北京若生智能科技有限公司
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erythropoietin (Epocain / Epokine)

✓ Approved

HK inno.N · EPOR · 重组蛋白

什么是 erythropoietin？

erythropoietin 是一种重组蛋白，由HK inno.N研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Subcutaneous Injection。

药物档案

商品名Epocain, Epokine
公司HK inno.N
药物类别重组蛋白
分子靶点EPOR
给药途径Injectable (Others), Intravenous (IV), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, HK inno.N

作用机制

分子靶点

erythropoietin 作用于 1 个分子靶点：

EPORerythropoietin receptor (EPO-R)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

erythropoietin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved

相关研究文献

PubMedCureus2026-09-10

Assessment of Cultural Beliefs and Practices During the Postnatal Period Affecting Postpartum Recovery and Its Management in a Tertiary Care Hospital.

Gangadharaiah Mahendra M, Mudri Tejaswini M TM

The postpartum period is associated with several physiological and nutritional changes, during which women commonly follow culturally influenced dietary practices and traditional beliefs. These practices may influence maternal nutrition, physical activity, and postpartum recovery. The present study aimed to assess cultural beliefs, dietary practices, lifestyle-related factors, myths, and traditional postpartum practices among postnatal women attending a tertiary care hospital, and to examine their association with self-reported postpartum weight change. This prospective observational study was conducted among 100 postnatal women attending the Department of Obstetrics and Gynecology at Adichunchanagiri Institute of Medical Sciences, Karnataka, India, from January 2026 to April 2026. Data were collected using a predesigned semi-structured questionnaire developed after an extensive review of published literature and previously validated studies on postpartum cultural practices. The questionnaire underwent content validation by experts in obstetrics and community medicine and was pretested among 10 postnatal women to ensure clarity and feasibility before administration. It assessed sociodemographic characteristics, dietary practices, cultural beliefs, lifestyle modifications, preferred and restricted foods, and self-reported postpartum weight change. Data were analyzed using SPSS version 26.0 (Armonk, NY: IBM Corp.). Restriction in quantity of food intake was practiced by 97 (97.0%) women, while consumption of "hot foods" was reported by 87 (87.0%) participants. Reduced water intake was observed among 57 (57.0%) women. Head covering, confinement at home, and reduced physical activity were practiced by 92 (92.0%), 86 (86.0%), and 81 (81.0%) women, respectively. Restriction of curd and buttermilk was observed among 32 (32.0%) participants, whereas restriction of protein-rich foods was reported by eight (8.0%) women. Weight loss during the postpartum period was reported by 46 (46.0%) participants. Consumption of "hot foods" demonstrated a significant association with self-reported postpartum weight change (χ²=9.097, p=0.011), whereas no significant associations were observed for parity, mode of delivery, religion, restriction in quantity of food intake, or vegetable restriction (p>0.05). Traditional postpartum dietary practices and cultural beliefs were highly prevalent among postnatal women. Several culturally accepted food restrictions and lifestyle practices continued to influence postpartum dietary habits and were associated with self-reported postpartum weight change. However, given the cross-sectional design and reliance on self-reported outcome measures, these findings should be interpreted with caution. Further multicenter longitudinal studies with objective nutritional assessment are warranted.

PMID 42719719
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PubMedJournal of biomedical materials research. Part A2026-09-09

Bioluminescent Trace Labeling of Porous Protein Microcrystals for Evaluating Their Pharmacodynamics.

Jones Alec A, O'Brian Anika A, Lewis Isaac I, Shepherd Cole C et al.

In this exploratory pilot study, we evaluated bioluminescent trace labeling as a strategy for monitoring the in vivo distribution of cross-linked porous protein microcrystals grown from the CJ protein. CJ crystals doped with CJ-SpyTag003 were functionalized with SpyCatcher003-NanoLuciferase and imaged after intravenous administration in BALB/c mice. In vitro experiments confirmed that SpyCatcher-fusion proteins could be retained by CJ-SpyTag003 crystals and that NanoLuciferase remained active after association with the crystal scaffold. Following tail-vein injection, whole-animal IVIS imaging revealed early thoracic signal consistent with first-pass pulmonary exposure, followed by rapid signal decay. A subset of animals showed persistent hindlimb-associated signal, but terminal ex vivo imaging at 72 h showed no statistically significant organ-level differences after sensitivity analysis excluding one extreme muscle-associated value. These results demonstrate the feasibility of NanoLuciferase-based trace labeling for longitudinal imaging of CJ microcrystals while highlighting important interpretive limitations of substrate-dependent bioluminescence, including furimazine delivery, local substrate pooling, reporter stability, and the inability of bioluminescence alone to distinguish intact crystals from released or surface-associated NanoLuciferase. Overall, this work provides an initial in vivo imaging framework for CJ protein microcrystals and identifies particle size, reporter stability, and orthogonal tracking as priorities for future pharmacokinetic studies.

PMID 42713683
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PubMedFrontiers in pharmacology2026-09-09

The pathological mechanisms and potential therapeutic strategies for renal anemia.

Rao Jia-Xing JX, Zhou Hao-Ming HM, Leu Kim Fey KF, Liu Ming M et al.

Renal anemia (RA) is a common complication associated with chronic kidney diseases. Its pathological mechanism is attributed to the combined effects of insufficient production of erythropoietin by the kidneys, iron metabolism disorders, and chronic inflammatory conditions. The main pillars of medicine treatment for these aspects include erythropoiesis-stimulating agents, iron supplementation, and novel hypoxia-inducible factor prolyl hydroxylase inhibitors. Traditional Chinese medicine shows potential advantages across multiple targets in improving anemia and renal function in patients with RA. This review aims to systematically explain the current pathophysiological understanding of RA, examine the prevailing treatment approaches, and summarize the pharmacological mechanisms and research findings related to natural products and their active compounds used in RA treatment. This review is to provide new insights and references to support future in-depth research and clinical management of RA.

PMID 42713153
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PubMedJournal of visualized experiments : JoVE2026-09-09

Flow Cytometric Detection of Intracellular Proteins in K562 Human Erythroleukemia Cells Using Unconjugated Primary Antibodies.

Schippel Natascha N, Lyons Christina C, Sharma Shalini S

Flow cytometry is a powerful technique for quantitative analysis of protein expression at single-cell resolution. This protocol describes a workflow for detecting intracellular proteins in K562 human erythroleukemia cells using unconjugated primary polyclonal antibodies and fluorophore-conjugated secondary antibodies. Cells are sequentially fixed, permeabilized, and blocked before antibody staining. By varying the order of antibody incubation relative to fixation and permeabilization, the protocol enables assessment of proteins with surface or intracellular localization using separate staining workflows. Nuclear staining of splicing factor 3a subunit 1 (SF3A1) is demonstrated using an affinity-purified rabbit anti-SF3A1 polyclonal antibody, and antibody specificity is evaluated by dose-dependent inhibition of staining with the corresponding antigenic peptide. In addition, staining conditions are used to assess reactivity of an antibody targeting the intracellular domain of erythropoietin receptor. This standardized workflow expands the use of unconjugated primary antibodies in flow cytometry and provides a practical approach for evaluating protein expression and localization, as well as antibody specificity in K562 human erythroleukemia cells.

PMID 42714009
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PubMedMedicine international2026-09-09

Parvovirus B19-associated erythropoiesis-stimulating agent hyporesponsiveness in a patient on maintenance hemodialysis: A case report.

Eleftheriadis Theodoros T, Divani Maria M, Polyzou-Konsta Maria-Anna MA, Lykotsetas Evangelos E et al.

Parvovirus B19 is an uncommon cause of hypoproliferative anemia. In maintenance hemodialysis (HD), anemia is rarely explained by a single mechanism, and the viral suppression of erythropoiesis may be overlooked when infection, inflammation and iron deficiency occur concomitantly. The present case report describes the case of a 79-year-old man receiving chronic HD who was admitted twice with prolonged fever and was eventually treated for culture-negative mitral valve endocarditis. During the second hospitalization period, the hemoglobin level decreased from 8.8 to 7.7 g/dl, despite an increase in the level of recombinant human erythropoietin (rHuEPO) from 30,000 to 60,000 IU/week. The number of reticulocytes decreased from 2.07 to 0.95%, and a blood transfusion was required. The patient tested positive for Parvovirus B19 immunoglobulin M and immunoglobulin G, and polymerase chain reaction (PCR) confirmed active infection. Bleeding, hemolysis, vitamin B12 and folate deficiency, uncontrolled hypothyroidism, malignancy and inadequate dialysis were excluded. Intravenous immunoglobulin was administered at 0.4 g/kg/day for 5 days. By the time of discharge, the hemoglobin level had increased to 9.4 g/dl and reticulocytes had increased to 2.7%. Repeat PCR at follow-up, 20 days following discharge, yielded negative results. Severe iron deficiency was then evident, and following the administration of ferric carboxymaltose, the hemoglobin level further increased to 12.1 g/dl, allowing a reduction in rHuEPO. On the whole, the present case report underlines that Parvovirus B19, although rare, should remain in the differential diagnosis of erythropoiesis-stimulating agent-resistant anemia in patients undergoing HD.

PMID 42713039
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PubMedJMIR human factors2026-09-09

Examining Telemedicine Adoption After the COVID-19 Pandemic and Evaluating the Impact of a Virtual Hospital on Clinician Engagement: Longitudinal Survey Study.

Barkai Galia G, Edelman-Yaron Shany S, Amir Hadar H, Inbar-Lankry Havi H et al.

After the emergence of telemedicine as a major health care delivery mode during the COVID-19 pandemic, Sheba Medical Center (SMC) rapidly transitioned its outpatient clinics to telemedicine. A postimplementation satisfaction study revealed that while nearly 90% of patients reported a positive experience, only 38% of clinicians expressed high satisfaction. SMC soon established Sheba BEYOND, a dedicated virtual hospital. This initiative was accompanied by extensive efforts to improve the telemedicine experience. In 2025, a follow-up survey addressing clinician satisfaction and acceptance was conducted. This study aimed to explore whether clinician satisfaction improved and which barriers to clinician engagement persisted. An anonymous survey was distributed via a link to the staff of SMC's outpatient clinics. The survey inquired about user experience with the telemedicine digital platform, integration in workflow, barriers to use, perceived benefit to patients, and overall satisfaction. Clinicians who never or rarely perform telemedicine visits were classified as nonusers; all others were classified as users. The questionnaire included 21 questions, 2 additional questions for nonusers, and 5 additional questions for users. Overall satisfaction was ranked on a 10-point Likert scale. Descriptive statistics were calculated using SPSS (version 29.02; IBM Corp) and Microsoft Excel. A chi-square test of independence was used for categorical variables. We used a 2-tailed t test, with a probability of <.05 considered statistically significant. The survey was sent to 2735 clinicians, and 274 (10%) responded. Telemedicine users accounted for 52.6% (144/274). Among all respondents, 54.4% (149/274) were physicians, 30.3% (83/274) were paramedical staff, and 15.3% (42/274) were nurses. Clinical specialties across all respondents were internal medicine (36/274, 13%), psychiatry (34/274, 12%), pediatrics (36/274, 13%), oncology (31/274, 11%), and other specialties (137/274, 50%). Compared to the 2020 survey, a 41.9% increase was recorded in the number of users reporting a high level of satisfaction, from 37.7% (61/162) to 53.5% (77/144; P=.006). This increase was largely driven by a significant improvement in the oncology clinic, where users reporting a high level of satisfaction rose from 23.3% (10/43) to 63.6% (14/22; P=.01). In total, 64.4% (176/274) of respondents believed that telemedicine was advantageous for patient care and 66% (95/144) of users reported that telemedicine reduced their workload. Among the 103 video-visit users who answered the technical feedback questions, 62.1% (64/103) experienced problems in connecting to the patients' network and 32% (33/103) experienced connectivity problems in SMC. In fact, 80.6% (83/103) reported that they had to switch to the telephone at least once. Most of the 98 nonusers (80/98, 81.6%) stated that they did not perform telemedicine because it was mostly clinically inappropriate. This study demonstrates the positive impact of institutional change management strategy in promoting clinician engagement with telemedicine. However, persistent technical barriers and varying engagement highlight opportunities for refinement.

PMID 42715557
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