若生智能
Drug Database
BE

betamethasone dipropionate (DFD01 / DFD 01 / Sernivo)

✓ Approved

Encore Dermatology, Inc. · 类固醇 · 类固醇

什么是 betamethasone dipropionate？

betamethasone dipropionate 是一种类固醇，由Encore Dermatology, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名DFD01, DFD 01, Sernivo
公司Encore Dermatology, Inc.
药物类别类固醇, 小分子
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Encore Dermatology, Inc.

治疗适应症

betamethasone dipropionate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

相关研究文献

PubMedInflammopharmacology2026-07-26

Clove oil in combination with flurbiprofen attenuated imiquimod-induced psoriasis-like skin inflammation in a mouse model: A mechanistic study.

Xing Qianqian Q, Wang Shuaijie S, Zubair Hafiz Muhammad HM, Mustafa Aqib A et al.

Psoriasis is an immune-mediated chronic inflammatory skin disease characterized by scaly plaques, erythema, and thick skin. Psoriasis management is complicated and multifaceted as this disease is linked to serious systemic consequences like infections, psoriatic arthritis, cardiovascular diseases, and psychological complications. In the current study, a mice model of psoriasis was established by topical application of 5% imiquimod (IMQ) cream on the shaved dorsal skin and left ear pinna of mice for 7 days. The animals in treatment groups were treated topically with different concentrations of clove oil (CO) (5, 10 and 20%), alone and in combination with flurbiprofen (FBR 5 and 10%), and betamethasone and salicylic acid combination (betasalic® ointment, a standard drug) for the next 7 days. Disease induction and treatment responses were assessed based on modified psoriasis area and severity index (modified PASI) score. On day 15, animals were euthanised, and blood and skin samples were collected for biochemical and histopathological analyses, along with a quantitative assessment of psoriasis-associated inflammatory gene expression using RT-qPCR techniques. Phytochemical tests were performed to detect total tannin, flavonoid, phenolic, and saponin contents of CO. CO 20% and FBR 5% combination and betasalic ointment treatments resulted in a significant (p < 0.05) reduction in erythema, scaling, and skin thickness with an overall modified PASI score of 4.5 ± 0.29 and 4.33 ± 0.33 when compared with the DC group (PASI score = 12 ± 00). Complete blood count analysis revealed a significant reduction (p < 0.05) in total leukocytes, neutrophils, and lymphocytes counts in the CO 20% and FBR 5% combination and betasalic ointment treated groups as compared with DC group. Moreover, a significant decrease in the spleen-to-body weight index (SBWI) was observed in the CO 20% and FBR 5% combination and betasalic ointment treated groups as compared with SBWI of DC group, highlighting the potential immune regulatory properties of CO and FBR. Histopathological analysis of skin tissues revealed a significant improvement in epidermal architecture and a reduction in inflammatory cells infiltration in the treated groups. RT-qPCR analysis revealed down-regulation in the mRNA expression of pro-inflammatory and oxidative stress-inducing genes. Phytochemical analyses confirmed the presence of flavonoids, tannins, phenolic compounds, and saponins in the CO. Overall, these findings suggest that the clove oil-flurbiprofen combination has the potential to reduce skin inflammatory conditions possibly via modulation of oxidative and inflammatory pathways.

PMID 42502130
阅读全文 →
PubMedTrials2026-07-25

The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) trial-rationale for the selected lower steroid dose.

WHO ACTION Trials Collaborators

Antenatal corticosteroids (ACS), most commonly administered as betamethasone or dexamethasone, remain a cornerstone of care for women at risk of preterm birth. However, the standard 24-mg regimen introduced more than five decades ago has not undergone formal dose-finding evaluation. Emerging concerns regarding possible dose-related adverse effects, particularly among late preterm infants subsequently born at term, have renewed interest in optimizing corticosteroid exposure. Experimental data across species, supported by human pharmacokinetic analyses, indicate that fetal lung maturation is driven by sustained low corticosteroid concentrations rather than high peak levels. This commentary summarizes key experimental, pharmacokinetic, and modelling evidence that informed the selection of the lower-dose betamethasone phosphate regimen evaluated in the WHO ACTION-III trial and explains the scientific rationale for this dosing strategy. Pharmacokinetic modeling indicates that 2 mg betamethasone phosphate administered intramuscularly every 12 h for four doses achieves fetal concentrations within the 1 to 4 ng/mL range identified in experimental studies, while avoiding the supratherapeutic peaks observed with conventional regimens. The ACTION-III trial will evaluate whether this lower dose ACS regimen, chosen on the basis of carefully developed models and clinical studies, maintains clinical efficacy while potentially reducing unnecessary systemic corticosteroid exposure in women at risk of late preterm birth.Trial registration: ISRCTN11434567, registered on 7 June 2021.  https://www.isrctn.com/ISRCTN11434567?q=ACTION-III&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10 .

PMID 42498945
阅读全文 →
PubMedExperimental dermatology2026-07-25

Integrated Proteogenomics and Single-Cell Transcriptomics Prioritize Putative Protective Plasma Proteins for Hidradenitis Suppurativa.

Cheng Yuzhe Y, Ma Jingyi J, Niu Jun J

Translating hidradenitis suppurativa (HS) genetic susceptibility into actionable targets remains challenging, as most genome-wide association study loci lie in non-coding regions and tissue-level transcriptomics cannot easily distinguish causal drivers from secondary inflammation. In this study, we aimed to prioritize plasma proteins whose genetically predicted levels are causally associated with HS risk and to localize them within human skin at single-cell resolution. We performed two-sample Mendelian randomization (MR) using cis-pQTL instruments for 2923 plasma proteins from the UK Biobank Pharma Proteomics Project against HS summary statistics from FinnGen R12. Following multiple-testing correction and Bayesian colocalization with a prior-sensitivity grid, the intersection of false-discovery rate (FDR)-significant MR with colocalization evidence (PP.H4 ≥ 0.5) yielded three putative protective candidates: TNFRSF6B (OR = 0.748, 95% CI 0.666-0.840; PP.H4 = 0.648), FCRL2 (OR = 0.896, 95% CI 0.819-0.979; PP.H4 = 0.550), and APOD (OR = 0.789, 95% CI 0.647-0.963; PP.H4 = 0.503). All sensitivity MR tests were concordant. Single-cell transcriptomic analysis localized FCRL2 and APOD to specific cell populations. FCRL2 was predominantly expressed in B cells and NK cells, while APOD showed multi-cellular expression across cornified keratinocytes, macrophages, and dendritic cells. Furthermore, TNFRSF6B was below the skin detection threshold, supporting its biological role as a circulating decoy receptor. Together, our integrated proteogenomic and single-cell approach prioritizes TNFRSF6B, FCRL2, and APOD as putative protective plasma proteins for HS, with TNFRSF6B emerging as the most genetically robust candidate for future translational follow-up.

PMID 42499219
阅读全文 →
PubMedThe Journal of nutrition2026-07-25

Biological mechanisms underlying the cardiovascular effects of branched-chain amino acids: A proteome-wide Mendelian Randomization Study.

Zhang Junmeng J, van Dam Rob M RM, Zhao Jie V JV

Ischemic heart disease (IHD) is the leading cause of morbidity and mortality. Branched-chain amino acids (BCAAs) are associated with higher IHD risk, but the underlying biological pathways remain unclear. This study aims to explore these pathways using two-step proteome-wide Mendelian randomization. We examined the associations between genetic proxies for BCAAs and 2,922 proteins in the UK Biobank Pharma Proteomics Project (UKB-PPP), supplemented by a meta-analysis with data from deCODE to identify proteins associated with BCAAs. Then we tested their effects on IHD risk using CARDIoGRAMplusC4D (122,733 cases, 424,528 controls) and replicated in FinnGen (31,640 cases, 187,152 controls). We conducted sensitivity analyses using genetic instruments from deCODE. Proteins associated with IHD risk and, in a consistent direction, with genetically predicted BCAAs were considered potential mediators. Genetic proxies for BCAAs were associated with 40 proteins. Among these, six proteins showed consistent evidence of mediation, including complement component 1s (C1S), coagulation factor II (F2), granulin (GRN), proprotein convertase subtilisin/kexin type 9 (PCSK9), sex hormone-binding globulin (SHBG) and V-set and transmembrane domain-containing Protein 2 Like (VSTM2L). These proteins are involved in inflammation, coagulation, lipid metabolism and cellular stress response. All associations were robust across different analytical methods and replicated in independent datasets. Mediation analysis showed that these proteins accounted for 6.5% to 32.1% of the association between BCAAs and IHD risk. This study identified six proteins that potentially link BCAAs to IHD, implicating pathways related to inflammation, coagulation, lipid metabolism, and cellular stress responses. These findings provide novel mechanistic insights into the BCAA-IHD relationship and highlight potential protein targets for future prevention and intervention strategies.

PMID 42498029
阅读全文 →
PubMedCureus2026-07-25

Economic Burden and Cost Differences Between Branded and Generic Topical Antifungals in India.

Dt Prateek P, Dongerkery Kavitha K, Deolekar Pradnya P, Dahibhate Atharva A et al.

India's pharmaceutical market is characterized by a significant presence of both generic and branded drugs, particularly for common ailments such as superficial mycoses (SFMs), which pose a substantial public health and economic burden. Patients in tropical countries like India, which have common superficial mycoses, need prolonged treatment because of their recurrence rates after initial treatment and due to incomplete therapy. Given the high variability in drug pricing and the imperative for cost-effective healthcare, a pharmacoeconomic analysis comparing generic and branded topical antifungals in India is crucial to inform prescribing practices and optimize resource allocation. The price comparison of various topical antifungal medications from different brands was conducted by using the latest information from the "Monthly Index of Medical Specialties" August to October 2025, and 1mg online pharmacy and Jan Aushadhi website. The study calculated the total expenses for 30 mL and 30 g dosage forms, which included cream, ointment, lotion, eye drops, and shampoo products of each drug brand. We conducted a comparison between different drug brands through their cost ratio, and percentage cost variation (PCV) analysis was done, keeping generic medicines prices (retrieved from the Jan Aushadhi website) as baseline values. The data analysis showed a significant variation in the costs of different brands of topical antifungals in the Indian market. After analysis, we identified itraconazole 1% ointment to have the highest cost variation at 8335.1%, followed by clotrimazole dusting powder (4740%). Ketoconazole 2% cream, bifonazole 1% lotion, and sertaconazole shampoo showed the smallest variation at 3.29%, 3.5%, and 11.3%, respectively. When generic and branded topical antifungals were compared, the highest cost variation was seen for clotrimazole 1% cream (3431.7%), and the least variation was observed for ketoconazole 2% powder (135.4%). When combination topical antifungals were compared, the highest percentage cost variation of 1479.4% was seen for clotrimazole 1%w/w and beclomethasone dipropionate 0.025%w/w cream, and the least percentage cost variation of 38.8% was seen for terbinafine (1% w/w) + ciprofloxacin (1% w/w) + metronidazole (1% w/w) + clobetasol (0.05% w/w). The market for topical antifungal agents demonstrates substantial price variation among available products. Regulatory authorities, pharmaceutical manufacturers, and clinicians must collaborate to achieve optimal reductions in drug costs. Strict implementation of cost regulation policies, along with increased awareness among clinicians regarding the rational selection of cost-effective therapies, is essential.

PMID 42500790
阅读全文 →
PubMedBiological trace element research2026-07-23

Health and Regulatory Assessment of Hydroquinone, Mercury and Steroids in Skin-Lightening Creams Marketed in Pakistan.

Shujait Mahnoor M, Nawaz Ch M M, Hussain Naqi N

People from all over the world use cosmetics to enhance their physical appearance, seeking social acceptance. Most locally produced skin-lightening creams used in developing countries are a mixture of fat and water applied to the skin surface. These Skin Lightening creams may pose a potential health risk due to their inclusion of various highly toxic active ingredients like hydroquinone, mercury, and steroids. This study quantifies the levels of these toxic substances in ten commonly used SLC brands in Pakistan and their associated health risks in samples marketed in Lahore. To determine the concentration levels of various ingredients, including hydroquinone, steroids (Betamethasone, Dexamethasone, Hydrocortisone, and Prednisolone), and mercury, high-performance liquid chromatography, ultra violet- high-performance liquid chromatography, and a direct mercury analyzer were used, respectively. Health risks were assessed by calculating Chronic Daily Intake (CDI) and Hazard Quotient (HQ). Results showed that some samples exceeded international limits for hydroquinone (up to 5.56%) and mercury (up to 4.9 ppm), surpassing U.S Food and Drug Administration (USFDA), Pakistan Standards and Quality Control Authority (PSQCA), and World Health Organization (WHO) standards. The analysis also revealed undeclared corticosteroids in several samples: betamethasone (0.6-1.8% in 30% of samples), dexamethasone (1.4-6.4% in 20% of samples), hydrocortisone (0.4-8.5% in 50% of samples), and prednisolone (0.3-1.6% in 30% of samples). These findings suggest the need for improved regulatory enforcement in developing countries along with enhanced monitoring of Pakistan's cosmetic industry to effectively protect public health from the cumulative toxicity of hydroquinone, mercury, and corticosteroids.

PMID 42487054
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多betamethasone dipropionate