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collagenase (Plaquase / Nucleolysin / lipolysin)

✓ Approved

Johnson & Johnson Services, Inc. · 治疗药物

什么是 collagenase？

collagenase 是一种治疗药物，由Johnson & Johnson Services, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Topical。

药物档案

商品名Plaquase, Nucleolysin, lipolysin
公司Johnson & Johnson Services, Inc.
给药途径Injectable (Others), Topical
状态Approved
来源： ClinicalTrials.gov, Johnson & Johnson Services, Inc.

治疗适应症

collagenase 针对 10 个适应症，涉及 7 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersDecubitus ulcer✓ Approved
Injury, poisoning and procedural complicationsThermal burn✓ Approved
Skin and subcutaneous tissue disordersDiabetic foot✓ Approved
Musculoskeletal and connective tissue disordersDupuytren's contracture✓ Approved
Eye disordersGlaucoma✓ Approved

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相关研究文献

PubMedChemistry & biodiversity2026-09-10

Comparative Phytochemical and Biological Evaluation of Four Thymus Species From Türkiye for Dermocosmetic Applications.

Özdemir Nath Ebru E, Campos Pierre-Eric PE, Le Cabec Audrey A, Gündoğan Gül İpek Gİ et al.

Species of Thymus have long been used in Anatolia for wound healing and skin disorders. This study characterized metabolites and biological activities of four taxa-Thymus leucostomus (TL), Thymus sipyleus (TS), Thymus brachychilus (TB), and Thymus migricus (TM)-using UHPLC-HRMS/MS-based molecular networking, anti-aging enzyme inhibition assays, and cellular models (L929 fibroblasts, HaCaT keratinocytes, HUVEC endothelial cells). All taxa showed triterpene-rich profiles, though TL was enriched in polymethoxylated flavonoids and TM in diterpenes. Extracts strongly inhibited hyaluronidase, collagenase and elastase, with more modest tyrosinase inhibition; the highest values were recorded for TB (hyaluronidase, 89.64%), TM (elastase, 78.31%), and TL (collagenase, 82.92%; tyrosinase, 39.74%). Biologically, TL demonstrated the broadest cytocompatibility and significantly enhanced wound closure in fibroblast (≈84.7%) and keratinocyte (≈71.3%) models. TL and TS achieved nearly complete endothelial wound closure, suggesting potential pro-regenerative effects. TL showed lower cytotoxicity in HaCaT and HUVEC cells (IC50 ≈ 0.5 mg/mL), whereas TM exhibited stronger cytotoxicity in keratinocytes (IC50 ≈ 0.1025 mg/mL). TM moderately increased intracellular ROS levels in L929 fibroblasts, while TL and TS maintained ROS levels closer to control conditions. Overall, TL and TS displayed more balanced in vitro profiles regarding wound closure, oxidative balance, and enzyme inhibition, whereas TM required more cautious concentration-dependent interpretation.

PMID 42720075
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PubMedStroke2026-09-10

Modulation of Brain Injury After Intracerebral Hemorrhage via the Scalp-Skull-Dura Interface in Mice.

Li Peizheng P, Deng Ziling Z, Meng Ling L, Mao Lijuan L et al.

Neuroinflammation critically contributes to secondary brain injury after intracerebral hemorrhage (ICH). The skull-dura interface allows immune trafficking from skull bone marrow (SBM) to the brain, but its role in ICH remains unclear. ICH was induced in male C57BL/6J mice by collagenase injection. To compare the immune landscape of SBM and femur bone marrow (FBM), single-cell RNA sequencing was performed on sham-operated and ICH mice. Flow cytometry at serial time points, combined with cell-tracking experiments, was used to assess time-dependent neutrophil accumulation in SBM, dura, and brain, as well as the relative contribution of SBM- versus FBM-derived neutrophils after ICH. To test whether SBM-derived neutrophil migration contributes to neuroinflammation, the CXCR2 (C-X-C motif chemokine receptor 2) antagonist SB225002 was delivered subscalp. Finally, dural delivery of anti-CCL3 (C-C motif chemokine ligand 3) neutralizing antibodies was performed to determine the role of dural CCL3 in SBM neutrophil priming. Outcomes included evaluations of behavioral deficits, brain edema, integrity of the blood-brain barrier, hematoma removal, and brain neutrophil infiltration. Single-cell RNA sequencing revealed that ICH shifted hematopoiesis toward the myeloid lineage in both SBM and FBM; however, SBM neutrophils exhibited significantly stronger proinflammatory and migratory gene signatures than FBM neutrophils. Skull-derived neutrophils preferentially migrated to the dura and brain parenchyma post-ICH. Subscalp delivery of SB225002 reduced neutrophil infiltration, attenuated brain edema and blood-brain barrier disruption, and improved short-term and long-term neurological deficits. In addition, CCL3 was specifically upregulated in dural neutrophils after ICH. Unexpectedly, dural delivery of an anti-CCL3 antibody markedly reduced neutrophil accumulation in the brain and protected against ICH-induced brain injury, accompanied by inhibition of neutrophil activation in SBM but not in FBM. SBM may serve as a primary source of pathogenic neutrophils driving neuroinflammation after ICH. Targeting this immune compartment through the scalp-skull-dura interface represents an accessible strategy for mitigating ICH-induced brain injury.

PMID 42717864
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PubMedPlastic and reconstructive surgery2026-09-09

Surgical Fasciectomy Versus Collagenase Injection for Recurrent Dupuytren Contracture: A Randomized Controlled Trial.

Nordenskjöld Jesper J, Eckerdal David D, Lauritzson Anna A, Atroshi Isam I

Collagenase injection is effective in primary Dupuytren contracture but efficacy in treating recurrence has not been evaluated in randomized trials. The aim was to compare surgical fasciectomy and collagenase injection for recurrent Dupuytren contracture. In a single-center trial, 59 patients with recurrent Dupuytren contracture were randomized to fasciectomy (28 patients) or collagenase injection (31 patients). The primary endpoints were change in total active extension deficit (TAED) in treated fingers from baseline to 12 weeks and re-recurrence rate (TAED worsening ≥ 20° from 12 weeks to 2 years). Secondary endpoints included total passive extension deficit (TPED), QuickDASH, pain and satisfaction scores, and adverse events. Mean improvement in TAED from baseline to 12 weeks was 52° in the fasciectomy group versus 49° in the collagenase group (adjusted mean difference -1; 95% CI -9 to 8), and from baseline to 2 years 47° versus 34° (adjusted mean difference -8; 95% CI -23 to 7). The re-recurrence rate was 14.8% in the fasciectomy and 27.6% in the collagenase group (RR 1.9; 95% CI 0.6 to 5.6). Mean QuickDASH score showed clinically important worsening, baseline to 3 weeks, in the fasciectomy group only (adjusted mean between-group difference -11.7; 95% CI -18.5 to -5.0), with no other significant score differences. In the fasciectomy group there were 1 digital nerve and 2 digital artery lacerations. In recurrent Dupuytren contracture, the 2-year outcomes of surgical fasciectomy and collagenase did not show any statistically significant differences, but surgery was associated with more severe adverse events.

PMID 42714279
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PubMedFrontiers in oral health2026-09-09

A novel modified-curcumin 2.24 suppresses MMPs in a periodontal-relevant cell culture model: a pilot study.

Ho Isabella I, Leung Cindy C, Bhandari Nidhi N, Lee Hsi-Ming HM et al.

Matrix metalloproteinases (MMPs) play critical roles in periodontal tissue destruction. The present study evaluated the efficacy of a novel chemically modified curcumin 2.24 (CMC 2.24) in reducing MMP levels, activity, and its activation, in a periodontal relevant cell culture model involving human mononuclear THP-1 cells. In addition, the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway played a key role in the inflammatory process in response to various stimuli such as cytokines, bacterial antigens, and endotoxin lipopolysaccharide (LPS). Therefore, the effect of CMC 2.24 on p38 MAPK levels was evaluated as well. THP-1 monocytes were cultured and stimulated with LPS in the presence or absence of 5 µM CMC 2.24, Chemically modified tetracycline 3 (CMT-3), or doxycycline for 6 or 18 h. Conditioned media (CM) were analyzed for MMP-9 and collagenase levels using gelatin and collagen zymography. In addition, LPS-treated CM were incubated with 4-Aminophenylmercuric acetate (APMA) in the presence or absence of the above agents for an hour. MMP activation was evaluated by gelatin zymography. THP-1 MMP enzyme activity was analyzed using a fluorogenic substrate. p38 MAPK levels in THP-1 cell lysates were determined using the western blot technique. CMC 2.24 significantly reduced elevated MMP-9 and collagenase levels compared to LPS controls. CMC 2.24 also inhibited APMA-induced activation of MMP-9 and reduced MMP enzymatic activity. Further, CMC 2.24 significantly suppressed p38 MAPK levels, whereas CMT-3 and doxycycline showed limited or no effect. CMC 2.24 functions as a highly pleiotropic inhibitor, acting at multiple regulatory levels: reducing MMP levels, activation, and enzymatic activity, while also downregulating MAPK signaling. These findings highlight CMC 2.24 as a promising therapeutic candidate for the modulation of inflammation-associated matrix degradation in chronic inflammatory diseases such as periodontitis.

PMID 42712432
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PubMedJournal of agricultural and food chemistry2026-09-09

Oral Ingestion of Jellyfish Collagen Hydrolysate Effectively Delivers a Bioactive Tripeptide, Gly-3Hyp-4Hyp, into the Blood and Skin.

Taga Yuki Y, Iwasaki Yu Y, Kusubata Masashi M, Mizuno Kazunori K

A growing body of literature reports the health benefits of the jellyfish collagen hydrolysate. However, although hydroxyproline (Hyp)-containing oligopeptides absorbed into the bloodstream are considered responsible for the biological functions of collagen hydrolysate, the active ingredient specific to jellyfish collagen remains unclear. Here, we revealed that a collagenase-digested cannonball jellyfish collagen hydrolysate is highly enriched with a bioactive tripeptide, Gly-3Hyp-4Hyp (15.6 mg/g). In humans, oral ingestion of the jellyfish collagen hydrolysate resulted in a 7.8-fold higher blood absorption of Gly-3Hyp-4Hyp than that of ingesting bovine collagen hydrolysate. Remarkably, its concentration surpassed that of Pro-Hyp, which is conventionally the predominant blood-absorbable peptide. Furthermore, in mice, Gly-3Hyp-4Hyp was efficiently delivered to the skin after jellyfish collagen hydrolysate administration, showing a 19-fold greater accumulation compared with the bovine group, whereas other Hyp-containing oligopeptides exhibited minimal transport. This remarkable bioavailability and effective tissue delivery suggest that Gly-3Hyp-4Hyp is a major candidate driving the biological functions of the jellyfish collagen hydrolysate.

PMID 42715523
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PubMedJournal of the American Chemical Society2026-09-09

Noninvasive Photoacoustic and Fluorescence Bimodality Imaging Differentiation of Vulnerable Atherosclerotic Plaques at Different Stages.

Jiang Qiaochu Q, Zhen Penghao P, Kong Xinru X, Yuan Zihan Z et al.

Vulnerable atherosclerotic plaques (VASPs), characterized by intense inflammation and a thin fibrous cap, pose a high risk for acute cardiovascular events. The conventional technique for their identification is angiography, but it remains challenging for angiography to differentiate VASPs at different stages. Herein, we report an activatable organic probe (RGD-IR-Dimer) for noninvasive dual-modal photoacoustic (PA) and fluorescence (FL) differentiation imaging of VASPs at different stages. This probe comprises a near-infrared chromophore, a collagenase-cleavable peptide substrate, and an αvβ3 integrin-targeting cyclic RGD moiety. For early-stage VASPs detection, after being intravenously administered, RGD-IR-Dimer selectively accumulates at atherosclerotic lesions via αvβ3-mediated targeting. High local concentration of RGD-IR-Dimer induces its self-assembly into nanofibers, turning the PA signal "on". In later VASPs, after the PA signal "on", the nanofibers are cleaved by the overexpressed matrix metalloproteinases, triggering a remarkable fluorescence "on" and a simultaneous PA "off". Thus, early-stage VASPs are characterized by an "on" PA signal, while the late-stage ones are characterized by an earlier "on" PA signal together with a later "on" FL signal. In cell models, RGD-IR-Dimer effectively discriminated between early- and late-stage VASPs. Since mouse models lack the neovascular architecture for modeling early-stage lesions, we evaluated the probe behavior in a mouse model of late-stage VASPs as a proof of concept, where it exhibited a time-dependent PA-to-FL signal transition. Our study demonstrates that RGD-IR-Dimer could be a promising probe for the noninvasive detection of high-risk plaques, potentially facilitating its early intervention.

PMID 42714533
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