ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

什么是 ethyl icosapentate？

ethyl icosapentate 是一种小分子，由Sumitomo Pharma Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名	MND2119, MND 2119, icosapent, Mochida
公司	Sumitomo Pharma Co., Ltd.
药物类别	小分子
给药途径	Oral (PO)
状态	Approved

来源： ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

治疗适应症

ethyl icosapentate 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域	疾病/病症	分期
Metabolism and nutrition disorders	Hyperlipidaemia	✓ Approved
Metabolism and nutrition disorders	Hypertriglyceridaemia	Phase III

相关研究文献

PubMedJournal of the science of food and agriculture2026-09-10

Comparative metabolomic and microbiome characterization of herbal and traditional Baijiu during in vitro gastrointestinal digestion.

Li Jia J, Xiong Xinyi X, Lu Shiguang S, Li Qiang Q et al.

Herbal Baijiu (HB) and traditional Baijiu (TB) contain complex chemical matrices whose metabolic fate during gastrointestinal digestion and subsequent impact on gut microbiota remain unclear. This study systematically compared HB and TB through in vitro gastrointestinal digestion to evaluate the differences in digestive profiles and microbial communities. Volatile metabolite profiling demonstrated that HB maintained higher stability of ester compounds, particularly ethyl pentanoate, throughout digestion, whereas TB accumulated higher levels of potentially undesirable compounds such as 2,4-di-tert-butylphenol during small intestinal digestion. Moreover, non-volatile metabolites analysis revealed clear separation between HB and TB after gastric and small intestinal digestion, while minimal differences were observed during oral digestion. HB exhibited a greater number of differential metabolites during small intestinal digestion than TB, indicating stronger digestion-induced metabolic remodeling. KEGG enrichment analysis indicated that HB was associated with lipid metabolism, bile acid biosynthesis, and one-carbon metabolism pathways, whereas TB predominantly enriched glutathione metabolism and aromatic amino acid metabolism, reflecting stronger oxidative stress responses. During fermentation, HB promoted a more beneficial and functionally diverse microbial profile, characterized by enrichment of Bifidobacterium and Lactobacillus, as well as dynamic succession of Clostridium (63.81% at 24 h) and Veillonella (54.52% at 72 h). Correlation analysis further linked HB-associated metabolites with beneficial microbial genera, whereas TB was associated with Acidaminococcus and Fusobacterium nucleatum. HB and TB exhibited distinct digestion-dependent metabolic and microbial trajectories. HB more effectively modulated digestion-derived metabolites and promoted a more favorable gut microbial profile compared with TB. © 2026 Society of Chemical Industry.

PMID 42719956

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PubMedRSC advances2026-09-10

Synthesis of Sb(iii)-immobilized on nitrogen-doped mesoporous silica nanotubes for efficient and green preparation of pyrazolopyranopyrimidines: comprehensive characterization, green chemistry evaluation and computational antifungal profiling against 5TZ1.

Jafari Taadi Zahra Z, Moradi Leila L, Moazeni Bistgani Azam A

In this study, a novel heterogeneous nanocatalyst, Sb(iii) immobilized on nitrogen-doped mesoporous silica nanotubes (N-MSNTs/Sb(iii)), was successfully synthesized. This catalyst was then applied in a one-pot, four-component synthesis of pyrazolopyranopyrimidine derivatives via the condensation of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes, and barbituric/thiobarbituric acid. Comprehensive characterization using FT-IR, FE-SEM, EDS, HR-TEM, XRD, and BET/BJH analyses confirmed its structural features. Notably, HR-TEM revealed hollow nanotubular structures with an inner diameter of ∼23 nm and a wall thickness of 27 nm. Moreover, BET/BJH measurements exhibited a type IV isotherm, indicative of a highly porous structure, with a remarkable specific surface area of 1255 m2 g-1, a pore volume of 0.71 cm3 g-1, and an average pore diameter of 2.26 nm. Catalytic evaluations demonstrated the superior performance of N-MSNTs/Sb(iii) in aqueous media at room temperature, affording the target compounds in high yields (78-96%) within short reaction times (35-85 min). This remarkable efficiency stems from synergistic activation of support by the nitrogen sites and active Sb(iii) Lewis acidic species. Furthermore, the catalyst exhibited excellent stability, maintaining its initial activity over five consecutive reuse cycles. Finally, molecular docking simulations were performed against the antifungal target 5TZ1. The results confirmed that the carbonyl and NH groups within the synthesized molecular scaffolds establish favorable binding interactions, highlighting the promising drug-like properties of the final products.

PMID 42719317

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PubMedThe journal of physical chemistry. B2026-09-10

Fuel Desulfurization via Ionic Liquid Extraction: Mechanistic Understanding from PMF Simulations.

Kassim Fuwad M FM, Wilson-Kovacs Robert S RS, Acevedo Orlando O

Regulatory mandates have imposed strict limits on allowable sulfur content in petroleum fuels to minimize atmospheric pollutants. While conventional desulfurization methods are highly effective at removing simple, reactive sulfur compounds, e.g., thiols and sulfides, they struggle in the removal of refractory sulfur compounds that are aromatic, sterically hindered, or electronically stabilized. Ionic liquids (ILs) are particularly well-suited to extract these problematic compounds, e.g., thiophenes and their derivatives, given their complementary physical properties. However, choosing and optimizing ILs that suit industrial desulfurization requirements has been challenging. In this work, potentials of mean force simulations on a biphasic oil-IL system have been performed to investigate IL-based extractive desulfurization (EDS) efficiency by examining the transfer of two aromatic sulfur compounds, thiophene (TH) and dibenzothiophene (DBT), and an oxidized derivative (DBTO2) from the model oil dodecane into 12 unique ILs. The ILs were constructed using combinations of 1-alkyl-3-methylimidazolium [CnMIM] cations, where n = 2, 4, and 8 (i.e., ethyl, butyl, and octyl), respectively, with the anions: thiocyanate [SCN], tetrafluoroborate [BF4], hexafluorophosphate [PF6], and bis(trifluoromethylsulfonyl)amide [NTf2]. The study investigates how interfacial charge density, cation ordering, electrostatic interactions, π-π stacking, free-volume formation, hydrophobicity, and oil dissolution into the IL phase collectively influence sulfur compound extraction efficiency and selectivity, while also evaluating the enhanced thermodynamics associated with combined oxidative and extractive desulfurization (ODS-EDS). Detailed molecular-level characterization of the IL-oil interfacial environment is provided to elucidate the key structural and energetic features governing sulfur compound partitioning and extraction behavior in imidazolium-based ILs.

PMID 42720368

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PubMedRSC advances2026-09-10

Simultaneous electrochemical detection of multiple heavy metal cations using multi-walled carbon nanotubes functionalized with a ferrocenyl-based 1,4-disubstituted-1,2,3-triazole complex.

Al Khalyfeh Khaled K, Taher Deeb D, Al-As'ad Randa R, Alasoufi Ali M AM et al.

Voltammetric sensing platforms based on screen-printed carbon electrodes (SPCEs) offer a promising solution for simultaneous detection of heavy metal ions, such as cadmium (Cd2+), lead (Pb2+), and copper (Cu2+), with high sensitivity, selectivity, and reliability. Surface modification with functional materials can substantially enhance the effective electroactive area, promote analyte pre-concentration, and facilitate electron-transfer kinetics. In this study, carboxylated multi-walled carbon nanotubes (HOOC-MWCNTs) functionalized with a ferrocenyl-containing triazole-complex (1,1-bis[[(4-ferrocenyl-1,2,3-triazole-1-yl-methyl)dimethylsilyl]ethyl]ferrocene) are proposed as electrode-modifier materials. The modified electrodes were characterized by Raman spectroscopy, energy-dispersive X-ray analysis, and scanning electron microscopy. Cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques were used to evaluate the electrochemical and sensing properties, respectively. CV measurements showed a significantly higher oxidation peak current and reduced peak-to-peak potential separation (ΔE p) for Fc-triazole@HOOC-MWCNT@SPCE compared with the unmodified electrodes, indicating an increased electroactive surface area and improved electron-transfer kinetics. SWV measurements enabled the easy distinction of redox reactions at distinct characteristic potentials of different metal species. Hence, an effective sensing performance for Cd2+, Pb2+, and Cu2+ was achieved over the concentration range of 1 µM to 1000 µM, with limits of detection (LoDs) of 8.0 nM for Cd2+, 23.4 nM for Pb2+, and 23.6 nM for Cu2+. Selectivity, reproducibility, and stability were explored over a period of 20 days. The practical applicability of the modified electrode for determining the target cations in real water samples was demonstrated with reliable results.

PMID 42719856

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PubMedJournal of the International Society of Sports Nutrition2026-09-10

Creatine formulations and repeated sprint training: effects on physical and physiological adaptations in soccer players during the short-term preparation phase.

Duan Changyuan C, Wang Zaitao Z, Wang Qianjin Q

This research examined the impact of various creatine (Cr) supplementation formulations during a 4-week preparatory phase on the efficacy of repeated sprint training (RST) and on improvements in physical and physiological performance in male soccer athletes. A total of forty collegiate young soccer players volunteered for the study. They were randomly divided into four groups: creatine monohydrate (Cr-Mon, n = 10), creatine ethyl ester (Cr-Ee, n = 10), creatine hydrochloride (Cr-Hcl, n = 10), and placebo (PL, n = 10). All athletes engaged in a 4-week training intervention, three times a week (i.e. 12 sessions), and physical (countermovement vertical jump [CMVJ], 20-m sprint, and L-run) and physiological (Wingate anaerobic power and incremental exercise tests) performance were assessed both before and after the training period. All training groups improved physical and physiological performance following the 4-week intervention period (p < 0.05). Additionally, the groups receiving the Cr supplement exhibited significantly greater changes (p = 0.001) in physical performance, peak power output, and fatigue index compared to the PL group. However, no significant differences were found among the groups regarding mean power output and VO2max. Notably, the Ee and Hcl forms of Cr showed superior gains (p < 0.05) in physical performance and peak power compared to the Mon form after the 4-week intervention. The results underscore the importance of Cr ingestion in enhancing adaptations for short-term physical performance tasks, highlighting the effectiveness of the Ee and Hcl forms in further improving the CMVJ, 20-m sprint, L-run, and peak power among soccer players during the short-term preparation phase.

PMID 42720250

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PubMedFrontiers in veterinary science2026-09-10

Anti-inflammatory, analgesic, and anti-immune-mediated polyarthritis activities of topically applied polarity fractions of Clematis florida var. Plena and their underlying mechanisms.

Lei Ting T, Zheng Jiabing J, Han Jie J, Chen Nian N et al.

Clematis florida var. Plena (C. florida) holds significant potential as a topical treatment for immune-mediated polyarthritis (IMPA); however, its active fractions and mechanisms of action remain poorly understood. Given the chemical complexity of herbal remedies, this study adopted a bioactivity- and mechanism-driven approach, focusing on the effects of polarity-based fractions rather than isolated compounds. C. florida was extracted with 70% ethanol and sequentially partitioned into petroleum ether (PE), ethyl acetate (EA), n-butanol (BU), and water (WA) fractions. Phytochemical analysis was conducted to determine the distribution of saponins and flavonoids. Anti-inflammatory and analgesic activities were evaluated using xylene-induced ear edema and acetic acid-induced writhing models, respectively. Therapeutic efficacy was assessed in a rat model of adjuvant-induced arthritis via topical application. Joint tissues were analyzed using H&E and Safranin O-Fast Green staining, immunohistochemistry, and Western blotting to investigate histological changes and signaling pathways (ERK and NF-κB). Phytochemical analysis revealed that the extract is rich in saponins and flavonoids, which exhibit distinct distribution patterns across fractions of varying polarity. All fractions exhibited anti-inflammatory effects in the ear edema model and analgesic activity in the writhing test. In the arthritis model, topical application of the EA, BU, and WA fractions significantly attenuated paw swelling and reduced serum levels of TNF-α, COX-2, rheumatoid factor, and IL-6. Histological staining confirmed partial protection against joint destruction. Mechanistic studies revealed that these fractions enhanced ERK phosphorylation and suppressed NF-κB activation in joint tissues. The EA, BU, and WA fractions of C. florida possess significant topical therapeutic potential against IMPA. The anti-arthritic effects are likely associated with the modulation of ERK and NF-κB signaling pathways. This study elucidates the pharmacodynamic basis of C. florida fractions, positioning them as promising candidates for the development of topical treatments for animal joint disorders.

PMID 42718479

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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

什么是 ethyl icosapentate？

药物档案

治疗适应症

相关研究文献

Comparative metabolomic and microbiome characterization of herbal and traditional Baijiu during in vitro gastrointestinal digestion.

Synthesis of Sb(iii)-immobilized on nitrogen-doped mesoporous silica nanotubes for efficient and green preparation of pyrazolopyranopyrimidines: comprehensive characterization, green chemistry evaluation and computational antifungal profiling against 5TZ1.

Fuel Desulfurization via Ionic Liquid Extraction: Mechanistic Understanding from PMF Simulations.

Simultaneous electrochemical detection of multiple heavy metal cations using multi-walled carbon nanotubes functionalized with a ferrocenyl-based 1,4-disubstituted-1,2,3-triazole complex.

Creatine formulations and repeated sprint training: effects on physical and physiological adaptations in soccer players during the short-term preparation phase.

Anti-inflammatory, analgesic, and anti-immune-mediated polyarthritis activities of topically applied polarity fractions of Clematis florida var. Plena and their underlying mechanisms.

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