsion gels were formed using coconut cake albumin modified by ultrasonication and carboxymethylation (CCA-UC) in this study. The results evidenced that ultrasonication and carboxymethylation increased the emulsifying capacity (from 67.51 to 143.65 m2/g) and emulsion stability (from 70.37 to 87.18%) of CCA by improving its solubility and interface sorption capacity, enhancing the zeta potential, and reducing droplets' size (p < 0.05). CCA and CCA-UC formed compact emulsion gel when concentration was more than 10 g/100 g. Compared with the CCA-emulsion gel, CCA-UC-emulsion gel had more compact and denser gel structure, higher crystallinity (38.65%), bound water content and viscosity, and lower energy storage (G'), loss modulus (G"), and loss factor. Furthermore, CCA-UC-emulsion gel showed superior thermal and oxidative stability, and higher chewiness (35.83 g), springiness (0.90), hardness (67.44 g), and cohesiveness (0.85) than CCA-emulsion gel. Additionally, CCA-UC-emulsion gel exhibited superior intestinal digestion rate, higher curcumin encapsulation (89.64%) and loading efficiency (204.01 μg/g), better photostability, and superior bioaccessibility (49.08%). However, more specific mechanisms should be investigated in the further work. These findings revealed that ultrasonication assisted with carboxymethylation was an effective way to improve the emulsion gel properties of CCA and increase the bioaccessibility of curcumin. However, more specific mechanisms should be investigated in the further work.

PMID 42718976

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prezatide copper acetate (GHK:Cu / vulnerary, ProCyte / Iamin Hydrating Gel)

什么是 prezatide copper acetate？

药物档案

治疗适应症

相关研究文献

Determination of Molecular Interactions between Copper Pigments and Soybean Oil Alkyd Resins in Paints: A Spectroscopic Study.

Copper and iron engage distinct metabolic programs for cellular survival.

Understanding the reactivity of copper current collectors in lithium batteries - an operando XAS study.

Antioxidant Activities of Pentacyclic Triterpenes From Melipona beecheii Propolis and Their Semisynthetic Derivatives.

Intraperitoneal Copper-Manganese Nanozyme Suppresses Peritoneal Metastasis with Antitumor Immune Activation.

Preparation, characterization, stability, and application in curcumin of the emulsion gels stabilized with coconut cake albumin modified by ultrasonication and carboxymethylation.

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