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naloxone HCl (REZENOPY)

✓ Approved

Scienture Inc. · OPRM1

什么是 naloxone HCl？

naloxone HCl 是一种治疗药物，由Scienture Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Inhaled。

药物档案

商品名REZENOPY
公司Scienture Inc.
分子靶点OPRM1
给药途径Inhaled
状态Approved
来源： ClinicalTrials.gov, Scienture Inc.

作用机制

分子靶点

naloxone HCl 作用于 1 个分子靶点：

OPRM1opioid receptor mu 1 (MOR1, LMOR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

naloxone HCl 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsToxicity to various agents✓ Approved

相关研究文献

PubMedMetabolites2026-07-27

Cheonggukjang-Derived Bacillus Strains Exhibit Protective Effects Against HCl/Ethanol-Induced Gastric Injury Associated with Reduced Inflammatory Responses.

Lee Yun-Seong YS, Kim Sooah S

Hydrochloric acid (HCl)/ethanol-induced gastric mucosal injury is closely associated with oxidative stress and inflammatory responses. Probiotics are promising therapeutic agents for gastrointestinal disorders. Therefore, this study evaluated the preventive effects of Cheonggukjang-derived Bacillus strains on HCl/ethanol-induced gastric mucosal injury in a rat model (n = 5 per group), with emphasis on inflammatory mechanisms. Eight-week-old male Sprague-Dawley rats were orally administered Bacillus amyloliquefaciens C393 1.0 × 109 CFU (B393), Bacillus subtilis C439 1.0 × 109 CFU (B439), or B. subtilis C512 1.0 × 109 CFU (C512). Gastric injury was induced by oral administration of HCl/ethanol (150 mM HCl in 60% ethanol). HCl/ethanol exposure significantly increased symptom scores, gastric mucosal lesion area, and histopathological damage. Pretreatment with B393 and B439 significantly attenuated these alterations. Moreover, HCl/ethanol administration increased gastric secretion volume and decreased gastric pH, both of which were significantly normalized by B393 and B439. Serum levels of pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin-6, were significantly elevated following HCl/ethanol exposure but were markedly reduced by B393 and B439. Immunohistochemical analysis demonstrated that nuclear factor-kappa B activation in gastric tissues was significantly suppressed in these groups. These findings indicate that Cheonggukjang-derived Bacillus strains exert strain-specific gastroprotective effects possibly by suppressing NF-κB-mediated inflammatory signaling.

PMID 42506433
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

Synthesis of Analcime and ZSM-5 Zeolite by Diatomite Without Organic Structure-Directing Agent and Adsorption Properties of Their Acid-Modified Samples on Toluene.

Pan Fanghui F, Wang Jianxiang J, Iqbal Javed J, Yu Fei F et al.

Zeolites are porous aluminosilicate crystalline materials that are widely used for the adsorption of volatile organic compounds (VOCs). The synthesis of zeolites without organic structure-directing agents (OSDAs) is attractive because of its low cost and environmental friendliness. In this study, analcime and the ZSM-5 zeolite were synthesized from natural diatomite under OSDA-free conditions through different crystallization routes. Analcime was prepared by regulating the hydrothermal conditions, while the ZSM-5 zeolite was synthesized by combining hydrothermal condition regulation with seed-induced crystallization. Hydrochloric acid modification was further used to improve the pore structures and adsorption properties of the zeolites. The optimum acid treatment conditions were 1.0 mol·L-1 HCl for analcime and 0.5 mol·L-1 HCl for the ZSM-5 zeolite. After acid modification, the specific surface area and pore volume of analcime increased to 271.7 m2·g-1 and 0.130 cm3·g-1, respectively, and its tolune adsorption capacity increased from 18.3 mg·g-1 to 23.2 mg·g-1, corresponding to a 26.6% improvement. For the ZSM-5 zeolite, the optimal modified sample showed a specific surface area of 307.9 m2·g-1, a pore volume of 0.172 cm3·g-1, and a toluene adsorption capacity of 65.4 mg·g-1, which was 5.5% higher than that of the unmodified sample. Adsorption kinetic analysis indicated that pore diffusion played an important role in toluene adsorption, while acid modification introduced additional acid sites that contributed to chemisorption. Overall, the ZSM-5 zeolite showed a higher adsorption capacity than analcime because of its larger surface area, higher pore volume, and more accessible adsorption sites. This study provides a low-cost and environmentally friendly route for preparing diatomite-derived zeolite adsorbents for VOC removal.

PMID 42506497
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PubMedActa parasitologica2026-07-27

Axenic Cultivation of the First Human-Derived Breviata anathema from a Patient with Fascioliasis in West Bengal, India.

Sardar Sanjib Kumar SK, Ghosal Ajanta A, Saito-Nakano Yumiko Y, Suzuki Jun J et al.

To establish axenic cultivation of a human-derived Breviata anathema (strain T76) isolated from the stool of a patient with fascioliasis and to characterize its biological properties. T76 was maintained in American Type Culture Collection (ATCC) medium 207, supplemented with sulfate-reducing Desulfovibrio desulfuricans and co-cultured with Pseudomonas aeruginosa, at 30 °C. Axenic cultivation was attempted by transferring T76 flagellates to various axenic culture media supplemented with antibiotics for parasitic intestinal protozoan species. The 18 S rRNA gene sequence of T76 exhibited significant homology with the free-living, bacterivorous B. anathema (ATCC 50338), a member of the rare clade Obazoa. Axenic cultivation of B. anathema (T76) was achieved in YIGADHA-S medium, in which gluconic acid and dihydroxyacetone replaced glucose as energy substrates. B. anathema (T76) was isolated from a patient with fascioliasis, exposed through consumption of aquatic plants from ponds, a known habitat of this organism. Axenic cultivation of T76 was established in YIGADHA-S medium, originally developed for Entamoeba dispar, and cyst-like spherical bodies harboring flagellates were observed and exhibited resistance to 0.1 N HCl.

PMID 42507263
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PubMedMembranes2026-07-27

A Pseudoenzymatic Regulatory Role of the Noncatalytic Subunit of the Neurotoxin Vipoxin at Arachidonic-Acid-Containing Membrane Interfaces.

Petrova Svetla S, Mircheva Kristina K, Sotirovska Evgenia E, Grozev Nikolay Alexandrov NA et al.

Secreted phospholipases A2 (sPLA2s) act at lipid interfaces where enzymatic turnover is strongly influenced by membrane packing and interfacial physicochemical conditions. Vipoxin, a heterodimeric neurotoxin from Vipera ammodytes meridionalis, is one such complex, comprising a catalytically active sPLA2 subunit (VBC) and a catalytically impaired homolog, VAC, suggesting a pseudoenzymatic regulatory role. Using SAPC Langmuir monolayers as a model of arachidonic-acid-containing membranes, we monitored the compensated monolayer area change, ΔA(t), under barostatic conditions as an integrated readout of the interfacial behavior of Vipoxin and its isolated subunits. The responses revealed pronounced modulation by surface pressure and by the acidic acetate versus basic Tris-HCl subphase environment: VBC retained high catalytic competence under both conditions, whereas Vipoxin displayed greater environmental sensitivity, consistent with VAC-dependent modulation of enzyme-membrane coupling. VAC, although lacking canonical catalytic activity, produced measurable interfacial effects under acidic conditions and high lateral pressure. Analysis using the interfacial quality parameter Qm demonstrated that VAC modifies the pressure dependence of the heterodimer and stabilizes interfacial accommodation of VBC. These findings indicate that VAC functions as a pseudoenzymatic regulatory subunit whose role emerges from dynamic coupling between enzymatic activity and lipid interfacial organization.

PMID 42506206
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PubMedThe Journal of physiology2026-07-27

μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice.

Kalajian Eva J EJ, Stettler Marco K MK, Smith Gregory D Conradi GDC, Del Negro Christopher A CA

Opioid-induced respiratory depression (OIRD) is mediated, in part, by μ-opioid receptor (μOR) signalling in the respiratory rhythmogenic preBötzinger complex (preBötC). However, it has been unclear whether opioids affect excitatory or inhibitory neurons, which ion channels are modulated, and by what signalling mechanism. This study clarifies these questions. We quantify Oprm1 (μOR gene) expression in preBötC glutamatergic, GABAergic, and glycinergic neurons and show that 67%-77% of each subpopulation express Oprm1 at commensurate levels, suggesting that all preBötC neurons may respond to opioids. We demonstrate that μOR agonist DAMGO increases passive K+ conductance in glutamatergic neurons, specifically via membrane-delimited modulation of Kir3 channels. Inhibitory neurons do not respond to DAMGO despite Oprm1 expression. These results suggest that opioid modulation of Kir3 reduces excitability of glutamatergic preBötC neurons, which may contribute to OIRD. We propose that therapies that attenuate membrane-delimited Gβγ signalling may prevent fatal apnoea while circumventing limitations of μOR antagonists like naloxone. KEY POINTS: μ-Opioid receptor activation depresses excitability only in glutamatergic interneurons of the respiratory rhythmogenic preBötzinger complex. Whole-cell and single-channel patch clamp recordings show that μ-opioid receptor agonist DAMGO increases Kir3 conductance by increasing channel activity through a membrane-delimited signalling mechanism. New interventions that reverse opioid-induced respiratory depression could target signalling molecules downstream from the μ-opioid receptor and attenuate Gβγ-Kir3 interactions as an alternative to conventional receptor antagonists.

PMID 42503432
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PubMedBioresource technology2026-07-26

Waste biomass valorisation into high-performance CO2 adsorbents: Feedstock-dependent effects of demineralisation and KOH activation.

Jerzak Wojciech W, Dutka Barbara B, Sokołowski Krystian K, Kalemba-Rec Izabela I et al.

This study investigated the feedstock-dependent development of porosity and CO2 adsorption performance in waste-derived biochars prepared from spent coffee grounds, chicken manure and onion peels. The precursors were pyrolysed at 800 °C and subsequently modified by HCl demineralisation and KOH activation under identical conditions. The results showed that the response to sequential modification was strongly controlled by the intrinsic properties of the precursor, particularly ash content, mineral composition and carbon matrix structure. HCl treatment was especially important for chicken-manure-derived biochar, where mineral removal improved pore accessibility, whereas KOH activation was primarily responsible for the development of micro- and mesoporosity. Among the activated samples, OP-BDA exhibited the highest BET surface area, increasing from 88.8 to 1474.6 m2/g. However, SCG-BDA showed the highest CO2 uptake, reaching 95.3 cm3/g at 20 °C and 100 kPa, despite its lower BET surface area. Correlation analysis confirmed that CO2 adsorption was governed mainly by ultra-micropore and narrow micropore development rather than by total surface area alone. Surface nitrogen- and oxygen-containing functionalities may provide additional local affinity, but their role appeared secondary to the dominant effect of microporosity. The activated biochars also showed favourable CO2/N2 selectivity, low isosteric heat of adsorption and good cyclic stability. These findings demonstrate that appropriately selected waste biomass can be converted into effective CO2 adsorbents, although further optimisation of reagent use, washing effluents and process economics is required.

PMID 42501900
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