Daewoong Pharmaceutical · 小分子 · 小分子
deoxycholic acid 是一种小分子，由Daewoong Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。
| 商品名 | DWJ 211, DWJ211 |
| 公司 | Daewoong Pharmaceutical |
| 药物类别 | 小分子 |
| 给药途径 | Injectable (Others), Subcutaneous Injection |
| 状态 | Approved |
deoxycholic acid 针对 1 个适应症，涉及 1 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Surgical and medical procedures | Head and neck plastic surgery | ✓ Approved |
Li Xue-Qing XQ, Thelingwani Roslyn Stella RS, Bertilsson Leif L, Diczfalusy Ulf U et al.
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Liu Yuanchao Y, Hao Yufan Y, Hu Huiping H, Yong Tianqiao T et al.
Ganoderma leucocontextum, a fungus discovered by our group, is highly valued for its immune modulation and anti-tumor polysaccharides significantly. Thus, this research aims to select a substrate formulation to enhance its polysaccharides and reveal the underlying mechanism. Seven distinct substrate formulations, incorporating combinations of fruit-tree wood, bagasse, oak wood, and cottonseed hulls, were explored. Interesting, the fruiting bodies grown on GMTZ fruit-tree wood-bagasse formulation showed the highest polysaccharide content at 3.19 ± 0.56% (p < 0.01 or 0.05). Moreover, GMTZ efficiently channeled resources toward diterpenoids synthesis at the expense of flavonoid and most triterpenoid production. It also dramatically enhanced androgen synthesis, while showing no corresponding accumulation of storage lipids or certain hormone signals, reinforcing a specific metabolic commitment. Furthermore, PCA analysis of the metabolomics confirmed the profound impact of substrate formulations. Correlation analysis revealed that GMTZ promoted a growth-and-synthesis metabolic phenotype, which was characterized by metabolic signatures of supporting anabolism and cellular homeostasis. In contrast, formulations that induced the defense-and-stress phenotype were often rich in lignin, which diverted resources toward detoxification and stress responses and suppressed growth-oriented metabolite synthesis. Moreover, prostaglandin A1, deoxycholic acid, cucurbitacin E, and 1-hydroxy-2-naphthoic acid were found to be positively correlated with polysaccharide synthesis. In addition, networks for polysaccharide biosynthesis were mapped and it was proposed, accordingly, that prostaglandin A1-phosphoglucomutase may be a mechanism by which GMTZ enhances polysaccharides. This research provided a substrate formulation for elevating polysaccharides in G. leucocontextum.
Li Jie J, Li Mingyang M, Song Yan Y, Xu Zeyu Z et al.
The efficient industrial production of citric acid by A. niger requires overcoming the limitations of substrate uptake and citrate export on the citrate synthesis efficiency. This study addresses these obstacles using a transporter engineering strategy, modifying the endogenous high-affinity glucose transporter MstF and citrate exporter CexA. The "push-pull" strategy was used to improve citric acid production by increasing glucose import and citrate export. A single overexpression of mstF improved citric acid production, reaching 179.35 g/L in the H7 strain. However, cexA high expression impaired dense mycelium pellet formation and affected the expression of key genes, resulting in reduced citric acid production. For balancing intracellular accumulation and secretion of citrate, simultaneous overexpression of mstF and cexA increased citric acid production and efficiency. In a 30 L fermenter, strain A5 achieved a citric acid titer of 185.91 g/L, a productivity of 3.21 g/h/L, and a shortened fermentation cycle. Collectively, these results provide a reference for the industrial production of citric acid and other organic acids.
Çamkıran Volkan V, Us Gediz Doğay GD, Aksoy Eray E, Kılıç Şahhan Ş et al.
A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomography (CT) angiography and compared its diagnostic performance with serum uric acid. In this retrospective, single-center study, 258 adults who underwent coronary CT angiography between January 2023 and December 2024 were included. Coronary calcification was scored using the Agatston method by 2 cardiologists. Clinical, demographic, and laboratory data were collected. The uric acid index was calculated as Ln [triglycerides × uric acid × glucose/2]. Univariable and hierarchical multiple logistic regression analyses were performed. Seventy-one patients (27.5%) showed ≥50% stenosis. Those with stenosis were older and had higher Agatston scores, creatinine, uric acid, glucose, HbA1c, and lower high-density lipoprotein cholestrol (HDL-C). In the final multiple models adjusted for age, sex, creatinine and Agatston score, the uric acid index remained a strong independent predictor of ≥50% stenosis (odds ratio [OR] = 1.988, P = .019, 95% confidence interval [CI] = 1.117-3.538). The index demonstrated significant incremental predictive value over the base model, with a Net Reclassification Improvement (NRI) of 0.500 (P < .05) and an Integrated Discrimination Improvement (IDI) of 0.029. The area under the curve for the uric acid index (0.688) exceeded that of uric acid (0.664). In a real-world coronary CT angiography cohort, the composite uric acid index independently predicted significant coronary stenosis. Its incremental predictive value requires validation in larger, prospective studies.
Irwin Sophie S, Elliott Julie J, Li Fan F, Ruiz Paola P et al.
To examine associations between plasma bile acids, systemic and gut inflammation, and intestinal bile acid receptor expression in people with HIV (PWH). Retrospective case-control study using paired plasma and colorectal biopsy samples from adults with and without HIV. Samples from 31 PWH and 21 people without HIV (PWOH) were analyzed. Plasma bile acids were quantified by targeted liquid chromatography-mass spectrometry (LC-MS) and cytokines by multiplex assays. Bile acid receptors farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) were quantified in gut tissue by quantitative reverse-transcriptase (qRT)-PCR, and immunohistochemistry with digital image analysis to localize receptor expression. Intestinal inflammation was assessed by histopathology. Group comparisons, multivariable regression, and Pearson correlations were used to evaluate relationships among bile acids, inflammation, and receptor expression. Decreased levels of the primary bile acid chenodeoxycholic acid [P < 0.001, false discovery rate (FDR) = 0.002] as well as decreased levels of conjugated secondary bile acids glycochenodeoxycholic acid (P < 0.001, FDR=0.001), and taurochenodeoxycholic acid (P = 0.007, FDR = 0.02), and glycoursodeoxycholic acid (P = 0.008, FDR = 0.02) were observed in PWH. Antiretroviral therapy may also be a contributor to bile acid alterations with decreased glycodeoxycholic acid (P = 0.02, FDR = 0.19). There was no difference in FXR expression in the gut, but PWH had higher TGR5 expression (P < 0.001), which correlated with intestinal inflammation histopathology scores (r = 0.56, P = 0.004). PWH had decreased plasma primary and secondary bile acids. In addition, PWH had higher TGR5 expression in the gut, which correlated with intestinal inflammation. Reduced anti-inflammatory bile acid signaling may be one potential mechanism contributing to ongoing inflammation in HIV.
Zhang Weiyou W, Sun Yongpeng Y, Meng Xianghua X, Dou Rutong R
In conventional hydraulic fracturing of low-permeability sandstone reservoirs, polymer-gel leak-off creates low-permeability filter cakes that impair productivity. This study proposes a prepad acid fracturing technique using a fluoroboric acid (HBF4) pre-flush to dissolve gel residues and mineral fines. A fully coupled mathematical model integrates HBF4 hydrolysis kinetics, multi-mineral surface reactions, porosity-permeability evolution via the Panda-Lake model, and dynamic leak-off coefficient feedback. Simulations show HBF4 decreases monotonically along the fracture while HF peaks at 40-60 m from wellbore. Acid concentration in the leak-off zone decays exponentially, defining a gel-dissolution zone within 0.5 m of the fracture wall. Acid dissolution increases near-wall porosity to 12-15% and permeability to 2.5-3.5 mD (3- to 4-fold). The leak-off coefficient varies dynamically: high in the acid-dominated zone (1.5-2.2 × 10-3 m/√min) favoring gel dissolution, and low in the gel-dominated zone (≈0.8 × 10-3 m/√min) promoting fracture extension. Compared with conventional polymer gel fracturing, the proposed method achieves a 15.9% higher stimulation ratio and 22.5% higher productivity after 100 days, despite slightly shorter fractures. The core advantage is restoring leak-off zone permeability from 0.45 mD to 0.85 mD and increasing gel filter cake permeability from 8 × 10-4 mD to 0.1 mD, with an average relative error of 8.2% against experimental data. These findings provide theoretical guidance for optimizing prepad acid fracturing in gel-damaged low-permeability sandstones.
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