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tamsulosin

✓ Approved

Ethypharm Corp. · ADRA1A · 小分子

什么是 tamsulosin？

tamsulosin 是一种小分子，由Ethypharm Corp.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司Ethypharm Corp.
药物类别小分子
分子靶点ADRA1A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Ethypharm Corp.

作用机制

分子靶点

tamsulosin 作用于 1 个分子靶点：

ADRA1Aadrenoceptor alpha 1A (ALPHA1AAR, ADRA1C)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

tamsulosin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersBenign prostatic hyperplasia✓ Approved

相关研究文献

PubMedJournal of clinical medicine2026-10-27

Association Between Chronic Tamsulosin Therapy and Intraoperative Hemodynamics During Spinal Anesthesia: A Prospective Observational Study.

Kuvvet Yoldaş Tuba T, Gümüş Nevin Esra NE, Ateşalp Aylin A, Yoldaş Mehmet M

Background: This prospective observational study investigated the association between chronic tamsulosin therapy and intraoperative hemodynamic changes in patients undergoing elective transurethral resection of the prostate (TUR-P) under spinal anesthesia. Methods: Adult patients scheduled for elective TUR-P under spinal anesthesia were prospectively enrolled. Patients receiving long-term tamsulosin therapy comprised the tamsulosin group, whereas those with no history of α1-adrenergic blocker use served as the control group. Hemodynamic variables, including mean arterial pressure (MAP) and heart rate, were recorded before spinal anesthesia and at predefined time points during the first 60 min after spinal anesthesia. Results: A total of 115 patients were analyzed (tamsulosin, n = 56; control, n = 59). Baseline MAP was comparable between groups. The adjusted linear mixed-effects model demonstrated a significant group × time interaction for MAP (F(5, 565.10) = 8.34, p < 0.001). Adjusted between-group MAP differences were -4.9 mmHg (95% CI, -8.8 to -1.0; p = 0.015) at 5 min, -17.0 mmHg (95% CI, -20.2 to -13.8; p < 0.001) at 30 min, and -16.4 mmHg (95% CI, -19.5 to -13.3; p < 0.001) at 60 min. Criteria-defined hypotension occurred in 21/56 (37.5%) patients in the tamsulosin group and 17/59 (28.8%) in the control group (p = 0.32). Conclusions: Chronic tamsulosin therapy was associated with lower intraoperative MAP values during spinal anesthesia, without a statistically significant increase in the incidence of clinically defined hypotension. These findings suggest that chronic tamsulosin use may be associated with a different intraoperative blood pressure response following spinal anesthesia.

PMID 42941492
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PubMedThe Journal of emergency medicine2026-10-26

Epidemiology of Nephrolithiasis Among United States Emergency Departments Over a 9-Year Period.

Riley Grace V GV, Buell Kevin G KG, Moyer Eric E, Bernard Kyle K et al.

Nephrolithiasis is a common emergency department (ED) presentation, yet contemporary national data on management trends are limited. To characterize recent trends in diagnostic evaluation, management, and disposition for adult ED patients with nephrolithiasis. This cross-sectional study analyzed United States ED encounters from January 1, 2016 to December 31, 2024 using the Epic Cosmos database, including all adult patients (≥18 years) with an ICD-10 diagnosis of nephrolithiasis. Outcomes included hospital admission, imaging utilization, urine culture collection, medication administration, discharge prescription, and procedural intervention. Descriptive statistics were utilized to characterize the study population. To account for the longitudinal expansion of the database, time-stratified odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the general ED population as a background comparator. Significance of temporal shifts was assessed using Cochran-Armitage tests. Of 248,564,812 ED encounters, 2,762,879 (1.1%) were for nephrolithiasis. Hospital admission rates increased from 8.9% in 2016 to 12.7% in 2024. Computed tomography (CT) utilization increased (73.8-89.8%), outpacing general ED trends (OR 27.2-45.6), while ultrasound declined (5.8-3.8%). In the ED, opioid use fell (61.5-49.7%), exceeding background reductions (OR 6.6-4.8), while ketorolac was the most common analgesic administered (61.6%). Tamsulosin remained the top discharge prescription (47.2%). Procedural interventions were uncommon, though stent placement increased from 3.0% to 6.8%. We identified rising hospital admission rates and an increase in CT utilization, while there was a decline in ultrasound. This divergence between practice patterns and evidence-based guidelines, highlights critical opportunities for quality improvement.

PMID 42933196
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PubMedCureus2026-10-23

Emergency Management of Obstructing Ureteric Stones: A Closed-Loop Audit of Hot Ureteroscopy Uptake Against Getting It Right First Time (GIRFT) Standards.

Girgis Ayman E AE

National guidance recommends hot (same-admission) ureteroscopy and laser lithotripsy as the default definitive treatment for suitable obstructing ureteric stones, rather than defaulting to temporizing measures such as ureteric stent insertion. The primary aim was (1) to determine the proportion of emergency ureteric stone cases managed by hot ureteroscopy against the GIRFT standard. Secondary aims were (2) to describe the pattern of emergency management and identify deviations from evidence-based practice, and (3) to assess the impact of a targeted action plan on the hot ureteroscopy rate. In addition, this article reports emergent findings identified during data review, including inter-surgeon variation in hot ureteroscopy uptake and individual case-level governance considerations, which were not prespecified analyses but are presented descriptively for their quality-improvement value. Cycle 1 (baseline) captured all emergency ureteric stone admissions over a three-month period (March to May 2024). Following presentation of results and an agreed action plan, cycle 2 (re-audit) captured all surgically-managed cases over the subsequent three-month period (August to October 2024). The primary outcome was the proportion of surgically-managed cases treated by hot ureteroscopy. Cycle 1 identified 48 admissions, of which 22 were managed surgically; hot ureteroscopy was performed in only five (22.7%), with 17 (77%) judged retrospectively suitable. Tamsulosin was prescribed for all conservatively-managed stones regardless of size or location, contrary to trial and guideline evidence discussed below. Following the action plan, cycle 2 identified 20 surgically-managed cases; hot ureteroscopy rose to 10 (50%), more than doubling cycle 1's rate. Seven of the 10 stented-only cases were retrospectively judged suitable for hot ureteroscopy; individual surgeon rates ranged up to 100%, against a department average of 50%. A structured closed-loop audit with an explicit action plan more than doubled the hot ureteroscopy rate for obstructing ureteric stones, moving practice closer to national standards. Residual missed opportunities and surgeon-level variation support a dedicated hot ureteroscopy list and further audit cycles.

PMID 42910114
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PubMedUrologia internationalis2026-10-20

Efficacy of cetirizine, tamsulosin and their combination as medical expulsive therapy for distal ureteral stones: a prospective randomized study.

Hasan Ahmed Mahmoud AM, Ahmed Amr Alameldeen AA, Sayed Reham Farouk RF, AbdelRazek Mostafa M

Background The management of ureteral stones, particularly those measuring less than 10 mm, has garnered considerable attention in urological research, with the goal of enhancing non-invasive treatment methods. Medical expulsive therapy is notable for its low invasiveness and cost. To assess the efficacy and safety of tamsulosin alone, cetirizine alone, as well as their combination in treating distal ureteric stones sized 5-10 mm. Between March 2021 and March 2024, patients presented with lower ureteral stones 5-10 mm were randomly assigned to four groups: group A (121 patients) took tamsulosin 0.4 mg; group B (120 patients) took cetirizine 5 mg; group C (119 patients) took a combination of tamsulosin 0.4 mg and cetirizine 5 mg; and group D (120 patients) received analgesics on demand as a control group. We evaluated stone passage rates, time required for stone expulsion, total analgesic dosage, and any recorded side effects. All outcomes were recorded and analyzed accordingly. Group C exhibited the highest rate of stone expulsion among all groups (85.8% vs. 67%, 55%, and 25% in groups A, B, and D respectively, p = 0.0001). Group C had a substantially shorter time required for stone expulsion in comparison with groups A, B, and D (13.15 ± 5.3 days vs. 14.95 ± 6.95, 17.57 ± 6.21, and 20.94 ± 5.58 days respectively, p < 0.0001). A statistically significant reduction in the total analgesic requirements was demonstrated in group C (p < 0.0001). Except for retrograde ejaculation which was evident in groups A and C (40 %, 37.7 % respectively versus 0% in the other groups, p < 0.0001), no substantial variations regarding the side effects were observed among the groups. Combined therapy with tamsulosin and cetirizine significantly improves stone expulsion rate, shortens expulsion time, and reduces analgesic requirements compared with either therapy alone.

PMID 42900654
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PubMedIndian journal of orthopaedics2026-10-19

Author's Response to "Letter to the Editor: Sex Imbalance and the Interpretation of Tamsulosin Efficacy in Hip Fracture Surgery".

Tripathy Sujit Kumar SK, Varghese Paulson P, Khan Shahnawaz S, Patel Ranjan Kumar RK et al.

Postoperative urinary retention (POUR) is a clinically relevant complication following hip-fracture surgery. In response to concerns regarding the marked sex imbalance between treatment groups in the TamPOUR-Hip randomized trial, we further examined the influence of sex on the observed treatment effect of perioperative tamsulosin. Although the crude incidence of POUR was lower in the tamsulosin group than in the placebo group (16.7% vs 33.3%), adjustment for potential confounders demonstrated no independent protective effect of tamsulosin (adjusted odds ratio 0.99, 95% confidence interval 0.16-5.82; P = 0.990). Female sex emerged as a strong independent predictor of POUR. Overall, POUR occurred in 24 of 54 women (44.4%) compared with 6 of 66 men (9.1%), while sex-stratified analyses showed no significant treatment effect within either subgroup. Previous studies have similarly reported a relatively high incidence of urinary retention among women undergoing hip-fracture surgery. These findings indicate that the apparent crude reduction in POUR with tamsulosin was largely influenced by unequal sex distribution rather than an independent pharmacological effect. Nevertheless, tamsulosin was associated with lower pre-void and post-void bladder volumes, suggesting improved bladder emptying. Future adequately powered trials should incorporate sex-stratified or block randomization and prespecified sex-specific analyses to better define the role of sex and tamsulosin in POUR prevention after hip-fracture surgery.

PMID 42894530
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PubMedIndian journal of orthopaedics2026-10-19

Letter to the Editor: Sex Imbalance and the Interpretation of Tamsulosin Efficacy in Hip Fracture Surgery.

Sağlıcak Harun H

PMID 42894523
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