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superoxide dismutase (orgotein, Isnardi / Interceptor / SOD, Isnardi)

✓ Approved

Sanofi S.A · 治疗药物

什么是 superoxide dismutase？

superoxide dismutase 是一种治疗药物，由Sanofi S.A研发。该药已获批，用于治疗相关适应症。

药物档案

商品名orgotein, Isnardi, Interceptor, SOD, Isnardi
公司Sanofi S.A
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

治疗适应症

superoxide dismutase 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Eye disordersGlaucoma✓ Approved
Hepatobiliary disordersHepatitis✓ Approved
Skin and subcutaneous tissue disordersSkin disorder✓ Approved
Skin and subcutaneous tissue disordersDermatosis✓ Approved

相关研究文献

PubMedPlant growth regulation2026-10-26

Panicum virgatum L. salt tolerance improved by inoculation with multi-stress tolerant Bacillus.

Lachhab Assia A, Whalen Joann K JK

Soil salinity is a key limiting factor for agricultural production, even for moderately salt-tolerant crops such as switchgrass (Panicum virgatum L.). We hypothesized that switchgrass resistance to salt stress will increase when seeds are inoculated with bacteria that support plant physiological (antioxidant enzymes, proline) and morphological (root system architecture) adaptations in salt-affected soil. In this study, we inoculated switchgrass seed with multi-stress tolerant bacteria, either Bacillus velezensis H1B18 or Bacillus mojavensis H1B5, and grew the seed in salt-affected soils with electrical conductivity from 0.5 to 9.8 dS m⁻¹. Compared to uninoculated switchgrass, plants inoculated with Bacillus strains had greater superoxide dismutase and catalase enzyme activities, which counteract oxidative stress, and accumulated 22-271% more proline after 4 wk. Furthermore, switchgrass inoculated with Bacillus maintained its root system architecture (root total length, surface area, and volume) as the soil salinity increased. This produced taller plants with more above-ground biomass. For example, the B. velezensis H1B18-inoculated switchgrass was 54-161% taller and had 3.3-7.4 times more shoot biomass than the uninoculated switchgrass. Overall, switchgrass resistance to salt stress was improved by multi-stress tolerant Bacillus that promoted plant growth, physiological and morphological traits in salt-affected soils. The online version contains supplementary material available at https://doi.org/10.1007/s10725-026-01530-8.

PMID 42928718
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PubMedInternational journal of fertility & sterility2026-10-26

Role of Crocin and Mesenchymal Stem Cells Combined Therapy in Reducing Testicular Ischemia-Reperfusion Injury in Rats.

Boostani Saman S, Asghari Ahmad A, Esmaeili Gouvarchin Ghaleh Hadi H, Tajik Parviz P

Testicular torsion is a urological emergency that obstructs blood flow and causes ischemic damage, potentially leading to infertility or orchiectomy. This study aimed to evaluate the combined effects of mesenchymal stem cells (MSCs) and crocin on testicular ischemia-reperfusion (I/R) injury in rats. In this experimental study, 50 adults male Wistar rats were randomly divided into five groups: sham-operated (no ischemia or treatment), ischemia only, crocin-treated, MSC-treated, and combined crocin and MSCs. Testicular ischemia was induced by rotating the left testis for three hours, followed by reperfusion. Crocin (100 mg/kg) was administered intraperitoneally, and MSCs (3×10⁴ cells) were administered intraperitoneally. After 21 days of reperfusion, histological evaluation, using the Johnsen spermatogenesis scoring system, and assessment of oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS)] were performed. Combination therapy significantly improved the Johnsen score compared to the ischemia-only group (P<0.05) indicating enhanced spermatogenesis. MDA levels were significantly reduced, while antioxidant enzyme activities (SOD, GPx and TAS) were significantly increased in the combined treatment group compared to the untreated ischemic group (P<0.05). Each of crocin and MSCs individually exerted protective effects; however, the combined treatment showed a more pronounced overall improvement in testicular structure and oxidative status. Co-administration of MSCs and crocin effectively attenuated testicular I/R injury in rats by improving spermatogenesis and antioxidant defense, suggesting potential therapeutic value for reducing testicular torsion-related damage.

PMID 42929013
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PubMedShock (Augusta, Ga.)2026-10-26

Preliminary Exploration of the Hepatoprotective Effect of Nanocrystalline Curcumin Against Traumatic Hemorrhagic Shock-Induced Liver Injury in a Desert Dry-Heat Environment: A Network Pharmacology-Based Study.

Chen Changxu C, Shen Caifu C, Shi Chuankai C, Zhou Enning E et al.

Traumatic hemorrhagic shock (THS) under desert dry-heat conditions can exacerbate secondary liver injury, highlighting the need for effective therapeutic interventions. This study investigated the protective effects of nanocrystalline curcumin (NC-Cur) against THS-induced liver injury in a desert dry-heat environment and explored its potential molecular mechanisms. Network pharmacology, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, and protein-protein interaction network analysis were used to identify candidate targets. Molecular docking and molecular dynamics simulations examined curcumin-protein interactions. Forty male Sprague-Dawley rats were randomly assigned to control, model, solvent, or NC-Cur treatment groups (n = 10 each). The model, solvent, and treatment groups underwent traumatic hemorrhagic shock under desert dry-heat conditions. Hepatic injury was assessed by histopathology, serum aminotransferases, inflammatory cytokines, oxidative stress markers, and Western blotting. Network analysis identified 116 overlapping targets, with heat shock protein 90 alpha A1 (HSP90AA1), AKT serine/threonine kinase 1 (AKT1), and B-cell lymphoma 2 (BCL-2) prioritized as the core targets. Docking predicted favorable interactions with all three proteins, while molecular dynamics simulations supported stable binding between curcumin and HSP90AA1. Compared with untreated model rats, NC-Cur-treated rats showed attenuated hepatic histopathological injury, reduced alanine and aspartate aminotransferases, tumor necrosis factor-α, interleukin-1β, and malondialdehyde, and increased superoxide dismutase. Western blotting indicated reduced HSP90AA1 and increased phosphorylated AKT1 expression after NC-Cur treatment, with changes also observed in BCL-2 expression. These findings suggest that NC-Cur may alleviate liver injury associated with THS under desert dry-heat conditions in male rats, potentially involving HSP90AA1-AKT1-BCL-2-related signaling.

PMID 42929369
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PubMedJournal of orthopaedic surgery (Hong Kong)2026-10-26

Effect of enhanced recovery after surgery (ERAS) nursing on postoperative outcomes in patients undergoing total knee arthroplasty.

Zhu Luling L, Song Xinwei X, Li Huijun H, Dou Ling L et al.

ObjectiveThis study aimed to evaluate the effects of enhanced recovery after surgery (ERAS) nursing on patients undergoing total knee arthroplasty (TKA) and its impact on knee joint scores.MethodsOne hundred patients who underwent TKA were randomly divided into an intervention group and a control group, with 50 patients in each group. The control group received routine nursing, while the intervention group received ERAS nursing. Postoperative rehabilitation indicators were compared between the two groups, including the time to first postoperative oral intake, first urination, first ambulation, straight-leg raising, and hospital stay. Two weeks after the intervention, both groups were evaluated using the American Knee Society Score (AKSS). Knee range of motion (ROM), Visual Analogue Scale (VAS) scores, superoxide dismutase (SOD) levels, inflammatory factor levels, Lysholm Knee Scoring Scale scores, Berg Balance Scale scores, time to achieve 90° of active knee flexion, AIMS2-SF scores, and nursing satisfaction were also assessed.ResultsThe intervention group had shorter times to first postoperative oral intake, urination, ambulation, straight-leg raising, and hospital stay compared with the control group (all P < 0.001). After the intervention, the intervention group showed higher AKSS and ROM scores, lower VAS scores, higher SOD levels, and lower IL-1β and TNF-α levels compared with the control group (P < 0.001). Additionally, the intervention group had better Lysholm Knee Scoring Scale scores (P < 0.001) and Berg Balance Scale scores (P < 0.001), a shorter time to achieve 90° of active knee flexion (P < 0.001), higher AIMS2-SF scores (P < 0.001), and greater nursing satisfaction (P = 0.020) compared with the control group.ConclusionERAS nursing was associated with improved short-term rehabilitation outcomes, better knee function, reduced pain, and higher patient satisfaction following TKA.

PMID 42929248
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PubMedJournal of tropical medicine2026-10-26

Green-Synthesized Silver Nanoparticles Improve Cognitive Function and Modulate Nrf2/HO-1-BDNF-Related Gene Expression in Experimental Chronic Toxoplasmosis.

Khaksarian Mojtaba M, Khalaf Amal Khudair AK, Shojaee Saeedeh S, Shakib Pegah P et al.

This study aimed to evaluate the neuroprotective effects of silver nanoparticles (AgNPs) green-synthesized using the ethanolic extract of Muscari neglectum against Toxoplasma gondii-induced cognitive impairment and to explore the underlying Nrf2/BDNF and oxidative stress-related mechanisms. Chronic toxoplasmosis was experimentally induced in mice using the Tehran strain of T. gondii. Forty-eight mice were randomly allocated into six experimental groups, including a noninfected control group, an infected untreated control group, and four treatment groups receiving pyrimethamine (PYM, 20 mg/kg), donepezil (DON, 2 mg/kg), AgNPs (10 mg/kg), or AgNPs (20 mg/kg). Spatial learning and memory capabilities were assessed using the Morris water maze test. Post-treatment, brain cyst number and size were determined via microscopic examination. Additionally, quantitative real-time PCR was employed to evaluate the expression levels of genes associated with oxidative stress and neuroprotection, including brain-derived neurotrophic factor (Bdnf), NADPH oxidase 2 (Nox2), superoxide dismutase 2 (Sod2), catalase (Cat), glutathione peroxidase 1 (Gpx1), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (Hmox1). Treatment with AgNP resulted in a significant, dose-dependent improvement in behavioral performance, evidenced by reduced escape latency and enhanced exploration of the target quadrant (p < 0.001). Moreover, AgNP administration markedly decreased both the number and size of brain Toxoplasma cysts, with the 20 mg/kg dose demonstrating superior efficacy compared to PYM (p < 0.01). Molecular analyses indicated significant upregulation of Nrf2, Hmox1, Bdnf, Sod2, Cat, and Gpx1, accompanied by downregulation of Nox2 expression in mice treated with AgNP (p < 0.001). These findings suggest that green-synthesized AgNP exert significant, dose-dependent antiparasitic and neuroprotective effects in the context of chronic toxoplasmosis. AgNP notably reduced brain cyst burden, enhanced spatial learning and memory, and normalized oxidative stress-related gene expression. Importantly, AgNP exhibited greater efficacy than both PYM and DON, indicating their potential as a promising therapeutic approach for neurotoxoplasmosis.

PMID 42928771
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PubMedCells2026-10-26

Dental Pulp Stem Cell-Derived Small Extracellular Vesicle miR-100-5p Attenuates Neuronal Oxidative Stress via Regulating the mTOR-Autophagy Signaling Axis.

Zhou Wenli W, Zhao Yanfang Y, Yang Fengtang F, Zhang Wensheng W et al.

Excessive accumulation of reactive oxygen species (ROS) in the brain and the resulting oxidative stress are core drivers of neurodegenerative processes. Human dental pulp stem cells (DPSCs) secrete small extracellular vesicles (sEVs) abundant in functional microRNAs, which possess prominent regenerative capacity. The present study investigated the neuroprotective effects of DPSC-derived sEVs (DPSC-sEVs) against oxidative injury in SH-SY5Y neuronal cells and elucidated the underlying molecular mechanisms. DPSC identity was confirmed via flow cytometric immunophenotyping and multipotent differentiation assays. sEVs were isolated from DPSC-conditioned medium and characterized by transmission electron microscopy, nanoparticle tracking analysis and detection of canonical exosomal markers (CD63, CD81, and TSG101). An in vitro model of neuronal oxidative stress was established using hydrogen peroxide (H2O2). Cell viability, apoptosis, intracellular ROS levels, and lactate dehydrogenase (LDH) release, as well as the levels/activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA), were assessed to evaluate the protective effects of sEVs. Candidate miRNAs in sEVs were screened by quantitative real-time PCR (qPCR). Direct binding of miR-100-5p to the 3' untranslated region (3'UTR) of mammalian target of rapamycin (mTOR) was verified via dual-luciferase reporter assay. Autophagic activity was evaluated by immunoblotting and immunofluorescence staining of LC3B/p62. Pretreatment with DPSC-sEVs significantly ameliorated H2O2-induced neuronal oxidative damage and apoptosis. Mechanistically, sEV miR-100-5p conferred neuroprotective and antioxidant properties by inhibiting mTOR signaling and activating autophagy in vitro. Blockade of miR-100-5p or pharmacological inhibition of autophagy by 3-methyladenine (3-MA) largely abolished these protective effects. In conclusion, DPSC-sEVs attenuate neuronal oxidative stress by reversing mTOR-mediated suppression of autophagy, and this protective effect is dependent on the function of miR-100-5p in SH-SY5Y cells. The miR-100-5p/mTOR/autophagy axis mediates the neuroprotective effects of DPSC-sEVs, representing a promising therapeutic candidate for oxidative stress-associated neurodegenerative diseases that merits further in vivo validation.

PMID 42929816
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