leptospirosis vaccine

✓ Approved

什么是 leptospirosis vaccine？

leptospirosis vaccine 是一种疫苗，由China National Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

公司	China National Pharmaceutical
药物类别	疫苗
给药途径	Injectable (Others)
状态	Approved

来源： ClinicalTrials.gov, China National Pharmaceutical

相关研究文献

PubMedCureus2026-09-10

At the Interface of Urban Exposure and Infection: A Classical Case of Leptospirosis in New York City.

Lopez Priscila P, De Oliveira Cox Bruna B, Schliep Tjark T

Leptospirosis is a zoonotic spirochetal infection transmitted through exposure to water or soil contaminated with animal urine, often associated with unsanitary living conditions and environmental exposure. Early recognition and prompt initiation of appropriate antimicrobial therapy are critical to prevent severe complications, including multiorgan failure and death. We present a case of a 43-year-old man from New York City (NYC) with alcohol use disorder who was experiencing homelessness and presented with bilateral lower extremity myalgias after sleeping outdoors on a soccer field while intoxicated several days prior. He was initially managed for sepsis of unknown origin with broad-spectrum antibiotics. Subsequent diagnostic testing confirmed leptospirosis, prompting de-escalation to targeted therapy with ceftriaxone. The patient improved clinically despite developing severe acute kidney injury and hyperbilirubinemia and was discharged to complete a course of doxycycline, with a favorable outcome.

PMID 42719684

阅读全文 →

PubMedFrontiers in immunology2026-09-10

A bivalent oral yeast vaccine displaying Nocardia seriolae FHA and LMBV MCP confers protection in largemouth bass (Micropterus salmoides).

Lu Jianfei J, Gu Boge B, Yu Pengzhen P, Chen Jiong J

Largemouth bass ranavirus (LMBV) and Nocardia seriolae are major pathogens affecting largemouth bass (Micropterus salmoides), causing significant economic losses. In this study, recombinant yeasts expressing the fibronectin-binding protein A (FHA) of N. seriolae or the major capsid protein (MCP) of LMBV were constructed using the yeast surface display (YSD) system. Based on these recombinant strains, a bivalent oral yeast-based vaccine was developed and its protective efficacy was systematically evaluated. Oral administration of the vaccine induced specific antibodies against FHA and MCP in serum, as well as increased the transcription levels of adaptive immune genes (IgM, IgT, MHC-II) and innate immune genes (IL-1β, TNF-α, IFN-1, Mx2) in the hindgut, liver, and spleen. Importantly, the bivalent oral vaccine provided significant protection against both pathogens in largemouth bass, with relative percent survival (RPS) values of 56.7% against N. seriolae and 63.3% against LMBV. Meanwhile, the oral vaccine reduced pathogen loads and alleviated histopathological lesions. In summary, these findings suggest that the bivalent oral vaccine developed in this study could serve as a promising strategy for controlling N. seriolae and LMBV infections in largemouth bass aquaculture.

PMID 42718698

阅读全文 →

PubMedMicrobiology resource announcements2026-09-10

Genomic characterization of the attenuated human cytomegalovirus strain TR-VAC developed for subviral particle vaccine production.

Schmidt Hanno H, Hewel Charlotte C, Büscher Nicole N, Linke Matthias M et al.

We report the complete genome sequence of the attenuated human cytomegalovirus strain TR-VAC, developed for subviral particle vaccine production. Oxford Nanopore duplex sequencing confirmed all engineered modifications, including UL130 repair, UL25 stop codons, ddFKBP insertion, GFP deletion, and retention of the bacterial artificial chromosome backbone, without large-scale structural rearrangements.

PMID 42720293

阅读全文 →

PubMedTropical doctor2026-09-10

Vaccine hesitancy in peripheral communities: Combating digital malpractice.

Siddiqui Gulnaz Fatima GF, Siddiqui Shahid Akhtar SA

PMID 42720454

阅读全文 →

PubMedCureus2026-09-10

Recurrent Mumps in a Fully Vaccinated Young Adult With a Prior Breakthrough Infection: A Case Report.

Ramadugu Rithika R, Pidikiti Chandra Varshini CV, Cordero Peña Alesha A, Almonte Angelis A et al.

Mumps is a vaccine-preventable viral disease that typically presents with parotid gland swelling and constitutional symptoms. Although widespread immunization has substantially reduced disease incidence, outbreaks continue to occur among vaccinated populations, raising concerns regarding waning immunity and vaccine failure. Recurrent mumps following both prior natural infection and complete vaccination is uncommon and remains infrequently reported. We describe a 21-year-old woman who presented with a four-day history of fever, malaise, myalgia, and progressive painful swelling of the left parotid gland associated with difficulty chewing and speaking. She had received two doses of measles-mumps-rubella (MMR) vaccine according to the national immunization schedule and had a documented history of mumps infection at nine years of age, occurring after she had already completed her two-dose MMR series (vaccine-breakthrough infection). Physical examination revealed tender unilateral parotid enlargement, cervical lymphadenopathy, and evidence of undernutrition with a body mass index of 16.7 kg/m². Laboratory evaluation demonstrated iron deficiency anemia. Further evaluation, including positive mumps RT-PCR and positive anti-mumps IgM serology, confirmed acute mumps infection, while investigations excluded alternative causes of parotid enlargement. The patient was managed conservatively with isolation, supportive care, nutritional supplementation, and symptomatic treatment, resulting in complete clinical recovery without complications. This case highlights that recurrent mumps can occur despite prior natural infection and complete MMR vaccination. Although waning immunity and host factors such as undernutrition may have contributed to susceptibility, a causal relationship cannot be established from a single case. Continued surveillance and awareness of breakthrough infections remain important, particularly in resource-limited settings.

PMID 42719503

阅读全文 →

PubMedFrontiers in public health2026-09-10

Correction: Economic evaluation of including the EV71 vaccine in the national immunization program: a modeling study in Guangxi, China.

He Quan Q, Liao Xiaoting X, Deng Linlin L, Su Zhengqin Z et al.

[This corrects the article DOI: 10.3389/fpubh.2026.1842766.].

PMID 42719227

阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

leptospirosis vaccine

什么是 leptospirosis vaccine？

药物档案

相关研究文献

At the Interface of Urban Exposure and Infection: A Classical Case of Leptospirosis in New York City.

A bivalent oral yeast vaccine displaying Nocardia seriolae FHA and LMBV MCP confers protection in largemouth bass (Micropterus salmoides).

Genomic characterization of the attenuated human cytomegalovirus strain TR-VAC developed for subviral particle vaccine production.

Vaccine hesitancy in peripheral communities: Combating digital malpractice.

Recurrent Mumps in a Fully Vaccinated Young Adult With a Prior Breakthrough Infection: A Case Report.

Correction: Economic evaluation of including the EV71 vaccine in the national immunization program: a modeling study in Guangxi, China.

了解更多leptospirosis vaccine