北京若生智能科技有限公司
Drug Database
TE

teriparatide (Xinfutai)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · 重组蛋白

什么是 teriparatide？

teriparatide 是一种重组蛋白，由Shenzhen Salubris Pharmaceuticals Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Xinfutai
公司Shenzhen Salubris Pharmaceuticals Co., Ltd.
药物类别重组蛋白
分子靶点PTH1R
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Shenzhen Salubris Pharmaceuticals Co., Ltd.

作用机制

分子靶点

teriparatide 作用于 1 个分子靶点：

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

teriparatide 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedBMC geriatrics2026-10-26

Long-term trends, age-period-cohort patterns, and future projections of incident stroke with comorbid hypertension and diabetes among older adults in Shenzhen, China: a population-based surveillance study.

Xu Ping P, Li Zhixue Z, Xu Ying Y, Hou Yunfeng Y et al.

Older adults with stroke frequently have coexisting hypertension and diabetes, a high-risk cardiometabolic profile that complicates prevention, long-term management, and health service planning. However, population-based evidence on the long-term incidence trajectory of stroke occurring with both conditions remains limited, particularly in rapidly urbanizing settings undergoing population ageing. This study examined long-term trends, age-period-cohort patterns, and future projections of incident stroke with comorbid hypertension and diabetes among older adults in Shenzhen, China. This population-based retrospective surveillance study used data from the Shenzhen Cardiovascular and Cerebrovascular Disease Registry System. Incident stroke events registered between 1 January 2004 and 31 December 2023 among adults aged ≥ 60 years were identified, and 40,128 events with comorbid hypertension and diabetes were included. Crude incidence rates (CIRs) and age-standardized incidence rates (ASIRs) were calculated. Joinpoint regression, age-period-cohort analysis, and Bayesian age-period-cohort modeling were used to assess temporal trends, estimate age, period, and cohort effects, and project incidence trends from 2024 to 2033. From 2004 to 2023, the number of incident stroke events with comorbid hypertension and diabetes increased from 314 to 3,336, and the ASIR rose from 141.12 per 100,000 in 2004 to 414.78 per 100,000 in 2023. Joinpoint regression showed overall increasing trends in CIR and ASIR across the study period, with average annual percent changes of 5.44% and 6.14%, respectively, while identifying a late-period decline after 2017. Incidence levels were generally higher in males than in females. Age-period-cohort analysis showed marked age effects, elevated period-related risks in recent periods, and increasing cohort effects across successive birth cohorts. Bayesian projections suggested that both CIR and ASIR may increase from 2024 to 2033, with larger projected increases in males. Among older adults in Shenzhen, the burden of stroke with comorbid hypertension and diabetes showed a long-term upward trajectory over the study period. Model-based projections suggested that the burden may increase from 2024 to 2033, particularly among males and older age groups. These findings provide population-level descriptive and projection evidence that may inform risk stratification and health service planning for ageing urban populations.

PMID 42928102
阅读全文 →
PubMedIranian journal of biotechnology2026-10-26

Peeled Cladodes of Opuntia ficus-indica as a Superior Plant-Based Culture Medium for Enhanced Microbial Cultivation.

Khaled Boufares B, Fatima Dahlia D, Badra Boubakeur B, Merah Othmane O

Conventional microbiological media often present drawbacks such as high costs, reliance on non-sustainable resources, and limitations in supporting diverse microbial species. This study addresses these challenges by exploring a novel plant-based culture medium. This study aimed to develop and evaluate two specific formulations of culture media from Opuntia ficus-indica: Medium A, using whole cladode powder, and Medium B, using peeled cladode powder. Two Opuntia-based culture media were formulated: Medium A from whole cladode powder and Medium B from peeled cladode powder. The organoleptic and chemical properties of each medium were determined. In vitro assays were conducted to evaluate the effect of these novel media on bacterial and fungal growth and survival. Medium B, formulated from peeled cladode powder, demonstrated significantly superior performance, supporting approximately 61% more bacterial colonies for E. coli and 57% more for S. aureus, along with 44% and 64% increases in fungal radial growth rates for Aspergillus niger and Fusarium oxysporum, respectively, compared to Medium A. The organoleptic properties and chemical composition of Medium B also met the standards for an effective plant-based culture medium. The findings indicate that the novel culture medium based on peeled cladode not only enhances microbial culturability but also holds strong potential as a sustainable, effective, and low-cost alternative for routine microbiological cultivation and biotechnology applications.

PMID 42928813
阅读全文 →
PubMedGels (Basel, Switzerland)2026-10-26

Turmeric-Loaded Type A Gelatin Hydrogels: In Vitro Assessment for Oral Wound Management Applications.

Gutierrez-Jimenez Yareth Idalia Ayerim YIA, Garcia-Contreras Rene R, Serrano-Diaz Paloma Netzayeli PN, Flores-Arriaga Juan Carlos JC et al.

Oral surgical wounds may benefit from local biomaterials capable of delivering bioactive compounds while remaining compatible with gingival cells. This study evaluated type A gelatin hydrogels containing turmeric powder (1.5, 3.1, or 12.5 mg per preparation) and a separate series prepared with a 25 mg/mL turmeric stock in dimethyl sulfoxide (DMSO). The hydrogels were assessed for macroscopic integrity, supernatant absorbance, MTT responses in human gingival fibroblasts (HGFs), prostaglandin E2 (PGE2), and exploratory microbial response against Staphylococcus aureus and Candida albicans. Powder-loaded matrices lost macroscopic integrity within approximately 45 min in PBS and 30 min in trypsin. Powder-loaded formulations generally produced MTT signals near control values, whereas several DMSO-stock formulations showed lower signals at later exposures. PGE2 did not show consistent dose-dependent suppression after normalization of the corresponding MTT-derived relative metabolic signal. Agar diffusion showed an approximate 2.4 mm clearance beyond the specimen edge against S. aureus for the 1.5 mg formulation and none against C. albicans; the gelatin control also showed visible clearance, and higher turmeric loadings did not produce measurable zones. Colony recovery decreased across the DMSO-stock formulations, but most plate counts were below the conventional countable range and were therefore interpreted descriptively. Overall, the findings provide an early in vitro characterization of rapidly disintegrating gelatin-turmeric hydrogels and identify matrix stability and assay limitations as major constraints that require further validation.

PMID 42929961
阅读全文 →
PubMedDentistry journal2026-10-26

Assessment of Air Polishing with Erythritol Powder on the Removal of Biofilm and Dental Calculus: An Ex Vivo Pilot Study.

Cobb Charles M CM, Harrel Stephen K SK, Zhao Donggao D

Background: Air polishing with erythritol powder has recently been promoted as a method for removing calculus and biofilm in periodontal pockets of up to 9 mm depth. This ex vivo study was conducted to determine the impact of erythritol air polishing, for various time periods, on subgingival calculus and associated biofilm. Methods: Specimens consisted of 33 extracted teeth. Test sites with visible calculus were circumscribed using a 4 mm trephine bur on the root surface of each specimen. Positive controls were treated with air-water spray only. Test site treatment consisted of air polishing with erythritol powder with a 14 µm particle size. Fifteen positive control and 15 test specimens were subdivided into 3 groups of 5 specimens each and treated for 5, 10 and 15 s, respectively. The remaining three specimens were untreated negative controls. All specimens were examined using SEM. Selected specimens were subjected to EDS analysis. Results: Calculus was observed in all specimens across all treatment groups. Bacteria embedded in calculus and the extracellular polymeric matrix were consistently present across treatment groups. Treatment duration was associated with a reduction in surface biofilm, but no duration of treatment eliminated calculus or deeply embedded bacteria. Conclusions: The results of this ex vivo pilot study suggest that erythritol air polishing of calculus-laden root surfaces does not completely remove subgingival calculus or calculus-embedded microbes. Following treatment, smear layers with embedded microbes were noted on 55% of specimens. The study results suggest that erythritol air polishing protocols, in a clinical setting, may still be dependent on subgingival scaling and root planning to achieve the traditional endpoints of periodontal therapy.

PMID 42930409
阅读全文 →
PubMedBiotech (Basel (Switzerland))2026-10-26

Pharmaceutical Residues in Human Urine from Patients Under Antiretroviral Regimens and Self-Reported Healthy Individuals Before and After Three Months' Storage: Implication for Agricultural Reuse in Pretoria, South Africa.

Lizbelt Mugivhisa Liziwe ML, Faith Baloyi Khanyi BK, Oladeji Oluwaseun Mary OM, Olatunji Olatunde Stephen OS et al.

Background/Objectives: Pharmaceutical residues in human urine have raised serious concerns about the safe reuse of urine in agriculture. The current study investigates and compares the concentrations of pharmaceuticals in urine samples collected from male patients undergoing active antiretroviral regimens and self-reported "healthy individuals" at a government hospital in Pretoria, South Africa, and determines how the residues changed during three months of ambient storage, which is the usual recommendation before use in agriculture. Methods: The urine samples were collected in a plastic bottle to prevent fecal contamination, and 15 targeted compounds were analyzed using solid-phase extraction and liquid chromatography-mass spectrometry. The linearity ranged from 0.9910 to 0.9999, 75.5% to 99.1% for recovery, and intra-day and inter-day precision were below 6%. The urine from each group was collected into one pooled sample and then analyzed both pre- and post-storage. Results: Thirteen pharmaceuticals were detected in urine from patients on regular medication before storage; in "healthy individuals", detections rose from eight to twelve after storage. Concentrations in the composite samples after storage were higher for some of the compounds but lower for others, including caffeine, nevirapine, prednisolone and 17α-ethinylestradiol. Metformin was highest overall at 1186.25 µg/L and remained at 806.68 µg/L after storage. The highest concentration for all the pharmaceuticals was reported for metformin, with a value of 1186.25 µg/L, occurring in the group of patients on a regular regimen. There could be a possibility that the rise can be attributed to the hydrolysis of conjugated metabolites during storage; however, no analysis of conjugates was carried out. Conclusions: This study shows the need for appropriate treatment of human urine prior to its reuse as fertilizer and echoes the importance of further research into human exposure pathways and effective pharmaceutical removal strategies.

PMID 42930069
阅读全文 →
PubMedBiosensors2026-10-26

Porous Transducers and Hybrid Recognition for Bulky Nitrosamine Impurities: Toward 3D-MXene-Aptamer Detection of Tricyclic NDSRIs.

Shah Tirath T, Patel Ankur A, Shah Jignesh J, Shah Darshil D

Pharmaceutical quality control faces an emerging problem with Tricyclic nitrosamine drug substance-related impurities (NDSRIs), for example, N-nitroso clozapine. The impurities preserve the compl ete structure of their parent active pharmaceutical ingredients, which consist of bulky lipophilic molecules with restricted conformational flexibility. The retention of bulky lipophilic structures from the parent active pharmaceutical ingredients in these impurities results in their complete overlap with other substances, which causes matrix ion suppression and weak ionization and unstable mass-spectrometric responses. The LC-MS/MS method functions as the official standard but its workflow requires excessive solvent use and produces complicated equipment systems, which prevent its use for routine ultra-trace monitoring. This narrative review analyzes hybrid electrochemical sensing technology to determine if it can solve the current problem by using tricyclic NDSRIs steric complexity as a functional benefit for detection purposes. The research combines data from nitrosamine detection with studies on porous 3D-printed electrodes, MXene electrochemistry, molecularly imprinted polymers, aptamer engineering and the computational systematic evolution of ligands by exponential enrichment (SELEX), molecularly imprinted polymer (MIP) and signal-off aptasensing. This review presents that planar electrodes create an unfavorable structure for bulky tricyclic analytes because they lead to surface obstruction and increased resistance during charge transfer. This review demonstrates that gyroid and TPMS-type porous scaffolds with a Ti3C2Tx MXene coating offer superior internal surface area, enhanced diffusion channels and accelerated electron movement. The dual MIP-aptamer system enables selective recognition by using MIP to perform shape-based target capture and specimen protection and aptamer to recognize specific molecular targets. The design process for aptamers includes E/Z nitrosamine isomer modeling, docking and molecular dynamics, and AI-based sequence selection methods, which form the core approach to targeting N-nitroso clozapine (N-CZN)-like proteins. This research outlines a new technique, which uses steric hindrance to block redox-probe entry, thus generating an electrical signal through current reduction. This review presents a fundamental operational model which supports the development of eco-friendly portable electrochemical devices to detect tricyclic NDSRIs with maximum sensitivity.

PMID 42930082
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多teriparatide