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snake venom antibody-2 (ViperaTAb)

✓ Approved

MicroPharm · 多克隆抗体 · 多克隆抗体

什么是 snake venom antibody-2？

snake venom antibody-2 是一种多克隆抗体，由MicroPharm研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名ViperaTAb
公司MicroPharm
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, MicroPharm

治疗适应症

snake venom antibody-2 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsVenom poisoning✓ Approved

相关研究文献

PubMedJournal of immunological methods2026-07-27

An in vitro efficacy analysis of bothropic antivenom against venoms of different Bothrops species.

Silva Lucas Tadeu LT, Heneine Luiz Guilherme Dias LGD, de Oliveira Luciana Souza LS, Guerra-Duarte Clara C et al.

Antivenoms are the only specific medications available for the treatment of snakebite envenomation, which represents an important global public health concern. The success of treatment depends, in part, on the ability of the antivenom used to bind to and neutralize the toxins present in the venom. To achieve this efficacy, it is important that the immunizing venom pool be representative of the snake fauna to be covered, which is challenging given the inter- and intraspecific variability among snake venoms. In Brazil, snakes of the genus Bothrops are responsible for most snakebite accidents, and the antivenom used in the country is produced from a pool of five different Bothrops venoms (B. jararaca, B. jararacussu, B. alternatus, B. moojeni, and B. neuwiedi). However, quality control of antivenom efficacy during the production process was carried out exclusively against B. jararaca venom. Thus, the aim of this study was to develop and standardize an avidity ELISA for the analysis of serum samples obtained from horses immunized with the Bothrops venom pool against the different venoms that comprise this pool, also including B. atrox venom, as an auxiliary tool for evaluating antivenom efficacy. The avidity ELISA revealed variations in avidity both among the four batches of equine serum samples analyzed (inter-batch variation) and among the six Bothrops venoms included in the study (intra-batch variation).The avidity ELISA showed good applicability for Bothrops venoms and good intra- and inter-plate repeatability, suggesting the potential of this assay for implementation in preliminary efficacy evaluations of Bothrops antivenom production.

PMID 42503390
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PubMedToxins2026-07-27

Post-Mortem Effects as a Variation Factor in Lachesis muta Venom.

Tavares Mariana Silva MS, Moitas Melissa Inácio MI, Serino-Silva Caroline C, Sant'Anna Savio Stefanini SS et al.

Snakebite incidents could occur even with deceased animals due to improper animal manipulation, since the venom may retain biochemical activity. However, it is unclear what alterations death may cause in snake venom, because even in well-preserved genera, such as Lachesis, venom is susceptible to variation due to several factors. Therefore, the purpose of this research is to compare Lachesis muta venom characteristics before and after its death. The investigation encompasses protein profile analyses, immune recognition by antivenom, and enzymatic and biological activities. Venom samples were collected from the same individual at three distinct time points: two samples while the specimen was alive and a sample post-mortem. In RP-HPLC, a shift in peak intensity was observed in the peptide and protease elution regions. The post-mortem sample presented more PLA2 and LAAO enzymatic activities and a decrease in the coagulation capacity. All samples were well immuno-recognized by anti-Bothrops/Lachesis serum. Data suggest that L. muta venom maintains its functional and immunological integrity throughout senescence and following the animal's death. The preservation of its biochemical properties supports the clinical relevance of accidents involving dead snakes and justifies the inclusion of such venoms in antivenom manufacturing protocols, providing a strategic alternative during supply shortages.

PMID 42506708
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PubMedToxins2026-07-27

Integrated Venom Gland Transcriptomic and Venom Proteomic Analyses of the Digger Wasp Cerceris japonica.

Kazuma Kohei K, Tani Naoki N, Konno Katsuhiro K, Kawaguchi Migaku M et al.

Digger wasps are solitary apoid wasps that excavate ground nests and use venom to paralyze insect prey. Recent phylogenetic analyses suggest that digger wasps belong to an ancient lineage of aculeate Hymenoptera and share an evolutionary ancestry with other venomous hymenopterans, including bees and ants. Although the venoms of ants, bees, and social wasps have been extensively studied, those of digger wasps remain poorly characterized in terms of their composition, molecular diversity, and biological activity. In this study, we investigated the venom of the digger wasp Cerceris japonica using integrated transcriptomic and proteomic analyses. We identified 19 toxin-like proteins and peptides, 14 non-toxin-associated components, and 11 novel peptides and proteins with no detectable similarity to known peptides and proteins. Among these, peptide Cj 2 exhibited insecticidal activity but showed no antimicrobial, hemolytic, or nicotinic acetylcholine receptor-modulating activities. These findings provide new insights into the molecular diversity and biological activities of digger wasp venom, expand our understanding of venom evolution in venomous hymenopterans, and serve as a framework for elucidating the conserved and lineage-specific features of hymenopteran venoms.

PMID 42506727
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PubMedJournal of arthropod-borne diseases2026-07-27

Evaluation of the Cytotoxic Effects of Odontobuthus doriae Crude Venom on the MCF-7 Breast Cancer Cell Line.

Tashakori Ghazal G, Mohammadpour-Dounighi Nasser N, Akhavan Amir Ahmad AA, Basseri Hamid Reza HR et al.

Scorpion venom is a complex mixture containing toxic peptides, free amino acids, enzymes, nucleotides, lipids, amines, mucoproteins and other bioactive components. It has been reported to exhibit a range of medicinal properties, including anticancer, antithrombotic, anticoagulant, fibrinolytic, analgesic, antitumor and antiepileptic effects. This study aimed to evaluate the anticancer effects of crude venom from Odontobuthus doriae on the Michigan Cancer Foundation-7 (MCf-7) breast cancer cell line. 2×104 MCF-7 cancer cells were cultured in T25 flasks containing Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin. After overnight incubation, the culture medium was replaced with different concentrations of crude venom (0.2, 0.48, 0.97, 1.95, 3.9, 7.81, 15.62, 31.25, 62.5, 125, 250, 500 μg/mL). The cytotoxic effects were assessed using the MTT reduction assay at 24, 48 and 72 hours post-treatment, performed in triplicate. Absorbance was measured at 570 nm using an ELISA reader. A concentration-dependent decrease in cell viability was observed. A statistically significant difference in cytotoxicity was observed between the 24 hour and the 48/72-hour treatments, while no significant difference was noted between the 48 and 72 hour time points. The IC50 values were calculated to be 4.775 μg/mL (24 h), 31.87 μg/mL (48 h), and 3.543 μg/mL (72 h). The crude venom of O. doriae exhibits significant cytotoxic effects against MCF-7 breast cancer cells in a dose- and time-dependent manner, suggesting its potential as a natural anticancer agent.

PMID 42504180
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PubMedToxins2026-07-27

Animal Venoms Targeting Cellular Mechanisms: Advances and Implications for Drug Discovery and Disease Therapy.

Mathai Lucienne L, Nair Bipin G BG, Alangode Aswathy A

Animal venoms are complex biochemical systems composed of proteins, peptides, and small molecules with bioactivity. Traditionally regarded as toxic agents, venom components are increasingly recognized as valuable molecular libraries that can modulate cellular processes in human disease pathophysiology. This review highlights the translational potential of venom-derived molecules, with emphasis on clinically approved venom-derived drugs such as captopril, while also discussing their therapeutic potential for diseases such as cancer, autoimmunity, cardiovascular diseases, chronic pain, neuropsychiatric disorders, and infectious diseases. Special emphasis is given to the mechanisms by which these toxins modulate ion channels, enzymes, and receptor systems. Recent advances in venomics, harnessing proteomics, transcriptomics, and high-throughput screening, are also discussed, which can accelerate the clinical translation of venom-derived therapeutics. Key challenges related to assessing the immunogenicity of the venom-derived compounds, bioavailability, and safety have also been addressed alongside emerging strategies to overcome them. Collectively, these advances can provide a logical framework for developing novel therapeutics, bridging the gap between toxinology and drug discovery.

PMID 42506706
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PubMedToxins2026-07-27

Enhanced Protection Against Toxicity of Nemopilema nomurai Venom Using a PEG-EGCG/Tetracycline Hydrochloride Micellar Nanocomplex.

Li Jie J, Hu Yanan Y, Qian Yunfeng Y, Luo Sai S et al.

Jellyfish stings are the most common type of marine life injuries. However, at present, the treatment measures against jellyfish stings are mostly empirical and supportive, with uncertain therapeutic outcomes, and there is a lack of specific antidotes based on the toxic mechanism of jellyfish venom in clinical practice. In our previous study, polyphenol epigallocatechin-3-gallate (EGCG) was found to neutralize the toxicity of jellyfish Nemopilema nomurai venom (NnV) in vivo and in vitro. Herein we further demonstrated that EGCG exerted its antagonistic effect against NnV through inhibiting the oxidative stress, pro-apoptotic proteins, and systemic inflammatory responses. Subsequently, we constructed a polyethylene glycol (PEG)-EGCG/tetracycline hydrochloride (HTC) co-loaded micellar nanocomplex in order to enhance the stability and bioavailability of EGCG in vivo, which successfully integrated the membrane-repair function of PEG, the enzyme inhibitory effect of HTC and the antioxidant properties of EGCG. Notably, this micellar nanocomplex demonstrated significant protective effects against both functional damage and pathological alterations in a non-lethal NnV-envenomed mouse model. When administered 1 h after NnV envenomation, EGCG (40 mg/kg), HTC and PEG-EGCG (containing 40 mg/kg EGCG) only partially improved abnormal blood biochemical indicators and moderately alleviated histopathologic damage, and PEG-EGCG/HTC containing merely 8 mg/kg EGCG completely mitigated the toxic reactions in envenomed mice. In the preventive regimen, the administration of EGCG, HTC or PEG-EGCG 30 min before exposure showed no significant improvement in abnormal blood biochemical indicators and histopathologic damage, while PEG-EGCG/HTC could still significantly improve the functional impairments and histopathologic damage of the heart and liver in NnV-envenomed mice. These findings suggest the clinical translational potential of PEG-EGCG/HTC against jellyfish envenomation.

PMID 42506698
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