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sumatriptan (Alsuma autoinjector / sumatriptan, King / Alsuma)

✓ Approved

US WorldMeds, LLC · HTR1D · 小分子

什么是 sumatriptan？

sumatriptan 是一种小分子，由US WorldMeds, LLC研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Alsuma autoinjector, sumatriptan, King, Alsuma
公司US WorldMeds, LLC
药物类别小分子
分子靶点HTR1D
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, US WorldMeds, LLC

作用机制

分子靶点

sumatriptan 作用于 1 个分子靶点：

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sumatriptan 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersMigraine✓ Approved

相关研究文献

PubMedAnimal science journal = Nihon chikusan Gakkaiho2026-09-10

Lipidomic and Metabolomic Profiling of Breast Muscle Between Squabs and Adult White King Pigeons.

Li Wanqing W, Zhang Yi Y, Wang Yiman Y, Chen Jing J et al.

This study systematically investigated age-related variations in meat quality traits, lipidomic profiles, and metabolomic profiles of breast muscle from White King pigeons, comparing 28-day-old squabs (D28) and 12-month-old adult pigeons (M12). Six biological replicates were used per group (n = 6). Physicochemical analyses and ultra-high performance liquid chromatography-tandem mass spectrometry were employed to characterize these differences. Results showed significant disparities in meat quality between the two age groups: D28 pigeons exhibited significantly higher lightness (L*), redness (a*), and yellowness (b*) values at 24-h postslaughter, along with higher water-loss rate alongside lower shear force (p < 0.05), reflecting more tender muscle texture despite weaker water retention capacity. In contrast, M12 pigeons had higher springiness but lower cohesiveness and gumminess (p < 0.05). Lipidomic analysis identified 553 lipid molecules, with 174 differential lipids categorized into six classes. D28 pigeons had significantly higher levels of glycerolipids (GLs) and fatty acyls (FAs), while M12 pigeons showed elevated saccharolipids (SLs) and prenol lipids (PRs). Metabolomic profiling detected 19,019 metabolites, among which 984 were differentially abundant (screening criteria: variable importance in projection (VIP) ≥ 1, fold change (FC) > 1.2 or FC < 0.83, FDR-adjusted p < 0.05), predominantly enriched in amino acid metabolism. Correlation analysis revealed that acylcarnitines (AcCa) and phosphatidylinositol (PI) were positively correlated with water-loss rate and L24 values (r > 0.8, p < 0.05), whereas lysophosphatidylethanolamines (LPEs), L-threonic acid, and β-glycerophosphoric acid showed positive associations with shear force and cooking loss (r > 0.8, p < 0.05). These findings reveal statistical associations between lipid/metabolite profiles and age-driven differences in pigeon breast meat quality, and identify potential candidate lipid and metabolite biomarkers correlated with pigeon meat quality phenotypes. These results identify candidate biomarkers associated with breast meat quality in male White King pigeons at two ages and offer preliminary exploratory omics data for subsequent pigeon meat research, rather than universal guidance for breeding and production.

PMID 42720194
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PubMedEcology and evolution2026-09-10

Fine-Scale Population Genomics Reveals Genetic Differentiation in the Brooding Amphipod Cheirimedon femoratus Across the South Shetland Islands, Antarctica.

Jo Euna E, Sepahvand Vahid V, Ahn Yong-Uk YU, Kang Seunghyun S et al.

Antarctic marine ecosystems are sensitive to environmental change, and impacts on processes such as population connectivity will play a fundamental role in future population dynamics and persistence, affecting short-term demography and long-term evolution. We investigated the population genomics of the common benthic brooding Antarctic amphipod Cheirimedon femoratus (Pfeffer, 1888), using 8837 high-quality single-nucleotide polymorphisms (SNPs) from 87 individuals collected at 4 sites in the South Shetland Islands, separated by up to 200 km: Deception Island, King George Island, Livingston Island, and Snow Island. While Admixture, F ST, principal component analysis (PCA), and demographic (Ne) analyses revealed a generally weak population genetic structure, Livingston Island emerged as a distinct population, especially compared to King George Island. All populations showed a heterozygote deficit with positive inbreeding coefficients (F IS), particularly high in the Snow Island population (~0.55). Tajima's D test suggested overall neutral evolution, although slight variation was observed among sites. Despite the limited dispersal potential of this brooding species, the observed connectivity may be maintained through passive dispersal, likely via floating macroalgae or ice-rafted debris, facilitated by prevailing regional ocean currents. This may enhance the population resilience of Antarctic benthic communities under environmental change, including regional warming and shifts in ocean circulation, compared to more isolated populations. Our findings underscore the complex interplay between passive connectivity and fine-scale differentiation in shaping Antarctic benthic invertebrate diversity.

PMID 42718912
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PubMedPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2026-09-10

Tension in the solar energetic proton paradigm for historical cosmogenic nuclide events.

Cliver Ed E, Hudson Hugh H, Fletcher Lyndsay L

'Miyake events' are exceptional increases in atmospheric 14C recorded in tree rings that, if confirmed, are accompanied by simultaneous 10Be and 36Cl enhancements in ice cores. During the last 15 000 years, six such events have been confirmed. They are generally thought to originate in solar flares that produce strong high-energy solar proton events. The 774 CE Miyake event is currently estimated to have been produced by a flare with a soft X-ray (SXR) flare classification of X430. A recently constructed size distribution of SXR events from 1975 to 2022 permits an estimate of the 'return time' for any given SXR event. We extrapolate the observed distribution to obtain a flare return time of ⋟106 years for all six of the Miyake events. We examine various possibilities (e.g. overestimates of greater than 200 MeV proton fluences, episodes of multiple smaller flares) to reduce the tension between the estimated long return (waiting) times for these extreme flares and the 15 000-year observation interval. We conclude that the most likely explanation for the inferred outsized proton events is a yet unknown Dragon-King type mechanism or scenario that can increase high-energy solar proton fluences in certain events by one to two orders of magnitude. This article is part of the Theo Murphy meeting issue 'Radiocarbon and cosmic radiation events'.

PMID 42720027
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PubMedPlastic and reconstructive surgery. Global open2026-09-10

Impact and Predictors of Surgical Outcomes in Mastopexy after Massive Weight Loss.

AlHassan Turki S TS, Alhwsawi Halah A HA, Alsaif Malak M, Alghamdi Abdulaziz M AM et al.

Post-massive weight loss (MWL) patients present unique anatomical challenges for mastopexy, including diminished parenchymal support and poor skin elasticity. Regional data on mastopexy outcomes in Saudi Arabia remain limited despite the increasing demand for postbariatric body contouring. This retrospective comparative study reviewed 89 patients who underwent mastopexy between May 2021 and May 2025 at King Abdulaziz Medical City, Riyadh. Patients were categorized into post-MWL (n = 33) and non-MWL (n = 56) groups. Demographics, operative techniques, complications, revision rates, and satisfaction outcomes were analyzed. Logistic regression was performed to identify predictors of complications and dissatisfaction. Baseline characteristics were comparable between groups, except for prior gastric sleeve surgery, which was more frequent among post-MWL patients (66.7% versus 16.1%, P < 0.001). The inverted-T incision was the predominant approach in both groups. Implant augmentation was more common in the post-MWL cohort (33.3% versus 17.9%). Overall complication rates were similar between post-MWL and non-MWL patients (27.3% versus 21.4%), although infection was significantly higher in the post-MWL group (12.1% versus 1.8%, P = 0.04). Revision rates were comparable (9.1% versus 7.1%), and satisfaction remained high in both groups (87.9% versus 89.3%). Multivariable analysis identified no independent predictors of complications or dissatisfaction. Mastopexy after MWL achieved early complication and satisfaction outcomes comparable to those of non-MWL patients. These findings suggest that appropriate technique selection, including parenchymal support and careful pedicle planning, can support favorable early outcomes in post-MWL mastopexy.

PMID 42719929
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PubMedMedical science monitor : international medical journal of experimental and clinical research2026-09-10

Bibliometric Analysis of Plant-Derived Irrigants, Intracanal Medicaments, and Natural Compounds Against Enterococcus faecalis in Endodontics.

Arslanparcasi Hazal Faiz HF, Arslanparcasi Mehmet Ali MA

BACKGROUND The aim of this study was to bibliometrically map the Web of Science Core Collection-indexed literature related to plant-derived irrigants, intracanal medicaments, and natural compounds investigated against Enterococcus faecalis in endodontics. MATERIAL AND METHODS The literature search was conducted in the Web of Science Core Collection database on March 31, 2026; it included English-language articles and reviews indexed from 2010 through March 31, 2026. Descriptive bibliometric analyses were performed using Web of Science tools. Author keyword co-occurrence and author co-citation analyses were conducted using VOSviewer. RESULTS In total, 144 publications were evaluated. Scientific output greatly increased after 2020, and the highest number of publications was recorded in 2024; data for 2026 represented partial-year coverage through the search date. The total number of citations was 1311, whereas citations excluding self-citations totaled 1179. The average number of citations per publication was 9.1, and the H-index was 22. The leading journal was Cureus Journal of Medical Science. The most prolific authors were Bottino MC and Carvalho CAT. Based on full counting, India, Brazil, and Egypt were the leading countries. The most productive institutions were Egyptian Knowledge Bank, Egypt; The Institute for Medicinal Plant Research "Dr. Josif Pančić," Serbia; and King Khalid University, Saudi Arabia. Keyword co-occurrence analysis showed thematic clustering around antibacterial efficacy, biofilm control, and comparisons with conventional endodontic agents. CONCLUSIONS This bibliometric map characterizes publication output, citation structure, leading contributors, and thematic clustering within the defined indexed literature subset.

PMID 42717475
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PubMedSurgical laparoscopy, endoscopy & percutaneous techniques2026-09-10

Nasogastric Tube Versus Surgical Enterostomy in Obstructed Esophageal Cancer: A Comparison of Time-to-Treatment, Costs, and Nutritional Outcomes.

Chennavasin Papawee P, Chobarporn Thitiporn T, Tharavej Chadin C, Mesiri Dudsadee D

Locally advanced esophageal cancer often presents with dysphagia and malnutrition, necessitating enteral feeding during chemoradiotherapy (CRT). This study compares the outcomes of pretreatment nasogastric tube (NGT) versus surgical enterostomy (SE) feeding. A retrospective cohort study was conducted at King Chulalongkorn Memorial Hospital evaluating 98 patients with high-grade obstruction. To minimize selection bias, propensity score matching was utilized. Primary outcomes analyzed included time to treatment, health care costs for intervention, complications associated with enteral access, and nutritional outcomes. This study evaluated 97 patients (NGT: n=78, SE: n=19). To account for baseline differences, propensity score matching was executed using T-stage and pretreatment BMI. NGT patients had a significantly shorter waiting time to start CRT (16.2 vs. 36.7 d, P=0.033, 95% CI: [1.72, 39.20]), a lower cost of enteral access (11,194 THB vs. 28,250 THB, P<0.001, 95% CI: [13,237.06, 20,058.26]), a shorter length of hospital stay (2.3 vs. 5.9 d, P<0.001, 95% CI: [2.06, 5.06]), and a higher rate of resuming oral intake posttreatment (68% vs. 15.8%, P=0.001, 95% CI: [1.55, 13.43]). Nutritional outcomes were comparable between both groups, while both cohorts experienced significant declines in body weight and prognostic nutritional index (PNI) during CRT and then recovered within 3 months of completing treatment. Key limitations of this study include a small sample size and potential selection bias from the retrospective design. NGT feeding may be a favorable option compared to open enterostomy for obstructed esophageal cancer patients in a limited resource setting, enabling faster treatment initiation and lower health care costs without compromising nutritional outcomes.

PMID 42720680
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