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vincristine sulfate

✓ Approved

Pierre Fabre S.A. · 小分子 · 小分子

什么是 vincristine sulfate？

vincristine sulfate 是一种小分子，由Pierre Fabre S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

公司Pierre Fabre S.A.
药物类别小分子
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Pierre Fabre S.A.

治疗适应症

vincristine sulfate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

相关研究文献

PubMedAntibodies (Basel, Switzerland)2026-10-26

Purification of Bioactive Natural Antibodies to PD-1 Known as Regulatory Rheumatoid Factor from Human Blood Plasma.

Menshikova Daria D, Terentiev Alexey A, Ivanov Pavel P, Cherednichenko Alexandr A et al.

Regulatory rheumatoid factor (regRF) is a recently discovered population of natural anti-idiotypic antibodies carrying a shared paratope specific to the PD-1 molecule. Normally, regRF exerts a cytotoxic effect on PD-1-expressing T lymphocytes, including autoreactive ones, thereby controlling their expansion. The specificity for PD-1 indentifies regRF as a promising therapeutic agent for suppressing autoimmune reactions via the PD-1 pathway. The aim of this study was to develop gentle methods for regRF isolation from healthy blood plasma, which would preserve the bioactivity of regRF. Ammonium sulfate precipitation was used for crude regRF purification. A search for suitable affinity sorbents was carried out. The purified regRF was tested for its bioactivity. Ammonium sulfate precipitation at 35% saturation, followed by extraction with 28% saturated ammonium sulfate solution, allowed the separation of regRF from a portion of non-target IgG and high-molecular-weight fibrinogen. RegRF showed high affinity for Cibacron Blue and no binding to Protein A. Sequential affinity chromatography on immobilized Cibacron Blue and Protein A enabled the purification of regRF from non-target immunoglobulins and low-molecular-weight fibrinogen. The purified regRF samples showed binding to PD-1 and reduced the PD-1+CD4+ T lymphocyte count in vitro. Thus, we have identified sorbents and conditions for the purification of biologically active regRF.

PMID 42930040
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PubMedGels (Basel, Switzerland)2026-10-26

Xanthan Gum/Lignin Double-Interpenetrating Network Cryogels: Preparation, Characterization, and Water Purification Performance.

Lazar Maria Marinela MM, Humelnicu Doina D, Raschip Irina Elena IE, Avram Raluca-Elena RE et al.

The development of multifunctional, bio-based materials capable of simultaneously addressing microbial contamination and inorganic pollutants is of increasing interest for sustainable water purification. In this study, xanthan gum (XG)/lignin(LN) double-interpenetrating network (DN) cryogels were prepared and investigated as porous, multifunctional materials for antimicrobial applications and water purification. The cryogel architecture combines the abundant oxygen-containing functional groups of XG and LN with an interconnected porous network generated under cryogenic conditions. The prepared networks were comprehensively characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), dynamic vapor sorption (DVS), swelling analysis, and uniaxial mechanical testing to evaluate their structural, morphological, physicochemical, and mechanical properties. Their Cu2+ sorption performance was subsequently assessed by atomic absorption spectroscopy (AAS), and the experimental equilibrium data were analyzed using the Langmuir, Freundlich, and Sips isotherm models. The single-network (SN) XG-based materials exhibited Cu2+ sorption capacities of 62.13-109.81 mg/g, whereas the DN cryogels showed higher capacities of 111.87-120.84 mg/g. The Sips model provided the best description of the equilibrium data, with (R2) values of 0.991-0.994 and substantially lower (χ2) values than the Langmuir and Freundlich models, indicating heterogeneous sorption sites with finite saturation capacity. Importantly, the Cu2+-loaded SN and DNs exhibited sorption efficiency toward sulfate ions, demonstrating their potential for sequential contaminant removal. Sulfate sorption capacities reached 694.53 mg/g for the SN.X2/Cu2+ composite and up to 812.53 mg/g for the DN.XL3/Cu2+ composite. In addition, the prepared materials demonstrated antimicrobial activity against two Gram-negative (Escherichia coli, Salmonella Typhimurium) and two Gram-positive (Staphylococcus aureus, Listeria monocytogenes) bacterial strains. The results demonstrate that XG/LN DN cryogels combine effective metal-ion and sulfate sorption with antimicrobial activity, providing promising bio-based platforms for water purification and potentially extending the functional lifetime of the material through sequential contaminant removal.

PMID 42929949
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PubMedCureus2026-10-26

CD20-Positive B-Cell Non-Hodgkin Lymphoma Associated With Recurrent Acute Pancreatitis, Bilateral Renal Lesions, and Retroperitoneal Lymphadenopathy.

Sarfraz Rehan R, Ledesma Leon Magnie L ML, Nabi Dunia D, Hernandez Carratala Laura L et al.

Acute pancreatitis is most often caused by gallstones, alcohol use, or hypertriglyceridemia, whereas malignancy is an uncommon association. We report a case of a 29-year-old woman with recurrent acute pancreatitis without a clearly dominant, identifiable cause. Although she reported intermittent heavy weekend alcohol use, recurrence after initial improvement, increasing lactate dehydrogenase (LDH), bilateral renal cortical lesions, and progressive retroperitoneal lymphadenopathy suggested a systemic process. Core biopsy of a retroperitoneal lymph node demonstrated a CD20-positive B-cell non-Hodgkin lymphoma with a Ki-67 proliferation index of up to 80%. Limited tissue and nondiagnostic flow cytometry prevented definitive subclassification; diffuse large B-cell lymphoma (DLBCL) remained in the differential diagnosis. One documented cycle of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was administered during a subsequent hospitalization, with short-term symptomatic, pancreatic enzyme, and renal improvement. The patient was subsequently lost to follow-up. This case emphasizes the importance of considering lymphoproliferative disease when recurrent pancreatitis is accompanied by progressive systemic imaging abnormalities.

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PubMedCells2026-10-26

LEDGF/p75 Mediates Chemoresistance in Leukemia in a Context Dependent Manner.

Akele Thatcher Zinabu TZ, Iglesias-Herrero Cecilia C, Van Belle Siska S, Pretto Samantha S et al.

Lens epithelium-derived growth factor p75 (LEDGF/p75), also known as PSIP1, is a chromatin-associated protein involved in transcriptional regulation, stress adaptation, and leukemia maintenance. In KMT2A-rearranged leukemia (KMT2A-r), LEDGF/p75 tethers KMT2A fusion complex to chromatin and is essential for leukemogenesis. However, its contribution to therapy resistance across different leukemic subtypes remains poorly defined. Here, we investigated the role of LEDGF/p75 in therapy response across leukemia models with diverse genetic backgrounds. We show that LEDGF/p75 depletion sensitizes KMT2A-r T cell acute lymphoblastic leukemia (T-ALL) cells to cytarabine, whereas depletion of LEDGF/p75 in KMT2A-r B cell acute lymphoblastic leukemia (B-ALL) cells protects against cytarabine-induced apoptosis, highlighting context-specific functions of LEDGF/p75. Notably, in chronic myeloid leukemia (CML) cells harboring BCR-ABL fusion, loss of LEDGF/p75 increases sensitivity to vincristine and BCR-ABL inhibitors. Mechanistically, transcriptomic and protein analysis revealed that LEDGF/p75 depletion in CML cells is associated with reduced JAK2-STAT5 signaling, upregulation of apoptotic transcriptional programs, and suppression of proliferation and drug resistance gene signatures. Together, these findings demonstrate a context-dependent role of LEDGF/p75 in leukemic therapy resistance and identify LEDGF/p75 as a therapeutic vulnerability that could be exploited to enhance treatment sensitivity in selected leukemic subtypes, including BCR-ABL-positive CML.

PMID 42929838
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PubMedGels (Basel, Switzerland)2026-10-26

Insights into the Protonation State and Counterion Interactions of Linear Polyethyleneimine Materials.

Byrne Agustín J AJ, Vladimir Daniel D, Garro-Linck Yamila Y, Copello Guillermo J GJ et al.

Polyethyleneimine (PEI) polymers are widely used in the synthesis of nanoparticles, hydrogels and composite materials for biotechnological and environmental applications. However, the solid-state structural organization of linear PEI (L-PEI) materials, and how it is influenced by molecular weight, protonation state and counterion type, have not yet been comprehensively studied. In this work, solid-state nuclear magnetic resonance (ss-NMR), X-ray powder diffraction (XRD), small-angle X-ray scattering (SAXS) and time-domain NMR (TD-NMR) experiments were combined with theoretical calculations to analyze the local chemical environments, crystalline and nanoscale organization, and molecular mobility of L-PEI materials with different molecular weights. The analyzed materials were the free base (PEI·FB), the hydrochloride (PEI·HCl), the trifluoroacetate (PEI·TFA), and the sulfate-containing forms of L-PEI (PEI·Na2SO4 and PEI·H2SO4), as well as an intermediate protonation state obtained by the heterogeneous treatment with HCl-saturated isopropanol. Proton, 13C or 15N ss-NMR studies evidenced different chemical environments associated with changes in protonation state and counterion identity. Furthermore, XRD and SAXS showed that these variables, together with molecular weight and sample preparation conditions, influenced the crystalline arrangement and characteristic nanoscale organization of the polymer chains. Moreover, TD-NMR revealed the presence of three dynamically distinct proton populations, assigned to rigid, interfacial, and mobile domains, whose relative contributions and relaxation behavior varied among the PEI materials. Finally, high-resolution magic-angle spinning (HRMAS) NMR experiments were used to study different PEI-gel materials and films as well as the crosslinking of protonated PEI and sulfate ions.

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PubMedDalton transactions (Cambridge, England : 2003)2026-10-26

Tailoring phase modifiers for selective uranium extraction: conventional and phosphate ores.

Gautier M M, Lin J J, Guerinoni E E, Daronnat L L et al.

Selective uranium extraction from sulfate and phosphate-based leachates remains challenging due to co-extraction of impurities such as Mo, Zr, and Fe, which limits process efficiency and economic viability. This study investigates how the nature and concentration of phase modifiers influence uranium selectivity across three mining systems: two conventional uranium ores and one phosphate-associated ore. U, Mo and Zr were quantified by ICP-OES, while Fe was analyzed by gamma-ray spectrometry. Results show that phase modifier effects on selectivity are highly system dependent. In AMEX-based sulfate systems, increasing EXXAL 10 enhances selectivity through systematic improvements in extraction performance: in Mine A, U/Zr increases from 50 to 221 at 50 vol% (vs. 5 vol% industrial conditions), while in Mine B, U/Mo increases from 377 to 1459 at 22 vol%, with optimal U/Zr selectivity between 10-50 vol%. In contrast, the phosphate-based Mine C exhibits a weakly structured organic phase, with dimer-dominated extractant species and limited sensitivity to phase modifier addition; optimal selectivity is achieved at low modifier content, where 2 vol% EXXAL 13 increases the U/Fe ratio from 61 to 214. These results highlight the importance of system-specific phase modifier optimization for maximizing uranium selectivity. SAXS analysis further reveals that extractant molecules self-assemble into reverse aggregates whose structure and inter-aggregate interactions are strongly influenced by phase modifier concentration. Crucially, these structural modifications directly correlate with selectivity variations, demonstrating that phase modifier effects are fundamentally mediated through changes in extractant aggregation in the organic phase.

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