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Purethal Mites (Purethal Mites)

✓ Approved

HAL Allergy Group · 治疗药物

什么是 Purethal Mites？

Purethal Mites 是一种治疗药物，由HAL Allergy Group研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Purethal Mites
公司HAL Allergy Group
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, HAL Allergy Group

治疗适应症

Purethal Mites 针对 3 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersAllergy to animal✓ Approved
Eye disordersConjunctivitis allergic✓ Approved

相关研究文献

PubMedInternational journal for parasitology. Parasites and wildlife2026-10-25

First record of water Mite (Arrenurus spp.) ectoparasitism on dragonflies (Odonata: Anisoptera) in Bangladesh.

Rahman Khondoker Md Zulfiker KMZ, Akter Farjana F, Mia Md Shohag MS

Water mites, as ectoparasites, are known to significantly impact the flight behavior, fitness, and reproductive success of their aquatic insect hosts. Although water mite infestations on dragonflies have been documented globally, the ectoparasitic relationship between dragonflies and water mites has remained completely unexplored in Bangladesh. Therefore, for the first time in Bangladesh, this study investigated the prevalence, intensity, host selection, sex bias, and site specificity of larval water mite infestation in dragonflies in a semi-urban lentic ecosystem on the Jahangirnagar University campus, Bangladesh, from June 2023 to April 2024. During the study period, 2627 dragonfly individuals from 20 species were checked for the presence of water mite larvae; 318 individuals from 6 species were found infested, yielding an infestation prevalence of 12.11%. All the larvae were identified as a single genus, Arrenurus sp. Among the infested dragonflies, the highest of 35.60% prevalence was exhibited by C. servilia, and the highest mean parasitic intensity was recorded in A. panorpoides (13.75 mites/host). Most of the mite larvae (83.51%) were attached ventrally to the thoracic segments, whereas the ventral surface of the abdomen and wings harboured 16.44% and 0.05% mite larvae, respectively. Besides, a female-biased infestation trend was observed, with overall parasitic intensity of 13.18 and 11.62 in female and male dragonflies, respectively. The findings of this study indicate that dragonflies in the sampling area are actively parasitized by Arrenurus water mite larvae, thereby providing nutrition and dispersal for these ectoparasites in freshwater ecosystems of Bangladesh. These preliminary results reveal a previously unexplored expansion in the geographic range of ectoparasitic interactions between Arrenurus water mite larvae and Odonata and warrant the need for additional research into the potential long-term fitness implications of these ectoparasites for tropical dragonfly populations.

PMID 42926857
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PubMedJournal of natural products2026-10-23

Enzymatic Hydrogen Cyanide Release from Mandelonitrile Esters in Oribatid Mites.

Moriyama Daisuke D, Takahara Chihiro C, Shimano Satoshi S, Shimizu Nobuhiro N

Arthropods use chemical defenses against predators by releasing toxic or repellent compounds from specialized exocrine glands. Oribatulid mites (Oribatida: Oribatulidae) contain mandelonitrile hexanoate (MNH); when they are subjected to physical stimuli, MNH decomposes to release hydrogen cyanide (HCN), suggesting that cyanogenesis is an effective defense strategy in these mites. However, the underlying process remains unclear. Here, we investigated the defensive secretions of the oribatid mites, Phauloppia adjecta and Oribatula sakamorii, and identified MNH and mandelonitrile octanoate (MNO), along with the sesquiterpenes β-selinene and calarene. Chiral gas chromatography analysis determined the absolute configurations of MNH and MNO as the (R)-isomers, consistent with the configuration of mandelonitrilea known defensive compound in polydesmid millipedes. (R)-MNO did not undergo spontaneous hydrolysis in water at pH 3-8, suggesting that a mite-derived enzyme is required for HCN production. In vitro experiments showed that a crude mite enzyme extract incubated with (R)-MNO generated over 200 nmol of HCN, whereas negligible production occurred in the controls. These findings support an enzyme-dependent cyanogenic defense mechanism wherein mandelonitrile esters stored in the oil glands release HCN upon enzyme interaction during disturbance, potentially protecting conspecifics from predation.

PMID 42913393
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PubMedPlant physiology2026-10-23

MITE insertions generate enhancers for iron transporter CwIRT1 activation in citrus.

Zhou Xingxing X, Liu Shengjun S, Fan Zhengyan Z, Peng Jiaxuan J et al.

Iron (Fe) deficiency constrains citrus productivity in alkaline soils. Although the high-affinity Fe transporter IRT1 is essential for Fe acquisition, its transcriptional regulation in citrus remains unclear. Here, we reveal that differential tolerance to Fe deficiency between Fe-sensitive Poncirus trifoliata (P. trifoliata) and Fe-tolerant Citrus wilsonii Tanaka (C. wilsonii) is linked to rapid induction of CwIRT1. We further identify two unique miniature inverted-repeat transposable elements (MITE1 and MITE2) in the promoter region of CwIRT1, which act as Fe-deficiency-responsive enhancers. These two MITEs respectively generate binding sites for the transcription factors CwERF12 and CwARF12, both of which are upregulated under low-Fe conditions. CRISPR/Cas9-mediated dual knockout of CwERF12 and CwARF12, but not single mutations, suppresses CwIRT1 expression and reduces root Fe uptake. We propose that MITEs carrying TF-binding motifs can serve as enhancers recruiting stress-responsive transcription factors to activate CwIRT1, highlighting transposable element-mediated cis-regulatory as a driver of nutrient stress adaptation in perennial crops.

PMID 42913484
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PubMedJournal of invertebrate pathology2026-10-23

The honey bee mite Tropilaelaps mercedesae can feed on paper wasp brood: Preliminary laboratory evidence.

Gill Maggie C MC, Medwell Jane J, Janashia Irakli I

Tropilaelaps mercedesae is an emerging parasite of honey bees, but how do Tropilaelaps mites survive on native hosts when these bees swarm and abscond? Although occasional associations with non-Apis hymenopterans have been reported, they have never been tested experimentally. We exposed larvae of the bumble bee Bombus terrestris and the paper wasp Polistes dominula (n = 10 per species) to five adult female T. mercedesae each and monitored mite survival for up to 120 h. Live mites were recorded for up to 108 h on P. dominula and 36 h on B. terrestris, and mite survival was longer on P. dominula (larva-level hazard ratio = 0.44, 95% CI: 0.25-0.79). No feeding-associated lesions were detected on B. terrestris larvae or the unexposed controls, whereas feeding-associated lesions were found on all ten exposed P. dominula larvae (2-39 per larva) and on the pupal cuticle of one individual after larval-pupal metamorphosis. These findings provide the first experimental evidence that T. mercedesae can feed on P. dominula brood under laboratory conditions. These results suggest that transient interactions with non-Apis hymenopterans deserve further investigation, particularly in relation to the persistence and reinfestation dynamics of Tropilaelaps populations associated with migratory Apis dorsata.

PMID 42914072
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PubMedJournal of microbiological methods2026-10-23

Epidemiological modeling and optimal intervention strategies for seasonal scrub typhus infection in human population mediated by mites and rodents.

Kashyap Tarun T, Kumar Rakesh R

Scrub typhus is a re-emerging vector-borne disease of significant public health concern, particularly in endemic regions where seasonal factors strongly influence transmission dynamics. Individuals engaged in agricultural and field-based activities are particularly vulnerable to increased exposure to infected mites, especially during the monsoon season, thereby underscoring the importance of adopting appropriate preventive measures to reduce transmission risk. Motivated by this, we developed a mathematical model with optimal control to describe the transmission dynamics of scrub typhus in humans, incorporating a seasonally varying transmission rate in the human population. The proposed model ensures positivity and boundedness of solutions, with disease persistence characterized by the basic reproduction number and equilibrium stability examined analytically. The scrub typhus incidence data from Mizoram, India, spanning January 2021 to December 2022 is utilized for data fitting and estimation. It is found that the proposed full model outperforms the sub-models in terms of goodness-of-fit statistics, with AIC (234.71), AICc (251.63), and BIC (246.49) and Akaike weight (0.84505), thereby providing stronger support for its selection. It is found that scrub typhus infection dynamics are highly sensitive to the β2 and β3 transmission rates, where the infection peak is observed during the monsoon season. This study may provide valuable information to guide policymakers in implementing evidence-based approaches for the prevention and control of scrub typhus infection.

PMID 42918311
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PubMedFood chemistry2026-10-23

Ultrasound-assisted glycation reduces the IgE cross-reactivity of yellow mealworm protein with conformational modification.

Wang Jian J, Tang Jingqi J, He Jian J, Yang Zhaowei Z et al.

Edible insects, particularly yellow mealworm (Tenebrio molitor) protein (YMP), are promising sustainable protein sources, yet their cross-reactivity with allergens from other arthropods (e.g., crustaceans and house dust mites) raises safety concerns. This study investigated the effects of ultrasound-assisted glycation with xylo-oligosaccharides (XOS) on the IgE reactivity and conformational structures of YMP. Using serum pools from crustacean-allergic, dust mite-allergic, and co-allergic individuals, we showed that ultrasound-assisted glycation reduced the cross-reactive IgE-binding capacity of YMP by up to 53.9% and suppressed basophilic degranulation, with glycation as the main contributor and ultrasound providing an additional benefit in the crustacean-allergic pool. Structural analyses showed modest secondary structure changes, including increased α-helix and decreased random coil contents, and reduced surface hydrophobicity. Correlation analysis indicated these parameters were associated with IgE binding. Collectively, ultrasound-assisted glycation reduced YMP IgE cross-reactivity, possibly through conformational changes altering epitope accessibility, offering preliminary insights for insect protein ingredients with reduced allergenicity.

PMID 42914865
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