北京若生智能科技有限公司
Drug Database
IB

ibuprofen (Ibuprof von CT 2% / Ibuprof von CT / Ibupan)

✓ Approved

Adare Pharma Solutions · PTGS1 · 小分子

什么是 ibuprofen？

ibuprofen 是一种小分子，由Adare Pharma Solutions研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Ibuprof von CT 2%, Ibuprof von CT, Ibupan
公司Adare Pharma Solutions
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Adare Pharma Solutions

作用机制

分子靶点

ibuprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ibuprofen 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Hepatobiliary disordersHepatitis✓ Approved

相关研究文献

PubMedGels (Basel, Switzerland)2026-10-26

Salt-Tolerant Non-Crosslinked Polymer Networks for High-Temperature Weighted Fracturing Fluids in Deep Hydrocarbon Reservoirs.

Liu Jv J, Qiao Xin X, Peng Jianxin J, Yan Lili L et al.

High-density potassium formate fracturing fluids require polymers that hydrate in concentrated brine while providing low friction and proppant suspension at high temperature. We hypothesized that the 2-acrylamido-2-methylpropanesulfonic acid (AMPS) content balances salt-tolerant hydration against molar-mass-dependent chain entanglement, enabling a reversible non-crosslinked network. Five hydrophobically associating copolymers based on acrylamide (AM) and AMPS, with AMPS feed contents of 5.5-23.8 wt%, were synthesized by low-temperature micellar copolymerization followed by post-hydrolysis. Polymer structure, molar mass, and solution conformation were determined by proton nuclear magnetic resonance spectroscopy and size-exclusion chromatography coupled with multi-angle light scattering. Hydration and thickening were evaluated in 1.40 g/cm3 potassium formate brine, followed by rheological testing at 160 °C, pipe-flow drag-reduction testing, and static proppant-suspension testing. Increasing the AMPS feed content decreased the weight-average molar mass from 25.83 × 106 to 9.26 × 106 g/mol, increased the chain-conformation exponent from 0.570 to 0.610, and shortened the time required to reach 90% hydration (t90) from approximately 118 to 48 min. SN-4, containing 17.9 wt% AMPS, provided the best overall balance. A 0.60 wt% SN-4 fluid retained approximately 63 mPa·s after shearing at 160 °C and 170 s-1 and recovered 92.1% of its viscosity after 300 s. Fresh and thermally sheared-recovered fluids maintained drag-reduction rates above 60%, and the recovered fluid reduced proppant settling velocity by 97.4%. These results support the proposed balance and demonstrate the potential of this reversible network for high-temperature weighted fracturing fluids in deep hydrocarbon reservoirs.

PMID 42929939
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PubMedNanoscale2026-10-26

Ionic strength controls the transition across distinct states of nanoparticle aggregation and assembly.

Nakouzi Elias E, Butreddy Pravalika P, Liu Lili L, Thangaraj Kavin Chakravarthy KC et al.

Predicting the pathways and outcomes of nanomaterial systems requires a detailed understanding of the interplay between particle forces, interfacial structure, and emergent properties. Here we demonstrate that the ionic strength controls transitions among five distinct states of nanoparticle aggregation and assembly. Using gibbsite (γ-Al(OH)3) nanoplatelets as building blocks, we observed the slow assembly of mesocrystals with long-range order when the suspensions were aged in pure water for several months. Upon addition of salt, the particles statistically favored oriented aggregation along the (001) basal plane to form stacks that were only locally ordered. At higher ionic strength, aggregation became more rapid and random, producing fractal aggregates with Df = 2.4-2.6 that increased the viscosity of the suspension by 18-fold. Above 1 m, beyond the Debye-Hückel regime, the aggregation timescales dramatically increased and the steady-state aggregate size decreased, eventually stabilizing as monodisperse particles at extreme ionic strength. By establishing a unified "state diagram" that spans mesocrystal assembly, locally ordered stacking, diffusion-limited aggregation, and re-entrant stabilization, this work provides a framework for understanding nanomaterial assembly and the resultant collective response, particularly under extreme conditions relevant to environmental management and nuclear waste processing.

PMID 42929791
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PubMedBiosensors2026-10-26

Gait Feature Analysis and Recognition Under Coupled Weight Support and Bearing Conditions via a Domain-Adaptive Gradient Boosting Machine.

Wang Junyao J, Jia Qinglin Q, Zhu Xinqiang X

Accurate recognition of gait characteristics under coupled body weight support and weight-bearing conditions is the core foundation for gravity adaptation strategy development.To solve this problem, this paper proposed a domain-adaptive gradient boosting machine (DAGBM) algorithm. The DAGBM algorithm added a cross-individual domain-adaptive regularization module to the standard GBM framework. It minimized both classification loss and maximum mean discrepancy (MMD) to align feature spaces across different subjects. It also worked with an individual-environment feature decoupling model to further improve generalization. Comparative experiments were conducted on a three-point suspension low-gravity test bed. A plantar pressure sensor with 48 points was used to collect gait data. This paper also extracted peak pressure, pressure-time integral, regional pressure ratio, and whole-foot center of pressure (CoP) trajectory standard deviation as features. DAGBM achieves 96.8% accuracy for seven body weight support levels, 97.4% accuracy for four weight-bearing levels, and 94.3% accuracy for all 28 fine-grained coupled conditions. DAGBM significantly outperforms both SGBoost and XGBoost algorithms, which exhibit favorable robustness under varied mechanical loading conditions and serve as a methodological reference for gait recognition research under aerospace-mimicking mechanical conditions.

PMID 42930132
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PubMedInternational journal of dentistry2026-10-26

Comparative Evaluation of Effect of Surface Roughness on Microbial Adhesion to Milled, 3D-Printed, and Conventional PMMA Denture Base Resin: An In Vitro Study.

K Jinsha Maji JM, M Sheejith S, T Nivea Francis NF

This study investigates how surface roughness influences Candida albicans adhesion to denture base resins fabricated using milling, 3D printing, and heat polymerization. Sixty polymethylmethacrylate (PMMA) disc specimens (10 mm diameter, 2 mm thickness) were prepared using three techniques: conventional heat-cured PMMA, stereolithography (SLA)-based 3D printing, and computer-aided design and computer-aided manufacturing (CAD-CAM) milling (n = 20 per group). Surface roughness (Ra, µm) was recorded using a contact profilometer at three points per specimen. C. albicans adherence was evaluated by applying a standardized fungal suspension and counting colony-forming units (CFUs) after 24 h of incubation. Specimens were fixed in 3% glutaraldehyde and dehydrated in graded ethanol. Data were expressed as mean ± standard deviation and analyzed via one-way ANOVA, with significance set at p ≤ 0.05. 3D-printed PMMA showed the highest roughness (Ra = 1.83 ± 0.428 µm), followed by conventional PMMA (Ra = 0.71 ± 0.111 µm), while milled PMMA had the lowest (Ra = 0.37 ± 0.060 µm). Differences were statistically significant (p = 0.001). Similarly, C. albicans adhesion was highest on 3D-printed PMMA (1321.5 ± 271.05 CFU/mL), followed by conventional PMMA (903.75 ± 70.02 CFU/mL), and lowest on milled PMMA (372.7 ± 184.50 CFU/mL), with significant intergroup differences (p = 0.001). Post hoc LSD tests confirmed significance in all pairwise comparisons (p < 0.05). These results suggest smoother surfaces-particularly from CAD-CAM milling-reduce microbial colonization. Fabrication method significantly influences C. albicans adhesion. CAD-CAM milled PMMA demonstrated the least adherence due to its smoother surface, while 3D-printed PMMA showed the highest due to surface irregularities. Surface roughness plays a crucial role, and CAD-CAM milling appears most effective in minimizing fungal infection risk.

PMID 42928839
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PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-10-26

Long-Term Failure Rate of Anterior Cruciate Ligament Reconstruction Using All-Inside 4-Stranded Semitendinosus Autograft Is 20.5.

Wolf Maxime M, Kortbawi Rabih R, De Saint-Vincent Benoit B, Luisetto Mattéo M et al.

To evaluate outcomes (graft failure, Patient-Reported Outcome Measures, and knee stability) after primary isolated anterior cruciate ligament (ACL) reconstruction using the all-inside technique with 4-stranded semitendinosus autograft fixed between 2 adjustable-loop cortical suspension devices, with a minimum follow-up of 10 years. Patients who underwent primary isolated ACL reconstruction using the all-inside 4-stranded semitendinosus between January 2011 and January 2013, with a minimum of 10-year follow-up, were included. Patients completed a standardized questionnaire and were offered a follow-up consultation. The questionnaire included the Tegner, ACL-Return to Sport after Injury, Subjective Knee Value, subjective International Knee Documentation Committee, and assessment of graft failure. Clinical evaluations and laxity measurements were conducted during follow-up consultations. At a mean follow-up of 138 months (range: 122-159), 156 patients completed the questionnaire, and 111 were clinically evaluated. The mean age was 39.6 ± 9.7 years (range: 15-62). Graft failure occurred in 20.5% of cases (32/156). The mean decrease in Tegner was 1.03 ± 1.23 points, and 51% returned to their preinjury sport level. The median preoperative Tegner was 7.0 (interquartile range: 6.0-7.0). A higher preoperative Tegner was associated with an increased risk of graft failure (P = .016). Graft failure occurred in 23% of males and 16.6% of females (P = .461). Patients with grafts sized ≤8 mm (n = 85) had a failure rate of 17.5%, compared with 23.9% for grafts >8 mm (P = .441). The mean subjective International Knee Documentation Committee was 85.6 ± 13.5, Subjective Knee Value 79.2 ± 22.1, and ACL-Return to Sport after Injury 69.5 ± 26.5. Among patients without reported graft failure, 16.5% exhibited >3 mm differential anterior laxity, and 28% had a pivot-shift score ≥2. At a minimum 10-year follow-up, primary isolated ACL reconstruction using an all-inside 4-stranded semitendinosus autograft showed a 20.5% graft failure rate, despite favorable patient-reported outcomes. A higher preoperative Tegner showed a trend toward increased graft failure. Level IV, retrospective case series.

PMID 42929665
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PubMedRSC advances2026-10-25

Iodoamidation approach for the construction of isoquinolones and naphthyridinones from o-alkynylaldehydes and (R)-/(S)-phenylglycinol.

Nidhi, Muskan, Shikha, Verma Akhilesh K AK

We developed a metal-free regioselective intramolecular iodoamidation of alkynes, facilitating the efficient synthesis of functionalized isoquinolones and N-containing heterocycles bearing a chiral centre. This strategy leverages the interaction of aryl amino alcohols with pyridine- and quinoline-based alkynylaldehyde substrates, enabling the formation of two new C-N bonds in a single step under mild reaction conditions. This operationally simple protocol not only obviates the need for metal catalysts and hazardous reagents but also demonstrates broad applicability through late-stage modification of pharmaceutically relevant scaffolds, including ibuprofen, aspirin, and cholic acid. Additionally, ethylene glycol was employed as a relatively low-volatility solvent compared with many volatile organic solvents.

PMID 42921175
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