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prezatide copper acetate (GHK:Cu / vulnerary, ProCyte / Iamin Hydrating Gel)

✓ Approved

ProCyte · 小分子 · 小分子

什么是 prezatide copper acetate？

prezatide copper acetate 是一种小分子，由ProCyte研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名GHK:Cu, vulnerary, ProCyte, Iamin Hydrating Gel
公司ProCyte
药物类别小分子
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, ProCyte

治疗适应症

prezatide copper acetate 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersDecubitus ulcer✓ Approved
General disorders and administration site conditionsImpaired healing✓ Approved
Injury, poisoning and procedural complicationsThermal burn✓ Approved
Skin and subcutaneous tissue disordersDiabetic foot✓ Approved

相关研究文献

PubMedBiology2026-10-27

Single-Cell Transcriptomic Analysis Reveals Copper Metabolism Heterogeneity and Phenotypic Remodeling in Vaginal Anterior Wall Stromal Cells in Pelvic Organ Prolapse.

Wang Zhi Z, Huang Shouqi S, Hu Ming M, Xue Hongyang H et al.

Pelvic organ prolapse (POP) is a common disease characterized by disordered extracellular matrix (ECM) remodeling of pelvic support tissues. Copper dysregulation drives fibrosis in multiple diseases, whereas its function in POP remains unclear. We analyzed single-cell transcriptomes of 90,578 cells from 21 vaginal wall samples (5 controls, 16 POP). ECM remodeling was the most robustly upregulated module in POP fibroblasts, accompanied by decreased copper metabolism and senescence scores. Fibroblasts resolved into nine subpopulations, with copper metabolism activity decreased in eight, most prominently in p53/senescence-like states. High-copper fibroblasts were enriched for TNFα/NF-κB, inflammatory, hypoxic, and EMT programs. Copper metabolism correlated with senescence (rho = 0.56, p = 0.010) but not ECM remodeling (rho = -0.02, p = 0.92). Smooth muscle cells shifted toward a synthetic phenotype, negatively correlating with copper metabolism. CellChat and trajectory inference revealed ECM ligand-driven interactions and temporal copper-ECM gene dynamics. Elesclomol reduced fibroblast viability and induced apoptosis and senescence in a copper-dependent manner. These findings suggest that copper metabolism dysregulation contributes to POP stromal remodeling and may serve as a potential therapeutic target.

PMID 42939442
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PubMedPolymers2026-10-27

Some Synthetic Approaches for Copper-Containing Terpyridine-Functionalized Polysiloxane Complexes.

Kryukova Sofia S SS, Votchel Elena R ER, Baykov Sergey V SV, Boyarskiy Vadim P VP et al.

Terpyridine-containing polysiloxanes (tpy-PMHS and tpy-PDMS) were synthesized via hydrosilylation and used as macromolecular ligands for coordination with copper(I) and copper(II) precursors. As a result, a series of novel polymer-metal complexes (Cu-tpy-PMHS and Cu-tpy-PDMS) with diverse architectures (cross-linked and end-functionalized polymers) and different copper oxidation states were obtained. These polymer-metal complexes were comprehensively characterized by solid-state NMR, UV-vis, X-ray photoelectron spectroscopy and thermogravimetric analysis. The redox activity of the cross-linked Cu-tpy-PMHS-2 sample was investigated using cyclic voltammetry. Cu-tpy-PDMS-1 exhibited catalytic activity in mechanochemical azide-alkyne cycloaddition, affording the target product in 80% yield.

PMID 42942627
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PubMedJournal of the American Chemical Society2026-10-27

Systematic Ligand Modification Tunes the Stability and Reactivity of Copper Complexes for the Electrocatalytic Reduction of Carbon Dioxide.

Ramasubramanian Ramamoorthy R, Dayawansa Charasee Laddika CL, Lee Jyun-Chi JC, Xu Rui-Ze RZ et al.

Compared to first-row transition metal complexes, such as Mn, Fe, Co, and Ni, the development of molecular copper electrocatalysts for CO2 reduction has been plagued by the instability of low-valent Cu intermediates, which are prone to undergo demetallation or aggregation. A series of rational and systematic ligand modifications was employed to transform a CO2-fixing yet electrochemically unstable pyridine-2,6-dicarboxamide copper complex into a stable electrocatalytic system. Guided by the Hard-Soft Acid-Base principle, incorporation of a thioether donor into the nitrogen-based pincer framework stabilized Cu(I) intermediates, thereby promoting reversible electron transfer and mitigating the instability of the hard nitrogen-donor environment. Furthermore, the introduction of a macrocyclic structure not only enhances the overall stability of the complex but also minimizes structural reorganization to support the redox reversibility of the redox-active ligand. The resulting complex mediated the electroreduction of CO2 to CO through an alternating sequence of electron-transfer (E) and chemical (C) steps (ECEC mechanism). The mechanistic studies identified the key CO2-bound and protonated HCO2-bound copper intermediate species using a combination of spectroscopic tools, complementary in situ electrochemical methods, and isotopic labeling. In addition, comparative experimental and computational analyses of the copper complexes further revealed the factors governing catalyst stability. These results demonstrate that the interplay among the coordination sphere, redox-active ligand, and ligand rigidity dictates the electrocatalytic performance and stability of molecular copper complexes. This work provides design principles and mechanistic insights applicable to both homogeneous electrocatalysts and copper-complex-derived heterogeneous systems for CO2 reduction.

PMID 42938046
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PubMedAntioxidants (Basel, Switzerland)2026-10-27

ADSCs-Exo Attenuate HIRI in Miniature Pigs: Pharmacological Evidence for a Potential Association Between Copper-Associated Alterations and Ferroptosis-Related Responses.

Lu Xiangyu X, Li Pujun P, Cao Lei L, Liu Tao T et al.

Hepatic ischemia-reperfusion injury (HIRI) involves multiple forms of regulated cell death, but the relationship between copper-associated alterations and ferroptosis-related responses remains incompletely understood. This study investigated whether pharmacological modulation of intracellular copper homeostasis was accompanied by corresponding changes in ferroptosis-associated responses, and vice versa, during HIRI, and evaluated whether adipose-derived mesenchymal stem cell-derived exosomes (ADSCs-Exo) attenuate injury-associated alterations under OGD/R and HIRI conditions. Primary piglet hepatocytes were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R), followed by bidirectional pharmacological modulation of copper homeostasis and ferroptosis-associated responses. The major response patterns were further evaluated in a laparoscopic miniature pig model of HIRI combined with partial hepatectomy. OGD/R induced copper and iron dyshomeostasis, mitochondrial dysfunction, redox imbalance, alterations in cuproptosis-related markers, and ferroptosis-associated changes. Relative to the OGD/R group, ADSC-Exo treatment attenuated these injury-associated abnormalities. Pharmacological reduction in intracellular copper loading was accompanied by decreased Fe2+ accumulation and restoration of GSH, AIFM2, SLC7A11, and GPX4, whereas increased copper loading produced the opposite pattern. Conversely, pharmacological enhancement in ferroptosis-associated responses increased Cu2+ accumulation and aggravated alterations in the cuproptosis-related markers SLC31A1, FDX1, LIAS, and DLAT, whereas pharmacological suppression of ferroptosis-associated responses attenuated these changes. These bidirectional pharmacological response patterns are consistent with a potential reciprocal association between copper-associated alterations and ferroptosis-related responses but do not establish bona fide cuproptosis, direct molecular interaction, or target-specific causality. In miniature pigs, HIRI was accompanied by hepatic injury, mitochondrial dysfunction, hepatic copper accumulation, alterations in cuproptosis-related markers, ferroptosis-associated changes, and reduced GPX4 expression. Relative to untreated IRI animals, ADSC-Exo administration was associated with attenuation of these injury-related abnormalities. The coordinated changes in GPX4, TAX1BP1, and MAP1LC3B are hypothesis-generating and support the working hypothesis that TAX1BP1/MAP1LC3B-associated autophagic processes may contribute to GPX4 homeostasis; however, autophagic flux, GPX4 turnover, and direct TAX1BP1-GPX4 interaction were not assessed. Because a non-injured ADSC-Exo-only control was not included, the present study does not determine the independent effects of ADSCs-Exo under baseline conditions. Thus, the observed ADSC-Exo-associated effects should be interpreted specifically within the OGD/R and HIRI settings examined here.

PMID 42939909
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PubMedAntonie van Leeuwenhoek2026-10-27

Therapeutic potential of the exometabolic crude ethyl acetate extract of an endophytic Bacillus sp. against multidrug-resistant pathogens associated with cancer patients.

Elebiary Deyaa M DM, El-Sherbiny Gamal M GM, Sharaf Mohamed H MH, Elnady Maha S MS et al.

The alarming emergence of multidrug-resistant bacterial pathogens (MDRBPs), esp.ecially associated with cancer patients, necessitates the exploration of novel biological agents as endophytic microorganisms that are natural reservoirs of bioactive substances. The purpose of the present study was to isolate endophytic bacteria and evaluate the exometabolic crude ethyl acetate extract against MDRBPs in vitro and in vivo, study their effects on cancer cells and wound recovery, and elucidate some mechanisms supporting their efficacy. In our study, a bacterium was isolated from Sp.inacia oleracea and identified as a Bacillus isolate closely related to Bacillus amyloliquefaciens and deposited in GenBank as PX736878. The exometabolic crude ethyl acetate of Bacillus sp. exhibited a strong antibacterial activity against MDRBPs, and the highest activity was against Klebsiella pneumoniae (21.2 mm). The MIC values showed its efficacy, particularly at 500 µg/ml. The extract also exhibited significant anti-biofilm activity sp.ecifically against K. pneumoniae. The cytotoxicity assays showed a selective toxicity of Bacillus sp. extract against the cancer cell lines (HCT116 and MCF7). In vivo, significant wound healing potential of the exometabolic crude ethyl acetate of Bacillus sp. was demonstrated by histological evidence of near-normal tissue regeneration. The strong activities exometabolic crude ethyl acetate of Bacillus sp. were due to the high antioxidant capacity. GC-MS analysis further supported our results and identified diverse bioactive compounds in the exometabolic crude ethyl acetate of Bacillus sp., including Diketopyrazine, fatty acids, and dipeptides. In conclusion, the extract of exometabolic crude ethyl acetate extract of Bacillus sp. is a promising multifunctional agent with strong antibacterial, anti-biofilm, antioxidant, and anticancer properties. This could be a new way to fight MDRBPs and aid damaged tissue to heal.

PMID 42934348
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PubMedAntioxidants (Basel, Switzerland)2026-10-27

Serum and Plasma Zinc and Copper Levels in Oral Leukoplakia: A Systematic Review and Meta-Analysis.

Wiśniewski Patryk P, Stępniewska Monika M, Melion Piotr P, Poloczek Zuzanna Z et al.

Oral leukoplakia (OL) is a common oral potentially malignant disorder in which oxidative imbalance and altered trace-element homeostasis may contribute to pathogenesis. This systematic review and meta-analysis evaluated serum/plasma zinc and copper concentrations in patients with OL versus healthy controls. Following PRISMA and Cochrane recommendations (PROSPERO: CDR420261427977), PubMed, Scopus, Web of Science, and Cochrane were searched for observational studies comparing circulating zinc and/or copper levels in OL and controls. Study quality was assessed using the Newcastle-Ottawa Scale and certainty of evidence using GRADE. Hedges' g with 95% confidence intervals (CIs) was pooled. Ten studies including 495 participants were analyzed. Zinc concentrations were significantly lower in OL (8 studies; 431 participants; g = -1.84, 95% CI: -3.25 to -0.43; p = 0.01; I2 = 96.85%), whereas copper concentrations were significantly higher (9 studies; 449 participants; g = 1.20, 95% CI: 0.70-1.70; p < 0.001; I2 = 81.90%). Sensitivity analyses confirmed the direction of both associations. Certainty of evidence was very low. Patients with OL showed lower circulating zinc and higher copper concentrations than healthy controls. Given the substantial heterogeneity and very low certainty of evidence, these findings should be interpreted as group-level differences only and do not establish a specific metabolic, pathogenic, causal, or diagnostic role of Zn or Cu in OL.

PMID 42939886
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