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ribavirin + PEG-IFNalpha-2a (Copegus + Pegasys / Pegasys + Copegus / Pegasys/Copegus)

✓ Approved

Roche · IFNAR2 · 小分子

什么是 ribavirin + PEG-IFNalpha-2a？

ribavirin + PEG-IFNalpha-2a 是一种小分子，由Roche研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Oral (PO)、Subcutaneous Injection。

药物档案

商品名Copegus + Pegasys, Pegasys + Copegus, Pegasys/Copegus
公司Roche
药物类别小分子
分子靶点IFNAR2
给药途径Injectable (Others), Oral (PO), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Roche

作用机制

分子靶点

ribavirin + PEG-IFNalpha-2a 作用于 1 个分子靶点：

IFNAR2interferon alpha and beta receptor subunit 2 (IFNARB, IFN-alpha-REC)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ribavirin + PEG-IFNalpha-2a 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsHepatitis C✓ Approved

相关研究文献

PubMedChembiochem : a European journal of chemical biology2026-10-26

Violet Phosphorus Nanodots for Long-Term Cell Imaging With Persistent Intracellular Stability.

Dai Shiling S, Zhao Xinyi X, Liu Zhengyi Z, Hu Kerui K et al.

Long-term cellular imaging probes with high photoluminescence intensity/stability and high biocompatibility are crucial for advanced in vitro cell imaging and long-term cell tracing. However, conventional organic fluorescent dyes are prone to photobleaching and require assistance to enter cells. Here, NH2-PEG-NH2 was adopted to modify violet phosphorus quantum dots to obtain PEG-VPNDs with strong and stable photoluminescence, where bond contacts were built between NH2-PEG-NH2 and phosphorus through P─N and P─O to keep robust structures. The PEG-VPNDs have been demonstrated to have outstanding photoluminescence stability both in solution and intracellular environments. No photoluminescence decay was observed after 60 days of storage under ambient conditions or after continuous irradiation with a 300 W xenon lamp for 3 h, in contrast to the photobleaching observed in organic fluorescent dyes. The PEG-VPNDs were also demonstrated to easily enter A2780 and SKOV3 cells and stay outside the nucleus without any assistance, where no decay was observed for photoluminescence of PEG-VPNDs even for 96 h. The PEG-VPNDs have been demonstrated to have high viability in A2780 and SKOV3 cells with concentration of 144 ppm. The photoluminescence performance with high intracellular stability and high biocompatibility makes PEG-VPNDs a promising candidate for long-term bioimaging, cell tracing and other biomedical applications.

PMID 42928630
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PubMedThe journal of applied laboratory medicine2026-10-26

Establishment of Sex-Specific Reference Intervals for Total and Post-PEG Prolactin on an Automated Analyzer.

Miller Jessica J, Leung Jason J, Cheng Pow Lee PL, Wang Xiao Yan XY et al.

The detection of macroprolactin with common prolactin immunoassays complicates the clinical diagnosis of true hyperprolactinemia, thereby causing clinical confusion. We aimed to establish sex-specific reference intervals (RIs) for total and post-polyethylene glycol (PEG) prolactin on the Abbott Alinity i Prolactin Assay. Total prolactin was measured in serum samples from 121 males and 126 females using the current Abbott Alinity i prolactin assay pre- and post-PEG precipitation. Reference intervals were established using R. The RIs for total prolactin was 72.3 to 634.0 mIU/L (3.4 to 29.8 ug/L) for males and 68.1 to 791.5 mIU/L (3.2 to 37.2 ug/L) in females. The post-PEG prolactin RIs established were 46.8 to 361.7 mIU/L (2.2 to 17.0 ug/L) in males and 40.4 to 517.0 mIU/L (1.9 to 24.3 ug/L) in females. The upper limit of these RIs are 75% and 53% lower than total prolactin RIs for males and females respectively, depicting precipitation of a macroprolactin and/or a mixture of dimeric and macroprolactin by PEG. The current convention in macroprolactin reporting is to report the results as a percentage of prolactin recovered post-PEG precipitation compared to total prolactin, with a typical cutoff of <40% recovery to indicate positivity for macroprolactin. These findings support the potential use of assay-specific post-PEG reference intervals as a quantitative complement to percentage recovery reporting and may help to identify patients with elevated post-PEG prolactin concentrations who warrant further clinical evaluation.

PMID 42928585
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PubMedInorganic chemistry2026-10-26

Solution and Mechanochemical Reactions of a Diphosphene with Elemental Sulfur.

Kawase Yuria Y, Ito Kanta K, Omi Cocoro C, Ota Kei K et al.

The bulky Eind-substituted diphosphene, (Eind)P═P(Eind) (1a), reacted with an excess of elemental sulfur (S8) in solution at elevated temperatures to produce an isolable monomeric P(V) species, dithioxophosphorane, (Eind)P(═S)2 (4a), along with cleavage of the P═P double bond (Eind = 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl). A three-membered P2S ring compound with formally P(II) centers, thiadiphosphirane, (Eind)P(S)P(Eind) (2a), was isolated as an intermediate in this solution-phase reaction. In contrast, mechanochemical treatment of 1a with S8 by ball milling under solid-state conditions afforded a P(I)/P(III) mixed-valent diphosphorus species, diphosphene sulfide, (Eind)(S═)P═P(Eind) (3a), which gradually isomerized to 2a at room temperature. The sulfurized products 2a, 3a, and 4a were characterized by 31P NMR spectroscopy, and the molecular structures of 2a and 4a were confirmed by single-crystal X-ray diffraction (SC-XRD) analysis. The structural and electronic properties of these sulfurized products were further investigated using density functional theory (DFT) calculations.

PMID 42929623
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PubMedGels (Basel, Switzerland)2026-10-26

Potential and Safety Assessment of a Hydrogel as a Vitreous Substitute Following Vitrectomy in an Ex Vivo Porcine Model.

Sojdeh Soheil S, Bejandi Zahra Bibak ZB, Castillo Miranda M, Tsougranis Gregory G et al.

To develop and preliminarily evaluate a hyaluronic acid-1,4-butanediol diglycidyl ether (HA-BDDE)/polyethylene glycol-tyramine (PEG-Tyramine) dual-hydrogel designed as a transparent and injectable vitreous substitute with suitable optical, rheological, and cytocompatibility characteristics for potential application following vitrectomy. HA-BDDE and PEG-Tyramine were prepared separately and combined to form a dual-hydrogel formulation. The resulting hydrogel was characterized using attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, oscillatory rheometry, and spectrophotometry to evaluate its chemical, rheological, and optical properties. Cytocompatibility was assessed using retinal pigment epithelial (RPE) cells through the methyl thiazolyl tetrazolium (MTT) assay and Live/Dead fluorescence staining. Ex vivo performance was evaluated following hydrogel injection into porcine eyes after vitrectomy, with assessment of macroscopic transparency, structural integrity, and retention within the vitreous cavity. The HA-BDDE/PEG-Tyramine formulation formed a transparent and macroscopically homogeneous hydrogel phase. Spectroscopic analyses demonstrated the characteristic chemical functionalities and molecular environments associated with the HA- and PEG-containing components. Rheological analysis showed predominantly elastic, gel-like behavior, with the storage modules exceeding the loss modulus across the investigated frequency range. The hydrogel exhibited measurable and relatively stable visible-light transmission across the evaluated wavelength range. RPE cells maintained high metabolic activity during the culture period, while Live/Dead imaging demonstrated predominantly viable cells with limited dead-cell staining. In the ex vivo porcine model, the hydrogel remained within the vitreous cavity and maintained its macroscopic transparency and structural integrity during the observation period. The HA-BDDE/PEG-Tyramine dual-hydrogel exhibited favorable optical, rheological, cytocompatibility, and short-term ex vivo retention characteristics. These findings support further investigation of this dual-hydrogel system as a potential injectable vitreous substitute following vitrectomy.

PMID 42929934
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PubMedACS applied materials & interfaces2026-10-26

Copper Oxide-Loaded Graphdiyne Nanocomposites with Hyperthermia-Enhanced Nanozyme Activity for Cuproptosis-Apoptosis Anticancer Therapy.

Wang Jianxin J, Huang Tong T, Zhang Chunmei C, Sun Yunfeng Y et al.

Cuproptosis is an emerging copper-dependent form of regulated cell death, mechanistically distinct from apoptosis, pyroptosis, and other canonical cell-death pathways, and holds considerable potential for tumor therapeutic applications. In the present study, graphdiyne (GDY) serves as an ideal substrate for the firm immobilization and homogeneous dispersion of CuO nanoparticles. Subsequent polyethylene glycol (PEG) functionalization further enhances the biocompatibility of the hybrid system, yielding CuO/GDY-PEG nanocomposites. The catalase and peroxidase-like activities of CuO nanozymes alleviate hypoxia in the tumor microenvironment (TME) and generate cytotoxic reactive oxygen species, which inducing tumor-cell apoptosis. In addition, this nanocomposite can sustainably deplete glutathione in the TME, disrupt the oxidative balance of the TME, and improve therapeutic efficiency. Photothermal therapy is introduced to facilitate hyperthermia-enhanced tumor nanocatalytic therapy synergistically. More importantly, the intracellular copper overload of tumor cells is caused by the entry of CuO/GDY-PEG nanocomposites into cells. After internalization into tumor cells, CuO/GDY-PEG nanocomposites release Cu2+, which accumulates intracellularly in a mitochondrial-respiration-dependent manner. FDX1 mediates the reduction of Cu2+ to toxic Cu+. The generated Cu+ then binds to lipoylated DLAT and triggers DLAT oligomerization. The formation of insoluble DLAT aggregates elevates cytotoxicity and ultimately drives cuproptosis-mediated cell death. This may synergize with apoptosis to fight tumors systemically.

PMID 42929144
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PubMedPeerJ2026-10-26

Long-term effects of seed priming with polyethylene glycol on sweet sorghum: from enhanced drought tolerance and photosynthesis to improved field yield.

Yao Luhua L, Li Sennan S, Huang Jianhua J, Wang Jiayu J et al.

Seed priming is a cost-effective strategy to enhance crop stress tolerance, yet the persistence of its effects throughout the life cycle and the underlying molecular mechanisms remain largely unexplored, particularly in sweet sorghum, a valuable bioenergy crop vulnerable to drought. This study aims to investigate whether polyethylene glycol (PEG) priming enhances drought tolerance in sweet sorghum and its associated molecular responses, and whether these effects persist to improve yield under field conditions. Sweet sorghum seeds were primed with PEG6000 (150 g L-1) or left unprimed. Priming effects were evaluated through physiological and transcriptomic analyses under controlled drought conditions, followed by field validation across multiple cultivars over two consecutive growing seasons. PEG priming significantly improved seedling growth and photosynthetic capacity under drought stress, with biomass increased by 67.3% compared to unprimed controls. Transcriptomic analysis revealed that priming upregulated key genes in the target of rapamycin (TOR) pathway (TOR1 and LST8) and genes involved in photosystem II repair and carbon metabolism. Notably, the beneficial effects persisted to maturity, increasing biomass by 31.4-46.6% and panicle weight by 45.4-72.5% across three cultivars under field conditions. PEG priming enhances drought tolerance in sweet sorghum through TOR-mediated regulation of photosynthesis and carbon metabolism, with sustained benefits that translate to improved yield in the field. This study provides a mechanistic basis for seed priming as an effective and practical strategy to enhance crop productivity in water-limited environments.

PMID 42928915
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