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sumatriptan (Alsuma autoinjector / sumatriptan, King / Alsuma)

✓ Approved

US WorldMeds, LLC · HTR1D · 小分子

什么是 sumatriptan？

sumatriptan 是一种小分子，由US WorldMeds, LLC研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Alsuma autoinjector, sumatriptan, King, Alsuma
公司US WorldMeds, LLC
药物类别小分子
分子靶点HTR1D
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, US WorldMeds, LLC

作用机制

分子靶点

sumatriptan 作用于 1 个分子靶点：

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sumatriptan 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersMigraine✓ Approved

相关研究文献

PubMedPeerJ2026-10-25

Screening for metabolic dysfunction-associated steatotic liver disease in type 2 diabetes patients using the fibrosis-4 score in medina-retrospective study.

Almohammadi Mohammed Abdullah MA, Alsadi Ziyad Esam ZE, Alenezi Ahmad Basheer AB, Ahmed Faisal Mahmoud FM et al.

Type 2 diabetes mellitus (T2DM) is a global health problem closely linked to metabolic dysfunction-associated steatotic liver disease (MASLD) and advanced fibrosis. The fibrosis-4 (FIB-4) index is a standard noninvasive tool for estimating fibrosis risk. This study aimed to describe the demographics, metabolic parameters, comorbidities, and T2DM duration of patients in Medina and to screen for MASLD using the FIB-4 score. At King Salman Diabetic Center, Medina, Saudi Arabia, a cross-sectional study was conducted among 280 T2DM patients aged >35 years. Data were gathered from electronic medical records. FIB-4 levels were calculated and categorized as low (<1.3), intermediate (1.3-2.67), or high (>2.67) risk. Statistical analysis was performed with IBM SPSS Statistics 30, with p < 0.05 considered significant. A total of 87.9%of the 280 participants had low-risk FIB-4 scores, 11.4% had intermediate risk scores, and 0.7% had high risk scores. Individuals with FIB-4 ≥ 1.3 were predominantly male (64.7% vs. 43.5%, p = 0.0271) and older (median age: 56 vs. 52 years, p = 0.009). The risk groups were not significantly different in terms of body mass index (BMI) and lipid profiles, glycemic control, hypertension, or diabetes duration. A significant proportion of T2DM patients had intermediate- or high-risk FIB-4 scores. These findings endorse the need for screening for liver fibrosis in T2DM patients, particularly those at increased risk. Early detection and appropriate management are essential to prevent progression to advanced liver disease.

PMID 42927374
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PubMedCardiology research and practice2026-10-25

The Association Between Myocardial Infarction and Loneliness Among Adults in the Saudi Population: A Comparative Analytical Study.

Alshammari Hessah H, Alshafi Norah N, Alhowaish Tharaa T, Almohsen Lina L et al.

Cardiovascular disease (CVD) represents a major global health crisis, accounting for a significant fraction of overall morbidity and mortality rates. While growing evidence indicates that poor cardiovascular health may be associated with higher loneliness, studies on this association within the Middle Eastern context, particularly in Saudi Arabia, are limited. Given the unique social and cultural characteristics of Saudi Arabia, this study aimed to examine the association of myocardial infarction (MI) and loneliness among adults in the country. This comparative analytical study, using questionnaires, was conducted at King Khaled University Hospital in Riyadh. We recruited 173 Saudi adult patients aged between 18 and over 70 years with a confirmed diagnosis of MI and compared them with 446 Saudi adult healthy participants without CVD. Participants completed the validated Arabic translation of the De Jong Gierveld Loneliness Scale. Sociodemographic, behavioral, clinical, and treatment-related data were also collected. Bivariate and multivariable logistic regression analyses were used to identify the association between high loneliness and MI (score ≥ 3). A high loneliness score was reported by 28.4% of all participants. Multivariable analysis identified statistically significant associations between loneliness and the presence of heart disease, younger age, physical inactivity, and smoking (OR = 4.88, 95% CI 2.46-9.67, p < 0.001). In cardiac patients, higher physical activity and better diabetes management were correlated with lower loneliness scores, whereas chronic kidney dysfunction significantly increased loneliness scores (p = 0.03). We found that, within the highly culturally and socially oriented population of Saudi Arabia, MI in adults was associated with greater loneliness compared to healthy participants. Loneliness is also significantly associated with smoking, physical inactivity, and comorbidities in MI patients. These findings highlight the need for culturally tailored interventions that integrate psychosocial support into cardiac care, particularly for vulnerable subgroups.

PMID 42920893
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PubMedPediatric transplantation2026-10-25

The Relationship Between Estimated and Measured Glomerular Filtration Rate in Pediatric Hematopoietic Stem Cell Transplant Candidates.

Monagel Dania A DA, Altaf Wid F WF, Bokhari Maya F MF, Afif Afnan Bin AB et al.

Accurate assessment of renal function through glomerular filtration rate (GFR) is a vital parameter in determining eligibility for hematopoietic stem cell transplantation (HSCT), as conditioning regimens often include nephrotoxic agents. Technetium-99 m diethylenetriaminepentaacetic acid (Tc-99m DTPA) nuclear scans are commonly used to measure GFR, but creatinine-based formulas may be more convenient and cost-effective. This study compared three contemporary creatinine-based equations, the bedside Schwartz, Full Age Spectrum (FAS), and CKiD U25 creatinine equations with the Tc-99 m DTPA measured GFR (mGFR) in pediatric HSCT candidates. This retrospective cohort included 100 transplant episodes in pediatric patients undergoing autologous or allogeneic HSCT at King Abdulaziz Medical City, Jeddah. Agreement was evaluated using mean bias, standard deviation of the differences (precision), 95% limits of agreement, root-mean-square error, P10, P30, Lin's concordance correlation coefficient, and Bland-Altman analyses using both absolute and percentage differences. Exploratory subgroup analyses were conducted by sex and transplant type. The cohort included 59 male and 41 female transplant episodes; 57 were autologous and 43 were allogeneic. Mean Tc-99 m DTPA mGFR was 113.0 mL/min/1.73 m2. Mean eGFR values were 112.4 for Schwartz, 102.2 for FAS, and 98.3 mL/min/1.73 m2 for U25. Schwartz had the smallest mean absolute bias (-0.6 mL/min/1.73 m2) but poor concordance (CCC 0.19), wide limits of agreement (-57.8 to 56.6), P10 of 27%, and P30 of 76%. FAS and U25 showed systematic underestimation, with biases of -11.0 and -14.7 mL/min/1.73 m2, respectively. Root-mean-square error was 29.0, 30.2, and 31.7 mL/min/1.73 m2 for Schwartz, FAS, and U25, respectively. Performance remained limited across sex and transplant-type subgroups. None of the three creatinine-based equations demonstrated sufficient individual-level agreement with Tc-99 m DTPA mGFR to replace measured GFR in pediatric HSCT candidates. Schwartz showed minimal average bias but substantial imprecision, whereas FAS and U25 tended to underestimate mGFR. Creatinine-based eGFR remains useful for routine monitoring, but radionuclide measurement should be retained when precise renal assessment may affect transplant eligibility or nephrotoxic drug dosing.

PMID 42921903
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PubMedFrontiers in medicine2026-10-24

Understanding ChatGPT adoption among medical students: an integrated theoretical model of psychological barriers and individual factors.

Lone Ayoob A, Alshebami Ali Saleh AS, Dar Imtiyaz Ahmad IA, Iqbal Naved N

The growing adoption of generative artificial intelligence (GenAI), particularly ChatGPT, has created new opportunities for medical education by supporting learning, problem-solving, and knowledge acquisition. However, evidence regarding the psychological and individual factors influencing ChatGPT adoption among medical students remains limited. This study develops and tests an integrated theoretical model that combines Privacy Theory, Technostress Theory, Affect Theory, Diffusion of Innovation Theory, and the Theory of Planned Behavior to explain ChatGPT adoption. A quantitative cross-sectional study was conducted among undergraduate medical students at King Faisal University, Saudi Arabia using a structured, self-administered questionnaire. The proposed model examined the effects of privacy concern, technophobia, guilt feelings, and innovativeness on behavioral intention and ChatGPT usage behavior, with behavioral intention serving as the mediating variable. Data were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The findings showed that innovativeness had a significant positive relationship with behavioral intention (β = 0.579, p < 0.001), while behavioral intention had a strong positive relationship with ChatGPT usage behavior (β = 0.777, p < 0.001). In addition, behavioral intention significantly mediated the relationship between innovativeness and ChatGPT usage behavior (β = 0.450, p < 0.001). In contrast, privacy concern, technophobia, and guilt feelings were not significantly related to behavioral intention, and their indirect relationships with ChatGPT usage behavior were also not significant. Within the proposed model, personal innovativeness was the only antecedent significantly associated with behavioral intention, whereas the psychological barriers were not statistically significant. By integrating five complementary theoretical perspectives into a single framework, this study extends current understanding of generative AI adoption in medical education and highlights behavioral intention as the key mechanism linking individual characteristics to actual use. The findings provide theoretical insights and practical guidance for promoting the responsible and effective integration of ChatGPT into medical education through initiatives that foster innovativeness and AI literacy.

PMID 42920499
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PubMedFrontiers in oncology2026-10-24

From armed-conflict to care: clinical outcomes, diagnostic challenges, and psychosocial burden in children evaluated for suspected cancer displaced from Gaza and treated at a regional center of excellence.

Rihani Rawad R, Amer Shrouq S, Barbar Maha M, Shamieh Omar O et al.

Conflict-related displacement profoundly disrupts pediatric cancer care, yet clinical outcomes data for evacuated children treated at regional oncology centers remain scarce. We describe the clinical characteristics, diagnostic challenges, nutritional and psychosocial burden, and outcomes of children evacuated from Gaza and treated at King Hussein Cancer Center (KHCC), Jordan. We conducted a retrospective cohort study of patients aged ≤21 years evacuated from Gaza to KHCC between November 2023 and March 2026. Demographic and clinical characteristics, cancer type and stage, diagnostic concordance, nutritional and psychosocial status, and survival outcomes were assessed. Overall survival (OS) and event-free survival (EFS) were estimated using Kaplan-Meier methods. A total of 169 patients were included; median age was 6.7 years (range, 0.01-21.3), and 62% were male. Median time from symptom onset to presentation was 3 months (range, 1-62). Among staged solid tumors, lymphomas, and brain tumors, 41.6% had distant disease at presentation. All patients with leukemia presented with systemic disease at diagnosis, and all patients with retinoblastoma presented with moderate-to-advanced intraocular disease (International Intraocular Retinoblastoma Classification Groups C-E), with 83% classified as high-risk (Groups D/E). Diagnostic discordance occurred in 19.5% of cases. Nutritional and psychosocial burden was substantial: 26.3% were underweight (44/167 assessed), 50.3% had vitamin D deficiency (75/149 assessed), and 41.4% reported clinically significant psychological distress. During a median follow-up of 8.0 months, 24 patients died (14.2%), including 2.4% who died within 30 days of presentation. One- and 2-year OS were 81.3% (95% CI, 72.1-87.7%) and 75.7% (95% CI, 64.6-83.7%), respectively; corresponding EFS estimates were 76.5% (95% CI, 67.0-83.6%) and 70.6% (95% CI, 59.4-79.3%). PICU-admitted patients had markedly lower 1-year OS (52.7% vs 86.8%; HR, 5.56; log-rank P<0.0001) and EFS (48.9% vs 81.8%; HR, 4.27; log-rank P<0.0001). Children evacuated from Gaza presented with advanced disease, diagnostic discordance, malnutrition, and substantial psychosocial burden, reflecting the clinical consequences of conflict-related disruption of healthcare. Despite these challenges, multidisciplinary care at a regional center of excellence achieves meaningful survival outcomes. These findings underscore the need for protected humanitarian evacuation pathways, integrated supportive care, and sustainable international funding for pediatric oncology services in conflict settings.

PMID 42920479
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PubMedThe European journal of neuroscience2026-10-23

Spinorphin Ameliorates Nitroglycerin-Induced Migraine-Like Responses and Trigeminovascular Neuroinflammation Potentially Through Opioid Receptor-Mediated Mechanisms.

Demir Cemalettin C, Torun Ibrahim Ethem IE, Baranoglu Kilinc Yasemin Y, Kilinc Erkan E

Enhancement of endogenous opioid signaling through inhibition of enkephalin degradation has emerged as a potential strategy for pain control, yet its role in migraine remains unclear. This study investigated whether spinorphin, an endogenous inhibitor of multiple enkephalinases, attenuates trigeminovascular activation and migraine-like responses in experimental migraine. Migraine-like pain was induced in male Wistar rats by nitroglycerin. The effects of spinorphin were evaluated using periorbital and plantar von Frey tests, followed by assessment of c-Fos levels in the trigeminal nucleus caudalis (TNC), calcitonin gene-related peptide (CGRP) levels in the trigeminal ganglion (TG) and TNC, and meningeal mast cell degranulation. Opioid receptor involvement was examined using nalmefene. In complementary ex vivo hemiskull preparations, capsaicin-evoked CGRP release was quantified, and the interaction between spinorphin and sumatriptan was investigated. Spinorphin dose-dependently alleviated cephalic and extracephalic mechanical hypersensitivity, reduced c-Fos levels, decreased CGRP concentrations in the TG and TNC, and inhibited meningeal mast cell degranulation. These protective effects were markedly attenuated by nalmefene, supporting the involvement of opioid receptor-mediated mechanisms. In ex vivo preparations, spinorphin selectively reduced capsaicin-induced CGRP levels in the superfusates without affecting basal CGRP levels, and this effect was abolished by nalmefene. Moreover, spinorphin enhanced the inhibitory effect of sumatriptan on capsaicin-stimulated CGRP levels. Spinorphin attenuates behavioral, neurochemical, and neuroinflammatory features of experimental migraine, at least partly through mechanisms involving endogenous opioid signaling. These findings suggest enkephalinase inhibition as a promising therapeutic approach for migraine and support further investigation of spinorphin as a potential adjunct to established antimigraine therapies.

PMID 42919102
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