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vincristine sulfate

✓ Approved

Pierre Fabre S.A. · 小分子 · 小分子

什么是 vincristine sulfate？

vincristine sulfate 是一种小分子，由Pierre Fabre S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

公司Pierre Fabre S.A.
药物类别小分子
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Pierre Fabre S.A.

治疗适应症

vincristine sulfate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

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Ferrous Sulfate and Folic Acid Supplementation in Pregnant People in Primary Health Care: a Cross-Sectional Study, Criciúma, 2022.

Campos-Rosa Jhonatan J, Puchivailo Ricardo Augusto Cardoso RAC, Schäfer Antônio Augusto AA, Meller Fernanda de Oliveira FO et al.

To evaluate the prevalence and factors associated with supplementation of ferrous sulfate and folic acid in pregnant people. A cross-sectional, representative study with pregnant people treated in Primary Health Care in Criciúma, Santa Catarina, in 2023. Ferrous sulfate and folic acid supplements were evaluated based on the prenatal booklet for pregnant people. The prevalence of supplementation was calculated with their respective 95% confidence intervals (95%CI). Crude and adjusted Poisson regression analyses (hierarchical model) were performed, estimating prevalence ratios (PR) and their respective 95%CI, to verify the associated factors. A total of 428 pregnant people were interviewed. Of these, 97.4% used ferrous sulfate supplementation during pregnancy, and 93.7% folic acid. The analyses indicated that the use of ferrous sulfate was higher in older pregnant people, with PR 1.06 (95%CI 0.99; 1.13), and who consumed alcohol during pregnancy, with PR 1.04 (95%CI 1.00; 1.08). Regarding the use of folic acid, it was higher among pregnant people who had at least six prenatal visits, with PR 1.10 (95%CI 1.01; 1.20). The results indicate high iron and folic acid supplementation among pregnant people in Primary Health Care. The identification of associated factors can guide more targeted and effective intervention strategies by Health Management.

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Control regimes of nitrate air pollution reconciled by multiphase dissociation equilibrium.

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Particulate nitrate is a major component of haze pollution, yet substantial debate exists regarding its effective control policies. Here, we develop a multiphase dissociation equilibrium equation, based on which the influence of meteorological conditions and chemical profiles can be decoupled, and the analytical expression of nitrate sensitivity to different species can be derived. With this framework, four nitrate control regimes are identified, namely the nitric-acid-control, ammonia-control, transition, and meteorology regimes. The framework also explains the trade-offs between sulfate and nitrate, and elucidates the influence of sulfate and non-volatile cations on the regime transitions. Across most Northern Hemisphere continental regions, and nearly all of China, particulate nitrate is generally more sensitive to nitric acid than to ammonia due to the universal NH3 excess. The framework provides transparent criteria for interpreting nitrate sensitivity and control regime classifications, serving as an important scientific basis for nitrate control policies and reactive nitrogen interactions.

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Unexpectedly rapid SO2 heterogeneous reaction on the surface of vehicular brake wear particles.

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Sulfate is a major aerosol component whose rapid growth in polluted air remains insufficiently explained. Here, we demonstrate that brake wear particles (BWPs), an emerging urban aerosol source, possess exceptional catalytic efficiency for SO2 oxidation and sulfate production under dark ambient conditions. Their SO2 uptake coefficient (up to 2.87 × 10-5) is orders of magnitude higher than those of mineral dust or soot. This remarkable reactivity originates from a self-sustained synergy between α-Fe2O3 and carbonaceous components: oxygen vacancies in α-Fe2O3 continuously activate atmospheric O2 and H2O to generate reactive oxygen species and Fe-OH for SO2 oxidation, while organics and elemental carbon promote H2O dissociation through proton abstraction and enhance SO2 adsorption at carbon defects, respectively. Together, these processes sustain cyclic catalysis and mitigate site deactivation. Our findings establish BWPs as a previously overlooked class of reactive aerosols, with broad implications for multiphase chemistry, atmospheric modeling, and air quality management.

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R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking.

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Heparan sulfate (HS) proteoglycans are information-rich macromolecules that can orchestrate extracellular signaling and cargo uptake across diverse cellular contexts. Ligands that can engage cell surface HS possess significant potential as probes to investigate or manipulate cell-matrix interactions. Here, we show that R17, an HS-binding protein from the rodent herpesvirus Peru, actively remodels the glycocalyx of pancreatic cancer cells. Recombinant R17 bound heparin in vitro and associated with the surface of pancreatic cancer cells to promote the dose-dependent clearance of HS via trafficking to lysosomes. R17 also reduced wound closure without detectable cytotoxicity, indicative of the ability of R17 to suppress cellular migration. Notably, HS depletion persisted upon cation-independent mannose-6-phosphate receptor knockdown, suggesting that clearance is independent of this mechanism. These findings identify R17 as an exogenous HS-binding protein that can drive HS clearance via endolysosomal trafficking and suggest an alternative approach to modulate HS-dependent functions.

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Endothelial glycocalyx glycan expression in lymphatic vasculature in mice.

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Lymphatic vessels are crucial for the drainage and transport of interstitial fluids, cells, and macromolecules. Like all other cells, lymphatic endothelial cells express a cell-surface glycocalyx, composed of carbohydrate-enriched molecules, that contributes to endothelial barrier maintenance and cell-cell communication. Although the endothelial glycocalyx has been increasingly studied in blood endothelium, little has been done to characterize it in lymphatics. In this study, among a variety of tested fixatives, Carnoy's fixative, a solution of ethanol, chloroform, and acetic acid, was determined to best preserve endothelial glycocalyx epitopes in lymphatics-on-chip microfluidic devices and mouse tissue sections. Dermal, lung, and lymph node tissues were isolated from male C57BL/6J mice and fixed with Carnoy's fixative. We aimed to determine the presence of prominent glycocalyx components, including heparan sulfate and chondroitin sulfate, across different mouse organs to characterize organ-specific differences. We hypothesized that, due to the different organ environment demands for fluid clearance and immune surveillance, the expression of major glycocalyx components would be heterogeneous. However, immunofluorescence imaging of these tissues demonstrated the presence of these glycans within LYVE-1-positive structures across the tested tissues. This conclusion provides a basis for further characterization and understanding of the composition, function, and potential alterations of the lymphatic endothelial glycocalyx across very distinct organs/tissues and conditions.

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Correlative spectroscopic and structural imaging provides a powerful approach for characterizing the microstructure of complex pharmaceutical formulations. Laser direct infrared (LDIR) spectroscopy is an emerging, rapid spectroscopic imaging technique that complements traditional approaches by enabling non-destructive chemical and morphological analysis over large sample surfaces within minutes. In this study, the capabilities of LDIR imaging were evaluated alongside Raman mapping, SEM-EDS, laser microscopy, and micro-CT as part of a correlative workflow to characterize the microstructure and chemical composition of pharmaceutical pellets. Resin embedding enabled consistent handling and structural preservation of extended-release pharmaceutical pellets across all imaging modalities. Two commercially available morphine sulfate ER pellets (ER-1 and ER-2) with different excipient compositions were used as model systems. Laser microscopy revealed distinct differences in surface topography, while micro-CT performed before milling confirmed inherent structural features. ER-1 displayed a smooth, intact core, whereas ER-2 exhibited internal cracks and cavities. Hyperspectral LDIR imaging successfully identified major components in both formulations (hit-quality index, HQI ≥ 0.83) with strong concordance to Raman mapping (HQI ≥ 0.85). The spatial distribution of the active pharmaceutical ingredient (API) revealed a layered structure in ER-1 and a homogeneous core in ER-2. This correlative workflow, combining resin embedding with multiple imaging modalities, underscores the value of LDIR and complementary techniques for comprehensive physicochemical characterization of complex drug products. These findings highlight the utility of correlative imaging for regulatory assessment and quality control of complex extended-release formulations.

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