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indometacin plaster

✓ Approved

Kowa · PTGS1 · 小分子

什么是 indometacin plaster？

indometacin plaster 是一种小分子，由Kowa研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。

药物档案

公司Kowa
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Transdermal
状态Approved
来源： ClinicalTrials.gov, Kowa

作用机制

分子靶点

indometacin plaster 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

indometacin plaster 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved

相关研究文献

PubMedJournal of education and health promotion2026-10-25

Efficacy of new a novel sawdust-plaster material related to improved pain reduction and healing among fracture patients: A randomized clinical trial.

Lafta Rasool R RR, Majeed Haider M HM

Acute fractures often require prolonged immobilization, which is frequently associated with significant pain and physical discomfort. This study aimed to evaluate the efficacy of an innovative birch sawdust-plaster mixture in reducing pain and improving clinical outcomes compared with traditional plaster of Paris. A single-blind, true experimental design was conducted between May and September 2025 in Baghdad, Iraq. A total of 56 adult patients with upper limb fractures who met the inclusion criteria were recruited and randomly allocated into two groups: the intervention group (n = 27, sawdust-plaster back-slab) and the control group (n = 29, traditional back-slab). Randomization was achieved using sequentially numbered, opaque, sealed envelopes. Data were collected using a sociodemographic sheet and the Visual Analogue Scale (VAS). Statistical analysis was performed using SPSS version 30 employing independent t-tests and Chi-square tests to compare outcomes. The intervention group demonstrated a statistically significant reduction in pain scores (25.24 \pm 4.1) compared with the control group (31.53 \pm 5.2; P = 0.039). In addition, the intervention group reported a shorter duration to reach clinical comfort (24.37 days) and a higher prevalence of mild pain levels (77.8%) postintervention. While age influenced pain perception in the intervention group, the primary improvements were attributed to the material's properties. The sawdust-plaster mixture is significantly more effective than traditional casting in reducing pain and accelerating clinical recovery. To improve patient outcomes, we propose that healthcare facilities integrate this low-cost and sustainable mixture into standard orthopedic protocols. Furthermore, it is recommended that nursing professionals and policy-makers advocate for the use of such eco-friendly materials to enhance patient satisfaction and minimize the physical burden of immobilization.

PMID 42924301
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PubMedCanadian prosthetics & orthotics journal2026-10-25

Towards more sustainable AFO manufacturing: An exploratory life cycle inventory of partially digital production.

Strenge O O, Krieger C C, Dilthey C C, Nasilowski L L et al.

Ankle-foot orthoses (AFOs) are medical devices supporting individuals with pathological gait. Manufacturing fully customized AFOs with a carbon dorsal leaf spring (C-AFOs) traditionally relies on manual processes involving material waste and resource consumption. Additive manufacturing (AM), commonly referred to as 3D printing, offers potential pathways toward a more sustainable production, yet its impact on sustainability-related metrics in orthosis manufacturing remains insufficiently examined. In this study a partially digital C-AFO manufacturing workflow was developed using AM, initially tested and it was investigated how the partial digitalization affects selected sustainability-related metrics compared to the established manual manufacturing workflow. An exploratory study was conducted at a German orthotic workshop, where a partially digital workflow for C-AFO manufacturing was developed and implemented. Two C-AFOs were produced using the traditional manual and the new partially digital workflow, while both workflows were analyzed and compared by means of a gate-to-gate life cycle inventory analysis in accordance with ISO 14040/44. Data collection encompassed the consumed material mass (divided into material incorporated into the C-AFO, in-house reusable material, potentially externally recyclable material, and disposable material), electrical energy consumption, and process water usage. Partial digitalization substantially reduced total material use by 4.59 kg (21%) and process water consumption by 12 L (83%), primarily by reducing the use of non-recyclable plaster models. Additionally, the proportions of in-house reusable and potentially externally recyclable materials increase, while the proportion of disposable material decreases. Conversely, electrical energy consumption increased by 15.96 kWh (172%), largely attributable to the 3D printing processes employed. Although the exploratory nature and limited scope of this study preclude general conclusions regarding overall workflow sustainability, the findings indicate that transitioning from manual to partially digital C-AFO manufacturing presents possible sustainability potential. A comprehensive evaluation within the framework of a complete life cycle assessment is recommended to substantiate these initial results.

PMID 42927370
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PubMedCanadian prosthetics & orthotics journal2026-10-25

Developing a research agenda in digital workflows for the fabrication of prostheses and orthoses.

Andrysek J J, Mayo A L AL, Ngan C C CC, Blocka D D et al.

Recent advancements in digital workflows, including the use of 3D printing, are transforming the prosthetics and orthotics (P&O) field. Digital technologies offer opportunities to deliver P&O services that are more efficient by reducing design and fabrication times, are less wasteful through the elimination or reduction of consumables, including plaster, foam and other materials, and are more repeatable by having digitally saved designs. Despite known advantages, the adoption of digital workflows in P&O has been inconsistent, underscoring the need for cross-sector collaboration to guide the field using evidence-informed approaches. To collaborate with key interest groups to identify priority areas for advancing the adoption and implementation of digital workflows in the P&O field. A modified Delphi approach was used to inform the structure of a Canada-wide initiative and involved participation of 79 representatives from key interest groups, including prosthetists, orthotists, technicians, biomedical engineers, researchers, and people with limb absence/difference. Research priorities were identified through online surveys followed by a hybrid meeting during which attendees engaged in small- and large-group discussions to refine and select priorities. Five key digital P&O research priorities were identified: (1) strengthening evidence on device quality and system performance compared to traditional methods; (2) developing economic and reimbursement models to support clinical integration; (3) improving education and training for digital workflows; (4) establishing standardized practice guidelines; and (5) increasing key interest group engagement to better understand user needs and perspectives. While the general components of digital workflows are now broadly understood, future efforts should focus on more specific contexts, and discussions should be more targeted and disaggregated (e.g., by device type, patient population, or care setting) and include experts with context-specific experience. This collaboration initiative provides a strategic roadmap for advancing the adoption of digital workflows in the P&O field and supports the development of national collaborations aimed at fostering innovations and evidence-based practice.

PMID 42927378
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PubMedAnais da Academia Brasileira de Ciencias2026-10-23

Preparing β-hemihydrate using massive and fibrous high-grade gypsum: from mineral-ore characterization to compressive strength assessment.

Guzzo Pedro L PL, Martins Felipe S FS, Idelfonso Mateus L ML, Araújo Carlos D F DE CDF et al.

Gypsum resources from the Araripe Sedimentary Basin (Northeastern, Brazil) are known for their mineralogical quality and simple mining practices. Among the varieties found there, two are notably pure: (i) a semi-opaque lump of coarse grains known locally as Johnson stone; (ii) a satin spar like form with fibers lying along the c-axis known as alabaster. The current practice has been to reject alabaster from the plaster manufacturing circuit. Questioning this, the aim here was to assess microscopic and structural properties of alabaster and Johnson stone after grinding, calcination and rehydration steps. Grinding and calcination were carried out in direct and inverse routes using ball milling and heating at atmospheric pressure. Rehydration of fine powders was designed to produce cubic specimens for compressive tests. X-ray diffraction, infrared spectroscopy and thermal analyses were adopted to assess structural changes related to gypsum-bassanite-gypsum conversions. Besides some peculiarities related to particle size, no deviation preventing alabaster processing was detected. The compressive strength measured in samples prepared with single and blended powders points to a rational destination of alabaster for plaster manufacturing. The inverse route can also be adopted for alabaster processing. An overview of the current challenges faced by the Araripe Gypsum Hub is updated.

PMID 42912001
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PubMedJournal of prosthodontic research2026-10-22

Integration of milled components in a fully digital workflow for removable partial dentures using a novel box-joint mechanism.

Nakanoda Shinichi S, Mine Atsushi A, Kuboki Takuo T

This report presents a proof-of-concept, fully digital workflow for fabricating removable partial dentures by integrating milled resin and titanium components via a box-joint interlocking mechanism. A bilateral free-end mandibular model was scanned and imported into computer-aided design (CAD) software. After arranging the artificial teeth, the denture outline was designed using non-uniform rational basis-spline curves while considering tooth position, denture contour, and undercut areas. The CAD surface model was exported in STL format and refined using mesh-modeling software to create a more organic morphology. It was then re-imported into the CAD environment, divided into multiple components, and equipped with box-joint mechanisms comprising sockets and socket mates to facilitate component assembly. These components were milled from prefabricated PMMA and Ti6Al4V discs, thereby eliminating the need for conventional resin polymerization or metal casting. The denture was designed to be assembled without a plaster working model because the box-joint mechanisms guided each component toward its predetermined position during assembly. In this technical demonstration, the box-joint mechanism enabled a model-free assembly process and simplified fabrication by eliminating the need for conventional curing and casting procedures. The components were designed to be guided into place unidirectionally and disassembled for adjustment, which may facilitate intraoral try-ins. The combination of CAD-based design and mesh modeling may provide a flexible workflow for removable partial denture fabrication. This report presents a proof-of-concept technical procedure; however, further investigation is required to evaluate the mechanical accuracy, durability, retention, and clinical performance of the proposed system.

PMID 42907412
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PubMedMaterials (Basel, Switzerland)2026-10-16

Investigations into Roman Mortar from Sucidava, Romania.

Finta Flavio Nicoale FN, Abrudeanu Marioara M, Negrea Denis Aurelian DA, Moga Sorin Georgian SG et al.

This study presents an interdisciplinary investigation of mortars from the Roman fortress of Sucidava, constructed in the 3rd century AD along the Danube River, at the northern frontier of the Roman Empire. The mortars were characterized using a multi-analytical approach, including macroscopic examination, optical microscopy, cathodoluminescence microscopy, scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDS), and qualitative phase analysis by X-ray diffraction (XRD). The results highlight the presence of two distinct mortar types: (i) a gray, coarse-grained masonry mortar consistent with opus caementicium, covered by a finishing layer, and (ii) a fine-grained red plaster mortar analogous to opus signinum, as described in ancient architectural treatises. The structural and compositional features of mortars sampled from the eastern wall of the Sucidava Fortress confirm the persistence of advanced Roman mortar technology in this northern frontier region, even after the division of the Roman Empire. The substitution of volcanic ash with bone ash led to the incorporation of phosphorus-bearing compounds, which, according to recent studies, contribute to enhanced mortar performance.

PMID 42882667
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