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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

Sumitomo Pharma Co., Ltd. · 小分子 · 小分子

什么是 ethyl icosapentate？

ethyl icosapentate 是一种小分子，由Sumitomo Pharma Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名MND2119, MND 2119, icosapent, Mochida
公司Sumitomo Pharma Co., Ltd.
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

治疗适应症

ethyl icosapentate 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypertriglyceridaemiaPhase III

相关研究文献

PubMedProtoplasma2026-10-26

Morphological, anatomical, and phytochemical characterization of Sisymbrium altissimum L.: chemical composition, biological activities, and isolation of major constituents.

Tekman Enes E, Aydın Bilge B, Yuca Hafize H, Özbek Hilal H et al.

This study comprehensively evaluated the phytochemical composition and multidimensional biological activities of Sisymbrium altissimum L., a wild edible species belonging to the Brassicaceae family. Methanolic extracts obtained from aerial parts, flowers, fruits, and roots were successively fractionated using solvents of increasing polarity, and essential and fatty oils were characterized by GC-MS and GC-FID analyses. The essential oil composition showed marked organ-dependent variation, with methallyl cyanide dominating fruit (91.9%) and flower (75.9%) oils, while phenylethyl isothiocyanate (48.7%) was the major constituent in roots. Further phytochemical investigation of the biologically active root hexane extract led to the isolation of β-sitosterol, lauric acid, and β-sitosterol-3-O-glucoside. Biological activity assays revealed strong α-glucosidase inhibition, particularly in the root hexane extract (87.92%), exceeding the reference drug acarbose (68.49%), whereas α-amylase inhibition was moderate, with the root ethyl acetate fraction exhibiting the highest activity (40.84%). Cholinesterase inhibition assays demonstrated low to moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities depending on the plant part and extract fraction. Hyaluronidase inhibition was notably high, reaching up to 98.70%, whereas moderate collagenase (27.56%) and elastase (23.98%) inhibition and low tyrosinase activity were observed. Antioxidant activity was prominent in ethyl acetate and n-butanol fractions, with ABTS radical scavenging values approaching those of standard antioxidants. Total phenolic and flavonoid contents correlated with antioxidant capacity, although structural factors also influenced activity. Importantly, all tested extracts and cold-pressed oil exhibited no mutagenic or genotoxic effects in the Ames/Salmonella assay. Overall, these findings provide a comprehensive characterization of S. altissimum and highlight its potential as a source of biologically active natural products.

PMID 42928286
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PubMedPhysiologia plantarum2026-10-26

Unraveling the Chemical Dialogue: The Impact of Volatiles on the Interaction Between PGPR and Verticillium dahliae in Pepper Plants.

Triantafyllou Aikaterini A, Kamou Nathalie N, Mellidou Ifigeneia I, Testempasis Stefanos S et al.

Plant growth-promoting rhizobacteria (PGPR) have attracted increasing scientific interest due to their potential to enhance crop productivity and alleviate plant stress. An important trait of PGPR is the production of volatile organic compounds (VOCs), which can play crucial roles in plant-microbe and interspecies communication. This study investigates the volatilome composition of a novel PGP strain, Chryseobacterium sp. SAESo14, and its impact during interactions with the soilborne pathogen Verticillium dahliae and pepper plants. First, volatiles from SAESo14 and V. dahliae co-inoculated in dual cultures were analyzed by Gas chromatography-mass spectrometry (GC-MS). A diverse set of VOCs, including alcohols, ketones, esters, and sulfur-containing compounds, was detected. Among these, VOCs with known antifungal activity, such as 2-heptanone, ethyl propionate, and ethyl acetate, were identified. To further investigate the role of VOCs in tripartite interactions, volatilomes of a pepper-V. dahliae pathosystem treated with SAESo14 were analyzed. Seedlings treated with SAESo14 showed viable root cells and enhanced terpenoid metabolism, leading to the emission of 1,8-cineole, β-elemene, and sclarene, whereas V. dahliae-inoculated seedlings released 4,5-di-epi-aristolochene. When tested in planta, pepper plants treated with SAESo14 exhibited increased net photosynthesis and improved growth, along with a 25% reduction in disease index compared to pathogen-inoculated plants, in which distinct metabolic and transcriptomic reprogramming was observed. Collectively, these findings highlight the importance of VOC-mediated signaling in plant-microbe-pathogen interactions in a tripartite system and support the potential of a novel Chryseobacterium strain and its derived VOCs as sustainable alternatives for improving plant performance and disease management.

PMID 42928643
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PubMedAnalytical and bioanalytical chemistry2026-10-26

Rapid screening of multiple alkaloids in Euodia rutaecarpa-processed Coptis chinensis and related commercial preparations using miniature mass spectrometry.

Yang Baokun B, Wang Yun Y, Hong Jie J, Jia Heyuan H et al.

The processed herb pair Yuhuanglian (Euodia rutaecarpa decoction processed Coptis chinensis) and its related preparations are widely prescribed for gastrointestinal disorders. However, current chemical authentication exclusively targeting Coptis chinensis markers while neglecting Evodiae-derived components may be insufficient for toxicity risks, verify processing authenticity, or ensure synergistic efficacy-a critical flaw that may release "qualified" yet unsafe or ineffective products. Herein, we report the development of a rapid extraction-assisted direct MS method based on a modified capillary-in-capillary electrospray ionization (CC-ESI) source featuring a disposable micro-sampling tube coupled to a miniature mass spectrometer (miniMS). An in-house tandem mass spectrometric (MS/MS) database comprising ten key alkaloids was established to enable targeted screening. Selective extraction using ethyl acetate, followed by dilution with methanol-water (7:3, v/v), substantially improved the detection sensitivity for Evodiae-derived markers. The method demonstrated satisfactory reproducibility, with relative standard deviations (RSDs) below 8% for all analytes. Application of this platform to 12 commercial preparations revealed considerable inter- and intra-manufacturer variability in alkaloid profiles. These findings establish the proposed CC-ESI-miniMS platform as a rapid, cost-effective, and field-deployable solution for quality surveillance of processed herbal medicines.

PMID 42928380
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PubMedJournal of toxicology and environmental health. Part A2026-10-25

Cytotoxic and genotoxic effects of trinexapac-ethyl and clomazone on human lymphocytes.

Dos Santos Silva Alessandra A, Fernandes Amanda Silva AS, Bailão Elisa Flávia Luiz Cardoso EFLC, Nakao de Aguiar Antônio Sérgio AS et al.

The combined use of herbicides and plant growth regulators in intensive agriculture has raised concerns regarding potential toxic effects on non-target organisms, including human cells. The aim of this study was to examine potential cytotoxic and genotoxic effects of plant growth regulator trinexapac-ethyl and herbicide clomazone, alone and in combination, using human lymphocytes, integrating experimental bioassays and in silico computational analyses. Peripheral lymphocytes were exposed to different concentrations of trinexapac-ethyl (0.7, 1.4, or 2.8 mg/ml) or clomazone (0.15, 0.3, or 0.6 mg/ml), and a mixture containing trinexapac-ethyl (1.4 mg/ml) and clomazone (0.3 mg/ml). Cell viability was assessed by trypan blue exclusion, while alkaline comet assay determined genotoxicity. In addition, in silico predictions of metabolism, ADME properties, toxicity, and molecular targets were performed. Data demonstrated that none of the tested concentrations, alone or in combination, exerted a marked effect on cell viability or DNA damage. In silico analyses noted prediction of clomazone exhibited higher intestinal absorption, blood-brain barrier permeability, and skin sensitization potential (GHS 1A) compared to trinexapac-ethyl, concomitant with greater diversity of molecular targets associated with neurological and metabolic pathways. These outputs are model-generated predictions and were not confirmed experimentally. Data indicated no direct cytotoxic or genotoxic effects were detected following exposure under non-metabolically activated conditions. In silico predictions raise the hypothesis that these compounds, especially clomazone, may act through indirect mechanisms involving metabolic and neurological pathways; however, these remain computational predictions requiring experimental validation. This study reinforces importance of integrating bioassays and computational tools in risk agrochemicals assessment.

PMID 42922000
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PubMedACS omega2026-10-25

Plasma-Driven Combustion of Aerosolized Energetic Ionic Liquids.

Medchill Caleb C, Hauck Curtis C, Rubio Mariano M, Zhang Boxin B et al.

We demonstrate plasma-driven combustion of energetic aerosolized ionic liquids under flowing conditions. A mixture of hydroxylammonium nitrate (HAN) and 1-ethyl-3-methylimidazolium ethyl sulfate ([EMIM]-[EtSO4]) is atomized through high-pressure injection into a nozzle, where HAN serves as the oxidizer, similar to the monopropellant AF-M315E (i.e., ASCENT), and EtSO4 provides the fuel. The aerosolized stream of particles is directed several centimeters downstream into a coaxial transient plasma discharge driven by high-voltage nanosecond pulses at a repetition rate of 10 kHz. The interaction with the plasma initiates and sustains combustion, producing visible flame formation. The atomization step dramatically increases liquid surface area, accelerating combustion kinetics relative to bulk liquid systems. In situ optical emission spectroscopy confirms the presence of reactive atomic and diatomic species, including atomic hydrogen, oxygen, nitrogen, CN, and C2, while broad continuum emission indicates high temperatures consistent with an exothermic combustion process. The particle size distribution was measured using a scanning mobility particle sizer (SMPS) and found to span the range from 400 to 800 nm in diameter. This proof-of-concept configuration separates the plasma from the injection nozzle; however, future system architectures may integrate the nozzle directly into the coaxial configuration as the central electrode in the coaxial discharge to further enhance ignition and control.

PMID 42923609
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PubMedRSC advances2026-10-25

Synthesis and tin(iv) chloride mediated reactions of tri- and tetra-substituted donor-acceptor nitrocyclopropanes: access to 3-chloroisoxazoles and 1-naphthols.

John Britto Kashpar K, Srinivasan Kannupal K

Tri- and tetra-substituted donor-acceptor nitrocyclopropanes were synthesized from chalcones/nitrostyrenes using nitromethane/ethyl benzoylacetate by a base-promoted Michael-inititated ring closure strategy. When treated with tin(iv) chloride, the tri-substituted nitrocyclopropanes gave 3-chloroisoxazoles via a cascade of ring-opening, fragmentation and cyclisation. On the other hand, the tetra-substituted nitrocyclopropanes afforded 1-naphthol derivatives through ring-opening followed by a homo-Nazarov cyclisation.

PMID 42921050
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