Adare Pharma Solutions · PTGS1 · 小分子
ibuprofen 是一种小分子，由Adare Pharma Solutions研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。
| 商品名 | Ibuprof von CT 2%, Ibuprof von CT, Ibupan |
| 公司 | Adare Pharma Solutions |
| 药物类别 | 小分子 |
| 分子靶点 | PTGS1, PTGS2 |
| 给药途径 | Oral (PO) |
| 状态 | Approved |
ibuprofen 作用于 2 个分子靶点：
| PTGS1 | prostaglandin-endoperoxide synthase 1 (COX3, PCOX1) |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2) |
ibuprofen 针对 2 个适应症，涉及 2 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Gastrointestinal disorders | Abdominal pain | ✓ Approved |
| Hepatobiliary disorders | Hepatitis | ✓ Approved |
Bargiacchi Giuditta G, De Marco Oriana O, Petruzzelli Luigi Annicchiarico LA, Tucci Celeste C et al.
Cross Claire E CE, Brockman Asa A AA, Ihrie Rebecca A RA, Irish Jonathan M JM
Suspension flow cytometry enables high-throughput cellular profiling at the single cell level, but these data lack positional information. Conversely, tissue-based imaging cytometry techniques reveal a cell's location within the tissue architecture and can provide insight into cell biology. It would be especially valuable if data analysis tools could incorporate data from imaging and flow cytometry platforms to gain complementary strengths when quantifying features of cells and populations. We hypothesized that per-cell Marker Enrichment Modeling (MEM) might provide a way to register cells between flow and imaging cytometry analysis. Here, we developed the Velociraptor machine learning workflow for cross-platform cytometry analysis. Velociraptor begins with a graph-based implementation of MEM to calculate per-cell quantitative phenotype labels. With this information, Velociraptor can then quickly calculate similarity between each cell's phenotype and search terms describing established cell types, cells of interest, or cells observed in other samples. Velociraptor was effective in registering cells within and between cytometry platforms. Integrated identification of cell populations was tested in several challenges, including comparisons of high dimensional datasets from cancer and immunology. Tested instrument types included imaging mass cytometry (IMC), cyclic immunohistochemistry (cycIHC), suspension mass cytometry (CyTOF), and suspension spectral flow cytometry (SFC). Between IMC and CyTOF, a comparison across imaging and flow cytometry platforms that use the same mass tag probes, Velociraptor accurately identified and registered immune cell types (median F1-measure of 0.81). Between SFC and CyTOF, a comparison of two fundamentally different probe types-fluorophores and metal tags-in suspension flow cytometry, Velociraptor was even more accurate at identifying and registering cells (concordance correlation coefficient of 0.99). Velociraptor was especially useful in heterogeneous samples where individual cells diverged in phenotype from the bulk population. In IMC imaging of human breast cancer, a previously unappreciated tumor cell subset was revealed by Velociraptor, characterized as CD15+, and validated as spatially segregated to the tumor core. In both cycIHC (8-dimensional imaging) and IMC imaging (40-dimensional imaging), Velociraptor accurately identified macrophages using a single search label as input. Notably, Velociraptor worked effectively with both extremely rare and highly abundant cell types and with cell search labels calculated from data and theoretical labels based on literature and expertise. The Velociraptor algorithm is freely available at https://github.com/cytolab.
Binidris Mutasim M, Shehata Menatalla M, Mahfouz Ahmed A, Abousaad Omar O et al.
Invasive meningococcal disease is a life-threatening infection that classically presents as meningitis or meningococcemia. Extra-meningeal manifestations, including pericarditis and septic arthritis, are uncommon and may complicate diagnosis, particularly in the absence of meningeal involvement. A previously healthy vaccinated man in his 50s presented with acute bilateral knee pain and swelling following a short history of fever, productive cough, fatigue, and dyspnea. Blood cultures grew Neisseria meningitidis serogroup W, whereas cerebrospinal fluid, synovial fluid, and pericardial fluid cultures remained negative. Cardiac magnetic resonance imaging demonstrated constrictive pericarditis with circumferential pericardial enhancement and pericardial effusion. The patient was successfully treated with intravenous ceftriaxone, colchicine, ibuprofen, pericardiocentesis, and bilateral knee washout, followed by oral ciprofloxacin. This case adds to the limited literature describing concurrent cardiac and musculoskeletal manifestations of invasive meningococcal disease without meningitis and shows the importance of early recognition, comprehensive investigation and multidisciplinary management of these uncommon presentations.
Shahed Talat Mahmud TM, Shuohan Fang F, Su Jing J, Du Changsen C et al.
In modern times, there has been a strong interest in the synthesis of latex particles for futuristic polymer colloid dispersion in the growth of the nanotechnology industry. Functional color latexes (FCL) are synthetic polymer suspension carriers for coloring moieties, with precisely tuned material behavior and properties to suit a particular purpose, attributed to the incorporation of selective functional groups or molecules. Various color latexes have been developed using delicate polymerization techniques such as miniemulsion, microemulsion, suspension, reversible addition-fragmentation chain transfer, and in situ, endowing FCLs with indoor formaldehyde-CO2 removal, antimicrobial activity, self-healing, structural color, anticounterfeiting, rewritable ability, fluorescence, self-cleaning, UV protection, and thermal stability beyond chromatic performance. Over the past few decades, FCL deposition technologies on numerous substrates have enabled widespread applications in smart textiles, flexible electronics, structurally colored coatings, packaging, and functional printing. The present study provides a comprehensive analysis of FCLs' improvement in the borderless application field and their association with synthesis-modification strategies, with attention to their role in intensifying ink properties and empowering digital printing pathways. Future perspectives are concluded by optimizing particle design and determining the appropriate synthesis method to enable feasible production of high-performance latex inks.
Zavaleta-Ruiz Jose L JL, Major Matthew J MJ, Pankaj Pankaj P
Deterioration of bone mineral density (BMD) in the residual femur after a transfemoral amputation (TFA) has been reported over the past five decades, with various potential explanations described in the literature. BMD loss is a critical risk factor of fracture and hence an important clinical concern for prosthesis users. This scoping review audited in vivo imaging studies that focused on BMD in individuals with TFA, with the aim to synthesize the status of knowledge on this topic, report on the mechanisms related to BMD status as hypothesized in the reviewed literature, and review BMD outcomes separately for prosthetic socket and bone-anchored suspension. Three databases (Scopus, PubMed, and Web of Science) were searched on December 1, 2024. Search keywords covered terms that reference bone mineralization (BMD, osteopenia, and osteoporosis) and TFA. Data were extracted for analysis and grouped according to reported prosthesis suspension for analysis. In total, 244 articles were screened, with 20 ultimately reviewed. Articles were published between 1969 and 2024. Fourteen articles reported the use of socket prosthesis and six used bone-anchored devices. The former group consistently reported BMD loss, while the latter presented maintenance or improvements. The socket prosthesis cohort was younger in age compared to bone anchored (range 24-73 vs. 47-58 years). Proposed reasons for BMD loss included disuse atrophy, bedrest post-surgery, gait asymmetry, and prosthesis influence. Articles reporting BMD status using socket prosthesis consistently reported demineralization despite interventions, with no consensus on the mechanical cause of BMD loss. Further, the bone-anchored group tended to demonstrate improvements in limb loading symmetry during ambulation and higher levels of bone loading compared to prosthetic socket use. The residual femur in persons with TFA has demonstrated bone demineralization, which appears to be less prevalent in bone-anchored devices compared to socket use. These findings warrant further analysis of the effects of prosthetic socket use on bone demineralization in persons with TFA.
Zhang Hanfu H, Wang Zihao Z, Yang Zhaoqing Z
Vero cells remain an indispensable continuous substrate for human viral vaccine manufacturing. Despite decades of empirical process optimization, intrinsic genomic instability, including segmental aneuploidy and dynamic chromatin rearrangements, continues to limit the durability of engineered phenotypes under sustained viral burden and bioreactor stress. Here, we review the expanding engineering toolkit for the Vero lineage across a three-layered functional framework: the membrane interface, cytoplasmic foundry, and nuclear blueprint, evaluating translational prospects at each level. Receptor transplantation and morphological reprogramming have broadened viral entry range and enabled suspension-adapted culture formats, while metabolic flux management and temporally controlled apoptosis modulation have addressed intracellular production bottlenecks, albeit often with trade-offs between productivity, biosafety, and long-term population stability. At the genomic level, targeted perturbations of transcriptional regulators and emerging epigenetic interventions offer more durable gains, yet expression drift, clonal heterogeneity, and karyotypic instability during extended passaging highlight the need for locus-level precision rather than constitutive trait installation. Looking forward, infection-responsive dynamic logic circuits and the systematic identification of Vero-specific genomic safe harbors could shift the paradigm toward a conditionally responsive manufacturing architecture. Collectively, these advances suggest a pathway for transitioning the Vero lineage from a passive, empirically optimized biological substrate into a conditionally responsive, genomically stable, and programmable platform for modern vaccine preparedness.
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