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indometacin plaster

✓ Approved

Kowa · PTGS1 · 小分子

什么是 indometacin plaster？

indometacin plaster 是一种小分子，由Kowa研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。

药物档案

公司Kowa
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Transdermal
状态Approved
来源： ClinicalTrials.gov, Kowa

作用机制

分子靶点

indometacin plaster 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

indometacin plaster 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved

相关研究文献

PubMedDentistry journal2026-07-27

The Influence of Material and Veneering Technique on the Marginal Fit of CAD/CAM Crowns.

Abdulhameed Nader N, Roulet Jean Francois JF, Hussein Hind H, Mahdi Zahraa Z et al.

Background: There are certain disadvantages to using CAD/CAM technologies. Marginal and internal accuracy of fit is valued as one of the most important criteria for the clinical quality and success of all-ceramic crowns. The assessment of the marginal fit of lithium disilicate and zirconia CAD/CAM crowns before and after ceramic layering is crucial. Methods: One ideally prepared model tooth was duplicated into 64 plaster models. A standardized wax pattern for a monolithic crown and a coping were produced and used to mill 16 lithium disilicate monolithic crowns and 16 cores using a soft milling process. 16 zirconia crowns and 16 cores were also fabricated. A factorial design with (material) (lithium disilicate [E] or zirconia [Z]); (design) (monolithic, [M] or (core) [C]); and (finish) (as-produced [P] or veneered/glazed [G]) was used to create the following groups: ZMP, ZMG, ZCP, ZCG, EMP, EMG, ECP, and ECG (n = 8). The milled restorations were treated accordingly using ZirLiner, IPS e.max Ceram, and IPS e.max Glaze. The restorations were cemented to their dies, embedded in epoxy resin, and sectioned into two planes with a diamond saw. Vertical and horizontal marginal fit at the finishing line was measured in a standardized way at four locations (mesial, distal, facial, and lingual). Results: There were no differences, p > 0.05, between all Z groups; however, they had significantly wider horizontal gaps, p < 0.05, (116 ± 5 µm) than E groups (64 ± 13 µm). Among lithium disilicate groups, the glazed monolithic (EMG) and veneered/glazed coping (ECG) subgroups showed significantly smaller horizontal gaps (approximately 50 ± 6 µm). Statistical analysis was performed using two-way ANOVA with a significance level set at α = 0.05. Conclusions: Veneering techniques did not affect zirconia. Lithium disilicate had a better marginal fit than zirconia, but this was influenced by veneering techniques. Lithium disilicate veneering and/or glazing significantly improved the marginal fit.

PMID 42505705
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PubMedInternational dental journal2026-07-21

Effects of Structural Designs on the Accuracy, Dimensional Stability, and Material Consumption of Digital Light Processing-Printed Models.

Liu Huan H, Wang Jiaying J, Zhao Yanfang Y, Zhang Yan Y et al.

To evaluate the effects of 4 structural designs on the accuracy, long-term dimensional stability and material efficiency of digital light processing (DLP)-printed resin dental models. A reference digital cast was obtained by scanning a standard maxillary plaster model with a tabletop 3D scanner to create 4 types of structural designs, including complete palatal solid (CPS), complete palatal hollow (CPH), horseshoe-shaped solid (HSS) and horseshoe-shaped hollow (HSH) designs. Digital casts with 4 structural designs were printed with a 3D printer with DLP technology. Material consumption and printing time were recorded. Afterwards, the printed casts were scanned by using a scanner to obtain standard research digital casts. All of the reference models and research digital casts were imported into Geomagic software for comparison and analysis of trueness and precision. The dimensional stability of the resin-printed models with 4 distinct structures within 28 days was evaluated and analysed. Differences between the reference and research digital casts were quantitatively indicated by the root mean square (RMS) value. On day 1, the HSS group exhibited the greatest trueness, whereas the CPS group exhibited the lowest precision. The solid models (CPS and HSS) remained stable over the 28 days. However, the hollow models (CPH and HSH) significantly deviated after 7 days. The HSS design reduced the printing time by 19%, and the material consumption by 30% compared to CPS. The structural design significantly influences the accuracy and dimensional stability of 3D-printed models. The HSS design offers the optimal balance between stability and material efficiency, thus making it clinically advantageous. The accuracy of the models in all of the groups remained within the clinically acceptable range. The structural design significantly influences model performance. The HSS design offers clinically advantageous for maxillary dental models.

PMID 42480138
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PubMedBone & joint open2026-07-20

Incidence of nonunion after open tibia fractures in Malawi : associated factors and Radiographic Union Score for Tibial fractures reliability.

Schade Alexander Thomas AT, Dimock Richard R, Mendes da Costa Thomas T, Nohakhelha Nyamulani N et al.

Open tibia fractures are a common and severe injury in low-income countries (LICs), and worsened by fracture-related infection (FRI). The Radiographic Union Score for Tibial fractures (RUST) is widely used to assess fracture healing, but its reliability and factors associated with nonunion in LICs remain unclear. We conducted a multicentre prospective cohort study in six hospitals across Malawi, enrolling 287 adults with open tibia fractures between February 2021 and March 2022. Participants underwent standardized clinical and radiological follow-up at three, six, and 12 months post-injury. Fracture union at follow-up was assessed independently by two reviewers using the RUST score. Patient function was measured using the Short Musculoskeletal Function Assessment (SMFA) score. Multilevel regression models examined associations between RUST scores, functional outcomes, baseline factors, and treatment methods. Participants had a median age of 34 years (IQR 25 to 44), and 84% (248/287) were male. Overall, 45/177 (25.4%) of participants with open tibia fractures had a nonunion at one year, with 34.2% (13/38) with FRI having nonunion compared with 15.4% (20/130) no FRI (p = 0.001). After adjusting for other variables, compared with external fixation, intramedullary nailing (odds ratio (OR) 1.35, 95% credible interval (CrI) 0.98 to 1.93) and plaster of Paris (POP) fixation (OR 2.05, 95% CrI 1.29 to 3.64) were associated with higher RUST scores. Each one-point increase in RUST score was associated with -4.1 (95% CrI -6.2 to -2.1) SMFA score, reflecting better function. Interobserver reliability of RUST was moderate (ICC 0.51, 95% CI 0.28 to 0.61), despite 74% of radiographs being of suboptimal quality at one year. Nonunion is common after open tibia fracture in Malawi, particularly with external fixation and FRI. The RUST score is reliable and correlates with patient function in LIC settings, even with variable radiograph quality. Poor function should prompt a careful assessment for nonunion and consideration of intervention where appropriate.

PMID 42472625
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PubMedData in brief2026-07-19

Heritage cracks dataset: Superficial damage.

Garcia-Chiquito Maybelin C MC, Alonso-Guzmán Elia M EM, Guzmán-Torres José A JA, Martínez-Molina Wilfrido W

The Heritage Cracks dataset contains a total of 1,716 high-resolution images documenting superficial cracking in ignimbrite masonry and lime-based plaster surfaces from heritage buildings in the historic center of Morelia, Mexico, a UNESCO World Heritage Site. A total of 686 images were acquired under real field conditions using smartphone cameras along representative streets and architectural elements with visible deterioration, while 1,030 images were generated through data augmentation. The dataset was designed to support artificial intelligence applications for cultural heritage inspection, particularly object detection and computer vision-based damage assessment. All images were organized, preprocessed, automatically oriented, resized to 640 × 640 pixels, and manually annotated with bounding boxes by specialists in construction pathology. Crack selection considered visible damage associated with weathering, material degradation, structural adjustment, environmental exposure, erosion, overload effects, and biological activity. The dataset is divided into training, validation, and testing subsets; includes image, annotation files, configuration metadata, and documentation to facilitate reproducibility. Its structure allows direct use in deep learning workflows, including YOLO-based models and other object-detection architectures. By providing field-acquired images from real heritage construction systems, this dataset contributes to the development, evaluation, and benchmarking of non-invasive tools for crack detection, preventive conservation, and structural health monitoring. It is useful for researchers, engineers, conservation specialists, and developers working on AI-assisted inspection of vulnerable historic infrastructure in Latin American urban heritage contexts.

PMID 42472180
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PubMedMedical science monitor : international medical journal of experimental and clinical research2026-07-19

Influence of Scan Body Geometry, Implant Angulation, and Interimplant Distance on the Accuracy of Maxillary Full-Arch Digital Implant Scans: An In Vitro Study.

Ekin Ebru Sümer ES, Uyar Sozdar Başkan SB, Güler Merve M, Ayna Emrah E

BACKGROUND This study compared the accuracy of different scan body geometries under different implant angulation and interimplant distance conditions. Evidence regarding full-arch digital implant scanning under these conditions remains limited. MATERIAL AND METHODS In this in vitro study, 5 implants were placed in maxillary edentulous plaster models representing 3 implant systems (Bioinfinity, Meisinger, and Mode). The reference implant was positioned perpendicular to the ridge crest at the midline. Implant angulations (5° and 10°) and interimplant distances (5 mm and 10 mm) were standardized. Scan bodies were attached to the master model, and each model was scanned 10 times using an intraoral scanner (TRIOS 5). Three-dimensional deviations were calculated. Data were analyzed using 1-way ANOVA and Tukey HSD tests (alpha=0.05). RESULTS No significant differences were observed among the groups at 5° angulation (P>0.05), whereas significant differences were detected at 10° angulation for implants 1 and 5 (P<0.01). Bioinfinity showed higher deviation values at implant 1, while Meisinger demonstrated higher deviations at implant 5. At a 10-mm interimplant distance (implants 1 and 2), significant differences were found among the groups (P<0.001), with Bioinfinity exhibiting lower deviation values. At a 5-mm distance, no significant difference was observed at implant 4 (P>0.05), whereas a significant difference was found at implant 5 (P<0.001), with the highest deviation in the Meisinger group. CONCLUSIONS Increased implant angulation and interimplant distance are associated with reduced accuracy and higher deviation values in digital full-arch scans. The influence of scan body geometry varies depending on implant position.

PMID 42471755
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PubMedFrontiers in microbiology2026-07-17

Expanding genomic resources for heritage science: characterization of selected microbial isolates from salt-weathered historic sites.

Fürnwein Lukas L, Lehner Elias E, Tichy Johannes J, Waldherr Monika M et al.

On historic masonry and plaster, moisture-driven salt crystallization cycles impose mechanical stress and create niches for halophilic and halotolerant microbial communities. Halotolerant/halophilic microorganisms isolated from these man-made heritage environments are usually not as well characterized as those isolated from natural environments and represent a genetic and biotechnological potential that has not been thoroughly studied to date. This study provides insights into the genomes of five selected halophilic and halotolerant microorganisms isolated from two salt-weathered heritage sites in Austria: the subterranean St. Virgil Chapel beneath St. Stephen's Cathedral (13th century) and the Charterhouse Mauerbach (14th century). Isolates displaying coloration under 10-20% NaCl were sequenced using Oxford Nanopore long-read technology, yielding complete genomes and plasmids. Functional annotation focused on metabolic, osmoregulatory and pigment biosynthesis pathways to elucidate adaptive strategies underpinning their persistence under extreme salinity. Comparative genomic analyses revealed variations between the isolated strains with their respective references, as well as species-specific traits that have not been described in detail before and confirmed the presence of robust carotenoid pathways including bacterioruberin synthesis in Halococcus, mixed C40/C50 carotenoids in Nesterenkonia, and C30/C40 carotenoids in Halobacillus. Furthermore, two isolates, Marinobacter sp. 119-V2 and Modicisalibacter sp. 110-V3, likely represent novel taxa, indicating that salt-weathered heritage sites represent a specific environmental niche that selects for specific microbial colonizers. By integrating cultivation, phenotypic characterization, and genomic analysis, this work advances beyond descriptive community surveys toward mechanistic understanding of microbial functions relevant to conservation science. Genome-informed insights into pigment biosynthesis and osmotic stress response help predict microbial behavior under environmental or treatment-induced salinity fluctuations, supporting the development of targeted, scientifically grounded preservation approaches for salt-affected cultural heritage.

PMID 42466124
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