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pancrelipase (Ultrase MT20 / Ultrase MT / Ultresa)

✓ Approved

Adare Pharma Solutions · PNLIP

什么是 pancrelipase？

pancrelipase 是一种治疗药物，由Adare Pharma Solutions研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Ultrase MT20, Ultrase MT, Ultresa
公司Adare Pharma Solutions
分子靶点PNLIP
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Adare Pharma Solutions

作用机制

分子靶点

pancrelipase 作用于 1 个分子靶点：

PNLIPpancreatic lipase (PL, PNLIPD)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

pancrelipase 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
InvestigationsFaecal fat increased✓ Approved
Gastrointestinal disordersSteatorrhoea✓ Approved
Gastrointestinal disordersPancreatic failure✓ Approved

相关研究文献

PubMedBiological trace element research2026-09-10

Combined sodium selenite-cinnabar suppresses mercury accumulation and modulates nephrotoxic responses in mice.

Zhuo Yuzhou Y, Liu Xiaoqin X, Dai Zhihui Z

Cinnabar (ZS) is a commonly used in traditional Chinese medicine (TCM), but its clinical application is limited owing to mercury (Hg) related toxicity. This study aimed to explore the kidney toxic and related mechanisms of ZS combined with sodium selenite (Na2SeO3). Eighty specific-pathogen-free (SPF) male Kunming (KM) mice were randomly divided into ten groups: control (0.5% CMC-Na), HgS (50 mg·kg- 1), ZhuShaAnShenWan (ZSASW) (600 mg·kg- 1), Hg(NO3)2 (1.2 mg·kg- 1), cinnabar-L(ZS-L) (50 mg·kg- 1), cinnabar-H (ZS-H) (200 mg·kg- 1), Na2SeO3 (1 mg·kg- 1), ZS-Na2SeO3 (50 mg/kg-1 mg·kg- 1), HgS-Na2SeO3 (50 mg·kg- 1-1 mg·kg- 1) and ZSASW-Na2SeO3 (600 mg·kg- 1-1 mg·kg- 1). All mice received intragastric administration once daily for 30 consecutive days. Kidney contents of Hg, selenium (Se) and other trace elements were measured by inductively coupled plasma-mass spectrometry (ICP-MS) and related detection instruments. Kidney histopathological lesions, cell apoptosis and serum levels of creatinine (Cre), blood urea nitrogen (BUN) and uric acid (UA) were detected to assess renal injury. The results demonstrated that the kidney cell apoptosis rate higher in Na2SeO3 (P < 0.05) and ZS-H groups (P < 0.05) than in ZS-L and ZS-Na2SeO3 combination groups. Serum kidney function indexes were obviously increased in HgS-Na2SeO3, Na2SeO3 groups compared with the control group (P < 0.05). The mercury content in the kidneys of the ZS-H group was 10.51 µg·g- 1, ZS-L group was 7.99 µg·g- 1, while that of the ZS-Na2SeO3 group was 3.43 µg·g- 1. Inorganic mercury exhibited stronger kidney accumulation capacity than ZS and ZSASW. The toxic effect of ZS is not equivalent to that of inorganic mercury. The content of Hg in kidney was positively correlated with the dose. Co-administration of Na2SeO3 and ZS could lower kidney mercury accumulation. This could result from suppressed intestinal Hg absorption or formation of inert in-vivo complexes. Relevant component interactions should be fully considered when evaluating the safety and toxicity of ZS.

PMID 42717168
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PubMedChemistry & biodiversity2026-09-10

Osteogenic Activity of New Dammarane-Type Saponins From Gynostemma pentaphyllum.

Duong Nguyen Tuan NT, Ha Tran Thi Thu TTT, Yen Duong Thi Hai DTH, Thao Do Thi DT et al.

Five dammarane-type saponins (1-5) were isolated from the aerial parts of Gynostemma pentaphyllum, including two new compounds, 2α,3β,12β,19,20(S)-pentahydroxydammar-24-ene 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside]-20-O-[β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside] (1) and 12-oxo-2α,3β,20(S)-trihydroxydammar-24-ene 3-O-(β-D-glucopyranoside)-20-O-[β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside] (2). The structures were elucidated through various spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR). Compounds 1-3 and 5 exhibited osteogenic activity by stimulating alkaline phosphatase (ALP) activity, collagen synthesis, and calcium mineralization in mouse osteoblastic MC3T3-E1 cells. Among these, compound 2 increased ALP activity by 1.30 ± 0.07- and 1.59 ± 0.16-fold at 2 and 1 µg/mL, respectively, whereas compound 1 increased collagen synthesis and calcium mineralization by 1.14 ± 0.05- and 1.24 ± 0.06-fold at 1 µg/mL, and compound 3 increased these parameters by 1.25 ± 0.07- and 1.14 ± 0.03-fold at 2 µg/mL, respectively.

PMID 42720111
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PubMedJournal of medicinal chemistry2026-09-10

Discovery and Crystallographic Study of Water-Soluble Quaternary Ammonium-Based PD-1/PD-L1 Inhibitors with Anti-Angiogenic Activity.

Xu Jianwei J, Yang Pan P, Yang Xixiang X, Shu Yaoyao Y et al.

Programmed death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) represents a critical immune checkpoint in cancer immunotherapy; however, most small-molecule PD-1/PD-L1 inhibitors suffer from poor aqueous solubility. Here, we designed a series of quaternary ammonium-based PD-1/PD-L1 inhibitors. Among them, QA9 exhibited potent PD-1/PD-L1 inhibition (IC50 = 18.7 nM), outperforming the lead compound NP19, and demonstrated a 600-fold improvement in water solubility (0.642 vs 0.001 mg/mL). X-ray crystallography revealed that QA9 stabilizes the PD-L1 dimer through multiple interactions, providing a structural basis for its high affinity. In MC38/Jurkat and HCT116/Jurkat coculture models, QA9 enhanced immune-mediated tumor cell death. Additionally, QA9 suppressed VEGF-A-induced tube formation and migration in HUVECs, which was associated with reduced FAK phosphorylation. Furthermore, in an MC38 mouse colon cancer model, QA9 showed robust antitumor activity without overt toxicity. Collectively, the quaternary ammonium strategy represents an effective approach to developing water-soluble PD-1/PD-L1 inhibitors with dual immunomodulatory and antiangiogenic functions.

PMID 42720488
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PubMedJournal of medical virology2026-09-10

Molecular Evidence of Human T‑Cell Leukemia Virus Type 1 Transmission by Needlestick Injury in Healthcare Workers.

Tokunaga Masahito M, Kuramitsu Madoka M, Saito Masumichi M, Yoshimori Miyuki M et al.

Human T‑cell leukemia virus type 1 (HTLV‑1) is a retrovirus that spreads primarily through cell-to-cell transmission. Occupational transmission of HTLV-1 by needlestick injury is considered exceedingly rare, with no reported molecularly confirmed cases. We report two healthcare workers who experienced accidental needlestick injuries while caring for patients seropositive for HTLV‑1 and subsequently seroconverted. Full‑length HTLV‑1 proviral sequencing revealed complete nucleotide identity between source patients and infected nurses. These strains belonged to the HTLV-1 subtype 1a Japanese subgroup but were distinct from 315 previously registered strains. Proviral integration site analysis demonstrated nonoverlapping integration profiles between source patients and healthcare workers, providing direct evidence of de novo HTLV‑1 infection rather than expansion of transferred infected cells. Longitudinal analysis in one case showed dynamic clonal turnover between 5 and 14 months after transmission; > 90% of infected-cell clones were replaced, although the proviral load remained stable and low. Serological profiling revealed transiently elevated immunoglobulin M responses to Gag p19 peptides during early infection, followed by gradual immunoglobulin G maturation. These findings provide the first molecular confirmation of HTLV‑1 transmission via needlestick injury resulting in de novo infection, revealing an under-recognized occupational exposure route and supporting reconsideration of post-exposure testing strategies, particularly in endemic regions.

PMID 42720182
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PubMedJournal of molecular histology2026-09-10

High TG/low HDL-C ratio-mimetic lipid stress drives diabetic atherosclerotic endothelial-macrophage dysfunction through glycocalyx disruption and CD36/ABCA1 imbalance.

Bi Lechang L, Zhao Wen W, Lu Mingjing M, Jiang Nan N et al.

A high triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is strongly associated with insulin resistance and atherosclerotic cardiovascular risk, but the cellular mechanisms linking this lipid imbalance to vascular injury remain incompletely defined. This study established a combined hyperglycemic/high TG/low HDL-C ratio-mimetic in vitro model using human coronary artery endothelial cells and THP-1-derived macrophages to investigate endothelial inflammation, glycocalyx disruption, monocyte recruitment, foam-cell formation, oxidative stress, and cholesterol efflux. High TG/low HDL-C ratio-mimetic stress significantly reduced endothelial viability, increased cytotoxicity, impaired transendothelial resistance, increased fluorescein isothiocyanate (FITC)-dextran permeability, and promoted syndecan-1 shedding. The lipid-stress condition induced endothelial inflammatory activation, with increased vascular cell adhesion molecule 1 (VCAM1), intercellular adhesion molecule 1 (ICAM1), E-selectin (SELE), C-C motif chemokine ligand 2 (CCL2), interleukin 6 (IL6), and C-X-C motif chemokine ligand 8 (CXCL8) expression, accompanied by enhanced THP-1 adhesion and transmigration. Glycocalyx and junctional injury were supported by increased heparanase (HPSE) expression and reduced syndecan-1 (SDC1), tight junction protein 1 (TJP1), cadherin 5 (CDH5), wheat germ agglutinin (WGA) staining, zonula occludens-1 (ZO-1) continuity, and vascular endothelial cadherin (VE-cadherin) integrity. Endothelial-conditioned lipid stress promoted macrophage foam-cell formation, increased CD36 scavenger receptor (CD36), oxidized low-density lipoprotein receptor 1 (OLR1), and peroxisome proliferator-activated receptor gamma (PPARG) expression, enhanced cholesterol accumulation, and suppressed ATP-binding cassette transporter A1 (ABCA1)-, ATP-binding cassette transporter G1 (ABCG1)-, scavenger receptor class B member 1 (SCARB1)-, and apolipoprotein E (APOE)-associated cholesterol efflux pathways. HDL rescue broadly attenuated endothelial inflammation, oxidative stress, barrier disruption, and macrophage foam-cell formation, whereas ApoA-I exerted protective effects across the selected endothelial and macrophage endpoints in which it was evaluated. CD36 inhibition reduced macrophage lipid accumulation, whereas heparanase inhibition preserved glycocalyx integrity. These findings identify the endothelial glycocalyx-nuclear factor kappa B (NF-κB)-CD36/ABCA1 axis as a mechanistic link between the high TG/low HDL-C ratio and diabetic atherosclerotic vascular dysfunction.

PMID 42717131
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PubMedJournal of microencapsulation2026-09-10

Coacervation-based co-encapsulation of curcumin and vitamin E in gelatine-alginate microcapsules: a comprehensive study on encapsulation efficiency, physical properties, structure and release behaviour.

Ltaief Chaima Belhadj CB, Zoghlami Aya A, El-Itawi Hassan H, Abdelhedi Ola O et al.

Curcumin and α-tocopherol (vitamin E) are lipophilic antioxidants limited by poor stability. To overcome this, both compounds were co-encapsulated in tannic acid-crosslinked gelatine-sodium alginate microcapsules via complex coacervation, comparing Ultra-Turrax (UT) and ultrasonication (US) homogenisation across core-to-wall ratios (1/1, 1/2, 1/3). Ultrasonication at a 1/3 ratio yielded the highest encapsulation efficiencies (94.3% curcumin, 91.0% vitamin E, vs. ∼41-44% untreated). These US microcapsules were smaller (227 nm), less porous (36.7%), and demonstrated progressive pH-dependent release over 72 h without an initial burst. Antioxidant activity was fully retained during simulated gastrointestinal digestion. Overall, ultrasonication-assisted complex coacervation provides an effective route for developing robust gelatine-alginate delivery systems for food and pharmaceutical formulations.

PMID 42717668
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