北京若生智能科技有限公司
Drug Database
ER

erythropoietin beta (CinnaPoietin ß / CinnaPoietin)

✓ Approved

Cinnagen Co · EPOR · 重组蛋白

什么是 erythropoietin beta？

erythropoietin beta 是一种重组蛋白，由Cinnagen Co研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Subcutaneous Injection。

药物档案

商品名CinnaPoietin ß, CinnaPoietin
公司Cinnagen Co
药物类别重组蛋白
分子靶点EPOR
给药途径Injectable (Others), Intravenous (IV), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Cinnagen Co

作用机制

分子靶点

erythropoietin beta 作用于 1 个分子靶点：

EPORerythropoietin receptor (EPO-R)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

erythropoietin beta 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved
Blood and lymphatic system disordersNephrogenic anaemia✓ Approved

相关研究文献

PubMedEntropy (Basel, Switzerland)2026-10-27

Weighted Beta Regression for Modeling Bounded Data.

Bourguignon Marcelo M, Gallardo Diego I DI, Vila Roberto R

A two-parameter weighted beta distribution is introduced for modeling bounded data, which has many similarities to the beta distribution. We propose a class of regression models where the response is weighted beta distributed and the two shape parameters that index the weighted beta distribution are related to covariates and regression parameters. The proposed regression model is a natural strong competitor of the beta regression model. We study the mathematical and statistical properties of the distribution, and we provide a useful interpretation of the parameters. The maximum likelihood method is used for estimating the model parameters. We conduct simulation studies to investigate the performance of the maximum likelihood estimators and the asymptotic confidence intervals of the parameters. We present an application of the proposed regression model to real bounded data.

PMID 42940841
阅读全文 →
PubMedImaging neuroscience (Cambridge, Mass.)2026-10-27

Beta-band dynamics during a naturalistic motor task: An OPM-MEG study.

Gibson Joseph J, Fildes Jessikah J, Kirby Alan A, Holmes Niall N et al.

Beta oscillations are a fundamental feature of brain activity, linked to long-range connectivity within canonical networks, inhibition of sensorimotor cortices, and the maintenance of a stable sensorimotor state in situations where the external world is predictable. The importance of beta oscillations in brain function is underscored by observations of their perturbation in neurological and psychiatric disorders. However, the precise role played by beta activity, particularly in mediating complex or skilful movements, remains incompletely understood. Here, we used a newly developed wearable optically pumped magnetometer-based magnetoencephalography (OPM-MEG) system to measure beta dynamics as participants learned to play a musical instrument. Twenty-two novice players took part in a study in which OPM-MEG data were recorded during two scanning sessions, while participants attempted to play a tune on a violin. Between the two sessions, participants received a violin lesson from an expert teacher. Results showed that robust data could be acquired during this naturalistic task, with beta oscillations decreasing in amplitude during movement and increasing upon movement cessation, as expected. Moreover, beta power while playing, in the motor and pre-motor areas, was significantly elevated after the lesson compared to before, and the movement-related modulation of beta amplitude was more pronounced after the lesson. These findings align with predictive coding models which suggest that beta amplitude should increase when individuals have greater certainty over the movements they carry out. Our study adds to an expanding literature on the role of beta oscillations and provides further evidence for the utility of OPM-MEG in naturalistic neuroscience.

PMID 42935830
阅读全文 →
PubMedBrain sciences2026-10-27

Age-Related Electrophysiological Reorganization During In-Phase and Anti-Phase Bimanual Coordination.

Liu Liqing L, Wu Jiale J, Zhao Zhihui Z, Liu Qing Q et al.

Background/Objectives: Healthy aging is associated with declines in bimanual coordination, particularly under more demanding coordination modes. However, the electrophysiological changes accompanying these behavioral differences and their relevance to performance remain unclear. This study examined age-group differences in behavioral performance, ERP responses, and beta-band dynamics during in-phase and anti-phase bimanual coordination. Methods: Forty-two right-handed adults were included in the primary analyses of a bimanual coordination task in both in-phase and anti-phase coordination modes. Behavioral outcomes included accuracy, reaction time, and inverse efficiency scores. EEG measures included P1, N1, and P3 responses, prestimulus beta power, fixed-window relative beta power, baseline-adjusted absolute beta power, and individualized cumulative event-related desynchronization burden. Results: The older group was slower and less efficient overall, with disproportionate accuracy and efficiency costs during anti-phase coordination. Electrophysiologically, aging was associated with larger early P1 responses, a sensor-level redistribution of P3 amplitude and latency, and higher prestimulus beta activity. Fixed-window relative beta and baseline-adjusted absolute beta showed age-group differences without corrected coordination effects, whereas individualized cumulative ERD burden showed age-group, coordination, and interaction effects. Conclusions: Healthy aging was associated with poorer discrete bimanual coordination performance, altered early visual and late positive ERP responses, and stronger cumulative beta suppression under demanding anti-phase coordination.

PMID 42939328
阅读全文 →
PubMedInsects2026-10-27

Characterization of a Stably Maintained, Highly Beta-Cypermethrin-Resistant Strain of the Bird Cherry-Oat Aphid Rhopalosiphum padi (Hemiptera: Aphididae).

Li Xinan X, Gong Peipan P, Zhao Zilan Z, Wang Fengfan F et al.

Insecticide resistance threatens effective pest management. In this study on Rhopalosiphum padi, a predominant wheat pest, a field-derived beta-cypermethrin-resistant strain (Beta-R strain) showed a 4623.50-fold resistance increase after 22 generations of beta-cypermethrin exposure and remained highly resistant (>4000-fold) after 40 generations without exposure. Beta-R strain exhibited a relative fitness of 0.92, high cross-resistance to lambda-cyhalothrin and bifenthrin, low-to-moderate resistance to sulfoxaflor, thiamethoxam, and imidacloprid, and negative or no resistance to omethoate and chlorpyrifos. The cytochrome P450 monooxygenases (P450s) and glutathione S-transferases (GSTs) contribute to this resistance. A homozygous spuer-kdr M918L mutation was identified in the IIS4-S6 region of the voltage-gated sodium channel gene in the Beta-R strain; however, transgenic Drosophila melanogaster assays showed that this mutation alone conferred only a 2.96-fold increase in beta-cypermethrin resistance. These findings show that resistant of R. padi to beta-cypermethrin can be retain high-level resistance without insecticide exposure, while also conferring high-level cross-resistance to other pyrethroids and low or negative resistance to other insecticides with different modes of action, with the resistance phenotype linked to upregulated P450/GST activities and an M918L mutation that makes only a minor contribution. These findings have significant implications for the management of resistance to pyrethroid insecticides in R. padi.

PMID 42940938
阅读全文 →
PubMedInternational journal of hypertension2026-10-27

Association Between β1-Selective Beta-Blocker Use and P-Wave Terminal Force in Lead V1 in Hypertensive Patients With Left Ventricular Hypertrophy.

Alpaslan Erkan E, Taş Sedat S, Taş Ümmü Ü, Eyüboğlu Mehmet M et al.

P-wave terminal force in lead V1 (PTFV1) is an electrocardiographic marker of atrial electrical abnormality. We investigated whether β1-selective beta-blocker use was associated with PTFV1 in hypertensive patients with echocardiographically confirmed left ventricular hypertrophy (LVH). This retrospective study included 182 eligible patients with essential hypertension and LVH selected from 1372 screened patients. Patients were classified as β1-selective beta-blocker users (n = 82) or nonusers (n = 100). Abnormal PTFV1 was defined as ≥ 0.04 mm s. Multivariable regression and sensitivity analyses were performed. PTFV1 was lower in beta-blocker users than in nonusers (0.024 [0.015-0.036] vs. 0.030 [0.020-0.048] mm s, p = 0.005). In the primary adjusted model, beta-blocker use was associated with lower PTFV1 (B = -0.008, standardized β = -0.202, 95% CI -0.014 to -0.002, p = 0.009), although model explanatory capacity was limited (R 2 = 0.064; adjusted R 2 = 0.021; overall p = 0.168). In an extended sensitivity analysis additionally adjusting for diabetes, renal function, and concomitant antihypertensive therapies, beta-blocker group status remained associated with lnPTFV1 (standardized β = 0.294, p < 0.001; R 2 = 0.147; adjusted R 2 = 0.081; overall p = 0.011). Beta-blocker use was also associated with lower odds of abnormal PTFV1 (OR = 0.43, 95% CI 0.22-0.84, p = 0.013). β1-Selective beta-blocker use was associated with lower PTFV1 and a lower likelihood of abnormal PTFV1. These findings suggest a more favorable atrial electrical profile but should be considered hypothesis-generating given the retrospective design and modest model explanatory capacity.

PMID 42936538
阅读全文 →
PubMedTurkish journal of haematology : official journal of Turkish Society of Haematology2026-10-27

Citrullinemia Type I Accompanied by Beta-Thalassemia Intermedia: Incidental Coexistence.

Şimşek Ayşe A, Kahraman Ayça Burcu AB

PMID 42935234
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多erythropoietin beta