北京若生智能科技有限公司
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piperacillin (piperacillin, KRKA / Isipen)

✓ Approved

Krka · 小分子 · 小分子

什么是 piperacillin？

piperacillin 是一种小分子，由Krka研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名piperacillin, KRKA, Isipen
公司Krka
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Krka

治疗适应症

piperacillin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedBiomedical reports2026-09-10

Metagenomic next-generation sequencing contributes to the diagnosis of Gardnerella vaginalis bacteremia associated with a rare extragenital infection and diagnostic challenges in a 13-year-old female patient: A case report.

Li Xiao X, Wang Jue J, Liu Feng-Wei FW, Yang Ting-Ting TT et al.

Gardnerella vaginalis (G. vaginalis) is a well-recognized cause of bacterial vaginosis but is rarely associated with extragenital infections, particularly in individuals without a history of sexual activity. Metagenomic next-generation sequencing (mNGS) enables unbiased detection of pathogens and has emerged as a valuable diagnostic approach for challenging infectious diseases. The current report outlines a case of G. vaginalis bacteremia in a 13-year-old female patient presenting with fever and acute bronchitis. Peripheral blood mNGS, combined with conventional microbiological investigations, was performed to identify the causative pathogen. Initial empirical treatment with piperacillin-tazobactam and azithromycin failed to control the recurrent fever. Traditional cultures of blood, cerebrospinal fluid and bone marrow aspirate all returned negative results, whereas peripheral blood mNGS identified G. vaginalis as the potential pathogen. Following targeted therapy with metronidazole for 3 days, the patient's body temperature returned to normal, and follow-up blood mNGS at discharge was negative for the pathogen. Due to its fastidious growth requirements, G. vaginalis is difficult to detect using conventional culture methods, which may lead to delayed diagnosis and false-negative results. The present case highlights the utility of mNGS for timely and accurate pathogen identification in diagnostically challenging infections. The current case also broadens the recognized clinical spectrum of G. vaginalis infections by demonstrating its potential to cause bloodstream infection with persistent fever in an adolescent without a reported history of sexual activity.

PMID 42719063
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PubMedHuman vaccines & immunotherapeutics2026-09-09

Sintilimab‑related cystitis/ureteritis in high‑grade endometrial stromal sarcoma: A case report and structured literature review.

Yang Shuhan S, Gao Ruike R, Li Daorui D, Shi Wenguang W et al.

Immune checkpoint inhibitors (ICIs) are cutting‑edge therapies in cancer treatment; however, they may trigger unique immune‑related adverse events (irAEs). Although irAEs can affect various organs, ICI‑induced cystitis/ureteritis has rarely been reported. We present a 44‑year‑old female patient with high‑grade endometrial stromal sarcoma who developed severe urinary frequency, urgency, and dysuria after three cycles of sintilimab combined with nab‑paclitaxel and carboplatin. Empirical antibiotic therapy failed to relieve her symptoms. Imaging revealed diffuse thickening of the bladder and ureteral walls with marked peri‑vesical and peri‑ureteral exudation. After treatment with methylprednisolone, the patient's symptoms improved dramatically. A subsequent urine culture grew Enterococcus faecalis, and the addition of piperacillin-tazobactam resulted in further symptom resolution. Following symptom resolution, she was rechallenged with sintilimab and developed only mild urinary tract symptoms. Subsequently, due to disease progression, treatment was switched to tislelizumab, and the urinary symptoms did not recur. The patient's urinary symptoms were sintilimab‑related cystitis/ureteritis with possible concomitant or partially suppressed bacterial infection. This case, together with a structured literature review of other immunotherapy‑related cystitis/ureteritis cases and subsequent ICI use, provides a practical reference for the diagnosis and management of ICI‑related urological irAEs and for subsequent anti‑tumor treatment.

PMID 42714310
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PubMedFrontiers in pharmacology2026-09-08

Construction and external validation of an early warning model for piperacillin/tazobactam-associated hypokalemia in critically ill patients.

Wang Yuan-Min YM, Zhao Fu-Kun FK, Ou-Yang Cang-Hong CH, Zhu Rong-Ping RP et al.

Hypokalemia is a common adverse event during piperacillin/tazobactam (TZP) therapy in critically ill patients. This study developed and externally validated machine learning models to predict hypokalemia using baseline variables. Data were obtained from the Medical Information Mart for Intensive Care (MIMIC)-IV database and an external cohort from the Third Affiliated Hospital of Zunyi Medical University. Hypokalemia was defined as the first serum potassium <3.5 mmol/L within 14 days after TZP initiation. Variables with >20% missing data were excluded; remaining missing values were imputed. Least Absolute Shrinkage and Selection Operator (LASSO) regression with 10-fold cross-validation based on binomial deviance was used for feature selection. Logistic Regression, Random Forest, Extreme Gradient Boosting Model (XGBoost), Adaptive Boosting (AdaBoost), and Gradient Boosting Machine models were developed. Performance was assessed with receiver operating characteristic curves, the area under the receiver operating characteristic curve (AUC), the area under the precision-recall curve (AUPRC), calibration, precision-recall analysis, and decision curve analysis. The internal cohort included 1,345 patients (594 hypokalemia), and the external cohort included 421 patients (159 hypokalemia). Internal AUCs were 0.759 (Random Forest), 0.738 (GBM), 0.735 (XGBoost), 0.716 (AdaBoost), and 0.694 (Logistic Regression). External AUCs were 0.668 (GBM), 0.654 (XGBoost), 0.648 (Random Forest), 0.645 (AdaBoost), and 0.620 (Logistic Regression). The Random Forest model achieved an AUPRC of 0.701 in the internal cohort, while GBM achieved the highest AUPRC in the external cohort (0.554). Calibration and decision curve analyses demonstrated acceptable agreement and potential clinical utility. SHapley Additive exPlanations (SHAP) analysis identified baseline potassium, potassium-wasting diuretic use, serum creatinine, age, renal disease, serum sodium, and albumin as the most influential predictors of TZP-associated hypokalemia. Machine learning models achieved moderate predictive performance. Baseline potassium and potassium-wasting diuretic use were the strongest predictors.

PMID 42707308
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PubMedCureus2026-09-08

Unusual Indirect Transmission of Pasteurella multocida Causing Bacteremia in an Immunocompetent Patient.

Kamatam Sravani S, Mogulla Swathi S, Bathina Bindu B, Roy Ashish K AK et al.

Pasteurella multocida is a gram-negative coccobacillus commonly found in the oral and respiratory flora of cats and dogs. Human infection typically occurs following animal bites or scratches and most commonly presents as skin and soft tissue infection. Respiratory infections and bacteremia are less common and are usually reported in elderly or immunocompromised individuals. We present a case of a previously healthy male with a one-week history of fever, nonproductive cough, fatigue, myalgias, chills, and generalized weakness. Workup revealed left lower lobe pneumonia and Pasteurella bacteremia. Further history revealed ownership of a household cat and routine cleaning of the cat's feeding dishes with the same cloth used for personal dishes, representing a possible route of indirect exposure. The patient was treated with intravenous piperacillin-tazobactam followed by oral trimethoprim-sulfamethoxazole, with subsequent clearance of bacteremia and complete radiographic resolution of pneumonia. Pasteurella infections are most associated with animal bites and scratches; however, non-bite transmission through animal saliva and contaminated fomites has been reported. Pneumonia with bacteremia is an uncommon manifestation, particularly in young immunocompetent hosts. This case highlights an unusual presentation of Pasteurella multocida bacteremic pneumonia in a healthy young adult and underscores the importance of obtaining a detailed animal exposure history, including indirect exposures, when evaluating patients with invasive Pasteurella infections.

PMID 42708089
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PubMedInfection and drug resistance2026-09-07

Late-Onset Sepsis and Meningitis Caused by Elizabethkingia meningoseptica: A Case Report.

Liao Shasha S, Qiu Shaoling S, Li Na N, Liu Yunyuan Y et al.

Elizabethkingia meningoseptica is a gram-negative bacillus. Increasing body of literature shows that opportunistic infections may be caused by this Gram negative bacillus in immunocompromised adults and neonates. We describe a case of a preterm neonate born at 33 weeks of gestation who presented with fever and reluctance to feed for two days at one month after birth. Initial laboratory tests of blood and cerebrospinal fluid cultures showed evidence of late-onset sepsis and meningitis caused by E. meningoseptica, which was sensitive to piperacillin/tazobactam, cefoperazone/sulbactam, trimethoprim/sulfamethoxazole, levofloxacin, and minocycline. The neonate underwent sequential anti-infective therapy regimens consisting of: 1) cefoperazone/sulbactam (2:1) in combination with levofloxacin; 2) cefoperazone/sulbactam (2:1) paired with rifampicin; and 3) linezolid administered concomitantly with rifampicin. The neonate exhibited clinical manifestations of ventricular dilatation accompanied by hydrocephalus. The neonate received an 85-day course of anti-infective treatment during hospitalization. Follow-up cranial computed tomography (CT) imaging performed four months post-discharge demonstrated complete resolution of the previously observed complications.

PMID 42703557
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PubMedJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy2026-09-07

Catheter salvage with antibiotic lock therapy for central venous port infection due to Pseudoxanthomonas sp. in a child with hemophilia B.

Akazawa Hidemasa H, Fukushima Shinnosuke S, Nakamoto Kenta K, Tsuji Shuma S et al.

Catheter-related bloodstream infections (CRBSIs) generally necessitate prompt catheter removal, which poses significant hemorrhagic risks in patients with hemophilia. Consequently, catheter salvage utilizing antibiotic lock therapy (ALT) serves as a critical adjunctive strategy. We describe an exceptionally rare case of CRBSI caused by Pseudoxanthomonas sp., an environmental Gram-negative bacillus, and its successful management. A 4-year-old boy with severe hemophilia B developed persistent bacteremia originating from an implanted central venous access port. The pathogen was identified as Pseudoxanthomonas sp. utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene sequencing. Catheter removal was deemed high-risk due to the patient's underlying hemophilia B and associated risk of major bleeding. Therefore, a catheter salvage strategy was pursued through a combination of systemic antimicrobial therapy and ALT. The patient received systemic antibiotics, adapting through piperacillin/tazobactam, ceftazidime, and trimethoprim-sulfamethoxazole. ALT was administered concurrently, initially using a ceftazidime-heparin lock solution, and later transitioning to a ciprofloxacin-heparin lock following an episode of suspected drug fever. Despite initial persistent bacteremia, this dual approach effectively eradicated the intraluminal infection. The central venous port was successfully retained with no recurrence observed over four months post-therapy. Systemic antimicrobial therapy combined with ALT can be an effective catheter-preserving strategy for high-risk patients with device-related infections caused by rare environmental non-fermenting Gram-negative organisms such as Pseudoxanthomonas sp.

PMID 42705605
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