ibuprofen (ibuprofen, Diffutab)

Paediatric Posterior Reversible Encephalopathy Syndrome (PRES) Induced by Ibuprofen Intake: A Case Report.

Bargiacchi Giuditta G, De Marco Oriana O, Petruzzelli Luigi Annicchiarico LA, Tucci Celeste C et al.

Disseminated meningococcal infection presenting with constrictive pericarditis and bilateral septic arthritis without meningitis: A case report.

Binidris Mutasim M, Shehata Menatalla M, Mahfouz Ahmed A, Abousaad Omar O et al.

Invasive meningococcal disease is a life-threatening infection that classically presents as meningitis or meningococcemia. Extra-meningeal manifestations, including pericarditis and septic arthritis, are uncommon and may complicate diagnosis, particularly in the absence of meningeal involvement. A previously healthy vaccinated man in his 50s presented with acute bilateral knee pain and swelling following a short history of fever, productive cough, fatigue, and dyspnea. Blood cultures grew Neisseria meningitidis serogroup W, whereas cerebrospinal fluid, synovial fluid, and pericardial fluid cultures remained negative. Cardiac magnetic resonance imaging demonstrated constrictive pericarditis with circumferential pericardial enhancement and pericardial effusion. The patient was successfully treated with intravenous ceftriaxone, colchicine, ibuprofen, pericardiocentesis, and bilateral knee washout, followed by oral ciprofloxacin. This case adds to the limited literature describing concurrent cardiac and musculoskeletal manifestations of invasive meningococcal disease without meningitis and shows the importance of early recognition, comprehensive investigation and multidisciplinary management of these uncommon presentations.

Detection of Crystalline Ibuprofen Components in Ibuprofen-Loaded SBA-15 Mesoporous Silica Using Time-Domain NMR.

Kobayashi Madoka M, Kato Fumitaka F, Okada Kotaro K

The present study evaluated the applicability of time-domain NMR (TD-NMR) for detecting crystalline ibuprofen components in ibuprofen-loaded mesoporous silica. Ibuprofen-loaded mesoporous silica samples with different drug loadings were prepared, and the physical state of ibuprofen was characterized by nitrogen adsorption, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), 13C solid-state NMR spectroscopy, and TD-NMR relaxation measurements. PXRD, DSC, and 13C solid-state NMR spectroscopy did not clearly detect crystalline ibuprofen in samples with ibuprofen loadings of 10-30%. By contrast, crystalline components were observed in samples with loadings of 40% or higher. These crystalline components were considered to originate predominantly from excess ibuprofen that crystallized outside the mesopores. In the T1 relaxation analysis using TD-NMR, IBU10-30 was mainly described by a monoexponential function, whereas IBU40-70 required a biexponential function, yielding a long T1 component associated with crystalline ibuprofen. In the T2 relaxation analysis, IBU40-70 exhibited an initial rapid decay that was described by a Gaussian function, whereas IBU10-30 showed a gradual exponential decay. The signal proportions of these NMR relaxation components increased with increasing ibuprofen loading and showed trends consistent with the apparent crystallinity estimated by DSC. These results suggest that TD-NMR, particularly T2 relaxation analysis, may serve as a complementary, nondestructive, and rapid method for evaluating the appearance and increase of crystalline ibuprofen components in mesoporous silica formulations and for monitoring changes in crystallinity.

Structure-driven photocatalytic degradation pathways of organic contaminants of emerging concern over TiO₂/CeO₂/g-C₃N₄: A molecular reactivity and life cycle perspective.

Puri Aarti A, Pant Kamal Kishore KK, Das Diganta Bhusan DB, Srivastava Vimal Chandra VC

Organic contaminants of emerging concern (OCECs) exhibit diverse molecular structures that critically determine their environmental persistence and degradation pathways. Most photocatalysis research remains focused on catalyst design, with limited mechanistic interpretation at the molecular level. Herein, we investigate structure-reactivity-sustainability relationships in visible-light-driven photocatalytic degradation of indigo carmine (IC), tetracycline (TTC), and ibuprofen (IBU) using a recyclable TiO₂/CeO₂/g-C₃N₄ (TiCe-gCN) heterojunction photocatalyst. The ternary composite exhibited enhanced activity and stability attributed to superior charge separation. Degradation kinetics followed pseudo-first-order behavior with rate constants in the order IC (0.0397 min⁻¹) > TTC (0.0215 min⁻¹) > IBU (0.0157 min⁻¹), reflecting intrinsic molecular reactivity differences. Mechanistic interpretation was achieved by coupling LC-MS transformation product analysis with DFT-derived descriptors including condensed Fukui indices, electrostatic potential maps, and HOMO-LUMO energy gaps. The analysis revealed distinct structure-dependent degradation behaviors: IC exhibited delocalized radical susceptibility facilitating rapid oxidative bond cleavage; TTC displayed localized reactivity leading to sequential hydroxylation and ring-opening; and IBU showed localized radical accessibility at benzylic positions promoting oxidative dealkylation. This is further strengthened using EPR spin-trapping experiments, providing evidence on the charge carrier and reactive species that participate in the photocatalytic process. Beyond degradation performance, life cycle assessment (LCA) was conducted to evaluate the environmental sustainability of the TiCe-gCN system, identifying electricity consumption during catalyst synthesis as the dominant burden across all impact categories. Projected grid decarbonization could reduce global warming potential (GWP) by 54.9% by 2040, highlighting the critical role of energy infrastructure in determining the sustainability of photocatalytic water treatment.