若生智能
Drug Database
TA

tamsulosin (tamsulosin WOWTAB / Harnal D)

✓ Approved

Astellas Pharma · ADRA1A · 小分子

什么是 tamsulosin？

tamsulosin 是一种小分子，由Astellas Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名tamsulosin WOWTAB, Harnal D
公司Astellas Pharma
药物类别小分子
分子靶点ADRA1A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Astellas Pharma

作用机制

分子靶点

tamsulosin 作用于 1 个分子靶点：

ADRA1Aadrenoceptor alpha 1A (ALPHA1AAR, ADRA1C)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

tamsulosin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersBenign prostatic hyperplasia✓ Approved

相关研究文献

PubMedEndoscopy2026-07-27

Immediate vs Step-up Endoscopic Transluminal Necrosectomy in Necrotizing Pancreatitis: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Dimitrov Dimo D, Wu Yizhong Y, Rodriguez Bjorn B, Qatomah Abdulrahman A et al.

Background Direct endoscopic necrosectomy (DEN) is commonly performed for walled-off necrosis (WON), yet optimal timing remains uncertain. Step-up strategies defer necrosectomy until clinical deterioration, whereas immediate DEN may provide earlier source control but risks unnecessary intervention. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing immediate versus step-up DEN. Methods Major databases were searched through April 26, 2026, for RCTs comparing immediate versus step-up DEN. The primary outcome was clinical success. Secondary outcomes included technical success, necrosectomy sessions, total interventions, length of stay, adverse events, bleeding, organ failure, mortality, recurrence, and readmission. Random-effects meta-analysis was performed using Hartung-Knapp adjustment. Certainty of evidence was assessed using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Results Five randomized trials, including 269 patients (134 immediate DEN; 135 step-up strategy), were analyzed. In four trials reporting standalone study-defined clinical success, immediate DEN was associated with higher success than step-up strategy (OR 2.56, 95% CI 1.03-6.37; p=0.046; I²=0%). A post hoc sensitivity analysis including ACCELERATE yielded a similar estimate (OR 2.59, 95% CI 1.33-5.04; p=0.017; I² = 0%). Immediate DEN was associated with shorter length of stay (MD -8.02 days, 95% CI -15.00 to -1.05; p=0.033; I²=42%). Technical success, necrosectomy sessions, total interventions, adverse events, bleeding, organ failure, mortality, and readmission did not differ significantly. Conclusions Immediate DEN was associated with higher clinical success and shorter hospital stay compared with a step-up strategy. These findings support selective consideration of immediate DEN in appropriate patients with WON, while timing remains individualized.

PMID 42503311
阅读全文 →
PubMedDentistry journal2026-07-27

Management of the Post-Extraction Socket with Buccal Dehiscence in the Esthetic Zone Associated with Immediate Implant Placement Using L-PRF and CTG for Periosteal Inhibition: A Case Report.

Balice Giuseppe G, Serroni Matteo M, Frisone Alessio A, Di Gregorio Stefania S et al.

Background: Management of post-extraction sockets with buccal dehiscence in the esthetic zone remains clinically challenging, particularly when immediate implant placement is indicated. Conventional approaches often rely on guided bone regeneration (GBR) with biomaterials, which may increase surgical complexity and morbidity. This case report evaluates the clinical and radiographic outcomes of a fully autologous approach combining leukocyte- and platelet-rich fibrin (L-PRF) and connective tissue graft (CTG) in conjunction with immediate implant placement. Methods: A 50-year-old healthy patient presenting with a fractured maxillary lateral incisor and buccal bone dehiscence underwent atraumatic extraction, immediate implant placement, and simultaneous site management using L-PRF membranes and CTG. Clinical and radiographic evaluations were performed at baseline (T0) and after 12 months (T1). Cone-beam computed tomography (CBCT) was used to assess horizontal bone thickness (HBT) at multiple apico-coronal levels and vertical evaluation parameters, including nasal floor-crest distance (NF-AC). Clinical outcomes included probing pocket depth (PPD), keratinized tissue width (KT), gingival thickness (GT) and patient-reported outcome measures (PROMs). Results: Radiographic analysis demonstrated increased HBT at all levels (+1.4 mm at 9 mm, +3.1 mm at 12 mm, +3.2 mm at 15 mm, and +2.6 mm at 18 mm). NF-AC showed a marked increase (+2.7 mm) and substantial reduction in the buccal dehiscence defect. Clinically, KT increased by +2.0 mm and GT by +1.8 mm. Healing was uneventful, with minimal postoperative discomfort and high patient satisfaction. Conclusions: Within the limitations of a single case report, the combined use of L-PRF and CTG with immediate implant placement was associated with favorable clinical and radiographic outcomes. These preliminary findings suggest that a fully autologous, biologically driven approach may represent a potential alveolar ridge preservation strategy and a biomaterial-sparing alternative to conventional GBR in carefully selected cases. Further controlled studies are required to confirm these observations and define the indications and limitations of this approach.

PMID 42505753
阅读全文 →
PubMedCurrent oncology (Toronto, Ont.)2026-07-27

Laparoscopically Harvested Pedicled Omental Flap in Immediate Unilateral Breast Reconstruction: A Systematic Review of Surgical Techniques and Clinical Outcomes.

Wu Annie M AM, Thirugnanasampanthar Surabi S, Brackstone Muriel M

Laparoscopically harvested pedicled omental flap (LHPOF) reconstruction is a minimally invasive autologous option for immediate breast reconstruction, but prior reviews have largely examined omental flaps broadly, combining open and laparoscopic harvests, free and pedicled transfers, and mixed reconstructive indications. This systematic review evaluated operative characteristics, peri-operative complications, and esthetic outcomes following LHPOF after oncologic breast surgery. MEDLINE, Cochrane and Embase were searched without language or date restrictions, with backward citation searching of included studies. Eligible studies included female patients undergoing immediate unilateral breast reconstruction with LHPOF after mastectomy or BCS. Twenty-two studies published between 2001 and 2025 were included, representing 1869 patients. Operative techniques were broadly consistent, most commonly involving transverse-colon-first omental harvest, preservation of the right gastroepiploic vessels, and tunnelling from the inframammary fold toward the xiphoid. Reported complications included omental fat necrosis, partial flap loss, hematoma, infection, epigastric bulging, and incisional or tunnel-site hernia. Esthetic outcomes were generally favourable but assessed using heterogeneous methods. Current evidence suggests this technique is feasible in selected patients and may offer favourable esthetic outcomes with limited donor-site morbidity. However, prospective comparative studies with standardized reporting are needed to define optimal patient selection, long-term safety, and esthetic durability.

PMID 42505212
阅读全文 →
PubMedGels (Basel, Switzerland)2026-07-27

In Vitro Release of Curcumin and Resveratrol from Polymeric Systems: Films and Hydrogel.

Goes Ana Júlia Panserini de AJP, de Queiroz Heloisa Januário Ribeiro HJR, Sidiropoulos Lorena Trezena LT, Vespasiano Ana Lídia Piccolo ALP et al.

Chronic wounds are a persistent clinical and public health challenge due to impaired tissue repair caused by sustained inflammation, oxidative stress, and cellular senescence. Natural polyphenols such as curcumin and resveratrol, alongside mesenchymal stem cell (MSC) secretome, have demonstrated complementary anti-inflammatory, antioxidant, and pro-angiogenic properties with potential for wound healing. This study reports two complementary in vitro investigations evaluating the release profiles of curcumin and resveratrol from two polymeric platforms: poly(vinyl alcohol)/sodium alginate/carboxymethylcellulose films (Study 1) and an acrylate copolymer-based hydrogel incorporating MSC secretome (Study 2). UV-Vis spectrophotometric analysis confirmed analytical selectivity with no interference from excipients. Resveratrol exhibited progressive and consistent release from the hydrogel. Curcumin compromised polymer matrix integrity and reduced resveratrol release efficiency. Also showed unsatisfactory release in both systems, attributed to its low aqueous solubility. These results support the use of resveratrol-loaded polymeric matrices as promising sustained-release platforms for bioactive wound dressings and highlight the need for nanoencapsulation strategies to improve curcumin bioavailability.

PMID 42505335
阅读全文 →
PubMedJournal of agricultural and food chemistry2026-07-27

Manganese-Exchanged Smectite Clays as a Potential Controlled-Release Fertilizer for Mn Nutrition: Comparative Evaluation of Mn-Laponite and Mn-Montmorillonite.

García-Rico María Del Carmen MDC, Lucena Juan J JJ, Aller Ana Carmen Perdigón ACP, Martín-Rodríguez Rosa R et al.

To mitigate the negative effects of conventional fertilization, a novel concept of clay-based controlled-release manganese (Mn) fertilizers was investigated. Three Mn-exchanged smectites were synthesized via cation exchange: one montmorillonite (Mn(NO3)2) and two laponites (Mn(NO3)2 and MnCl2). Their composition, stability, and Mn-release behavior were assessed in saline medium across pH 5.5-8.2. A hydroponic experiment with barley (Hordeum vulgare cv. Antonia), a Mn-sensitive species, was conducted at pH 8.2 using sand amended with Mn-clays and compared with MnSO4 and MnEDTA. All treatments rapidly corrected Mn deficiency. At 8 weeks, biomass under Mn-laponite2, Mn-montmorillonite, and conventional fertilizers was comparable to or higher than that of the deficient control. Mn-laponites provided rapid Mn availability, whereas Mn-montmorillonite exhibited slower, sustained release. Smectite type thus controls Mn-release dynamics, supporting the use of synthetic clays as fertilizers in calcareous systems, though field validation is still pending.

PMID 42503678
阅读全文 →
PubMedGels (Basel, Switzerland)2026-07-27

Structure-Property Relationships Governing Encapsulation and Release of Antibiotics from Calcium-Alginate Hydrogels.

Hebip İbrahim İ, Toprakçı İrem İ, Bozkurt Rabia Nur RN, Kurtulbaş Ebru E et al.

Understanding mass transport of structurally different drugs within ionically crosslinked hydrogel networks remains an important challenge in polymer-based delivery systems. In this study, hydrophilic amoxicillin (AMOX) and amphiphilic doxycycline (DOX) were encapsulated into calcium-alginate beads, respectively. A three-factor and three-level Box-Behnken design was utilized to examine the influences of alginate concentration (2-5%, w/v), CaCl2 concentration (1-3%, w/v), and gelation time (15-45 min) on encapsulation efficiency (EE). EE exhibited considerable variability for both AMOX (10-86%) and DOX (10-63%). Optimal EE values were achieved at almost 3.5% alginate and 3% CaCl2. The optimized gelation times differed between AMOX (45 min) and DOX (15 min), which is likely associated with differences in their physicochemical properties, although additional intermediate gelation times could further refine the optimal conditions. ANOVA identified CaCl2 concentration and the quadratic effect of alginate as the most influential parameters. Furthermore, both models demonstrated robust predictive capability (R2 > 0.98). In vitro release experiments demonstrated minimal drug diffusion in simulated gastric fluid (SGF) and significantly accelerated release in simulated intestinal fluid (SIF). These findings indicate a pH-responsive release behavior under simulated gastrointestinal conditions. The release profile was best represented by Higuchi and Korsmeyer-Peppas kinetic models. SEM and optical microscopy revealed uniform spherical beads with drug-dependent microstructural differences: hydrophilic AMOX produced smoother, wrinkled surfaces, whereas amphiphilic DOX induced localized cracking and heterogeneous microdomains. Furthermore, DLS and zeta potential measurements of the released fractions indicated nanoscale particle populations (≈190-225 nm) with moderate negative surface charge (≈-21 mV), suggesting stable colloidal dispersion during intestinal-phase release.

PMID 42505318
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多tamsulosin