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INJEX system

✓ Approved

Equidyne · 治疗药物

什么是 INJEX system？

INJEX system 是一种治疗药物，由Equidyne研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Subcutaneous Injection。

药物档案

公司Equidyne
给药途径Injectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Equidyne

治疗适应症

INJEX system 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedCardiology in the young2026-07-27

Evaluation of cardiac abnormalities in multi-system inflammatory syndrome in children related multi-organ dysfunction syndrome.

Christmas Ashlee A, West Alina N AN, Gooty Vasu V, Shah Samir S

Multi-system inflammatory syndrome in children hyperinflammation can cause multiple organ system dysfunction syndrome through mechanisms, including endothelial dysfunction and thrombotic microangiopathy. We evaluated potential endothelial damage and thrombotic microangiopathy as an underlying multi-system inflammatory syndrome in children associated multi-organ dysfunction syndrome pathophysiology. Cardiac dysfunction was assessed using echocardiogram and copeptin. In pediatric ICU multi-system inflammatory syndrome in children patients, multi-organ dysfunction syndrome and thrombotic microangiopathy criteria were established using medical record data. Terminal complement and copeptin levels were evaluated alongside imaging (including echocardiogram), blood work, signs and symptoms of multi-organ dysfunction syndrome, and interventions documented during hospitalisation. Copeptin level correlation with multi-organ dysfunction syndrome severity and biomarkers of cardiac dysfunction were analysed. Of 12 pediatric ICU patients with multi-system inflammatory syndrome in children, 7 (58.33%) patients met multi-organ dysfunction syndrome criteria, and 8 (66.67%) met thrombotic microangiopathy criteria. Renal (66.67%) and cardiovascular (58.33%) dysfunction were most associated with multi-organ dysfunction syndrome. Multi-system inflammatory syndrome in children patients had higher terminal complement and copeptin levels compared to eight control subjects. Copeptin had a significant negative relationship with left ventricular ejection fraction and positive relationships with B-type natriuretic peptide and blood urea nitrogen but no other markers of renal or cardiac dysfunction. There was a strong positive relationship between copeptin and terminal complement. Multi-system inflammatory syndrome in children requiring pediatric ICU admission are multi-organ dysfunction syndrome-susceptible due to underlying complement-associated thrombotic microangiopathy. Copeptin can be used as a marker of acute critical illness and systolic dysfunction in multi-system inflammatory syndrome in pediatric patients. These biomarkers would guide clinicians earlier in the diagnosis and treatment of thrombotic microangiopathy-related multi-organ dysfunction syndrome due to multi-system inflammatory syndrome in children. However, their utility as markers for myocardial injury, diastolic dysfunction, and the severity of multi-organ dysfunction syndrome needs further evaluation.

PMID 42504733
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PubMedThe Journal of chemical physics2026-07-27

Coherent dynamics of the spin-boson model in the ultra-strong coupling regime.

Acharyya Nirmalendu N, Richter Martin M, Fingerhut Benjamin P BP

Quantum mechanics describes the unitary time evolution of closed systems. In practice, every quantum system interacts with the environment, leading to an irreversible loss of coherence. The spin-boson model (SBM) is central to the understanding of the fundamental process of decoherence of a two-state quantum system interacting with a bosonic heat bath, but the nature of transient dynamics in the presence of hybrid diagonal and off-diagonal system-bath interactions remains much less explored. Here, we investigate how the hybrid system-bath interactions of an Ohmic environment induce localization in the bias-free SBM. For strong coupling to the environment, localization is strongly affected by a dynamically generated bias via the renormalization of the tunneling amplitude. We find that counteracting effects of Hamiltonian parameters on non-exponential short-time dynamics and long-time population equilibration can lead to a separation of timescales and transient quantum coherent dynamics that can persist even for ultra-strong system-bath interaction. The findings offer novel insight into the equilibration behavior of quantum devices operating in the ultra-strong coupling regime.

PMID 42504900
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PubMedEuropean heart journal. Quality of care & clinical outcomes2026-07-27

Impact of system efficiency on out-of-hospital cardiac arrest outcomes and hospital stay: an observational study from Lombardia CARe.

Marjin Corina C, Gaeta Maddalena M, Gentile Leandro L, Girardi Daniela D et al.

Out-of-hospital cardiac arrest (OHCA) remains a major public health concern, characterised by high mortality and substantial variability in survival rates. As patient and event characteristics are largely unmodifiable, system efficiency is essential to improve survival. We conducted a retrospective cohort study using data from the Lombardia Cardiac Arrest Registry, including 12,532 OHCA cases (2015-2023). Multivariate logistic regression models were applied to assess the relationship between emergency medical service (EMS) arrival time and prehospital mortality, as well as long-term outcomes according to system efficiency. Furthermore, a sub-cohort of 515 hospitalised patients was analysed to evaluate hospital stay and healthcare costs. Prehospital event mortality increased from 74.7% to 93.2% with longer EMS response time, with survival decreasing by 0.6% for each additional minute of EMS delay (OR 1.03; 95% CI 1.02-1.05). Higher system efficiency, characterised by bystander cardiopulmonary resuscitation and EMS arrival within 10 minutes, was associated with markedly higher survival at hospital admission (25.4% vs. 7.6%) and at 12 months (13.0% vs. 1.6%), as well as improved neurological outcomes and discharge survival among hospitalised patients. Higher hospital costs were observed among patients in the high-efficiency system group, while less efficient systems showed higher costs per survivor at 12 months follow-up (€61,781 vs. €48,985). System responsiveness is a key modifiable factor influencing outcomes after OHCA, with each minute of EMS delay substantially reducing survival odds. Enhancing the entire chain of survival is essential to improve patient outcomes and reduce the indirect societal costs associated with OHCA.

PMID 42504431
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PubMedJournal of imaging2026-07-27

Research on Integrated Technologies for Space Target Imaging, Ranging, and Communication.

Gu Xiansong X, Fu Qiang Q, Liu Zhuang Z, Wang Guan G et al.

The integration requirements of laser ranging, imaging, and communication functions in space target detection have placed higher demands on system performance. This paper takes a modularly designed integrated laser ranging, imaging, and communication system as an example and proposes a light source integration scheme based on fiber phased array beam splitting-coupling technology, effectively enhancing the system's integration level and compactness. The system employs a Cassegrain optical system and beam splitting structure to achieve functional integration of laser communication, ranging, and polarization imaging. Ground experiments were conducted to evaluate the functional feasibility of the proposed integrated architecture. The visible light polarization imaging experiments at kilometer-level distances demonstrate that polarization-derived information can improve target-background separability under haze and low-contrast conditions. The UAV-based dynamic ranging experiment verifies that the system can acquire, track, and range a moving cooperative target under the tested field conditions, with the measured results being consistent with the designed meter-level ranging requirement. In addition, a 1 km coherent free-space laser communication experiment achieved 20 Gbps QPSK signal transmission with a bit error rate on the order of 10-7. These results provide experimental support and design references for integrated optoelectronic terminals used in space target observation, space debris monitoring, and related long-distance sensing and communication applications.

PMID 42506138
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PubMedJournal of robotic surgery2026-07-27

Early clinical experience with the Toumai robotic system in general surgery: a systematic review of short-term outcomes and telesurgical applications.

Brucchi Francesco F, Stanco Rita R, Sperotto Beatrice B, Sassun Richard R et al.

The Toumai Surgical Robot System is an emerging robotic platform with potential advantages related to cost and native telesurgical capability. This systematic review evaluated the early clinical experience with the Toumai system in general surgery, focusing on procedural characteristics, perioperative outcomes, and 5G remote applications. A PRISMA-compliant systematic review was conducted. MEDLINE/PubMed, EMBASE, the Cochrane Library, and Web of Science were searched through March 2026. Studies reporting general surgical procedures performed with the Toumai system and postoperative outcomes were included. Purely urological or gynaecological series, conference abstracts, narrative reviews, and preclinical studies were excluded. Risk of bias was assessed using ROBINS-I. Eight studies were included: four retrospective cohorts, three prospective clinical trials, and one case report. All were conducted in China and comprised 416 patients, of whom 329 were treated with a confirmed Toumai system; 87 patients came from a mixed-platform HPB cohort and were considered supportive, platform-non-specific evidence. Procedures included HPB surgery, gastric surgery, cholecystectomy, inguinal hernia repair, colorectal surgery, and one vascular resection. Conversions were infrequent, blood loss was low, and complications were predominantly Clavien-Dindo I-II, with no procedure-related mortality. One propensity-score-matched study found no significant short-term differences between Toumai and da Vinci Xi radical gastrectomy. Two prospective studies demonstrated 5G remote surgery for radical gastrectomy over 15 km and cholecystectomy over 70 km. On ROBINS-I assessment, most included studies were judged to be at moderate risk of bias. Early evidence suggests that the Toumai system is feasible and safe in the short term across selected general surgical procedures, with distinctive 5G telesurgical capability. Comparative effectiveness, generalisability, and cost-effectiveness remain unproven.Study Registration: A review protocol was registered in PROSPERO (CRD420261428858).

PMID 42503579
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PubMedAsian journal of endoscopic surgery2026-07-27

Technical Feasibility and Setup Optimization of the HUGO RAS System for Robotic-Assisted Transaxillary Thyroidectomy: A Preclinical Study in a Porcine Model.

Kim Byung-Chang BC, Lee Young-Min YM, Kim Sookyung S, Kim Won Woong WW et al.

Robotic thyroidectomy has been increasingly adopted as a minimally invasive approach, with feasibility and safety established using existing robotic platforms. We report the first experimental application of the HUGO Robotic-Assisted Surgery (RAS) system for thyroidectomy via a transaxillary approach in a porcine model. All procedural steps, from flap creation to thyroid gland dissection, were completed successfully without technical difficulties. The presumed recurrent laryngeal nerve was identified and preserved throughout the procedure. This preclinical study demonstrates the technical feasibility of thyroidectomy using the HUGO RAS system. These findings support its applicability in human thyroid surgery and future clinical translation.

PMID 42503844
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